Histone methylation and aging: Lessons learned from model systems

McCauley, Brenna S.; Dang, Weiwei

doi:10.1016/j.bbagrm.2014.05.008

Cited by 93Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA MethylationGenomics and Chromatin Dynamics

Histone methylation and aging: Lessons learned from model systems

Open access

McCauley, Brenna S., Dang, Weiwei·2014·Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

DOI 10.1016/j.bbagrm.2014.05.008PMC PMC4240748

Open this paper in CoChat — free account

Abstract

Aging induces myriad cellular and, ultimately, physiological changes that cause a decline in an organism's functional capabilities. Although the aging process and the pathways that regulate it have been extensively studied, only in the last decade have we begun to appreciate that dynamic histone methylation may contribute to this process. In this review, we discuss recent work implicating histone methylation in aging. Loss of certain histone methyltransferases and demethylases changes lifespan in invertebrates, and alterations in histone methylation in aged organisms regulate lifespan and aging phenotypes, including oxidative stress-induced hormesis in yeast, insulin signaling in Caenorhabiditis elegans and mammals, and the senescence-associated secretory phenotype in mammals. In all cases where histone methylation has been shown to impact aging and aging phenotypes, it does so by regulating transcription, suggesting that this is a major mechanism of its action in this context. Histone methylation additionally regulates or is regulated by other cellular pathways that contribute to or combat aging. Given the numerous processes that regulate aging and histone methylation, and are in turn regulated by them, the role of histone methylation in aging is almost certainly underappreciated.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.bbagrm.2014.05.008

Cites

121 of 121 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Increased levels of heterochromatin-associated proteins, including histone H2A variant macroH2A and HP1β, were observed in tissues from old versus young mice and primates.
“and increased levels of the heterochromatin-associated proteins, including histone H2A variant macroH2A (associated with gene repression 67 ) and HP1 β , were observed in tissues from old versus young mice and primates 68,69 .”
From The roles of DNA, RNA and histone methylation in ageing and cancer (2019) · cites this paper as [69]
Ageing cells have an altered heterochromatin composition, including high levels of histone H2A variant macroH2A and HP1β.
“ageing cells have an altered heterochromatin composition, including high levels of histone H2A variant macroH2A and heterochromatin binding protein 1 (HP1 β) 68,69”
From The roles of DNA, RNA and histone methylation in ageing and cancer (2019) · cites this paper as [69]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Hallmarks of Aging
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
Identification of stem cells in small intestine and colon by marker gene Lgr5
Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687 · see citing works
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206 · see citing works
Autophagy and the Integrated Stress Response
Kroemer, G., Mariño, G., & Levine, B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.023 · Cited by 3,506 · see citing works
Extending Healthy Life Span—From Yeast to Humans
Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023 · see citing works
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
Bannister, A. J., Zegerman, P., Partridge, J. F., Miska, E. A., Thomas, J. O., Allshire, R. C., & Kouzarides, T. (2001) · Nature · doi:10.1038/35065138 · Cited by 2,903 · see citing works
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
Lachner, M., O'Carroll, D., Rea, S., Mechtler, K., & Jenuwein, T. (2001) · Nature · doi:10.1038/35065132 · Cited by 2,868 · see citing works
The genetics of ageing
Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739 · see citing works
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
Kimura, K. D., Tissenbaum, H. A., Liu, Y., & Ruvkun, G. (1997) · Science · doi:10.1126/science.277.5328.942 · Cited by 2,250 · see citing works
Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans
Herndon, L. A., Schmeissner, P. J., Dudaronek, J. M., Brown, P. A., Listner, K. M., Sakano, Y., Paupard, M. C., Hall, D. H., & Driscoll, M. (2002) · Nature · doi:10.1038/nature01135 · Cited by 1,214 · see citing works
SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span
Kawahara, T. L. A., Michishita, E., Adler, A. S., Damian, M., Berber, E., Lin, M., McCord, R. A., Ongaigui, K. C. L., Boxer, L. D., Chang, H. Y., et al. (2009) · Cell · doi:10.1016/j.cell.2008.10.052 · Cited by 1,090 · see citing works
Overview of caloric restriction and ageing
Masoro, E. J. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.012 · Cited by 1,054 · see citing works
Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair
Botuyan, M. V., Lee, J., Ward, I. M., Kim, J., Thompson, J. R., Chen, J., & Mer, G. (2006) · Cell · doi:10.1016/j.cell.2006.10.043 · Cited by 973 · see citing works
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
Molofsky, A. V., Slutsky, S. G., Joseph, N. M., He, S., Pardal, R., Krishnamurthy, J., Sharpless, N. E., & Morrison, S. J. (2006) · Nature · doi:10.1038/nature05091 · Cited by 972 · see citing works
Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks
Huyen, Y., Zgheib, O., DiTullio Jr, R. A., Gorgoulis, V. G., Zacharatos, P., Petty, T. J., Sheston, E. A., Mellert, H. S., Stavridi, E. S., & Halazonetis, T. D. (2004) · Nature · doi:10.1038/nature03114 · Cited by 884 · see citing works
A new murine model of accelerated senescence
Takeda, T., HOSOKAWA, M., TAKESHITA, S., Irino, M., Higuchi, K., Matsushita, T., Tomita, Y., Yasuhira, K., Hamamoto, H., & Shimizu, K. (1981) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(81)90084-1 · Cited by 871 · see citing works
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
Bracken, A. P., Kleine-Kohlbrecher, D., Dietrich, N., Pasini, D., Gargiulo, G., Beekman, C., Theilgaard-Mönch, K., Minucci, S., Porse, B. T., Marine, J.-C., et al. (2007) · Genes & Development · doi:10.1101/gad.415507 · Cited by 850 · see citing works
Regulation of the INK4b–ARF–INK4a tumour suppressor locus: all for one or one for all
Gil, J., & Peters, G. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1987 · Cited by 843 · see citing works
Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging
Shumaker, D. K., Dechat, T., Kohlmaier, A., Adam, S. A., Bozovsky, M. R., Erdos, M. R., Eriksson, M., Goldman, A. E., Khuon, S., Collins, F. S., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602569103 · Cited by 791 · see citing works
The Biology of Hematopoietic Stem Cells
Morrison, S. J., Uchida, N., & Weissman, I. L. (1995) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cb.11.110195.000343 · Cited by 774 · see citing works
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM
Sun, Y., Jiang, X., Chen, S., Fernandes, N., & Price, B. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504211102 · Cited by 738 · see citing works
DNA damage response and cellular senescence in tissues of aging mice
Wang, C., Jurk, D., Maddick, M., Nelson, G., Martin‐Ruiz, C., & Von Zglinicki, T. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00481.x · Cited by 696 · see citing works
Histone H4 lysine 16 acetylation regulates cellular lifespan
Dang, W., Steffen, K. K., Perry, R., Dorsey, J. A., Johnson, F. B., Shilatifard, A., Kaeberlein, M., Kennedy, B. K., & Berger, S. L. (2009) · Nature · doi:10.1038/nature08085 · Cited by 667 · see citing works
Self-citation
Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans
Greer, E. L., Maures, T. J., Ucar, D., Hauswirth, A. G., Mancini, E., Lim, J. P., Benayoun, B. A., Shi, Y., & Brunet, A. (2011) · Nature · doi:10.1038/nature10572 · Cited by 660 · see citing works
Genome-wide analysis of Polycomb targets in Drosophila melanogaster
Schwartz, Y. B., Kahn, T. G., Nix, D. A., Li, X., Bourgon, R., Biggin, M. D., & Pirrotta, V. (2006) · Nature Genetics · doi:10.1038/ng1817 · Cited by 610 · see citing works
CBP-mediated acetylation of histone H3 lysine 27 antagonizesDrosophilaPolycomb silencing
Tie, F., Banerjee, R., Stratton, C. A., Prasad-Sinha, J., Stepanik, V. A., Zlobin, A., Dı́az, M. O., Scacheri, P. C., & Harte, P. J. (2009) · Development · doi:10.1242/dev.037127 · Cited by 575 · see citing works
Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape
Shah, P. P., Donahue, G., Otte, G. L., Capell, B. C., Nelson, D. M., Cao, K., Aggarwala, V., Cruickshanks, H. A., Rai, T. S., McBryan, T., et al. (2013) · Genes & Development · doi:10.1101/gad.223834.113 · Cited by 550 · see citing works
Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging
Liu, L., Cheung, T. H., Charville, G. W., Hurgo, B. M. C., Leavitt, T., Shih, J., Brunet, A., & Rando, T. A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.043 · Cited by 544 · see citing works
Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans
Greer, E. L., Maures, T. J., Hauswirth, A. G., Green, E. M., Leeman, D. S., Maro, G. S., Han, S., Banko, M. R., Gozani, O., & Brunet, A. (2010) · Nature · doi:10.1038/nature09195 · Cited by 543 · see citing works
A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage
Chou, D. M., Adamson, B., Dephoure, N. E., Tan, X., Nottke, A. C., Hurov, K. E., Gygi, S. P., Colaiácovo, M. P., & Elledge, S. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012946107 · Cited by 529 · see citing works
New insights into the role of mitochondria in aging: mitochondrial dynamics and more
Seo, A. Y., Joseph, A.-M., Dutta, D., Hwang, J. C. Y., Aris, J. P., & Leeuwenburgh, C. (2010) · Journal of Cell Science · doi:10.1242/jcs.070490 · Cited by 522 · see citing works
Neural Stem Cell Detection, Characterization, and Age-Related Changes in the Subventricular Zone of Mice
Maslov, A. Y., Barone, T. A., Plunkett, R. J., & Pruitt, S. C. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4608-03.2004 · Cited by 522 · see citing works
A systematic RNAi screen for longevity genes in C. elegansPreprint
Hamilton, B., Dong, Y., Shindo, M., Liu, W., Odell, I., Ruvkun, G., & Lee, S. S. (2005) · Genes & Development · doi:10.1101/gad.1308205 · Cited by 513 · see citing works
Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60
Sun, Y., Jiang, X., Xu, Y., Ayrapetov, M. K., Moreau, L. A., Whetstine, J. R., & Price, B. D. (2009) · Nature Cell Biology · doi:10.1038/ncb1982 · Cited by 454 · see citing works
Elevated histone expression promotes life span extension
Feser, J., Truong, D., Das, C., Carson, J. J., Kieft, J., Harkness, T., & Tyler, J. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.08.015 · Cited by 435 · see citing works
The H3K27me3 demethylase JMJD3 contributes to the activation of theINK4A–ARFlocus in response to oncogene- and stress-induced senescence
Agger, K., Cloos, P. A. C., Rudkjær, L., Williams, K., Andersen, G., Christensen, J., & Helin, K. (2009) · Genes & Development · doi:10.1101/gad.510809 · Cited by 427 · see citing works
Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model
Burd, C. E., Sorrentino, J. A., Clark, K. S., Darr, D. B., Krishnamurthy, J., Deal, A. M., Bardeesy, N., Castrillon, D. H., Beach, D. H., & Sharpless, N. E. (2013) · Cell · doi:10.1016/j.cell.2012.12.010 · Cited by 419 · see citing works
MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites
Pei, H., Zhang, L. M., Luo, K., Qin, Y., Chesi, M., Fei, Y. F., Bergsagel, P. L., Wang, L., You, Z., & Lou, Z. (2011) · Nature · doi:10.1038/nature09658 · Cited by 412 · see citing works
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer
DiTullio, R. A., Mochan, T. A., Venere, M., Bártková, J., Sehested, M., Bártek, J., & Halazonetis, T. D. (2002) · Nature Cell Biology · doi:10.1038/ncb892 · Cited by 399 · see citing works
Double Strand Breaks Can Initiate Gene Silencing and SIRT1-Dependent Onset of DNA Methylation in an Exogenous Promoter CpG Island
O'Hagan, H. M., Mohammad, H. P., & Baylin, S. B. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000155 · Cited by 386 · see citing works
Age-related changes in learning and memory in the senescence-accelerated mouse (SAM)
Miyamoto, M., Kiyota, Y., Yamazaki, N., Nagaoka, A., Matsuo, T., Nagawa, Y., & Takeda, T. (1986) · Physiology & Behavior · doi:10.1016/0031-9384(86)90112-5 · Cited by 375 · see citing works
Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS
Barradas, M., Anderton, E., Acosta, J. C., Li, S., Banito, A., Rodriguez-Niedenführ, M., Maertens, G., Banck, M., Zhou, M.-M., Walsh, M. J., et al. (2009) · Genes & Development · doi:10.1101/gad.511109 · Cited by 352 · see citing works
Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors.
Jude, C. D., Climer, L. K., Xu, D.-Y., Artinger, E. L., Fisher, J., & Ernst, P. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.05.019 · Cited by 350 · see citing works
Evolution of the cellular stress proteome: from monophyletic origin to ubiquitous function
Kültz, D. (2003) · Journal of Experimental Biology · doi:10.1242/jeb.00549 · Cited by 349 · see citing works
Cellular senescence and organismal aging
Jeyapalan, J. C., & Sedivy, J. M. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.04.001 · Cited by 347 · see citing works
Correlated alterations in genome organization, histone methylation, and DNA–lamin A/C interactions in Hutchinson-Gilford progeria syndromePreprint
McCord, R. P., Nazario-Toole, A., Zhang, H., Chines, P. S., Zhan, Y., Erdos, M. R., Collins, F. S., Dekker, J., & Cao, K. (2012) · Genome Research · doi:10.1101/gr.138032.112 · Cited by 326 · see citing works
Functional senescence in Drosophila melanogaster
Grotewiel, M. S., Martin, I., Bhandari, P., & Cook-Wiens, E. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.04.001 · Cited by 324 · see citing works
Mechanisms that Regulate Stem Cell Aging and Life Span
Signer, R. A. J., & Morrison, S. J. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.01.001 · Cited by 320 · see citing works
DNA Damage-Induced Acetylation of Lysine 3016 of ATM Activates ATM Kinase Activity
Sun, Y., Xu, Y., Roy, K., & Price, B. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01382-07 · Cited by 319 · see citing works
Regulation of Yeast Chronological Life Span by TORC1 via Adaptive Mitochondrial ROS Signaling
Pan, Y., Schroeder, E. A., Ocampo, A., Barrientos, A., & Shadel, G. S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.018 · Cited by 313 · see citing works
HDAC inhibitor‐based therapies: Can we interpret the code?
New, M. I., Olzscha, H., & Thangue, N. B. L. (2012) · Molecular Oncology · doi:10.1016/j.molonc.2012.09.003 · Cited by 310 · see citing works
Cellular stress response pathways and ageing: intricate molecular relationships
Kourtis, N., & Tavernarakis, N. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.162 · Cited by 304 · see citing works
Aging, Stem Cells and Tissue Regeneration: Lessons from Muscle
Conboy, I. M., & Rando, T. A. (2005) · Cell Cycle · doi:10.4161/cc.4.3.1518 · Cited by 298 · see citing works
Role of Dot1-Dependent Histone H3 Methylation in G1 and S Phase DNA Damage Checkpoint Functions of Rad9
Wysocki, R., Javaheri, A., Allard, S., Sha, F., Côté, J., & Kron, S. J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.19.8430-8443.2005 · Cited by 288 · see citing works
Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis
Larson, K., Yan, S.-J., Tsurumi, A., Liu, J., Zhou, J., Gaur, K., Guo, D., Eickbush, T. H., & Li, W. X. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002473 · Cited by 284 · see citing works
Age-related changes of nuclear architecture in Caenorhabditis elegans
Haithcock, E., Dayani, Y., Neufeld, E., Zahand, A. J., Feinstein, N., Mattout, A., Gruenbaum, Y., & Liu, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506955102 · Cited by 279 · see citing works
Replicative Aging in Yeast: The Means to the End
Steinkraus, K. A., Kaeberlein, M. R., & Kennedy, B. K. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123509 · Cited by 279 · see citing works
Mll Has a Critical Role in Fetal and Adult Hematopoietic Stem Cell Self-Renewal
McMahon, K. A., Hiew, S., Hadjur, S., Veiga‐Fernandes, H., Menzel, U., Price, A. J., Kioussis, D., Williams, O., & Brady, H. J. M. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.07.002 · Cited by 274 · see citing works
The role of mitochondrial DNA mutations and free radicals in disease and ageing
Lagouge, M., & Larsson, N. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12055 · Cited by 270 · see citing works
Cellular senescence in vivo: a barrier to tumorigenesis
Prieur, A., & Peeper, D. S. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.01.007 · Cited by 260 · see citing works
Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway
Jin, C., Li, J., Green, C. D., Yu, X., Tang, X., Han, D., Xian, B., Wang, D., Huang, X., Cao, X., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.07.001 · Cited by 258 · see citing works
The H3K27 demethylase UTX‐1 regulates C. elegans lifespan in a germline‐independent, insulin‐dependent manner
Maures, T. J., Greer, E. L., Hauswirth, A. G., & Brunet, A. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00738.x · Cited by 256 · see citing works
Postsynthetic Trimethylation of Histone H4 at Lysine 20 in Mammalian Tissues Is Associated with Aging
Sarg, B., Koutzamani, E., Helliger, W., Rundquist, I., & Lindner, H. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205166200 · Cited by 252 · see citing works
Global heterochromatin loss
Tsurumi, A., & Li, W. X. (2012) · Epigenetics · doi:10.4161/epi.20540 · Cited by 248 · see citing works
Aging: Central role for autophagy and the lysosomal degradative system
Rajawat, Y. S., Hilioti, Z., & Bossis, I. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.05.001 · Cited by 247 · see citing works
A review and appraisal of the DNA damage theory of ageing
Freitas, A. A., & de Magalhães, J. P. (2011) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2011.05.001 · Cited by 242 · see citing works
Trials with ‘epigenetic’ drugs: An update
Nebbioso, A., Carafa, V., Benedetti, R., & Altucci, L. (2012) · Molecular Oncology · doi:10.1016/j.molonc.2012.09.004 · Cited by 237 · see citing works
PARP-1, PARP-2 and ATM in the DNA damage response: functional synergy in mouse development
Huber, A., Bai, P., Murcia, J. M. D., & Murcia, G. D. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.06.002 · Cited by 222 · see citing works
Epigenetic Regulation of Autophagy by the Methyltransferase G9a
de Narvajas, A. A.-M., Gomez, T. S., Zhang, J., Mann, A. O., Taoda, Y., Gorman, J. A., Herreros‐Villanueva, M., Gress, T. M., Ellenrieder, V., Bujanda, L., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00813-13 · Cited by 217 · see citing works
Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance
Siebold, A. P., Banerjee, R., Tie, F., Kiss, D. L., Moskowitz, J., & Harte, P. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907739107 · Cited by 216 · see citing works
Neural Stem and Progenitor Cells Retain Their Potential for Proliferation and Differentiation into Functional Neurons Despite Lower Number in Aged Brain
Ahlenius, H., Visan, V., Kokaia, M., Lindvall, O., & Kokaia, Z. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6003-08.2009 · Cited by 208 · see citing works
DNA Damage Signaling Triggers Degradation of Histone Methyltransferases through APC/CCdh1 in Senescent Cells
Takahashi, A., Imai, Y., Yamakoshi, K., Kuninaka, S., Ohtani, N., Yoshimoto, S., Hori, S., Tachibana, M., Anderton, E., Takeuchi, T., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2011.10.018 · Cited by 205 · see citing works
Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans
McColl, G., Killilea, D. W., Hubbard, A. E., Vantipalli, M. C., Melov, S., & Lithgow, G. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705028200 · Cited by 202 · see citing works
Chromatin structure as a mediator of aging
Feser, J., & Tyler, J. K. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.11.016 · Cited by 200 · see citing works
Chromatin remodeling in the aging genome of Drosophila
Wood, J. G., Hillenmeyer, S., Lawrence, C., Chang, C., Hosier, S., Lightfoot, W., Mukherjee, E., Jiang, N., Schorl, C., Brodsky, A. S., et al. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00624.x · Cited by 192 · see citing works
Epigenetic silencing mediates mitochondria stress-induced longevity
Schroeder, E. A., Raimundo, N., & Shadel, G. S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.003 · Cited by 186 · see citing works
Systematic Dissection of Roles for Chromatin Regulators in a Yeast Stress Response
Weiner, A., Chen, H. V., Liu, C. L., Rahat, A., Klien, A., Soares, L. M. M., Gudipati, M., Pfeffner, J., Regev, A., Buratowski, S., et al. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001369 · Cited by 167 · see citing works
Methylated H3K4, a Transcription-Associated Histone Modification, Is Involved in the DNA Damage Response Pathway
Faucher, D., & Wellinger, R. J. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001082 · Cited by 162 · see citing works
Different HATS of the ING1 gene family
Feng, X., Hara, Y., & Riabowol, K. T. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(02)02391-7 · Cited by 156 · see citing works
Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans
Kato, M., Chen, X., Inukai, S., Zhao, H., & Slack, F. J. (2011) · RNA · doi:10.1261/rna.2714411 · Cited by 156 · see citing works
Two SET domain containing genes link epigenetic changes and aging in Caenorhabditis elegans
Ni, Z., Ebata, A., Alipanahiramandi, E., & Lee, S. S. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00785.x · Cited by 154 · see citing works
γH2AX as a molecular marker of aging and disease
Mah, L.-J., El‐Osta, A., & Karagiannis, T. C. (2010) · Epigenetics · doi:10.4161/epi.5.2.11080 · Cited by 154 · see citing works
Kdm4b Histone Demethylase Is a DNA Damage Response Protein and Confers a Survival Advantage following γ-Irradiation
Young, L. C., McDonald, D., & Hendzel, M. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.491514 · Cited by 147 · see citing works
Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases
Hegde, M. L., Mantha, A. K., Hazra, T. K., Bhakat, K. K., Mitra, S., & Szczesny, B. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.01.005 · Cited by 141 · see citing works
Deficiency of H3K79 Histone Methyltransferase Dot1-like Protein (DOT1L) Inhibits Cell Proliferation
Kim, W., Kim, R., Park, G., Park, J., & Kim, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.328138 · Cited by 139 · see citing works
Polycomb Mediated Epigenetic Silencing and Replication Timing at the INK4a/ARF Locus during Senescence
Agherbi, H., Gaussmann-Wenger, A., Verthuy, C., Chasson, L., Serrano, M., & Djabali, M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005622 · Cited by 138 · see citing works
Global epigenetic changes during somatic cell reprogramming to iPS cells
Mattout, A., Biran, A., & Meshorer, E. (2011) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjr028 · Cited by 124 · see citing works
The Transcriptome of Prematurely Aging Yeast Cells Is Similar to That of Telomerase-deficient Cells
Lesur, I., & Campbell, J. L. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-10-0742 · Cited by 123 · see citing works
Histone H3K4me3 Binding Is Required for the DNA Repair and Apoptotic Activities of ING1 Tumor Suppressor
Peña, P. V., Hom, R. A., Hung, T., Lin, H., Kuo, A. J., Wong, R. P. C., Subach, O. M., Champagne, K. S., Zhao, R., Verkhusha, V. V., et al. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.04.061 · Cited by 121 · see citing works
ROS in AgingCaenorhabditis elegans: Damage or Signaling?
Back, P., Braeckman, B. P., & Matthijssens, F. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/608478 · Cited by 118 · see citing works
The role of ubiquitin–proteasome system in ageing
Lőw, P. (2011) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2011.02.005 · Cited by 114 · see citing works
Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage‐induced 53BP1 foci at G1/G2 cell‐cycle phases
Wakeman, T. P., Wang, Q., Feng, J., & Wang, X. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.50 · Cited by 113 · see citing works
The role of histone demethylases in cancer therapy
Hoffmann, I., Roatsch, M., Schmitt, M., Carlino, L., Pippel, M., Sippl, W., & Jung, M. (2012) · Molecular Oncology · doi:10.1016/j.molonc.2012.07.004 · Cited by 110 · see citing works
Aging, anti-aging, and hormesis
Rattan, S. I. S. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.01.006 · Cited by 108 · see citing works
Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome
Wood, S. H., Craig, T., Li, Y., Merry, B., & de Magalhães, J. P. (2013) · AGE · doi:10.1007/s11357-012-9410-1 · Cited by 105 · see citing works
Histone deacetylase regulates high mobility group A2-targeting microRNAs in human cord blood-derived multipotent stem cell aging
Lee, S., Jung, J.-W., Park, S., Roh, K.-H., Lee, S. Y., Kim, J. H., Kang, S.-K., & Kang, K. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0457-9 · Cited by 101 · see citing works
Role of ubiquitin–proteasome-mediated proteolysis in nervous system disease
Hegde, A. N., & Upadhya, S. C. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2010.07.006 · Cited by 96 · see citing works
Temporal and spatial transcriptional profiles of aging in Drosophila melanogasterPreprint
Zhan, M., Yamaza, H., Sun, Y., Sinclair, J. W., Li, H., & Zou, S. (2007) · Genome Research · doi:10.1101/gr.6216607 · Cited by 95 · see citing works
53BP1-mediated DNA double strand break repair: Insert bad pun here
Noon, A. T., & Goodarzi, A. A. (2011) · DNA repair · doi:10.1016/j.dnarep.2011.07.012 · Cited by 94 · see citing works
Histone H3 Modifications Associated With Differentiation and Long-Term Culture of Mesenchymal Adipose Stem Cells
Noer, A., Lindeman, L. C., & Collas, P. (2008) · Stem Cells and Development · doi:10.1089/scd.2008.0189 · Cited by 94 · see citing works
Identification of histone methylation multiplicities patterns in the brain of senescence-accelerated prone mouse 8
Wang, C.-M., Tsai, S.-N., Yew, T., Kwan, Y.-W., & Ngai, S. (2010) · Biogerontology (Dordrecht) · doi:10.1007/s10522-009-9231-5 · Cited by 94 · see citing works
DNA damage, chromatin, and transcription: the trinity of aging
Burgess, R. C., Misteli, T., & Oberdoerffer, P. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.07.005 · Cited by 72 · see citing works
Autophagy and ageing: Insights from invertebrate model organisms
Lionaki, E., Markaki, M., & Tavernarakis, N. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.05.001 · Cited by 69 · see citing works
The transcription factor ZBP‐89 suppresses p16 expression through a histone modification mechanism to affect cell senescence
Feng, Y., Wang, X., Xu, L., Pan, H., Zhu, S., Liang, Q. Y., Huang, B., & Lü, J. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07128.x · Cited by 68 · see citing works
HDACs and the senescent phenotype of WI-38 cells
Place, R. F., Noonan, E. J., & Giardina, C. A. (2005) · BMC Cell Biology · doi:10.1186/1471-2121-6-37 · Cited by 57 · see citing works
Stress‐associated H 3 K 4 methylation accumulates during postnatal development and aging of rhesus macaque brain
Han, Y., Han, D., Zheng, Y., Boyd-Kirkup, J. D., Green, C. D., Khaitovich, P., & Han, J. J. (2012) · Aging Cell · doi:10.1111/acel.12007 · Cited by 57 · see citing works
The farnesylated nuclear proteins KUGELKERN and LAMIN B promote aging‐like phenotypes in Drosophila flies
Brandt, A., Krohne, G., & Großhans, J. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00406.x · Cited by 55 · see citing works
PTEN controls β‐cell regeneration in aged mice by regulating cell cycle inhibitor p16 ink4a
Zeng, N., Yang, K., Bayan, J., He, L., Aggarwal, R., Stiles, J. W., Hou, X., Medina, V., Abad, D., Palian, B. M., et al. (2013) · Aging Cell · doi:10.1111/acel.12132 · Cited by 50 · see citing works
The Histone Demethylase Jarid1b (Kdm5b) Is a Novel Component of the Rb Pathway and Associates with E2f-Target Genes in MEFs during Senescence
Nijwening, J. H., Geutjes, E.-J., Bernards, R., & Beijersbergen, R. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025235 · Cited by 50 · see citing works
Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK–JMJD3–p16INK4a signaling axis
Lin, T.-Y., Cheng, Y.-C., Yang, H.-C., Lin, W.-C., Wang, C.-C., Lai, P.-L., & Shieh, S.-Y. (2011) · Oncogene · doi:10.1038/onc.2011.491 · Cited by 50 · see citing works
Gene silencing induced by oxidative DNA base damage: association with local decrease of histone H4 acetylation in the promoter region
Khobta, A., Anderhub, S. J., Kitsera, N., & Epe, B. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq170 · Cited by 47 · see citing works
ZRF1 controls oncogene-induced senescence through the INK4-ARF locus
Ribeiro, J. D., Morey, L., Mas, A., Gutierrez, A., Luis, N. M., Mejetta, S., Richly, H., Benitah, S. A., Keyes, W. M., & Di Croce, L. (2013) · Oncogene · doi:10.1038/onc.2012.241 · Cited by 41 · see citing works
Regulation of the DNA Damage Response and Gene Expression by the Dot1L Histone Methyltransferase and the 53Bp1 Tumour Suppressor
Fitzgerald, J., Moureau, S., Drogaris, P., O’Connell, E., Abshiru, N. A., Verreault, A., Thibault, P., Grenon, M., & Lowndes, N. F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014714 · Cited by 41 · see citing works
The accumulation of DNA repair defects is the molecular origin of carcinogenesis
Cha, H., & Yim, H. (2013) · Tumor Biology · doi:10.1007/s13277-013-1038-y · Cited by 34 · see citing works
Dissociation of the H3K36 demethylase Rph1 from chromatin mediates derepression of environmental stress-response genes under genotoxic stress inSaccharomyces cerevisiae
Liang, C., Wang, L., & Lo, W. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-11-0820 · Cited by 28 · see citing works
Histone H4 Lysine 20 of Saccharomyces cerevisiae Is Monomethylated and Functions in Subtelomeric Silencing
Edwards, C. R., Dang, W., & Berger, S. L. (2011) · Biochemistry · doi:10.1021/bi201120q · Cited by 27 · see citing works
Self-citation
Free and chromatin-associated mono-, di-, and trimethylation of histone H4-lysine 20 during development and cell cycle progression
Karachentsev, D., Druzhinina, M. K., & Steward, R. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.12.019 · Cited by 26 · see citing works
Epigenetics of induced pluripotency, the seven-headed dragon
Djuric, U., & Ellis, J. (2010) · Stem Cell Research & Therapy · doi:10.1186/scrt3 · Cited by 25 · see citing works
Deep SAGE analysis of the Caenorhabditis elegans transcriptome
Ruzanov, P., & Riddle, D. L. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq035 · Cited by 16 · see citing works
Transcriptome and Proteome Analysis in Human Senescent Fibroblasts and Fibroblasts Undergoing Premature Senescence Induced by Repeated Sublethal Stresses
Dierick, J., Pascal, T. G., Debacq‐Chainiaux, F., Eliaers, F., Remacle, J., Larsen, P. M., Roepstorff, P., & Toussaint, O. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06659.x · Cited by 10 · see citing works
Dissociation of the H3K36 demethylase Rph1 from chromatin mediates derepression of environmental stress-response genes under genotoxic stress in Saccharomyces cerevisiae
Lianga, C.-Y., Wanga, L.-C., & Loa, W.-S. (2013) · Cited by 1 · see citing works

Flagged first, then by citations

Sorted by citations

Epigenetics and aging
Pal, S., & Tyler, J. K. (2016) · Science Advances · doi:10.1126/sciadv.1600584 · Cited by 860 · see citing works
The roles of DNA, RNA and histone methylation in ageing and cancer
Michalak, E. M., Burr, M. L., Bannister, A. J., & Dawson, M. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0143-1 · Cited by 549 · see citing works
Transcriptional and epigenetic regulation of autophagy in aging
Lapierre, L. R., Kumsta, C., Sandri, M., Ballabio, A., & Hansen, M. (2015) · Autophagy · doi:10.1080/15548627.2015.1034410 · Cited by 339 · see citing works
Senescence in COPD and Its Comorbidities
Barnes, P. J. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034314 · Cited by 276 · see citing works
Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement
Tenchov, R., Sasso, J. M., Wang, X., & Zhou, Q. A. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00531 · Cited by 276 · see citing works
Mitochondrial Oxidative Stress, Mitochondrial DNA Damage and Their Role in Age-Related Vascular Dysfunction
Mikhed, Y., Daiber, A., & Steven, S. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160715918 · Cited by 257 · see citing works
The Microbiome and Aging
Bana, B., & Cabreiro, F. (2019) · Annual Review of Genetics · doi:10.1146/annurev-genet-112618-043650 · Cited by 207 · see citing works
Mechanisms of development of multimorbidity in the elderly
Barnes, P. J. (2015) · European Respiratory Journal · doi:10.1183/09031936.00229714 · Cited by 200 · see citing works
Epigenetics and Oxidative Stress in Aging
Guillaumet-Adkins, A., Yáñez, Y., Peris‐Díaz, M. D., Calabria, I., Palanca-Ballester, C., & Sandoval, J. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9175806 · Cited by 194 · see citing works
Oocyte ageing and epigenetics
Ge, Z., Schatten, H., Zhang, C.-L., & Sun, Q.-Y. (2014) · Reproduction · doi:10.1530/rep-14-0242 · Cited by 177 · see citing works
Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence
Gude, N. A., Broughton, K. M., Firouzi, F., & Sussman, M. A. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0061-5 · Cited by 166 · see citing works
Cardiac cell senescence: molecular mechanisms, key proteins and therapeutic targets
Luan, Y., Zhu, X., Jiao, Y., Liu, H., Huang, Z., Pei, J., Xu, Y., Yang, Y., & Ren, K. (2024) · Cell Death Discovery · doi:10.1038/s41420-023-01792-5 · Cited by 106 · see citing works
Abnormal Epigenetic Regulation of Immune System during Aging
Jasiulionis, M. G. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00197 · Cited by 100 · see citing works
Metformin directly targets the H3K27me3 demethylase KDM6A/UTX
Cuyàs, E., Verdura, S., Llorach-Parés, L., Fernández‐Arroyo, S., Luciano‐Mateo, F., Cabré, N., Štursa, J., Werner, L., Martı́n-Castillo, B., Viollet, B., et al. (2018) · Aging Cell · doi:10.1111/acel.12772 · Cited by 79 · see citing works
Role of physical exercise in the regulation of epigenetic mechanisms in inflammation, cancer, neurodegenerative diseases, and aging process
Ferioli, M., Zauli, G., Maiorano, P., Milani, D., Mirandola, P., & Neri, L. M. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28304 · Cited by 78 · see citing works
Epigenetic mechanisms related to cognitive decline during aging
Harman, M. F., & Martín, M. G. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24436 · Cited by 79 · see citing works
The Aging Metabolome—Biomarkers to Hub Metabolites
Sharma, R. B., & Ramanathan, A. (2020) · PROTEOMICS · doi:10.1002/pmic.201800407 · Cited by 76 · see citing works
The Evolution of Epigenetics: From Prokaryotes to Humans and Its Biological Consequences
Willbanks, A. R., Leary, M., Greenshields, M., Tyminski, C., Heerboth, S., LAPINSKA, K., HASKINS, K. M., & Sarkar, S. (2016) · Genetics & Epigenetics · doi:10.4137/geg.s31863 · Cited by 75 · see citing works
Splicing alterations in healthy aging and disease
Angarola, B. L., & Anczuków, O. (2021) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1643 · Cited by 69 · see citing works
Age-related changes in mesenchymal stem cells identified using a multi-omics approach
Peffers, M. J., Collins, J., Fang, Y., Goljanek‐Whysall, K., Rushton, Loughlin, J. A., Proctor, C. J., & Clegg, P. (2016) · European Cells and Materials · doi:10.22203/ecm.v031a10 · Cited by 67 · see citing works
Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice
Mattocks, D. A. L., Mentch, S. J., Shneyder, J., Ables, G. P., Sun, D., Richie, J. P., Locasale, J. W., & Nichenametla, S. N. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.12.003 · Cited by 68 · see citing works
Altered chromatin states drive cryptic transcription in aging mammalian stem cells
McCauley, B. S., Sun, L., Yu, R., Lee, M., Liu, H., Leeman, D. S., Huang, Y., Webb, A. E., & Dang, W. (2021) · Nature Aging · doi:10.1038/s43587-021-00091-x · Cited by 66 · see citing works
Self-citation
Balancing DNA repair to prevent ageing and cancer
Stead, E. R., & Bjedov, I. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112679 · Cited by 56 · see citing works
Caloric restriction induced epigenetic effects on aging
Zhai, J., Kongsberg, W. H., Pan, Y., Hao, C., Wang, X., & Sun, J. Y. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1079920 · Cited by 55 · see citing works
NRMT1 knockout mice exhibit phenotypes associated with impaired DNA repair and premature aging
Bonsignore, L. A., Tooley, J. G., Hoose, P. M. V., Wang, E., Cheng, A., Cole, M. P., & Tooley, C. E. S. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.03.012 · Cited by 45 · see citing works
Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy
Tezil, T., Chamoli, M., Ng, C.-P., Simon, R. P., Butler, V. J., Jung, M., Andersen, J. K., Kao, A. W., & Verdin, E. M. (2019) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-019-0037-7 · Cited by 40 · see citing works
The Role of Aging in Idiopathic Pulmonary Fibrosis
Leung, J., Cho, Y. S., Lockey, R. F., & Kolliputi, N. (2015) · Lung · doi:10.1007/s00408-015-9729-3 · Cited by 38 · see citing works
Unraveling Histone Loss in Aging and Senescence
Dubey, S. K., Dubey, R., & Kleinman, M. E. (2024) · Cells · doi:10.3390/cells13040320 · Cited by 32 · see citing works
A ride through the epigenetic landscape: aging reversal by reprogramming
Camillo, L. P. D. L., & Quinlan, R. B. A. (2021) · GeroScience · doi:10.1007/s11357-021-00358-6 · Cited by 30 · see citing works
Decoding the Regulatory Landscape of Ageing in Musculoskeletal Engineered Tissues Using Genome-Wide DNA Methylation and RNASeq
Peffers, M. J., Goljanek‐Whysall, K., Collins, J., Fang, Y., Rushton, M. D., Loughlin, J. A., Proctor, C. J., & Clegg, P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160517 · Cited by 30 · see citing works
Measuring pharmacogenetics in special groups: geriatrics
Seripa, D., Panza, F., Daragjati, J., Paroni, G., & Pilotto, A. (2015) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2015.1041919 · Cited by 28 · see citing works
Accelerated lung aging and chronic obstructive pulmonary disease
Yoon, Y.-S., Jin, M., & Sin, D. D. (2019) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2019.1580576 · Cited by 26 · see citing works
Epigenetic enzymes: A role in aging and prospects for pharmacological targeting
PASYUKOVA, E. G., Symonenko, A. V., Rybina, O. Y., & Vaiserman, A. M. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101312 · Cited by 27 · see citing works
Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging
Zhang, L., Xu, H., Ding, N., Li, X., Chen, X., & Chen, Z. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.715443 · Cited by 28 · see citing works
Metabolic switch in the aging astrocyte supported via integrative approach comprising network and transcriptome analyses
Acevedo, A., Torres, F., Kiwi, M., Baeza‐Lehnert, F., Barros, L. F., Lee‐Liu, D., & González-Billault, C. E. (2023) · Aging · doi:10.18632/aging.204663 · Cited by 25 · see citing works
Ready, SET, Go: Post-translational regulation of the histone lysine methylation network in budding yeast
Separovich, R. J., & Wilkins, M. R. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100939 · Cited by 25 · see citing works
Cxxc finger protein 1 maintains homeostasis and function of intestinal group 3 innate lymphoid cells with aging
Shen, X., Gao, X., Luo, Y.-K., Xu, Q.-H., Fan, Y., Hong, S., Huang, Z., Liu, X., Wang, Q.-Q., Chen, Z.-J., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00453-7 · Cited by 21 · see citing works
Role of epigenetics in the regulation of skin aging and geroprotective intervention: A new sight
Pozzo, L. D., Xu, Z., Lin, S., Wang, J., Wang, Y., Enechojo, O. S., Abankwah, J. K., Peng, Y., Chu, X., Zhou, H., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116592 · Cited by 22 · see citing works
Chromatin methylation and cardiovascular aging
Illi, B., Ciarapica, R., & Capogrossi, M. C. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.02.011 · Cited by 21 · see citing works
Insights into the Role of Histone Methylation in Brain Aging and Potential Therapeutic Interventions
Vitorakis, N., & Piperi, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417339 · Cited by 20 · see citing works
Epigenetics in Skin Homeostasis and Ageing
Dermitzakis, I., Kyriakoudi, S. A., Chatzianagnosti, S., Chatzi, D., Vakirlis, E., Meditskou, S., Μanthou, M. E., & Theotokis, P. (2025) · Epigenomes · doi:10.3390/epigenomes9010003 · Cited by 21 · see citing works
Pharmacological intervention in oxidative stress as a therapeutic target in neurological disorders
Sharma, S., Advani, D., Das, A., Malhotra, N., Khosla, A., Arora, V., Jha, A., Yadav, M., Ambasta, R. K., & Kumar, P. (2021) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgab064 · Cited by 17 · see citing works
Epigenetic mechanisms of dietary restriction induced aging in Drosophila
Lian, T., Gaur, U., Yang, D., Li, D., Li, Y., & Yang, M. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.08.015 · Cited by 17 · see citing works
Is Evidence Supporting the Subtelomere–Telomere Theory of Aging?
Libertini, G., Shubernetskaya, O., Corbi, G., & Ferrara, N. (2021) · Biochemistry (Moscow) · doi:10.1134/s0006297921120026 · Cited by 16 · see citing works
RETRACTED ARTICLE: Molecular Mechanisms of Aging: The Role of Oxidative Stress and Epigenetic Modifications
Айтбаев, К. А., Murkamilov, I. T., & Fomin, V. V. (2019) · Advances in Gerontology · doi:10.1134/s2079057019040027 · Cited by 16 · see citing works
Retracted
Human iPSC-Derived Neurons as A Platform for Deciphering the Mechanisms behind Brain Aging
Chao, C., Shen, P.-W., Tzeng, T., Kung, H., Tsai, T., & Wong, Y. (2021) · Biomedicines · doi:10.3390/biomedicines9111635 · Cited by 13 · see citing works
Pharmacogenetics of neurological and psychiatric diseases at older age: has the time come?
Lozupone, M., Panza, F., Stella, E., Montagna, M. L., Bisceglia, P., Miscio, G., Galizia, I., Daniele, A., Mauro, L. D., Bellomo, A., et al. (2016) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2017.1246533 · Cited by 14 · see citing works
Drosophila melanogaster as a Model for Studying the Epigenetic Basis of Aging
Solovev, I. A., Shaposhnikov, M. V., Kudryavtseva, A. V., & Moskalev, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-811060-7.00014-0 · Cited by 13 · see citing works
Caenorhabditis elegans,un modèle d’étude du vieillissement
Litke, R. R., Boulanger, É., & Fradin, C. (2018) · médecine/sciences · doi:10.1051/medsci/20183406017 · Cited by 13 · see citing works
The possible involvement of oxidative stress in the oocyte ageing process in goldfish Carassius auratus (Linnaeus, 1758)
Samarin, A. M., Samarin, A. M., Østbye, T.-K. K., Ruyter, B., Sampels, S., Burkina, V., Blecha, M., & Policar, T. (2019) · Scientific Reports · doi:10.1038/s41598-019-46895-1 · Cited by 13 · see citing works
Senescence of skeletal stem cells and their contribution to age-related bone loss
Wölfel, E. M., Guerra, P. F., Nørgård, M. Ø., Jeromdesella, S., Kjær, P. K., Elkjaer, A. S., Kassem, M. S., & Figeac, F. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111976 · Cited by 12 · see citing works
Histone Modification Changes During Aging
Cao, X., & Dang, W. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-811060-7.00015-2 · Cited by 14 · see citing works
Self-citation
Impact of chromosomal organization on epigenetic drift and domain stability revealed by physics-based simulations
Wakim, J. G., Sandholtz, S. H., & Spakowitz, A. J. (2021) · Biophysical Journal · doi:10.1016/j.bpj.2021.10.019 · Cited by 10 · see citing works
Su(var)3-9 mediates age-dependent increase in H3K9 methylation on TDP-43 promoter triggering neurodegeneration
Marzullo, M., Romano, G., Pellacani, C., Riccardi, F., Ciapponi, L., & Feiguin, F. M. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01643-3 · Cited by 10 · see citing works
Epigenetics and Ageing
Bellizzi, D., Guarasci, F., Iannone, F., Passarino, G., & Rose, G. (2019) · Springer eBooks · doi:10.1007/978-3-030-20762-5_7 · Cited by 10 · see citing works
AI-based investigation of molecular biomarkers of longevity
Kendiukhov, I. (2020) · Biogerontology · doi:10.1007/s10522-020-09890-y · Cited by 9 · see citing works
Epigenetics and bone diseases
Huang, T., Xiu, P., Li, Z., Zhou, Q., Huang, S., Wang, Y., Li, J., & Song, Y. (2018) · Genetics Research · doi:10.1017/s0016672318000034 · Cited by 8 · see citing works
Age- and sex-dependent alteration of functions and epigenetic modifications of vessel and endothelium related biomarkers
Han, S., AYDIN, M. M., Akansel, S., Usanmaz, S. E., Akçali, C., Uludağ, M. O., & Demirel-Yılmaz, E. (2018) · TURKISH JOURNAL OF BIOLOGY · doi:10.3906/biy-1803-59 · Cited by 8 · see citing works
The role of epigenetic modifications in the osteogenic differentiation of adipose-derived stem cells
Chen, R., Ren, L., Cai, Q., Zou, Y., Fu, Q., & Ma, Y. (2019) · Connective Tissue Research · doi:10.1080/03008207.2019.1593395 · Cited by 8 · see citing works
Aging and Aging-Related Senescence in Liver
Ganguly, S., Sakane, S., Hokutan, K., Zhang, V., Miciano, C., Wang, A., Brenner, D. A., & Kisseleva, T. (2025) · Seminars in Liver Disease · doi:10.1055/a-2637-2549 · Cited by 8 · see citing works
Identification of epigenetic histone modifications and analysis of histone lysine methyltransferases in Alexandrium pacificum
Zhu, Z., Liu, Y., Qi, J., & Sui, Z. (2022) · Harmful Algae · doi:10.1016/j.hal.2022.102323 · Cited by 7 · see citing works
Genomic instability and aging
Li, Z., Anugula, S., & Rasmussen, L. J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823761-8.00020-3 · Cited by 6 · see citing works
Age-associated regulation of chondrocyte hypertrophy in osteoarthritis: Mechanisms, therapeutic implications, and cartilage fate reprogramming
Ha, J. S., Jo, A., Yeo, E. J., Kim, Y. W., Lim, J.-Y., Yun, S., Moon, S. W., & Choi, W.-S. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103139 · Cited by 5 · see citing works
Unmasking the challenges of Kabuki syndrome in adulthood: A case series
Priestley, J. R. C., Rippert, A. L., Condit, C., Izumi, K., Kallish, S., & Drivas, T. G. (2023) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.32054 · Cited by 4 · see citing works
Effects of Salmonella enteritidis Vaccination on the Expression of Innate Immune Molecules and Histone Modifications in the Follicular Theca of Laying Hens
Kang, Y. E., Nii, T., Isobe, N., & Yoshimura, Y. (2019) · The Journal of Poultry Science · doi:10.2141/jpsa.0190034 · Cited by 4 · see citing works
New Aspects of the Pathophysiology of Diabetic Bone Fragility – Type 2 Diabetes Mellitus as a Disease of Accelerated Aging
Wölfel, E. M., & Kassem, M. S. (2025) · Current Osteoporosis Reports · doi:10.1007/s11914-025-00936-z · Cited by 3 · see citing works
A New Look at the Role of Radiation-Related Epigenetic Mechanisms in Diagnosis and Anticancer Therapies
Olichwier, A. J., Bruzgo-Grzybko, M., Kalita, I. S., Bielicka, N., Chabielska, E., & Gromotowicz‐Poplawska, A. (2025) · Cells · doi:10.3390/cells14231885 · Cited by 3 · see citing works
Histone modification clocks for robust cross-species biological age prediction and elucidating senescence regulation
Niu, Z., Liu, C., Fan, Y., & Gu, L. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2533687123 · Cited by 4 · see citing works
High-Throughput Rapid Yeast Chronological Lifespan Assay
Khawaja, A.-A.-W., Belak, Z. R., Eskiw, C. H., & Harkness, T. A. A. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0868-5_18 · Cited by 3 · see citing works
Methylation: A multifaceted modification — Looking at transcription and beyond
Whetstine, J. R. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.09.005 · Cited by 3 · see citing works
Epigenetics of Aging and Cancer: A Comprehensive Look
Hartley, A.-V., Martin, M., Jin, J., & Lu, T. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813939-4.00037-1 · Cited by 2 · see citing works
An Updated Review on the Significance of DNA and Protein Methyltransferases and De-methylases in Human Diseases: From Molecular Mechanism to Novel Therapeutic Approaches
Ghanbari, M., Khosroshahi, N. S., Alamdar, M., Abdi, A., Aghazadeh, A., Feizi, M. A. H., & Haghi, M. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867330666230607124803 · Cited by 2 · see citing works
In vitro post-ovulatory oocyte ageing in grass carp Ctenopharyngodon idella affects H4K12 acetylation pattern and histone acetyltransferase activity
Samarin, A. M., Samarin, A. M., Waghmare, S. G., Danielsen, M., Møller, H. S., Policar, T., Linhart, O., & Dalsgaard, T. K. (2023) · Fish Physiology and Biochemistry · doi:10.1007/s10695-023-01273-7 · Cited by 2 · see citing works
Epigenetic Alterations in Aging and Aging-Associated Diseases: Review
Gunes, S. O., & Bayramov, B. (2016) · Turkiye Klinikleri Journal of Medical Sciences · doi:10.5336/medsci.2016-51843 · Cited by 2 · see citing works
Healthy Aging and Epigenetic Drugs for Diabetes and Obesity
Meruvu, S., Bowman, J. D., & Choudhury, M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-811060-7.00020-6 · Cited by 2 · see citing works
RNA dysfunction in age-related macular degeneration: the role of U1 snRNP complex and neurodegenerative diseases
Bottós, J. M., Soares, E. S., Zimmer, C. G. M., Sinatti, V. V. C., Leal, C. B. Q. S., & Sallum, J. M. F. (2025) · International Journal of Retina and Vitreous · doi:10.1186/s40942-025-00736-8 · Cited by 1 · see citing works
Histone modifications in biological age determination: mechanisms, biomarkers, and therapeutic perspectives
Tripathi, A., Sharma, G., Pandey, V. K., Rustagi, S., Sharma, A. R., Jha, M., Debnath, A., Joy, J. G., Kim, J., & Jha, A. K. (2026) · GeroScience · doi:10.1007/s11357-026-02107-z · Cited by 1 · see citing works
Inhibitors of Jumonji C-Domain Histone Demethylases
Staller, P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800206-3.00020-3 · Cited by 1 · see citing works
Aging mechanism
Zeliger, H. I. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91890-9.00002-7 · Cited by 1 · see citing works
Research progress in technologies for protein methylation analysis
Wang, K., Li, H., & Ye, M. (2025) · Scientia Sinica Chimica · doi:10.1360/ssc-2025-0042 · Cited by 1 · see citing works
Biology, Genetics and Molecular Aspects of Aging
Elakkiya, M. R., Mohandas, K., Sureshkumar, T., & Saraswathy, C. D. B. (2025) · IGI Global eBooks · doi:10.4018/979-8-3693-9730-5.ch002 · Cited by 1 · see citing works
Acute-stress impairs cytoprotective mechanisms through neural inhibition of the insulin pathwayPreprint
Rosa, M. J. D., Veuthey, T., Florman, J., Grant, J., Blanco, G., Andersen, N., Donnelly, J. L., Rayes, D., & Alkema, M. J. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/294645 · Cited by 1 · see citing works
Genética do envelhecimento e seu impacto sobre a longevidade humana: teorias e evidências para prevenção das doenças do envelhecimento
da Cruz, I. B. M. (2015) · PAJAR - Pan-American Journal of Aging Research · doi:10.15448/2357-9641.2014.1.20082
DNA enzymes for peptide-nucleic acid conjugation and for lysine methylation
Chu, C. (2017) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Существуют ли доказательства в пользу субтеломерно-теломерной теории старения?
Libertini, G., Shubernetskaya, O. S., Corbi, G., & Ferrara, N. (2021) · Biochemistry (Moscow) · doi:10.31857/s0320972521120022
Parkinson's Disease Related to Food and Nutrition
Lelo, A. P., Carlo, K. M., Nadege, Z. L., Bongo, G. N., & Theophile, M. F. (2023) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/978-1-6684-5156-4.ch014
Reprogramación celular y rejuvenecimiento: aplicación en el cerebro senil
Canatelli-Mallat, M. (2023) · doi:10.35537/10915/160047
2-oxoglutarate-dependent dioxygenase family as a molecular sensor for cellular oxygen and metabolic sensing
Nakayama, K., & Minamishima, Y. A. (2025) · Folia Pharmacologica Japonica · doi:10.1254/fpj.25021
Epigenetic modifications and aging: intermittent fasting as a catalyst for positive epigenetic changes
Sharma, B., Negi, R., Jain, S., Chaudhury, S., & Singh, P. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-30060-8.00011-x
Histone methyltransferase SET-18/SMYD2-mediated activation of NADase TIR-1d/SARM1 increases mtROS to promote aging
Xue, D., Su, X., Lelo, A. P., Zhang, Y., Ba, X., Zou, C., Ma, A., Liu, Y., & Li, X. (2026) · iScience · doi:10.1016/j.isci.2026.114649
Osteoblastic cell senescence and their contribution to metabolic bone diseases
Wölfel, E. M., Figeac, F., Guerra, P. F., Nørgård, M. Ø., Jeromdesella, S., Kjær, P. K., Elkjaer, A. S., & Kassem, M. S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-13683-2.00012-8
Etude comparative des profils de réponses mécaniques, protéomiques et sécrétoires de fibroblastes jeunes et âgés
Boismal, F. (2021) · theses.fr (ABES) · doi:10.70675/b46879dez8548z48b4z8ea5z01fc12172485
Overview of hallmarks of aging
Sangeeth, A., Subramanian, M., Singh, A., & Singh, A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33159-6.00004-7

Authors: McCauley, B. S., & Dang, W.
Affiliations: Baylor College of Medicine (US)
Corresponding author: Dang, Weiwei
ORCID: Dang, Weiwei
Venue: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
Publisher: Elsevier BV
Published: 2014-12
Volume: 1839
Issue: 12
Pages: 1454-1462
ISSN: 1874-9399 (ISSN-L)
DOI: 10.1016/j.bbagrm.2014.05.008
PMC: PMC4240748
OpenAlex: W2023752776
Cited by: 93
References: 121
Citations by year: 2026: 6 · 2025: 9 · 2024: 4 · 2023: 11 · 2022: 3 · 2021: 13 · 2020: 3 · 2019: 12 · 2018: 7 · 2017: 5 · 2016: 8 · 2015: 10 · 2014: 2
FWCI: 0.93
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Cancer Prevention and Research Institute of Texas
National Institutes of Health
National Institute on Aging (R00AG037646)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: histone methylation, aging, lifespan, histone methyltransferase, histone demethylase, insulin signaling, Caenorhabditis elegans, yeast, senescence-associated secretory phenotype, transcriptional regulation
MeSH terms: Histone Methyltransferases, Aging, Animals, Histones, Humans, Methylation, Models, Biological, Progeria, Histone-Lysine N-Methyltransferase, Protein Processing, Post-Translational, DNA Methylation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Histone methylation and aging: Lessons learned from model systems

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks