PARP-1, PARP-2 and ATM in the DNA damage response: functional synergy in mouse development
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Poly(ADP-ribosyl)ation is an immediate DNA damage-dependent posttranslational modification of histones and nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) now constitute a superfamily of 18 proteins, encoded by different genes and displaying a common conserved catalytic domain. PARP-1 (113kDa), the founding member, and PARP-2 (62kDa) are both involved in DNA-break sensing and signaling when single strand break repair (SSBR) or base excision repair (BER) pathways are engaged. The generation by homologous recombination of deficient mouse models have confirmed the caretaker function of PARP-1 and PARP-2 in mammalian cells under genotoxic stress. This review summarizes our present knowledge on their physiological role in the cellular response to DNA damage and on the genetic interactions between PARP-1, PARP-2, Atm that play an essential role during early embryogenesis.
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PARP1 alone is responsible for about 90% of total PARP activity at least in response to DNA damage.
“PARP1 is the best-characterized member of the group, and it alone is responsible for about 90% of total PARP activity at least in response to DNA damage28,29.”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [29]
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- Authors
- Huber, A., Bai, P., Murcia, J. M. D., & Murcia, G. D.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Murcia, Josiane Ménissier de
- Murcia, Gilbert de
- Venue
- DNA Repair
- Publisher
- Elsevier BV
- Published
- 2004-08
- Volume
- 3
- Issue
- 8-9
- Pages
- 1103-1108
- ISSN
- 1568-7856 (ISSN-L)
- 1568-7864
- OpenAlex
- W2034058449
- Cited by
- 222
- References
- 38
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 8 · 2023: 9 · 2022: 3 · 2021: 9 · 2020: 11 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 9 · 2015: 15 · 2014: 11 · 2013: 12 · 2012: 13
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- DNA repair (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion, cc-by-nc-nd)
- Funders
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Keywords
- PARP1, PARP2, ATM, DNA damage response, poly(ADP-ribosyl)ation, single-strand break repair, base excision repair, homologous recombination, embryonic development, mouse development, genetic interactions
- MeSH terms
- Poly (ADP-Ribose) Polymerase-1, Animals, DNA Damage, DNA Repair, DNA-Binding Proteins, Heterozygote, Histones, Humans, Models, Biological, Poly(ADP-ribose) Polymerases, Signal Transduction, Protein Serine-Threonine Kinases, Oxidative Stress, Gene Expression Regulation, Developmental, Cell Cycle Proteins, Catalytic Domain, Tumor Suppressor Proteins, Cell Proliferation, Mice, Ataxia Telangiectasia Mutated Proteins
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