Cited by 128DNA Repair MechanismsBacterial Genetics and BiotechnologyCancer-related Molecular Pathways

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DNA replication as a target of the DNA damage checkpoint

Zegerman, Philip, Diffley, John F.X.·2009·DNA Repair

DOI 10.1016/j.dnarep.2009.04.023

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Abstract

Faithful inheritance of the genome from mother to daughter cell requires that it is replicated accurately, in its entirety, exactly once. DNA replication not only has to have high fidelity, but also has to cope with exogenous and endogenous agents that damage DNA during the life cycle of a cell. The DNA damage checkpoint, which monitors and responds to defects in the genome, is critical for the completion of replication. The focus of this review is how DNA replication is regulated by the checkpoint response in the presence of DNA damage and fork stalling agents.

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Authors: Zegerman, P., & Diffley, J. F. X.
Affiliations: Cancer Research UK (GB)
Corresponding author: Diffley, John F.X.
ORCID: Zegerman, Philip
Diffley, John F.X.
Venue: DNA Repair
Publisher: Elsevier BV
Published: 2009-09-02
Volume: 8
Issue: 9
Pages: 1077-1088
ISSN: 1568-7856 (ISSN-L)
1568-7864
DOI: 10.1016/j.dnarep.2009.04.023
OpenAlex: W2056492477
Cited by: 128
References: 240
Citations by year: 2025: 2 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 6 · 2018: 5 · 2017: 7 · 2016: 9 · 2015: 7 · 2014: 11 · 2013: 18 · 2012: 17
FWCI: 6.99
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: DNA repair (publishedVersion)
PubMed (publishedVersion)
Funders: Cancer Research UK
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: DNA replication, DNA damage checkpoint, replication fork stalling, replication fork restart, DNA damage response, replication regulation
MeSH terms: Replisomes, Animals, Cell Cycle, DNA Damage, DNA-Directed DNA Polymerase, DNA Replication, Eukaryotic Cells, Humans, Multienzyme Complexes, Replication Origin

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DNA replication as a target of the DNA damage checkpoint

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