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Adenovirus vector-based vaccine for infectious diseases
Open accessAbstract
Replication-incompetent adenovirus (Ad) vectors have been widely used as gene delivery vehicles in both gene therapy studies and basic studies for gene function analysis due to their highly advantageous properties, which include high transduction efficiencies, relatively large capacities for transgenes, and high titer production. In addition, Ad vectors induce moderate levels of innate immunity and have relatively high thermostability, making them very attractive as potential vaccine vectors. Accordingly, it is anticipated that Ad vectors will be used in vaccines for the prevention of infectious diseases, including Ebola virus disease and acquired immune deficiency syndrome (AIDS). Much attention is currently focused on the potential use of an Ad vector vaccine for coronavirus disease 2019 (COVID-19). In this review, we describe the basic properties of an Ad vector, Ad vector-induced innate immunity and immune responses to Ad vector-produced transgene products. Development of novel Ad vectors which can overcome the drawbacks of conventional Ad vector vaccines and clinical application of Ad vector vaccines to several infectious diseases are also discussed.
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Metadata
- Authors
- Sakurai, F., Tachibana, M., & Mizuguchi, H.
- Affiliations
- The University of Osaka (JP)
- Global Center for Medical Engineering and Informatics, The University of Osaka (JP)
- National Institute of Biomedical Innovation, Health and Nutrition (JP)
- Corresponding author
- Sakurai, Fuminori
- Mizuguchi, Hiroyuki
- Venue
- Drug Metabolism and Pharmacokinetics
- Publisher
- Elsevier BV
- Published
- 2022-02
- Volume
- 42
- Pages
- 100432
- ISSN
- 1347-4367 (ISSN-L)
- PMC
- PMC8585960
- OpenAlex
- W3213418684
- Cited by
- 148
- References
- 109
- Citations by year
- 2026: 16 · 2025: 42 · 2024: 37 · 2023: 32 · 2022: 21
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Drug Metabolism and Pharmacokinetics (acceptedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Agency for Medical Research and Development (20fk0108543h0001)
- Japan Society for the Promotion of Science (20H00664)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- adenoviral vector, vaccine vectors, infectious disease vaccines, gene delivery, innate immunity, immune response, Ebola virus disease, AIDS, COVID-19 pandemic
- MeSH terms
- COVID-19, SARS-CoV-2, Adenoviridae, Communicable Diseases, Genetic Vectors, Humans, Vaccines, Adenovirus Vaccines
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