Bone morphogenetic proteins and growth differentiation factors as drug targets in cardiovascular and metabolic disease
Abstract
Bone morphogenetic proteins (BMPs) and growth differentiation factors (GDFs) control the development and homeostasis of multiple tissue types in many organisms, from humans to invertebrates. These morphogens are expressed in a tissue-specific manner and they signal by binding to serine-threonine kinase receptors, resulting in coordinated changes in gene expression that regulate the differentiation and development of multiple tissue types. In addition, these proteins are regulated post-transcriptionally through binding to several soluble proteins. In this review we focus on a subset of BMPs and GDFs that have been implicated in the pathophysiology of type 2 diabetes and cardiovascular disease.
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BMP-7 is a multifunctional cytokine and has been implicated as a potential therapeutic agent for cardiovascular, metabolic, and degenerative diseases, mostly validated in mouse models.
“Originally identified as a bone inducer, BMP-7 is now being recognized as a multifunctional cytokine and has been implicated as a potential therapeutic agent for cardiovascular, metabolic, and degenerative diseases as mostly validated in mouse models 122.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [122]
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- Authors
- Tobin, J. F., & Celeste, A. J.
- Affiliations
- Wyeth (US)
- Corresponding author
- Tobin, James F.
- Venue
- Drug Discovery Today
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 11
- Issue
- 9-10
- Pages
- 405-411
- ISSN
- 1359-6446 (ISSN-L)
- OpenAlex
- W1981731801
- Cited by
- 50
- References
- 73
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 2 · 2014: 3 · 2013: 3 · 2012: 4
- FWCI
- 0.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drug Discovery Today (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Rheumatology › GDF15 and Related Biomarkers
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- bone morphogenetic proteins, growth differentiation factor, therapeutic target, type 2 diabetes, cardiovascular disease, morphogen signaling, serine/threonine kinase receptors, post-transcriptional regulation, tissue-specific gene expression
- MeSH terms
- Animals, Cardiovascular Agents, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans, Hypertension, Pulmonary, Hypoglycemic Agents, Kidney Diseases, Metabolic Diseases, Signal Transduction, Transforming Growth Factor beta, Bone Morphogenetic Proteins, Intercellular Signaling Peptides and Proteins, Atherosclerosis, Bone Morphogenetic Protein Receptors, Bone Morphogenetic Protein 7, Growth Differentiation Factor 3
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