The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability
Open accessAbstract
Accurate DNA replication and DNA repair are crucial for the maintenance of genome stability, and it is generally accepted that failure of these processes is a major source of DNA damage in cells. Intriguingly, recent evidence suggests that DNA damage is more likely to occur at genomic loci with high transcriptional activity. Furthermore, loss of certain RNA processing factors in eukaryotic cells is associated with increased formation of co-transcriptional RNA:DNA hybrid structures known as R-loops, resulting in double-strand breaks (DSBs) and DNA damage. However, the molecular mechanisms by which R-loop structures ultimately lead to DNA breaks and genome instability is not well understood. In this review, we summarize the current knowledge about the formation, recognition and processing of RNA:DNA hybrids, and discuss possible mechanisms by which these structures contribute to DNA damage and genome instability in the cell.
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Citations
Cites
Instability and decay of the primary structure of DNA
Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R., Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y., et al. (2007) · Science · doi:10.1126/science.1140321 · Cited by 3,075
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
Cramer, P., Bushnell, D. A., & Kornberg, R. D. (2001) · Science · doi:10.1126/science.1059493 · Cited by 1,247
Kinetics of Core Histones in Living Human Cells
Kimura, H., & Cook, P. R. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.7.1341 · Cited by 675
Dynamics of Replication-Independent Histone Turnover in Budding Yeast
Dion, M. F., Kaplan, T., Kim, M., Buratowski, S., Friedman, N., & Rando, O. J. (2007) · Science · doi:10.1126/science.1134053 · Cited by 556
Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases
Smolka, M. B., Albuquerque, C. P., Chen, S.-H., & Zhou, H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701622104 · Cited by 404
Hall, K. B., & McLaughlin, L. W. (1991) · Biochemistry · doi:10.1021/bi00108a002 · Cited by 112
Role for topoisomerase 1 in transcription-associated mutagenesis in yeast
Lippert, M. J., Kim, N., Cho, J.-E., Larson, R. P., Schoenly, N. E., O'Shea, S. H., & Jinks-Robertson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012363108 · Cited by 97
Cited by
Mechanisms and Consequences of Double‐Strand DNA Break Formation in Chromatin
Cannan, W. J., & Pederson, D. S. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25048 · Cited by 499
“Consistent with this prediction, defects in certain RNA processing enzymes produce hyper-recombination phenotypes can be suppressed by overexpression of RNase H (reviewed in Hamperl and Cimprich, 2014).”
BackgroundRegulation of long non-coding RNAs and genome dynamics by the RNA surveillance machinery
Nair, L., Chung, H., & Basu, U. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0209-0 · Cited by 203
AAV-mediated genome editing is influenced by the formation of R-loops
Puzzo, F., Crossley, M. P., Goswami, A., Zhang, F., Pekrun, K., Garzon, J. L., Cimprich, K. A., & Kay, M. A. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.09.035 · Cited by 4
Self-citationRibonucleotide errors, RNase HII, and ribonucleotide excision repair
Cresti, J. R., & Simmons, L. A. (2026) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2026.2704628
“RNA-DNA hybrids play a dichotomous role in cells; while they are essential for cell viability and may be tolerated in certain cases, persistent hybrids can lead to genome instability (Hamperl and Cimprich 2014).”
Metadata
- Authors
- Hamperl, S., & Cimprich, K. A.
- Venue
- DNA Repair
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 19
- Pages
- 84-94
- ISSN
- 1568-7856 (ISSN-L)
- 1568-7864
- OpenAlex
- W2003719212
- Cited by
- 262
- References
- 8
- FWCI
- 11.19
- Type
- journal article
- Language
- en
- Open access
- green
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