Brca1 Controls Homology-Directed DNA Repair

The double-strand-break repair model for recombination

Szostak, J. W., Orr-Weaver, T. L., Rothstein, R. J., & Stahl, F. W. (1983) · Cell · doi:10.1016/0092-8674(83)90331-8 · Cited by 2,437

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81847-4 · Cited by 1,459

XRCC3 promotes homology-directed repair of DNA damage in mammalian cellsPreprint

Pierce, A. J., Johnson, R. D., Thompson, L. H., & Jasin, M. (1999) · Genes & Development · doi:10.1101/gad.13.20.2633 · Cited by 1,384

Gatekeepers and caretakers

Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/386761a0 · Cited by 1,240

The Genetic Basis of Human Cancer

Vogelstein, B., & Kinzler, K. W. (1997) · Cited by 1,120

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

Sharan, S. K., Morimatsu, M., Albrecht, U., Lim, D., Regel, E., Dinh, C. Q., Sands, A., Gregor Eichele, C., Hasty, P., & Bradley, A. (1997) · Nature · doi:10.1038/386804a0 · Cited by 1,085

Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

Xu, X., Ohler, Z. W., Linke, S. P., Li, C., Gotay, J., Wang, X. W., Harris, C. C., Ried, T., & Deng, C. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80466-9 · Cited by 819

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

de Wind, N., Dekker, M., Berns, A. J. M., Radman, M., & Riele, H. T. (1995) · Cell · doi:10.1016/0092-8674(95)90319-4 · Cited by 780

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse.

Hakem, R., de la Pompa, J. L., Sirard, C., Mo, R., Woo, M., Hakem, A., Wakeham, A., Potter, J., Reitmair, A., Billia, F., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81302-1 · Cited by 680

Homology-directed repair is a major double-strand break repair pathway in mammalian cells

Liang, F., Han, M., Romanienko, P. J., & Jasin, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5172 · Cited by 649

Involvement of Brca2 in DNA Repair

Patel, K. J., Yu, V. P. C. C., Lee, H., Corcoran, A. E., Thistlethwaite, F. C., Evans, M. J., Colledge, W. H., Friedman, L. S., Ponder, B. A. J., & Venkitaraman, A. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80035-0 · Cited by 643

Stable Interaction between the Products of the BRCA1 and BRCA2 Tumor Suppressor Genes in Mitotic and Meiotic Cells

Chen, J., Silver, D. P., Walpita, D., Cantor, S. B., Gazdar, A. F., Tomlinson, G. E., Couch, F. J., Weber, B. L., Ashley, T., Livingston, D. M., et al. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80276-2 · Cited by 635

Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response

Zhong, Q., Chen, C.-F., Li, S., Chen, Y., Wang, C.-C., Xiao, J., Chen, P.-L., Sharp, Z. D., & Lee, W.-H. (1999) · Science · doi:10.1126/science.285.5428.747 · Cited by 626

RAD51 Interacts with the Evolutionarily Conserved BRC Motifs in the Human Breast Cancer Susceptibility Gene brca2

Wong, A. K. C., Pero, R. S., Ormonde, P. A., Tavtigian, S. V., & Bartel, P. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.51.31941 · Cited by 544

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos.Preprint

Ludwig, T. E., Chapman, D. L., Papaioannou, V. E., & Efstratiadis, A. (1997) · Genes & Development · doi:10.1101/gad.11.10.1226 · Cited by 539

XRCC2 and XRCC3, New Human Rad51-Family Members, Promote Chromosome Stability and Protect against DNA Cross-Links and Other Damages

Liu, N., Lamerdin, J. E., Tebbs, R. S., Schild, D., Tucker, J. D., Shen, M. R., Brookman, K. W., Siciliano, M. J., Walter, C. A., Fan, W., et al. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80078-7 · Cited by 534

The scid mutation in mice causes a general defect in DNA repair

Fulop, G. M., & Phillips, R. A. (1990) · Nature · doi:10.1038/347479a0 · Cited by 532

Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

Gowen, L. C., Johnson, B. L., Latour, A. M., Sulik, K. K., & Koller, B. H. (1996) · Nature Genetics · doi:10.1038/ng0296-191 · Cited by 489

Impairment of V(D)J Recombination in Double-Strand Break Repair Mutants

Taccioli, G. E., Rathbun, G. A., Oltz, E. M., Stamato, T. D., Jeggo, P. A., & Alt, F. W. (1993) · Science · doi:10.1126/science.8469973 · Cited by 451

Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs.

Riele, H. T., Maandag, E. R., & Berns, A. J. M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.11.5128 · Cited by 446

Double-strand break repair by interchromosomal recombination: suppression of chromosomal translocationsPreprint

Richardson, C. A., Moynahan, M. E., & Jasin, M. (1998) · Genes & Development · doi:10.1101/gad.12.24.3831 · Cited by 442

Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

Connor, F., Bertwistle, D., Mee, P. J., Ross, G. M., Swift, S., Grigorieva, E. F., Tybulewicz, V. L. J., & Ashworth, A. (1997) · Nature Genetics · doi:10.1038/ng1297-423 · Cited by 432

The Genetic Basis of Human Cancer

Rubin, C. M. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-129-9-199811010-00045 · Cited by 403

Hereditary nonpolyposis colorectal cancer (lynch syndromes I and II). I. Clinical description of resource

Lynch, H. T., Kimberling, W. J., Albano, W. A., Lynch, J. F., Biscone, K. A., Schuelke, G. S., Sandberg, A. A., Lipkin, M., Deschner, E. E., Mikol, Y. B., et al. (1985) · Cancer · doi:10.1002/1097-0142(19850815)56:4 · Cited by 400

The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment

Chen, P., Chen, C., Chen, Y., Xiao, J., Sharp, Z. D., & Lee, W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5287 · Cited by 394

Distinct somatic genetic changes associated with tumor progression in carriers of BRCA1 and BRCA2 germ-line mutations.

Tirkkonen, M., Johannsson, O. T., Agnarsson, B. A., Olsson, H. L., Ingvarsson, S., Karhu, R., Tanner, M., Isola, J. J., Barkardottir, R. B., Borg, Å., et al. (1997) · PubMed · Cited by 354

A targeted disruption of the murine Brca1 gene causes γ-irradiation hypersensitivity and genetic instability

Shen, S.-X., Ohler, Z. W., Xu, X., Li, C., Weinstein, M. B., Chen, L., Guan, X., Ried, T., & Deng, C. (1998) · Oncogene · doi:10.1038/sj.onc.1202243 · Cited by 329

Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development.Preprint

Liu, C., Flesken‐Nikitin, A., Li, S., Zeng, Y., & Lee, W. (1996) · Genes & Development · doi:10.1101/gad.10.14.1835 · Cited by 323

Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination

Johnson, R. D., Liu, N., & Jasin, M. (1999) · Nature · doi:10.1038/43932 · Cited by 323

Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier.

Tomlinson, G. E., Chen, T. T., Stastny, V., Virmani, A. K., Spillman, M. A., Tonk, V. S., Blum, J. L., Schneider, N. R., Wistuba, I. I., Shay, J. W., et al. (1998) · PubMed · Cited by 292

Radiation Mutagenesis: The Initial DNA Lesions Responsible

Ward, J. F. (1995) · Radiation Research · doi:10.2307/3579145 · Cited by 271

BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner.

Chen, Y., Farmer, A. A., Chen, C., Jones, D. C., Chen, P., & Lee, W. (1996) · PubMed · Cited by 267

Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene.

Tebbs, R. S., Zhao, Y., Tucker, J. D., Scheerer, J. B., Siciliano, M., Hwang, M. S., Liu, N., Legerski, R. J., & Thompson, L. H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.14.6354 · Cited by 257

Consecutive inactivation of both alleles of the pim-1 proto-oncogene by homologous recombination in embryonic stem cells

Riele, H. T., Maandag, E. R., Clarke, A. R., Hooper, M., & Berns, A. J. M. (1990) · Nature · doi:10.1038/348649a0 · Cited by 239

RAB22 and RAB163/mouse BRCA2: Proteins that specifically interact with the RAD51 protein

Mizuta, R., LaSalle, J. M., Cheng, H.-L., Shinohara, A., Ogawa, H., Copeland, N. G., Jenkins, N. A., Lalande, M., & Alt, F. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6927 · Cited by 235

BRCA1 Expression Restores Radiation Resistance in BRCA1-defective Cancer Cells through Enhancement of Transcription-coupled DNA Repair

Abbott, D. W., Thompson, M. E., Robinson‐Benion, C., Tomlinson, G. E., Jensen, R. A., & Holt, J. T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.26.18808 · Cited by 228

Preferential repair of ionizing radiation-induced damage in the transcribed strand of an active human gene is defective in Cockayne syndrome.

Leadon, S. A., & Cooper, P. K. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.22.10499 · Cited by 215

Isolation and cross-sensitivity of X-ray-sensitive mutants of V79-4 hamster cells

Jones, N. J., Cox, R., & Thacker, J. (1987) · Mutation Research/DNA Repair Reports · doi:10.1016/0167-8817(87)90011-3 · Cited by 207

Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice.Preprint

Lane, T. F., Deng, C., Elson, A., Lyu, M. S., Kozak, C. A., & Leder, P. (1995) · Genes & Development · doi:10.1101/gad.9.21.2712 · Cited by 198

Chromosomal double-strand break repair in Ku80-deficient cells.

Liang, F., Romanienko, P. J., Weaver, D. T., Jeggo, P. A., & Jasin, M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.8929 · Cited by 190

Loss of heterozygosity induced by a chromosomal double-strand break

Moynahan, M. E., & Jasin, M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.8988 · Cited by 186

The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family

Cartwright, R. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.13.3084 · Cited by 147

BRCA1 expression is induced before DNA synthesis in both normal and tumor-derived breast cells.

Vaughn, J. P., Davis, P. L., Jarboe, M. D., Hüper, G., Evans, A. C., Wiseman, R. W., Berchuck, A., Iglehart, J. D., Futreal, P. A., & Marks, J. R. (1996) · PubMed · Cited by 145

Radiation-induced chromosome damage in X-ray-sensitive mutants (xrs) of the Chinese hamster ovary cell line

Kemp, L. M., & Jeggo, P. A. (1986) · Mutation Research/DNA Repair Reports · doi:10.1016/0167-8817(86)90025-8 · Cited by 100

Mammary tumor formation in p53- and BRCA1-deficient mice.

Cressman, V. L., Backlund, D. C., Hicks, E., Gowen, L. C., Godfrey, V., & Koller, B. H. (1999) · PubMed · Cited by 82

Chromosome Instability Syndromes: Lessons for Carcinogenesis

Meyn, M. S. (1997) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-60505-5_6 · Cited by 73

Hereditary Nonpolyposis Colorectal Cancer

Thorland, E. C., & Thibodeau, S. N. (2007) · Springer eBooks · doi:10.1007/978-0-387-33227-7_19 · Cited by 65

Isolation of the Mouse Homologue of BRCA1 and Genetic Mapping to Mouse Chromosome 11

BENNETT, M. L., Haugen, A. C., Cochran, C., Brownlee, H. A., Fiedorek, F. T., & Wiseman, R. W. (1995) · Genomics · doi:10.1006/geno.1995.9963 · Cited by 42

Chromosome instability syndromes

Howell, R. T., & Taylor, A. M. R. (1992) · doi:10.1093/oso/9780199632909.003.0008 · Cited by 12

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Farmer, H., McCabe, N., Lord, C. J., Tutt, A. N. J., Johnson, D. A., Richardson, T. B., Santarosa, M., Dillon, K. J., Hickson, I., Knights, C., et al. (2005) · Nature · doi:10.1038/nature03445 · Cited by 6,683

The DNA damage response: putting checkpoints in perspective

Zhou, B.-B. S., & Elledge, S. J. (2000) · Nature · doi:10.1038/35044005 · Cited by 3,213

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

Audeh, M. W., Carmichael, J., Penson, R. T., Friedlander, M., Powell, B., Bell-McGuinn, K. M., Scott, C., Weitzel, J. N., Oaknin, A., Loman, N., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60893-8 · Cited by 2,279

Cell cycle checkpoint signaling through the ATM and ATR kinases

Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966

Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian Cancer

Ledermann, J. A., Harter, P., Gourley, C., Friedlander, M. L., Vergote, I. B., Rustin, G. J. S., Scott, C. L., Meier, W., Shapira‐Frommer, R., Safra, T., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1105535 · Cited by 1,891

Cancer Susceptibility and the Functions of BRCA1 and BRCA2

Venkitaraman, A. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00615-3 · Cited by 1,713

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

Bunting, S. F., Callén, E., Wong, N., Chen, H.-T., Polato, F., Gunn, A., Bothmer, A., Feldhahn, N., Fernandez-Capetillo, O., Cao, L., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.012 · Cited by 1,671

DNA repair pathways as targets for cancer therapy

Helleday, T., Petermann, E., Lundin, C., Hodgson, B., & Sharma, R. A. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2342 · Cited by 1,666

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

Tutt, A., Robson, M., Garber, J. E., Domchek, S. M., Audeh, M. W., Weitzel, J. N., Friedlander, M., Arun, B., Loman, N., Schmutzler, R. K., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60892-6 · Cited by 1,655

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

Chapman, J. R., Taylor, M. R. G., & Boulton, S. J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.07.029 · Cited by 1,726

BRCA1 and BRCA2: different roles in a common pathway of genome protection

Roy, R., Chun, J., & Powell, S. N. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3181 · Cited by 1,555

Insights into Molecular Classifications of Triple-Negative Breast Cancer: Improving Patient Selection for Treatment

Garrido-Castro, A. C., Lin, N. U., & Polyak, K. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-1177 · Cited by 1,451

XRCC3 promotes homology-directed repair of DNA damage in mammalian cellsPreprint

Pierce, A. J., Johnson, R. D., Thompson, L. H., & Jasin, M. (1999) · Genes & Development · doi:10.1101/gad.13.20.2633 · Cited by 1,384

Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition

McCabe, N., Turner, N. C., Lord, C. J., Kluzek, K., Białkowska, A., Swift, S., Giavara, S., O’Connor, M. J., Tutt, A. N. J., Zdzienicka, M. Z., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0140 · Cited by 1,311

Regulation of DNA repair throughout the cell cycle

Branzei, D., & Foiani, M. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2351 · Cited by 1,228

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S. J., & Qin, J. (2000) · Genes & Development · doi:10.1101/gad.14.8.927 · Cited by 1,221

Chromosomal stability and the DNA double-stranded break connection

van Gent, D. C., Hoeijmakers, J. H. J., & Kanaar, R. (2001) · Nature Reviews Genetics · doi:10.1038/35056049 · Cited by 1,219

Interaction of the Fanconi Anemia Proteins and BRCA1 in a Common Pathway

Garcia-Higuera, I., Taniguchi, T., Ganesan, S., Meyn, M. S., Timmers, C., Hejna, J., Grompe, M., & D'Andrea, A. D. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00173-3 · Cited by 1,198

Sensing and repairing DNA double-strand breaks

Jackson, S. P. (2002) · Carcinogenesis · doi:10.1093/carcin/23.5.687 · Cited by 1,149

Role of cell cycle in mediating sensitivity to radiotherapy

Pawlik, T. M., & Keyomarsi, K. (2004) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2004.03.005 · Cited by 1,155

BRCA2 Is Required for Homology-Directed Repair of Chromosomal Breaks

Moynahan, M. E., Pierce, A. J., & Jasin, M. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00174-5 · Cited by 1,007

Molecular views of recombination proteins and their control

West, S. C. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1127 · Cited by 977

A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2

Schlacher, K., Wu, H., & Jasin, M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.05.015 · Cited by 936

Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

Moynahan, M. E., & Jasin, M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2851 · Cited by 959

Repair of Strand Breaks by Homologous RecombinationPreprint

Jasin, M., & Rothstein, R. J. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012740 · Cited by 929

Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins

Prakash, R., Zhang, Y., Feng, W., & Jasin, M. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016600 · Cited by 869

A Synthetic Lethal Therapeutic Approach: Poly(ADP) Ribose Polymerase Inhibitors for the Treatment of Cancers Deficient in DNA Double-Strand Break Repair

Ashworth, A. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.16.0812 · Cited by 872

Accurate classification of BRCA1 variants with saturation genome editing

Findlay, G. M., Daza, R. M., Martin, B., Zhang, M. D., Leith, A. P., Gasperini, M., Janizek, J. D., Huang, X., Starita, L. M., & Shendure, J. (2018) · Nature · doi:10.1038/s41586-018-0461-z · Cited by 843

Mechanisms underlying mutational signatures in human cancers

Helleday, T., Eshtad, S., & Nik‐Zainal, S. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3729 · Cited by 861

The Fanconi anaemia/BRCA pathway

D'Andrea, A. D., & Grompe, M. (2003) · Nature Reviews Cancer · doi:10.1038/nrc970 · Cited by 822

The many substrates and functions of ATM.

Kastan, M. B., & Lim, D.-S. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35043058 · Cited by 779

Toward Maintaining the Genome: DNA Damage and Replication Checkpoints

Nyberg, K. A., Michelson, R. J., Putnam, C. W., & Weinert, T. A. (2002) · Annual Review of Genetics · doi:10.1146/annurev.genet.36.060402.113540 · Cited by 793

DNA repair, genome stability and cancer: a historical perspective

Jeggo, P. A., Pearl, L. H., & Carr, A. M. (2015) · Nature reviews. Cancer · doi:10.1038/nrc.2015.4 · Cited by 781

Inherited Mutations in Women With Ovarian Carcinoma

Norquist, B. M., Harrell, M. I., Brady, M. F., Walsh, T., Lee, M. K., Gülsüner, S., Bernards, S. S., Casadei, S., Qian, Y., Burger, R. A., et al. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2015.5495 · Cited by 794

Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage

Yoshida, K., & Miki, Y. (2004) · Cancer Science · doi:10.1111/j.1349-7006.2004.tb02195.x · Cited by 753

Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response

Wang, B., Matsuoka, S., Ballif, B. A., Zhang, D., Smogorzewska, A., Gygi, S. P., & Elledge, S. J. (2007) · Science · doi:10.1126/science.1139476 · Cited by 695

BACH1, a Novel Helicase-like Protein, Interacts Directly with BRCA1 and Contributes to Its DNA Repair Function

Cantor, S. B., Bell, D. W., Ganesan, S., Kass, E. M., Drapkin, R., Grossman, S., Wahrer, D. C. R., Sgroi, D. C., Lane, W. S., Haber, D. A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00304-x · Cited by 674

In search of the tumour-suppressor functions of BRCA1 and BRCA2

Scully, R., & Livingston, D. M. (2000) · Nature · doi:10.1038/35044000 · Cited by 643

DNA double-strand break repair: From mechanistic understanding to cancer treatment

HELLEDAY, T., LO, J., VANGENT, D., & ENGELWARD, B. (2007) · DNA Repair · doi:10.1016/j.dnarep.2007.02.006 · Cited by 640

The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability

Gudmundsdottir, K. K., & Ashworth, A. (2006) · Oncogene · doi:10.1038/sj.onc.1209874 · Cited by 643

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

Sy, S. M.-H., Huen, M. S. Y., & Chen, J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811159106 · Cited by 643

The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance

Bouwman, P., & Jonkers, J. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3342 · Cited by 615

Review of Poly (ADP-ribose) Polymerase (PARP) Mechanisms of Action and Rationale for Targeting in Cancer and Other Diseases

Morales, J. C., Li, L.-S., Fattah, F. J., Dong, Y., Bey, E. A., Patel, M., Gao, J., & Boothman, D. A. (2013) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukaryotgeneexpr.2013006875 · Cited by 629

Sister chromatid gene conversion is a prominent double‐strand break repair pathway in mammalian cells

Johnson, R. D., & Jasin, M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.13.3398 · Cited by 590

The Breast Cancer Susceptibility Gene BRCA1 Is Required for Subnuclear Assembly of Rad51 and Survival following Treatment with the DNA Cross-linking Agent Cisplatin

Bhattacharyya, A., Ear, U., Koller, B. H., Weichselbaum, R. R., & Bishop, D. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000276200 · Cited by 584

Secondary Somatic Mutations RestoringBRCA1/2Predict Chemotherapy Resistance in Hereditary Ovarian Carcinomas

Norquist, B. M., Wurz, K., Pennil, C. C., Garcia, R. L., Gross, J., Sakai, W., Karlan, B. Y., Taniguchi, T., & Swisher, E. M. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.34.2980 · Cited by 593

Regulation and mechanisms of mammalian double-strand break repair

Valerie, K. C., & Povirk, L. F. (2003) · Oncogene · doi:10.1038/sj.onc.1206679 · Cited by 594

The emerging genetic and molecular basis of Fanconi anaemia

Joenje, H., & Patel, K. J. (2001) · Nature Reviews Genetics · doi:10.1038/35076590 · Cited by 566

PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response

Zhang, F., Ma, J., Wu, J., Ye, L., Cai, H., Xia, B., & Yu, X. (2009) · Current Biology · doi:10.1016/j.cub.2009.02.018 · Cited by 575

Repair of DNA interstrand cross-links

Dronkert, M. L. G., & Kanaar, R. (2001) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(01)00092-1 · Cited by 565

ATM and Artemis promote homologous recombination of radiation‐induced DNA double‐strand breaks in G2

Beucher, A., Birraux, J., Tchouandong, L., Barton, O., Shibata, A., Conrad, S., Goodarzi, A. A., Krempler, A., Jeggo, P. A., & Löbrich, M. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.276 · Cited by 595

DNA‐damage repair; the good, the bad, and the ugly

Hakem, R. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.15 · Cited by 577

BRCA1 Is Associated with a Human SWI/SNF-Related Complex

Bochar, D. A., Wang, L., Beniya, H., Kinev, A. V., Xue, Y., Lane, W. S., Wang, W., Kashanchi, F., & Shiekhattar, R. (2000) · Cell · doi:10.1016/s0092-8674(00)00030-1 · Cited by 546

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

Difilippantonio, M. J., Zhu, J., Chen, H. T., Meffre, E., Nussenzweig, M. C., Max, E. E., Ried, T., & Nussenzweig, A. (2000) · Nature · doi:10.1038/35006670 · Cited by 556

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

Lee, J., Collins, K. M., Brown, A. L., Lee, C. H., & Chung, J. H. (2000) · Nature · doi:10.1038/35004614 · Cited by 529

DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis

Bernstein, C. (2002) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(02)00009-1 · Cited by 527

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

Tang, J., Cho, N. W., Cui, G., Manion, E. M., Shanbhag, N. M., Botuyan, M. V., Mer, G., & Greenberg, R. A. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2499 · Cited by 521

Frequent chromosomal translocations induced by DNA double-strand breaks

Richardson, C., & Jasin, M. (2000) · Nature · doi:10.1038/35015097 · Cited by 517

Oncogenes and Tumor Suppressor GenesPreprint

Lee, E. Y., & Muller, W. J. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003236 · Cited by 575

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

Tibbetts, R. S., Cortez, D., Brumbaugh, K. M., Scully, R., Livingston, D., Elledge, S. J., & Abraham, R. T. (2000) · Genes & Development · doi:10.1101/gad.851000 · Cited by 512

Genetic Steps of Mammalian Homologous Repair with Distinct Mutagenic Consequences

Stark, J. M., Pierce, A. J., Oh, J., Pastink, A., & Jasin, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.21.9305-9316.2004 · Cited by 501

BRCA1 and its toolbox for the maintenance of genome integrity

Huen, M. S. Y., Sy, S. M.-H., & Chen, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2831 · Cited by 517

Phase II, Open-Label, Randomized, Multicenter Study Comparing the Efficacy and Safety of Olaparib, a Poly (ADP-Ribose) Polymerase Inhibitor, and Pegylated Liposomal Doxorubicin in Patients With BRCA1 or BRCA2 Mutations and Recurrent Ovarian Cancer

Kaye, S. B., Lubiński, J., Matulonis, U. A., Ang, J. E., Gourley, C., Karlan, B. Y., Amit, A., Bell‐McGuinn, K. M., Chen, L.-M., Friedlander, M. L., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.36.9215 · Cited by 478

The Fanconi Anemia/BRCA pathway: new faces in the crowdPreprint

Kennedy, R. D., & D’Andrea, A. D. (2005) · Genes & Development · doi:10.1101/gad.1370505 · Cited by 471

Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations

Pfeiffer, P. (2000) · Mutagenesis · doi:10.1093/mutage/15.4.289 · Cited by 489

S-phase–specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51

Taniguchi, T., García-Higuera, I., Andreassen, P. R., Gregory, R. C., Grompe, M., & D’Andrea, A. D. (2002) · Blood · doi:10.1182/blood-2002-01-0278 · Cited by 458

Secondary BRCA1 Mutations in BRCA1 -Mutated Ovarian Carcinomas with Platinum Resistance

Swisher, E. M., Sakai, W., Karlan, B. Y., Wurz, K., Urban, N. D., & Taniguchi, T. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0088 · Cited by 459

Convergence of the Fanconi Anemia and Ataxia Telangiectasia Signaling Pathways

Taniguchi, T., García-Higuera, I., Xu, B., Andreassen, P. R., Gregory, R. C., Kim, S., Lane, W. S., Kastan, M. B., & D’Andrea, A. D. (2002) · Cell · doi:10.1016/s0092-8674(02)00747-x · Cited by 452

DNA double strand break repair in mammalian cells

Karran, P. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00069-1 · Cited by 454

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

Wu, X., Ranganathan, V., Weisman, D., Heine, W. F., Ciccone, D. N., O'Neill, T. B., Crick, K. E., Pierce, K. A., Lane, W. S., Rathbun, G. A., et al. (2000) · Nature · doi:10.1038/35013089 · Cited by 449

The Role of BRCA1 in the Cellular Response to Chemotherapy

Kennedy, R. D., Quinn, J. E., Mullan, P. B., Johnston, P. G., & Harkin, D. P. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh312 · Cited by 431

Homologous recombinational repair of DNA ensures mammalian chromosome stability

Thompson, L. H., & Schild, D. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(01)00115-4 · Cited by 435

miR-182-Mediated Downregulation of BRCA1 Impacts DNA Repair and Sensitivity to PARP Inhibitors

Moskwa, P., Buffa, F. M., Pan, Y., Panchakshari, R. A., Gottipati, P., Muschel, R. J., Beech, J. S., Kulshrestha, R., Abdelmohsen, K., Weinstock, D. M., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.12.005 · Cited by 436

Cell Cycle-dependent Complex Formation of BRCA1·CtIP·MRN Is Important for DNA Double-strand Break Repair

Chen, L., Nievera, C. J., Lee, A. Y., & Wu, X. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710245200 · Cited by 455

Recombinational DNA repair and human disease

Thompson, L. H., & Schild, D. (2002) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(02)00224-5 · Cited by 417

RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis

Lipkowitz, S., & Weissman, A. M. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3120 · Cited by 421

Tumour lineage shapes BRCA-mediated phenotypes

Jonsson, P., Bandlamudi, C., Cheng, M. L., Srinivasan, P., Chavan, S. S., Friedman, N. D., Rosen, E. Y., Richards, A. L., Bouvier, N., Selçuklu, S. D., et al. (2019) · Nature · doi:10.1038/s41586-019-1382-1 · Cited by 400

BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis.

Quinn, J. E., Kennedy, R. D., Mullan, P. B., Gilmore, P. M., Carty, M., Johnston, P. G., & Harkin, D. P. (2003) · PubMed · Cited by 400

BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ

Litman, R., Peng, M., Jin, Z., Zhang, F., Zhang, J., Powell, S., Andreassen, P. R., & Cantor, S. B. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.004 · Cited by 396

BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing

Zhao, W., Steinfeld, J. B., Liang, F., Chen, X., Maranon, D. G., Jian Ma, C., Kwon, Y., Rao, T., Wang, W., Sheng, C., et al. (2017) · Nature · doi:10.1038/nature24060 · Cited by 393

Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair

Nakanishi, K., Yang, Y.-G., Pierce, A. J., Taniguchi, T., Digweed, M., D'Andrea, A. D., Wang, Z.-Q., & Jasin, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407796102 · Cited by 384

Chemistry and Biology of DNA Repair

Schärer, O. D. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200200523 · Cited by 395

Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation.

Moynahan, M. E., Cui, T. Y., & Jasin, M. (2001) · PubMed · Cited by 382

The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia

Levran, O., Attwooll, C., Henry, R. T., Milton, K. L., Neveling, K., Rio, P., Batish, S. D., Kalb, R., Velleuer, E., Barral, S., et al. (2005) · Nature Genetics · doi:10.1038/ng1624 · Cited by 370

53BP1: pro choice in DNA repair

Zimmermann, M., & de Lange, T. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.09.003 · Cited by 387

Homologous repair of DNA damage and tumorigenesis:the BRCA connection

Jasin, M. (2002) · Oncogene · doi:10.1038/sj.onc.1206176 · Cited by 356

The antitumorigenic roles of BRCA1–BARD1 in DNA repair and replication

Tarsounas, M., & Sung, P. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0218-z · Cited by 385

Genetic Analysis of BRCA1 Function in a Defined Tumor Cell Line

Scully, R., Ganesan, S., Vlasakova, K., Chen, J., Socolovsky, M., & Livingston, D. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80238-5 · Cited by 359

Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography

Thompson, L. H. (2012) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.06.002 · Cited by 357

Regulation of Homologous Recombination by RNF20-Dependent H2B Ubiquitination

Nakamura, K., Kato, A., Kobayashi, J., Yanagihara, H., Sakamoto, S., Oliveira, D. V. N. P., Shimada, M., Tauchi, H., Suzuki, H., Tashiro, S., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.02.002 · Cited by 361

Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency

Cong, K., Peng, M., Kousholt, A. N., Lee, W. T. C., Lee, S., Nayak, S. U., Krais, J. J., VanderVere-Carozza, P. S., Pawelczak, K. S., Calvo, J. A., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.06.011 · Cited by 360

The relationship between the roles of BRCA genes in DNA repair and cancer predisposition

Tutt, A. N. J., & Ashworth, A. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(02)02434-6 · Cited by 344

53BP1 Mediates Productive and Mutagenic DNA Repair through Distinct Phosphoprotein Interactions

Callén, E., Virgilio, M. D., Kruhlak, M. J., Nieto-Soler, M., Wong, N., Chen, H. T., Faryabi, R. B., Polato, F., Santos, M. A., Starnes, L. M., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.023 · Cited by 356

Selective Inhibition of BRCA2-Deficient Mammary Tumor Cell Growth by AZD2281 and Cisplatin

Evers, B., Drost, R., Schut, E., de Bruin, M., van der Burg, E., Derksen, P. W. B., Holstege, H. H., Liu, X., van Drunen, E., Beverloo, H. B., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4953 · Cited by 327

Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response

Li, S., Ting, N. S. Y., Zheng, L., Chen, P., Ziv, Y., Shiloh, Y., Lee, E. Y.-H. P., & Lee, W. (2000) · Nature · doi:10.1038/35018134 · Cited by 336

Collaboration and competition between DNA double‐strand break repair pathways

Kass, E. M., & Jasin, M. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.07.057 · Cited by 326

Chk2 Phosphorylation of BRCA1 Regulates DNA Double-Strand Break Repair

Zhang, J., Willers, H., Feng, Z., Ghosh, J. C., Kim, S., Weaver, D. T., Chung, J. H., Powell, S. N., & Xia, F. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.2.708-718.2004 · Cited by 323

A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

Turner, N. C., Lord, C. J., Iorns, E. J., Brough, R., Swift, S., Elliott, R. J. R., Rayter, S., Tutt, A. N. J., & Ashworth, A. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.61 · Cited by 329

Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivationPreprint

Yu, V. P. C. C., Koehler, M., Steinlein, C., Schmid, M., Hanakahi, L. A., van Gool, A. J., West, S. C., & Venkitaraman, A. R. (2000) · Genes & Development · doi:10.1101/gad.14.11.1400 · Cited by 321

Pattern formation by local self-activation and lateral inhibition

Meinhardt, H., & Gierer, A. (2000) · BioEssays · doi:10.1002/1521-1878(200008)22:8 · Cited by 629

Caretaker Brca1: keeping the genome in the straight and narrow

Yu, V. P. C. C. (2000) · Breast Cancer Research · doi:10.1186/bcr37 · Cited by 17

Commentary Caretaker Brca1: keeping the genome in the straight and narrow

Yu, V. (2000)

BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a Brca1 transgene

Snouwaert, J. N., Gowen, L. C., Latour, A. M., Mohn, A. R., Xiao, A., DiBiase, L., & Koller, B. H. (1999) · Oncogene · doi:10.1038/sj.onc.1203334 · Cited by 197

BRCA1: a key player at multiple stages of homologous recombination in DNA double-strand break repair

Liu, Y., & Lu, L. (2021) · Genome Instability & Disease · doi:10.1007/s42764-021-00042-1 · Cited by 11

The Role of the BRCA1 Tumor Suppressor in DNA Double-Strand Break Repair

Zhang, J., & Powell, S. N. (2005) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0192 · Cited by 213