The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
The ubiquitous role of ubiquitin in the DNA damage response
Open accessAbstract
Protein ubiquitylation has emerged as an important regulatory mechanism that impacts almost every aspect of the DNA damage response. In this review, we discuss how DNA repair and checkpoint pathways utilize the diversity offered by the ubiquitin conjugation system to modulate the response to genotoxic lesions in space and time. In particular, we will highlight recent work done on the regulation of DNA double-strand breaks signalling and repair by the RNF8/RNF168 E3 ubiquitin ligases, the Fanconi anemia pathway and the role of protein degradation in the enforcement and termination of checkpoint signalling. We also discuss the various functions of deubiquitylating enzymes in these processes along with potential avenues for exploiting the ubiquitin conjugation/deconjugation system for therapeutic purposes.
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Cites
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Cited by
Komander, D., & Rape, M. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060310-170328 · Cited by 3,679
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
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V(D)J Recombination: Mechanisms of Initiation
Schatz, D. G., & Swanson, P. C. (2011) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132552 · Cited by 591
Moyal, L., Lerenthal, Y., Gana-Weisz, M., Mass, G., So, S., Wang, S.-Y., Eppink, B., Chung, Y. M., Shalev, G., Shema, E., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.02.015 · Cited by 403
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Metadata
- Authors
- Al-Hakim, A., Escribano-Diaz, C., Landry, M.-C., O’Donnell, L., Panier, S., Szilard, R. K., & Durocher, D.
- Venue
- DNA Repair
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 9
- Issue
- 12
- Pages
- 1229-1240
- ISSN
- 1568-7856 (ISSN-L)
- 1568-7864
- OpenAlex
- W2061462200
- Cited by
- 223
- References
- 34
- FWCI
- 11.81
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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