The DOI matches its Crossref record; 75 of the 79 references it cites were found in a registry or an index.
EXO1-A multi-tasking eukaryotic nuclease
Abstract
Exo1 was first isolated as a 5' --> 3' exonuclease activity induced during meiosis in fission yeast and since that time has been implicated in a multitude of eukaryotic DNA metabolic pathways that include DNA repair, recombination, replication, and telomere integrity. Involvement in multiple pathways affecting genomic stability makes EXO1 a logical target for mutation during oncogenesis. Here, we review studies in several experimental systems that shed light on the role of Exo1 in these DNA transaction pathways, particularly those that may relate to oncogenesis.
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“Experiments performed in yeast cells have suggested that in CLUV conditions no checkpoint is activated, not even during S phase; indeed, checkpoint deficient strains do not exhibit sensitivity to CLUV treatment [62].”
From Mind the gap: keeping UV lesions in check (2011) · cites this paper as [62]
In the citing paper
“Experiments performed in yeast cells have suggested that in CLUV conditions no checkpoint is activated, not even during S phase; indeed, checkpoint deficient strains do not exhibit sensitivity to CLUV treatment [62].”
From Mind the gap: keeping UV lesions in check (2011) · cites this paper as [62]
In the citing paper
“Even more surprisingly, NER is not important in these conditions, since NER-deficient cells are also not sensitive to CLUV.”
From Mind the gap: keeping UV lesions in check (2011) · cites this paper as [62]
Citations
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Yang, T., Bergstrom, E. N., Clarke, S., Imielinski, M. B., & Alexandrov, L. B. (2026) · Nature Cancer · doi:10.1038/s43018-026-01242-y
Metadata
- Authors
- Tran, P. T., Erdeniz, N., Symington, L. S., & Liskay, R. M.
- Affiliations
- St. Mary's Medical Center (US)
- Oregon Health & Science University (US)
- Columbia University (US)
- Corresponding author
- Liskay, R.Michael
- Venue
- DNA Repair
- Publisher
- Elsevier BV
- Published
- 2004-12
- Volume
- 3
- Issue
- 12
- Pages
- 1549-1559
- ISSN
- 1568-7856 (ISSN-L)
- 1568-7864
- OpenAlex
- W2019394964
- Cited by
- 201
- References
- 79
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 5 · 2023: 7 · 2022: 2 · 2021: 7 · 2020: 6 · 2019: 9 · 2018: 5 · 2017: 13 · 2016: 10 · 2015: 14 · 2014: 16 · 2013: 14 · 2012: 9
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- DNA repair (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (GM41784, GM 45413, R01GM045413, R01GM041784)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- EXO1, exonuclease, DNA recombination, DNA replication, telomere integrity, genome stability, carcinogenesis, meiosis, Schizosaccharomyces pombe, DNA metabolism
- MeSH terms
- Amino Acid Sequence, Animals, DNA Repair, Exodeoxyribonucleases, Humans, Molecular Sequence Data, Mutation, Neoplasms, Recombination, Genetic, Saccharomyces cerevisiae, Telomere, Protein Structure, Tertiary, DNA Repair Enzymes
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