The DOI matches its Crossref record; 240 of the 240 references it cites were found in a registry or an index.
DNA replication as a target of the DNA damage checkpoint
Abstract
Faithful inheritance of the genome from mother to daughter cell requires that it is replicated accurately, in its entirety, exactly once. DNA replication not only has to have high fidelity, but also has to cope with exogenous and endogenous agents that damage DNA during the life cycle of a cell. The DNA damage checkpoint, which monitors and responds to defects in the genome, is critical for the completion of replication. The focus of this review is how DNA replication is regulated by the checkpoint response in the presence of DNA damage and fork stalling agents.
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“and to combined treatment with gemcitabine - a deoxycytidine analog that inhibits DNA synthesis and further depletes dNTP pools by targeting ribonucleotide reductase159- and CHK1 inhibitors, that abrogate the CHK1-mediated checkpoint response to replicative stress160, 161.”
From Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy (2019) · cites this paper as [161]
Citations
Cites
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
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DNA Replication in Eukaryotic Cells
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E2F integrates cell cycle progression with DNA repair, replication, and G 2 /M checkpoints
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Cited by
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Control of cell cycle transcription during G1 and S phases
Bertoli, C., Skotheim, J. M., & de Bruin, R. A. M. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3629 · Cited by 1,567
Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy
Skoulidis, F., & Heymach, J. V. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0179-8 · Cited by 1,019
Maintaining genome stability at the replication fork
Branzei, D., & Foiani, M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2852 · Cited by 786
Eukaryotic DNA replication origins: many choices for appropriate answers
Méchali, M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2976 · Cited by 441
An overview of Cdk1-controlled targets and processes
Enserink, J. M., & Kolodner, R. D. (2010) · Cell Division · doi:10.1186/1747-1028-5-11 · Cited by 409
Metadata
- Authors
- Zegerman, P., & Diffley, J. F. X.
- Affiliations
- Cancer Research UK (GB)
- Corresponding author
- Diffley, John F.X.
- Venue
- DNA Repair
- Publisher
- Elsevier BV
- Published
- 2009-09-02
- Volume
- 8
- Issue
- 9
- Pages
- 1077-1088
- ISSN
- 1568-7856 (ISSN-L)
- 1568-7864
- OpenAlex
- W2056492477
- Cited by
- 128
- References
- 240
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 6 · 2018: 5 · 2017: 7 · 2016: 9 · 2015: 7 · 2014: 11 · 2013: 18 · 2012: 17
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- DNA repair (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cancer Research UK
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- DNA replication, DNA damage checkpoint, replication fork stalling, replication fork restart, DNA damage response, replication regulation
- MeSH terms
- Replisomes, Animals, Cell Cycle, DNA Damage, DNA-Directed DNA Polymerase, DNA Replication, Eukaryotic Cells, Humans, Multienzyme Complexes, Replication Origin
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