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Regulation of long non-coding RNAs and genome dynamics by the RNA surveillance machinery

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Nair, Lekha, Chung, Hachung, Basu, Uttiya·2020·Nature Reviews Molecular Cell Biology
DOI 10.1038/s41580-019-0209-0PMC PMC7107043
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Abstract

Much of the mammalian genome is transcribed, generating long non-coding RNAs (lncRNAs) that can undergo post-transcriptional surveillance whereby only a subset of the non-coding transcripts is allowed to attain sufficient stability to persist in the cellular milieu and control various cellular functions. Paralleling protein turnover by the proteasome complex, lncRNAs are also likely to exist in a dynamic equilibrium that is maintained through constant monitoring by the RNA surveillance machinery. In this Review, we describe the RNA surveillance factors and discuss the vital role of lncRNA surveillance in orchestrating various biological processes, including the protection of genome integrity, maintenance of pluripotency of embryonic stem cells, antibody-gene diversification, coordination of immune cell activation and regulation of heterochromatin formation. We also discuss examples of human diseases and developmental defects associated with the failure of RNA surveillance mechanisms, further highlighting the importance of lncRNA surveillance in maintaining cell and organism functions and health.

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  • Many transcripts differentially expressed in all five datasets were noncoding RNAs, which are well established targets for the RNA exosome and can include PROMPTs, antisense transcripts, and long noncoding RNAs.

    “Many of the transcripts that were differentially expressed in all five datasets were noncoding RNAs, which are well established to be targets for the RNA exosome and can include PROMPTs, antisense (AS) transcripts, and long noncoding RNAs (lncRNAs) as shown in Fig. 2B61–67.”

    From EXOSC3 G191 Variants Trigger System-Wide Recalibration of RNA Processing Machinery (2026) · cites this paper as [63]

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Cited by

Sorted by citations

Authors
Nair, L., Chung, H., & Basu, U.
Affiliations
  • Columbia University (US)
  • Columbia University Irving Medical Center (US)
Corresponding author
Basu, Uttiya
ORCID
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2020-02-04
Volume
21
Issue
3
Pages
123-136
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
DOI
10.1038/s41580-019-0209-0
PMC
PMC7107043
OpenAlex
W3005063916
Cited by
203
References
12
Citations by year
2026: 8 · 2025: 23 · 2024: 31 · 2023: 29 · 2022: 50 · 2021: 37 · 2020: 25
FWCI
3.40
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Reviews Molecular Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Allergy and Infectious Diseases (T32AI106711, R01AI099195, R01AI134988)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords
long non-coding RNA, RNA surveillance, RNA degradation, genome stability, embryonic stem cell pluripotency, immune cell activation, heterochromatin formation, post-transcriptional regulation, RNA-binding proteins, developmental disorders, human disease
MeSH terms
Animals, Gene Expression Regulation, Humans, Genome, RNA Stability, Chromatin Assembly and Disassembly, RNA, Long Noncoding

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