DNA replication as a target of the DNA damage checkpoint

ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

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DNA Replication in Eukaryotic Cells

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

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Chk1 is an essential kinase that is regulated by Atr and required for the G 2 /M DNA damage checkpoint

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A major developmental transition in early xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage

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E2F integrates cell cycle progression with DNA repair, replication, and G 2 /M checkpoints

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The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

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A major developmental transition in early xenopus embryos: II. control of the onset of transcription

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Geminin, an inhibitor of DNA replication, is degraded during mitosis.

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ATR and ATRIP: Partners in Checkpoint Signaling

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On the mechanism of DNA replication in mammalian chromosomes

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ATR disruption leads to chromosomal fragmentation and early embryonic lethality

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A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

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Choreography of the DNA Damage Response

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Genome instability: a mechanistic view of its causes and consequences

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Fork Reversal and ssDNA Accumulation at Stalled Replication Forks Owing to Checkpoint Defects

Sogo, J. M., Lopes, M., & Foiani, M. (2002) · Science · doi:10.1126/science.1074023 · Cited by 824

THE DNA REPLICATION FORK IN EUKARYOTIC CELLS

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Replication Dynamics of the Yeast Genome

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Radiosensitivity in ataxia-telangiectasia: a new explanation.

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Rapid Destruction of Human Cdc25A in Response to DNA Damage

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INTERACTIONS BETWEEN DEOXYRIBONUCLEOTIDE AND DNA SYNTHESIS

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GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks

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Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint

Byun, T. S., Pacek, M., Yee, M.-C., Walter, J. C., & Cimprich, K. A. (2005) · Genes & Development · doi:10.1101/gad.1301205 · Cited by 767

The DNA replication checkpoint response stabilizes stalled replication forks

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Components and Dynamics of DNA Replication Complexes in S. cerevisiae: Redistribution of MCM Proteins and Cdc45p during S Phase

Aparicio, O. M., Weinstein, D. M., & Bell, S. P. (1997) · Cell · doi:10.1016/s0092-8674(01)80009-x · Cited by 741

A Suppressor of Two Essential Checkpoint Genes Identifies a Novel Protein that Negatively Affects dNTP Pools

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Isolation of the Cdc45/Mcm2–7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase

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Inhibition of Eukaryotic DNA Replication by Geminin Binding to Cdt1

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Uninterrupted MCM2-7 function required for DNA replication fork progression.

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Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint

Tercero, J. A., & Diffley, J. F. X. (2001) · Nature · doi:10.1038/35087607 · Cited by 667

SOS Repair Hypothesis: Phenomenology of an Inducible DNA Repair Which is Accompanied by Mutagenesis

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Preventing re-replication of chromosomal DNA

Blow, J. J., & Dutta, A. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1663 · Cited by 664

A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication

Santocanale, C., & Diffley, J. F. X. (1998) · Nature · doi:10.1038/27001 · Cited by 663

S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex

Katou, Y., Kanoh, Y., Bando, M., Noguchi, H., Tanaka, H., Ashikari, T., Sugimoto, K., & Shirahige, K. (2003) · Nature · doi:10.1038/nature01900 · Cited by 649

Dormant origins licensed by excess Mcm2–7 are required for human cells to survive replicative stressPreprint

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DNA polymerase ? inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes

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A checkpoint regulates the rate of progression through S phase in S. cerevisiae in Response to DNA damage

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ATR Regulates Fragile Site Stability

Casper, A. M., Nghiem, P., Arlt, M. F., & Glover, T. W. (2002) · Cell · doi:10.1016/s0092-8674(02)01113-3 · Cited by 572

Yeast DNA Polymerase ε Participates in Leading-Strand DNA Replication

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Multiple mechanisms control chromosome integrity after replication fork uncoupling and restart at irreparable UV lesions

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Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro

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Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast

Zegerman, P., & Diffley, J. (2007) · Nature · doi:10.1038/nature05432 · Cited by 555

Genomic Expression Responses to DNA-damaging Agents and the Regulatory Role of the Yeast ATR Homolog Mec1p

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Control of the DNA damage checkpoint by Chk1 and Rad53 protein kinases through distinct mechanisms

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CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast

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Division of Labor at the Eukaryotic Replication Fork

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DNA damage signalling guards against activated oncogenes and tumour progression

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Mrc1 transduces signals of DNA replication stress to activate Rad53

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The Units of DNA Replication in Drosophila melanogaster ChromosomesPreprint

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Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication

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Mechanism of Replication-Coupled DNA Interstrand Crosslink Repair

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The DNA Replication and Damage Checkpoint Pathways Induce Transcription by Inhibition of the Crt1 Repressor

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The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast.Preprint

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Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast

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Aberrant cell cycle checkpoint function and early embryonic death in Chk1−/− micePreprint

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Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms

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Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

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Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathwayPreprint

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Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

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Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation.

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Survival of DNA Damage in Yeast Directly Depends on Increased dNTP Levels Allowed by Relaxed Feedback Inhibition of Ribonucleotide Reductase

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Claspin, a Novel Protein Required for the Activation of Chk1 during a DNA Replication Checkpoint Response in Xenopus Egg Extracts

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ATR Homolog Mec1 Promotes Fork Progression, Thus Averting Breaks in Replication Slow Zones

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Global response of Saccharomyces cerevisiae to an alkylating agent

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Genome-Wide Distribution of ORC and MCM Proteins in S. cerevisiae : High-Resolution Mapping of Replication Origins

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Regulation of DNA-replication origins during cell-cycle progression

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Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases

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Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication.

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Chk2 activates E2F-1 in response to DNA damage

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A Central Role for DNA Replication Forks in Checkpoint Activation and Response

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Regulation of Early Events in Chromosome Replication

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Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53Preprint

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S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state

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Excess Mcm2–7 license dormant origins of replication that can be used under conditions of replicative stress

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An ATR- and Cdc7-Dependent DNA Damage Checkpoint that Inhibits Initiation of DNA Replication

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DUN1 encodes a protein kinase that controls the DNA damage response in yeast

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Cdc7-Dbf4 Phosphorylates MCM Proteins via a Docking Site-Mediated Mechanism to Promote S Phase Progression

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Dynamics of DNA Replication in Mammalian Somatic Cells

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DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1

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Formation of a Preinitiation Complex by S-phase Cyclin CDK-Dependent Loading of Cdc45p onto Chromatin

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Transition in Specification of Embryonic Metazoan DNA Replication Origins

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Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases

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Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase.Preprint

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The events of the midblastula transition in Xenopus are regulated by changes in the cell cycle

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Regulation of Mammalian Ribonucleotide Reduction and dNTP Pools after DNA Damage and in Resting Cells

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The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1

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S-phase feedback control in budding yeast independent of tyrosine phosphorylation of P34cdc28

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Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication forkPreprint

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The Cdc7 protein kinase is required for origin firing during S phasePreprint

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The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage

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Exo1 Processes Stalled Replication Forks and Counteracts Fork Reversal in Checkpoint-Defective Cells

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MCM2–7 Complexes Bind Chromatin in a Distributed Pattern Surrounding the Origin Recognition Complex inXenopus Egg Extracts

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Cdc7p–Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway

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E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis

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Mrc1 and Tof1 Promote Replication Fork Progression and Recovery Independently of Rad53

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Gross Chromosomal Rearrangements and Elevated Recombination at an Inducible Site-Specific Replication Fork Barrier

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DNA-replication checkpoint control at the Drosophila midblastula transition

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