Insights into bone morphogenetic proteins in cardiovascular diseases

Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

Shi, Y., & Massagué, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00432-x · Cited by 5,860 · see citing works

Bone: Formation by Autoinduction

Urist, M. R. (1965) · Science · doi:10.1126/science.150.3698.893 · Cited by 5,529 · see citing works

Smad-dependent and Smad-independent pathways in TGF-β family signalling

Derynck, R., & Zhang, Y. E. (2003) · Nature · doi:10.1038/nature02006 · Cited by 5,370 · see citing works

2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.

Arnett, D. K., Blumenthal, R. S., Albert, M. A., Buroker, A. B., Goldberger, Z. D., Hahn, E. J., Himmelfarb, C. D., Khera, A., Lloyd-Jones, D., McEvoy, J. W., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000678 · Cited by 4,536 · see citing works

Untitled work

(2019) · doi:10.1161/cir.0000000000000677 · Cited by 4,501 · see citing works

A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.Preprint

Dudley, A. T., Lyons, K. M., & Robertson, E. J. (1995) · Genes & Development · doi:10.1101/gad.9.22.2795 · Cited by 1,135 · see citing works

Balancing the activation state of the endothelium via two distinct TGF‐β type I receptors

Goumans, M., Valdimarsdóttir, G., Itoh, S., Rosendahl, A., Sideras, P., & ten Dijke, P. (2002) · The EMBO Journal · doi:10.1093/emboj/21.7.1743 · Cited by 1,127 · see citing works

Signaling cross-talk between TGF-β/BMP and other pathways

Guo, X., & Wang, X. (2008) · Cell Research · doi:10.1038/cr.2008.302 · Cited by 1,027 · see citing works

BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.Preprint

Luo, G., Hofmann, C., Bronckers, A. L. J. J., Sohocki, M. M., Bradley, A., & Karsenty, G. (1995) · Genes & Development · doi:10.1101/gad.9.22.2808 · Cited by 1,020 · see citing works

Cytokine expression in advanced human atherosclerotic plaques: dominance of pro-inflammatory (Th1) and macrophage-stimulating cytokines

Frostegård, J., Ulfgren, A., Nyberg, P., Hedin, U., Swedenborg, J., Andersson, U., & Hansson, G. K. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00011-8 · Cited by 1,002 · see citing works

Bone morphogenetic protein receptors and signal transduction

Miyazono, K., Kamiya, Y., & Morikawa, M. (2009) · The Journal of Biochemistry · doi:10.1093/jb/mvp148 · Cited by 1,000 · see citing works

Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development

Zhang, H., & Bradley, A. (1996) · Development · doi:10.1242/dev.122.10.2977 · Cited by 988 · see citing works

Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

Loffredo, F. S., Steinhauser, M. L., Jay, S. M., Gannon, J., Pancoast, J. R., Yalamanchi, P., Sinha, M., Dall’Osso, C., Khong, D., Shadrach, J. L., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.015 · Cited by 948 · see citing works

Smooth muscle cell phenotypic switching in atherosclerosis

Gomez, D. A., & Owens, G. K. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs115 · Cited by 861 · see citing works

Defective Angiogenesis in Mice Lacking Endoglin

Li, D. Y., Sorensen, L. K., Brooke, B. S., Urness, L. D., Davis, E. C., Taylor, D. G., Boak, B. B., & Wendel, D. P. (1999) · Science · doi:10.1126/science.284.5419.1534 · Cited by 853 · see citing works

Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis

Oh, S. P., Seki, T., Goss, K. A., Imamura, T., Yi, Y., Donahoe, P. K., Li, L., Miyazono, K., ten Dijke, P., Kim, S., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.6.2626 · Cited by 852 · see citing works

The Global Burden of Cardiovascular Diseases and Risks

Roth, G. A., Mensah, G. A., & Fuster, V. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.11.021 · Cited by 831 · see citing works

Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis.Preprint

Mishina, Y. M., Suzuki, A., Ueno, N., & Behringer, R. R. (1995) · Genes & Development · doi:10.1101/gad.9.24.3027 · Cited by 776 · see citing works

Medial vascular calcification revisited: review and perspectives

Lanzer, P., Boehm, M., Sorribas, V., Thiriet, M., Janzen, J., Zeller, T., Hilaire, C. S., & Shanahan, C. M. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu163 · Cited by 742 · see citing works

Pulmonary Arterial Hypertension

Hassoun, P. M. (2021) · New England Journal of Medicine · doi:10.1056/nejmra2000348 · Cited by 714 · see citing works

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

David, L., Mallet, C., Mazerbourg, S., Feige, J., & Bailly, S. (2006) · Blood · doi:10.1182/blood-2006-07-034124 · Cited by 708 · see citing works

Activin Receptor-like Kinase (ALK)1 Is an Antagonistic Mediator of Lateral TGFβ/ALK5 Signaling

Goumans, M.-J., Valdimarsdottir, G., Itoh, S., Lebrin, F., Larsson, J., Mummery, C., Karlsson, S., & ten Dijke, P. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00386-1 · Cited by 689 · see citing works

Diagnosis and Treatment of Pulmonary Arterial Hypertension

Ruopp, N. F., & Cockrill, B. A. (2022) · JAMA · doi:10.1001/jama.2022.4402 · Cited by 682 · see citing works

Sotatercept for the Treatment of Pulmonary Arterial Hypertension

Humbert, M. J. C., McLaughlin, V. V., Gibbs, J. S. R., Gomberg‐Maitland, M., Hoeper, M. M., Preston, I. R., Souza, R., Waxman, A. B., Subías, P. E., Feldman, J., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2024277 · Cited by 615 · see citing works

Cardiovascular outcomes with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a meta-analysis

Bethel, M. A., Patel, R. A., Merrill, P., Lokhnygina, Y., Buse, J. B., Mentz, R. J., Pagidipati, N. J., Chan, J. C., Gustavson, S. M., Iqbal, N., et al. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(17)30412-6 · Cited by 599 · see citing works

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

Meynard, D., Kautz, L., Darnaud, V., Canonne-Hergaux, F., Coppin, H., & Roth, M.-P. (2009) · Nature Genetics · doi:10.1038/ng.320 · Cited by 587 · see citing works

Cloning and characterization of a human type II receptor for bone morphogenetic proteins.

Rosenzweig, B., Imamura, T., Okadome, T., Cox, G. N., Yamashita, H., ten Dijke, P., Heldin, C., & Miyazono, K. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7632 · Cited by 550 · see citing works

Bone Morphogenetic ProteinsPreprint

Katagiri, T., & Watabe, T. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021899 · Cited by 533 · see citing works

Signal transduction by bone morphogenetic proteins

Kawabata, M. (1998) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(97)00036-1 · Cited by 530 · see citing works

BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis

Scharpfenecker, M., van Dinther, M., Liu, Z., van Bezooijen, R. L., Zhao, Q., Pukac, L., Löwik, C. W. G. M., & ten Dijke, P. (2007) · Journal of Cell Science · doi:10.1242/jcs.002949 · Cited by 530 · see citing works

<i>Bmp2</i> is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

Ma, L., Lu, M.-F., Schwartz, R. J., & Martin, J. F. (2005) · Development · doi:10.1242/dev.02156 · Cited by 525 · see citing works

BMP10 is essential for maintaining cardiac growth during murine cardiogenesis

Chen, H., Shi, S., Acosta, L., Li, W., Lu, J. T., Bao, S., Chen, Z., Yang, Z., Schneider, M. D., Chien, K. R., et al. (2004) · Development · doi:10.1242/dev.01094 · Cited by 523 · see citing works

Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension

Long, L., Ormiston, M. L., Yang, X., Southwood, M. R., Gräf, S., Machado, R. D., Müeller, M., Kinzel, B., Yung, L., Wilkinson, J. M., et al. (2015) · Nature Medicine · doi:10.1038/nm.3877 · Cited by 506 · see citing works

Arteriovenous malformations in mice lacking activin receptor-like kinase-1

Urness, L. D., Sorensen, L. K., & Li, D. Y. (2000) · Nature Genetics · doi:10.1038/81634 · Cited by 443 · see citing works

Endoglin, an Ancillary TGFβ Receptor, Is Required for Extraembryonic Angiogenesis and Plays a Key Role in Heart Development

Arthur, H. M., Ure, J. M., Smith, A. J. H., Renforth, G. L., Wilson, D. I., Torsney, E., Charlton, R., Parums, D. V., Jowett, T., Marchuk, D. A., et al. (2000) · Developmental Biology · doi:10.1006/dbio.1999.9534 · Cited by 436 · see citing works

BMP Type II Receptor Is Required for Gastrulation and Early Development of Mouse Embryos

Beppu, H., Kawabata, M., Hamamoto, T., Chytil, A. M., Minowa, O., Noda, T., & Miyazono, K. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9670 · Cited by 420 · see citing works

Anti-Inflammatory Mechanisms in the Vascular Wall

Tedgui, A., & Mallat, Z. (2001) · Circulation Research · doi:10.1161/hh0901.090440 · Cited by 418 · see citing works

Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter

Miyazaki, Y., Oshima, K., Fogo, A. B., Hogan, B. L. M., & Ichikawa, I. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8256 · Cited by 412 · see citing works

An essential role of Bmp4 in the atrioventricular septation of the mouse heart

Jiao, K., Kulessa, H., Tompkins, K., Zhou, Y., Batts, L., Baldwin, H. S., & Hogan, B. L. M. (2003) · Genes &amp; Development · doi:10.1101/gad.1124803 · Cited by 366 · see citing works

Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker

Protze, S. I., Liu, J., Nussinovitch, U., Ohana, L., Backx, P. H., Gepstein, L., & Keller, G. M. (2017) · Nature Biotechnology · doi:10.1038/nbt.3745 · Cited by 366 · see citing works

TGF-β Signaling in Control of Cardiovascular Function

Goumans, M.-J., & ten Dijke, P. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022210 · Cited by 360 · see citing works

ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway

Larrivée, B., Prahst, C., Gordon, E., del Toro, R., Mathivet, T., Duarte, A., Simons, M., & Eichmann, A. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.02.005 · Cited by 359 · see citing works

Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat.

Vukičević, S., Basic, V., Rogić, D., Bašić‐Jukić, N., Shih, M. S., Shepard, A., Jin, D. C., Dattatreyamurty, B., Jones, W., Dorai, H., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2237 · Cited by 326 · see citing works

Molecular Basis of Bone Morphogenetic Protein-15 Signaling in Granulosa Cells

Moore, R. K., Otsuka, F., & Shimasaki, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207362200 · Cited by 326 · see citing works

Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models

Zeisberg, M., Bottiglio, C., Kumar, N., Maeshima, Y., Strutz, F. M., Muller, G. A., & Kalluri, R. (2003) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00191.2002 · Cited by 309 · see citing works

BMP signalling: agony and antagony in the family

Brazil, D. P., Church, R. H., Surae, S., Godson, C., & Martin, F. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.12.004 · Cited by 306 · see citing works

Alterations of β-adrenergic signaling and cardiac hypertrophy in transgenic mice overexpressing TGF-β1

Rosenkranz, S., Flesch, M., Amann, K., Haeuseler, C., Kilter, H., Seeland, U., Schlüter, K., & Böhm, M. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00578.2001 · Cited by 300 · see citing works

BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells

Li, X., Yang, H.-Y. L., & Giachelli, C. M. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.11.031 · Cited by 293 · see citing works

Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-κB (Nuclear Factor κB) Signals

Zhang, X., Li, Y., Yang, P., Liu, X., Lu, L., Chen, Y., Zhong, X., Li, Z., Liu, H., Ou, C., et al. (2020) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.119.313414 · Cited by 291 · see citing works

Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3

Gaussin, V., de Putte, T. V., Mishina, Y. M., Hanks, M. C., Zwijsen, A., Huylebroeck, D., Behringer, R. R., & Schneider, M. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042390499 · Cited by 284 · see citing works

Distinct roles of Wnt/β-catenin and Bmp signaling during early cardiogenesis

Klaus‐Bergmann, A., Saga, Y., Taketo, M. M., Tzahor, E., & Birchmeier, W. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703113104 · Cited by 279 · see citing works

Pulmonary Hypertension in Transgenic Mice Expressing a Dominant-Negative BMPRII Gene in Smooth Muscle

West, J. D., Fagan, K., Steudel, W., Fouty, B., Lane, K. B., Harral, J. W., Hoedt-Miller, M., Tada, Y., Ozimek, J., Tuder, R. M., et al. (2004) · Circulation Research · doi:10.1161/01.res.0000126047.82846.20 · Cited by 263 · see citing works

Cellular interpretation of multiple TGF-β signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads

Candia, A. F., Watabe, T., Hawley, S. H. B., Onichtchouk, D., Zhang, Y. E., Derynck, R., Niehrs, C., & Cho, K. W. Y. (1997) · Development · doi:10.1242/dev.124.22.4467 · Cited by 257 · see citing works

Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation

Dahlqvist, C., Blokzijl, A., Chapman, G., Falk, A., Dannaeus, K., Ibáñez, C. F., & Lendahl, U. (2003) · Development · doi:10.1242/dev.00834 · Cited by 251 · see citing works

ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension

Yung, L., Yang, P. B., Joshi, S. R., Augur, Z. M., Kim, S. S., Bocobo, G. A., Dinter, T., Troncone, L., Chen, P.-S., McNeil, M. E., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz5660 · Cited by 251 · see citing works

FGF2 Sustains NANOG and Switches the Outcome of BMP4-Induced Human Embryonic Stem Cell Differentiation

Yu, P., Pan, G., Yu, J., & Thomson, J. A. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.01.001 · Cited by 243 · see citing works

Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction

Hruska, K. A., Guo, G., Wozniak, M., Martin, D. R., Miller, S., Liapis, H., Loveday, K. S., Klahr, S., Sampath, T. K., & Morrissey, J. J. (2000) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2000.279.1.f130 · Cited by 243 · see citing works

RANKL Increases Vascular Smooth Muscle Cell Calcification Through a RANK-BMP4–Dependent Pathway

Panizo, S., Figueras, A. C., Encinas, M., Parisi, E., Valcheva, P., López‐Ongil, S., Coll, B., Fernández, E., & Valdivielso, J. M. (2009) · Circulation Research · doi:10.1161/circresaha.108.189001 · Cited by 242 · see citing works

Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells

Itoh, F., Itoh, S., Goumans, M., Valdimarsdóttir, G., Iso, T., Dotto, G. P., Hamamori, Y., Kedes, L., Kato, M., & ten Dijke, P. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600065 · Cited by 238 · see citing works

Pulmonary Arterial Hypertension: A Current Perspective on Established and Emerging Molecular Genetic Defects

Machado, R. D., Southgate, L., Eichstaedt, C. A., Aldred, M. A., Austin, E. D., Best, D. H., Chung, W. K., Benjamin, N., Elliott, C. G., Eyries, M., et al. (2015) · Human Mutation · doi:10.1002/humu.22904 · Cited by 227 · see citing works

Osteogenic differentiation of human mesenchymal stem cells is regulated by bone morphogenetic protein‐6

Friedman, M. S., Long, M. W., & Hankenson, K. D. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20719 · Cited by 227 · see citing works

Targeting BMP signalling in cardiovascular disease and anaemia

Morrell, N. W., Bloch, D. B., ten Dijke, P., Goumans, M., Hata, A., Smith, J., Yu, P. B., & Bloch, K. D. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.156 · Cited by 223 · see citing works

Structural insights into BMP receptors: Specificity, activation and inhibition

Yadin, D., Knaus, P., & Mueller, T. D. (2016) · Cytokine &amp; Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.11.005 · Cited by 221 · see citing works

ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif

Morikawa, M., Koinuma, D., Tsutsumi, S., Vasilaki, E., Kanki, Y., Heldin, C., Aburatani, H., & Miyazono, K. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr572 · Cited by 219 · see citing works

BMP-7 Is an Efficacious Treatment of Vascular Calcification in a Murine Model of Atherosclerosis and Chronic Renal Failure

Davies, M. R. P., Lund, R. J., & Hruska, K. A. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000068404.57780.dd · Cited by 215 · see citing works

Bone Morphogenetic Protein (BMP) Type II Receptor Deletion Reveals BMP Ligand-specific Gain of Signaling in Pulmonary Artery Smooth Muscle Cells

Yu, P. B., Beppu, H., Kawai, N., Li, E., & Bloch, K. D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502825200 · Cited by 213 · see citing works

Role of bone morphogenetic proteins in cardiac differentiation

VANWIJK, B., Moorman, A. F. M., & van den Hoff, M. J. B. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.11.022 · Cited by 213 · see citing works

Association between Initial Treatment Strategy and Long-Term Survival in Pulmonary Arterial Hypertension

Boucly, A., Savale, L., Jaïs, X., Bauer, F., Bergot, E., Bertoletti, L., Beurnier, A., BOURDIN, A. A., Bouvaist, H., Bulifon, S., et al. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202009-3698oc · Cited by 210 · see citing works

BMP signaling is required for septation of the outflow tract of the mammalian heart

Délot, E. C., Bahamonde, M. E., Zhao, M., & Lyons, K. M. (2002) · Development · doi:10.1242/dev.00181 · Cited by 208 · see citing works

Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease

Schafer, M. J., Atkinson, E. J., Vanderboom, P. M., Kotajarvi, B. R., White, T. A., Moore, M. M., Bruce, C. J., Greason, K. L., Suri, R. M., Khosla, S., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.023 · Cited by 206 · see citing works

Pulmonary Arterial Hypertension: Diagnosis, Treatment, and Novel Advances

Maron, B. A., Abman, S. H., Elliott, C. G., Frantz, R. P., Hopper, R. K., Horn, E. M., Nicolls, M. R., Shlobin, O. A., Shah, S. J., Kovács, G., et al. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202012-4317so · Cited by 205 · see citing works

BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia

Beppu, H., Ichinose, F., Kawai, N., Jones, R. C., Yu, P. B., Zapol, W. M., Miyazono, K., Li, E., & Bloch, K. D. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00239.2004 · Cited by 203 · see citing works

High glucose increases the expression of Cbfa1 and BMP-2 and enhances the calcification of vascular smooth muscle cells

Chen, N. X., Duan, D., O’Neill, K. D., & Moe, S. M. (2006) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfl429 · Cited by 201 · see citing works

Smad4 and β-Catenin Co-activators Functionally Interact with Lymphoid-enhancing Factor to Regulate Graded Expression of Msx2

Hussein, S. M. I., Duff, E. K., & Sirard, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305472200 · Cited by 198 · see citing works

A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2

Srinivasan, S. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg050 · Cited by 196 · see citing works

Circulating Growth Differentiation Factor 11/8 Levels Decline With Age

Poggioli, T., Vujić, A., Yang, P., Macias-Treviño, C., Uygur, A., Loffredo, F. S., Pancoast, J. R., Cho, M., Goldstein, J., Tandias, R. M., et al. (2015) · Circulation Research · doi:10.1161/circresaha.115.307521 · Cited by 192 · see citing works

Targeting transforming growth factor-β receptors in pulmonary hypertension

Guignabert, C., & Humbert, M. J. C. (2020) · European Respiratory Journal · doi:10.1183/13993003.02341-2020 · Cited by 192 · see citing works

Activation of Vascular Bone Morphogenetic Protein Signaling in Diabetes Mellitus

Boström, K. I., Jumabay, M., Matveyenko, A. V., Nicholas, S. B., & Yao, Y. (2010) · Circulation Research · doi:10.1161/circresaha.110.236596 · Cited by 190 · see citing works

GDF11 Does Not Rescue Aging-Related Pathological Hypertrophy

Smith, S., Zhang, X., Zhang, X., Gross, P., Starosta, T., Mohsin, S., Franti, M., Gupta, P., Hayes, D., Myzithras, M., et al. (2015) · Circulation Research · doi:10.1161/circresaha.115.307527 · Cited by 185 · see citing works

Postinfarction Gene Therapy Against Transforming Growth Factor-β Signal Modulates Infarct Tissue Dynamics and Attenuates Left Ventricular Remodeling and Heart Failure

Okada, H., Takemura, G., Kosai, K.-I., Li, Y., Takahashi, T., Esaki, M., Yuge, K., Miyata, S., Maruyama, R., Mikami, A., et al. (2005) · Circulation · doi:10.1161/01.cir.0000165066.71481.8e · Cited by 185 · see citing works

Generation of the epicardial lineage from human pluripotent stem cells

Witty, A. D., Mihic, A., Tam, R. Y., Fisher, S. A., Mikryukov, A., Shoichet, M. S., Li, R.-K., Kattman, S. J., & Keller, G. (2014) · Nature Biotechnology · doi:10.1038/nbt.3002 · Cited by 180 · see citing works

Syndromic and non‐syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway

Gomez, D. A., Zen, A. A. H., Borges, L. D. F., Philippe, M., Gutierrez, P. S., Jondeau, G., Michel, J., & Vranckx, R. (2009) · The Journal of Pathology · doi:10.1002/path.2516 · Cited by 178 · see citing works

Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation

Steinbicker, A. U., Sachidanandan, C., Vonner, A. J., Yusuf, R. Z., Deng, D. Y., Lai, C. S., Rauwerdink, K. M., Winn, J. C., Saez, B., Cook, C. M., et al. (2011) · Blood · doi:10.1182/blood-2010-10-313064 · Cited by 173 · see citing works

Focal Arterial Inflammation Precedes Subsequent Calcification in the Same Location

Abdelbaky, A., Corsini, E. M., Figueroa, A. L., Fontanez, S., Subramanian, S. S., Ferencik, M., Brady, T. J., Hoffmann, U., & Tawakol, A. A. (2013) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.113.000382 · Cited by 171 · see citing works

Anterior Endomesoderm Specification inXenopusby Wnt/β-catenin and TGF-β Signalling Pathways

Zorn, A. M., Butler, K., & Gurdon, J. B. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9257 · Cited by 170 · see citing works

BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF

Pulkkinen, H. H., Kiema, M., Lappalainen, J. P., Toropainen, A., Beter, M., Tirronen, A., Holappa, L., Niskanen, H., Kaikkonen, M. U., Ylä‐Herttuala, S., et al. (2020) · Angiogenesis · doi:10.1007/s10456-020-09748-4 · Cited by 169 · see citing works

BMP signaling in vascular biology and dysfunction

de Vinuesa, A. G., Abdelilah‐Seyfried, S., Knaus, P. I., Zwijsen, A., & Bailly, S. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.12.005 · Cited by 164 · see citing works

Involvement of Endogenous Bone Morphogenetic Protein (BMP) 2 and BMP6 in Bone Formation

Kugimiya, F., Kawaguchi, H., Kamekura, S., Chikuda, H., Ohba, S., Yano, F., Ogata, N., Katagiri, T., Harada, Y., Azuma, Y., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505166200 · Cited by 159 · see citing works

Atrioventricular cushion transformation is mediated by ALK2 in the developing mouse heart

Wang, J., Sridurongrit, S., Dudáš, M., Thomas, P. S., Nagy, A. R., Schneider, M. D., Epstein, J. A., & Kaartinen, V. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.07.035 · Cited by 158 · see citing works

Distinct Patterns of Transforming Growth Factor-β Isoform and Receptor Expression in Human Atherosclerotic Lesions

Bobik, A., Agrotis, A., Kanellakis, P., Dilley, R. J., Krushinsky, A. V., Smirnov, V. N., Tararak, E. M., Condron, M. M., & Kostolias, G. (1999) · Circulation · doi:10.1161/01.cir.99.22.2883 · Cited by 157 · see citing works

Bone Morphogenetic Proteins in Vascular Homeostasis and DiseasePreprint

Goumans, M., Zwijsen, A., ten Dijke, P., & Bailly, S. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a031989 · Cited by 157 · see citing works

Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats

Kinoshita, K., Iimuro, Y., Otogawa, K., Saika, S., Inagaki, Y., Nakajima, Y., Kawada, N., Fujimoto, J., Friedman, S. L., & Ikeda, K. (2006) · Gut · doi:10.1136/gut.2006.092460 · Cited by 152 · see citing works

Brachyury and SMAD signalling collaboratively orchestrate distinct mesoderm and endoderm gene regulatory networks in differentiating human embryonic stem cells

Faial, T., Bernardo, A. S., Mendjan, S., Diamanti, E., Ortmann, D., Gentsch, G. E., Mascetti, V. L., Trotter, M. W. B., Smith, J. C., & Pedersen, R. A. (2015) · Development · doi:10.1242/dev.117838 · Cited by 149 · see citing works

BMP-1/tolloid-like proteinases synchronize matrix assembly with growth factor activation to promote morphogenesis and tissue remodeling

Goff, S. V., HULMES, D. J. S., & Moali, C. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.02.006 · Cited by 147 · see citing works

Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formation

Levet, S., Ciais, D., Merdzhanova, G., Mallet, C., Zimmers, T. A., Lee, S., Navarro, F. P., Texier, I., Feige, J., Bailly, S., et al. (2013) · Blood · doi:10.1182/blood-2012-12-472142 · Cited by 145 · see citing works

Smads, Tak1, and Their Common Target Atf-2 Play a Critical Role in Cardiomyocyte Differentiation

Monzen, K., Hiroi, Y., Kudoh, S., Akazawa, H., Oka, T., Takimoto, E., Hayashi, D., Hosoda, T., Kawabata, M., Miyazono, K., et al. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.4.687 · Cited by 143 · see citing works

Bone Morphogenic Protein-4 Impairs Endothelial Function Through Oxidative Stress–Dependent Cyclooxygenase-2 Upregulation

Wong, W. T., Tian, X. Y., Chen, Y., Leung, F. P., Liu, L., Lee, H. K., Ng, C., Xu, A., Yao, X., Vanhoutte, P. M., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.222794 · Cited by 137 · see citing works

Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells

Shao, E. S., Lin, L., Yao, Y., & Boström, K. I. (2009) · Blood · doi:10.1182/blood-2009-01-199166 · Cited by 137 · see citing works

Human mesenchymal stem cells support megakaryocyte and pro-platelet formation from CD34+ hematopoietic progenitor cells

Cheng, L., Qasba, P., Vanguri, P., & Thiede, M. A. (2000) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(200007)184:1 · Cited by 136 · see citing works

Bone Morphogenetic Protein-4 Mediates Cardiac Hypertrophy, Apoptosis, and Fibrosis in Experimentally Pathological Cardiac Hypertrophy

Sun, B., Huo, R., Sheng, Y., Li, Y., Xie, X., Chen, C., Liu, H., Li, N., Li, C., Guo, W., et al. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.00562 · Cited by 131 · see citing works

Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension

Tu, L., Desroches‐Castan, A., Mallet, C., Guyon, L., Cumont, A., Phan, C., Robert, F., Thuillet, R., Bordenave, J., Sekine, A., et al. (2019) · Circulation Research · doi:10.1161/circresaha.118.313356 · Cited by 130 · see citing works

CTGF Inhibits BMP-7 Signaling in Diabetic Nephropathy

Nguyen, T. Q., Roestenberg, P., van Nieuwenhoven, F. A., Bovenschen, N., Li, Z., Xu, L., Oliver, N., Aten, J., Joles, J. A., Vial, C., et al. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007111261 · Cited by 128 · see citing works

SMAD4 Prevents Flow Induced Arteriovenous Malformations by Inhibiting Casein Kinase 2

Ola, R., Künzel, S. H., Zhang, F., Genet, G., Chakraborty, R., Pibouin-Fragner, L., Martin, K. A., Sessa, W. C., Dubrac, A., & Eichmann, A. (2018) · Circulation · doi:10.1161/circulationaha.118.033842 · Cited by 124 · see citing works

Bone Morphogenic Protein-4 Induces Hypertension in Mice

Miriyala, S., Nieto, M. C. G., Mingone, C. J., Smith, D., Dikalov, S., Harrison, D. G., & Jo, H. (2006) · Circulation · doi:10.1161/circulationaha.106.611822 · Cited by 123 · see citing works

Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension

Hodgson, J., Swietlik, E. M., Salmon, R. M., Hadinnapola, C., Nikolić, I., Wharton, J., Guo, J., Liley, J., Haimel, M., Bleda, M., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201906-1141oc · Cited by 123 · see citing works

The role of bone morphogenetic protein signaling in vascular calcification

Yang, P. B., Troncone, L., Augur, Z. M., Kim, S. S., McNeil, M. E., & Yu, P. B. (2020) · Bone · doi:10.1016/j.bone.2020.115542 · Cited by 123 · see citing works

BMP3 Suppresses Osteoblast Differentiation of Bone Marrow Stromal Cells via Interaction with Acvr2b

Kokabu, S., Gamer, L. W., Cox, K. A., Lowery, J. W., Tsuji, K., Raz, R., Economides, A. N., Katagiri, T., & Rosen, V. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-1168 · Cited by 119 · see citing works

Association of growth differentiation factor 11/8, putative anti-ageing factor, with cardiovascular outcomes and overall mortality in humans: analysis of the Heart and Soul and HUNT3 cohorts

Olson, K. A., Beatty, A. L., Heidecker, B., Regan, M. C., Brody, E. N., Foreman, T. M., Kato, S., Mehler, R. E., Singer, B. S., Hveem, K., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv385 · Cited by 117 · see citing works

Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett’s Esophagus

Palles, C., Chegwidden, L., Li, X., Findlay, J. M., Farnham, G., Castro-Giner, F., Peppelenbosch, M. P., Kovac, M. B., Adams, C., Prenen, H., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.10.041 · Cited by 113 · see citing works

GDF11 Protects against Endothelial Injury and Reduces Atherosclerotic Lesion Formation in Apolipoprotein E-Null Mice

Mei, W., Xiang, G., Li, Y., Li, H., Xiang, L., Lu, J., Xiang, L., Dong, J., & Liu, M. (2016) · Molecular Therapy · doi:10.1038/mt.2016.160 · Cited by 113 · see citing works

Defective Flow-Migration Coupling Causes Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia

Park, H., Furtado, J., Poulet, M., Chung, M., Yun, S., Lee, S., Sessa, W. C., Franco, C. A., Schwartz, M. A., & Eichmann, A. (2021) · Circulation · doi:10.1161/circulationaha.120.053047 · Cited by 108 · see citing works

The role of hepcidin and iron homeostasis in atherosclerosis

Wunderer, F., Traeger, L., Sigurslid, H. H., Meybohm, P., Bloch, D. B., & Malhotra, R. K. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104664 · Cited by 107 · see citing works

Smad Expression in Human Atherosclerotic Lesions

Kalinina, N., Agrotis, A., Antropova, Y., Ilyinskaya, O. P., Smirnov, V. N., Tararak, E. M., & Bobik, A. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000133605.89421.79 · Cited by 103 · see citing works

ALK1 Loss Results in Vascular Hyperplasia in Mice and Humans Through PI3K Activation

Alsina‐Sanchís, E., García-Ibáñez, Y., Figueiredo, A. M., Riera‐Domingo, C., Figueras, A., Matías‐Guiu, X., Casanovas, O., Botella, L. M., Pujana, M. Á., Riera-Mestre, A., et al. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.310760 · Cited by 103 · see citing works

Circulating transforming growth factor β1 and coronary artery disease

Wang, X. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00033-3 · Cited by 102 · see citing works

TGF-β1 Limits Plaque Growth, Stabilizes Plaque Structure, and Prevents Aortic Dilation in Apolipoprotein E-Null Mice

Frutkin, A. D., Otsuka, G., Stempien‐Otero, A., Sesti, C., Du, L., Jaffe, M., Dichek, H. L., Pennington, C. J., Edwards, D. R., Nieves‐Cintrón, M., et al. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.186593 · Cited by 100 · see citing works

Endoglin and alk1 as therapeutic targets for hereditary hemorrhagic telangiectasia

Ruiz-Llorente, L., Gallardo‐Vara, E., Rossi, E., Smadja, D. M., Botella, L. M., & Bernabéu, C. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1365839 · Cited by 100 · see citing works

Myocardin regulates BMP10 expression and is required for heart development

Huang, J., Elicker, J., Bowens, N. M., Liu, X., Cheng, L., Cappola, T. P., Zhu, X., & Parmacek, M. S. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63635 · Cited by 98 · see citing works

Targeted myocardial delivery of GDF11 gene rejuvenates the aged mouse heart and enhances myocardial regeneration after ischemia–reperfusion injury

Du, G., Shao, Z., Wu, J., Yin, W., Li, S.-H., Wu, J., Weisel, R. D., Tian, J., & Li, R. (2016) · Basic Research in Cardiology · doi:10.1007/s00395-016-0593-y · Cited by 98 · see citing works

The Role of Bone Morphogenetic Protein 7 (BMP-7) in Inflammation in Heart Diseases

Narasimhulu, C. A., & Singla, D. K. (2020) · Cells · doi:10.3390/cells9020280 · Cited by 95 · see citing works

Reduced left atrial cardiomyocyte PITX2 and elevated circulating BMP10 predict atrial fibrillation after ablation

Reyat, J. S., Chua, W., Cardoso, V. R., Witten, A., Kastner, P., Kabir, S. N., Sinner, M. F., Wesselink, R., Holmes, A. P., Pavlović, D., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.139179 · Cited by 92 · see citing works

Opposing roles and potential antagonistic mechanism between TGF-β and BMP pathways: Implications for cancer progression

Ning, J., Zhao, Y. C., Ye, Y., & Yu, J. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.02.033 · Cited by 89 · see citing works

Anti-Inflammatory and Antiatherogenic Role of BMP Receptor II in Endothelial Cells

Kim, C. W., Song, H. W., Kumar, S., Nam, D., Kwon, H., Chang, K. H., Son, D. J., Kang, D. W., Brodie, S. A., Weiss, D., et al. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300287 · Cited by 88 · see citing works

The signaling and functions of heterodimeric bone morphogenetic proteins

Guo, J., & Wu, G. (2012) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2012.02.001 · Cited by 88 · see citing works

Bone morphogenetic protein 6 and oxidized low-density lipoprotein synergistically recruit osteogenic differentiation in endothelial cells

Yung, L., Sánchez‐Duffhues, G., ten Dijke, P., & Yu, P. B. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv221 · Cited by 88 · see citing works

Heat Shock Protein 70 Enhances Vascular Bone Morphogenetic Protein-4 Signaling by Binding Matrix Gla Protein

Yao, Y., Watson, A. D., Ji, S., & Boström, K. I. (2009) · Circulation Research · doi:10.1161/circresaha.109.202333 · Cited by 87 · see citing works

BMP Signaling in Development, Stem Cells, and Diseases of the Gastrointestinal Tract

Zhang, Y., & Que, J. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034500 · Cited by 85 · see citing works

Bone Morphogenetic Protein 9 Reduces Cardiac Fibrosis and Improves Cardiac Function in Heart Failure

Morine, K., Qiao, X., York, S., NATOV, P. S., Paruchuri, V., Zhang, Y., Aronovitz, M. J., Karas, R. H., & Kapur, N. K. (2018) · Circulation · doi:10.1161/circulationaha.117.031635 · Cited by 84 · see citing works

BMP-7 Attenuates Inflammation-Induced Pyroptosis and Improves Cardiac Repair in Diabetic Cardiomyopathy

Elmadbouh, I. S., & Singla, D. K. (2021) · Cells · doi:10.3390/cells10102640 · Cited by 81 · see citing works

TGFβ and BMP signaling in cardiac cushion formation: Lessons from mice and chicken

Kruithof, B. P. T., Duim, S. N., Moerkamp, A. T., & Goumans, M. (2012) · Differentiation · doi:10.1016/j.diff.2012.04.003 · Cited by 79 · see citing works

BMP10-mediated ALK1 signaling is continuously required for vascular development and maintenance

Capasso, T. L., Li, B., Volek, H. J., Khalid, W., Rochon, E. R., Anbalagan, A., Herdman, C., Yost, H. J., Villanueva, F. S., Kim, K., et al. (2019) · Angiogenesis · doi:10.1007/s10456-019-09701-0 · Cited by 77 · see citing works

Different cardiovascular and pulmonary phenotypes for single- and double-knock-out mice deficient in BMP9 and BMP10

Bouvard, C., Tu, L., Rossi, M., Desroches‐Castan, A., Berrebeh, N., Helfer, E., Roelants, C., Liu, H., Ouarné, M., Chaumontel, N., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab187 · Cited by 76 · see citing works

Gene‐mediated osteogenic differentiation of stem cells by bone morphogenetic proteins‐2 or ‐6

Zachos, T. A., Shields, K. M., & Bertone, A. L. (2006) · Journal of Orthopaedic Research® · doi:10.1002/jor.20068 · Cited by 75 · see citing works

Regulation of Notch signaling genes during BMP2-induced differentiation of osteoblast precursor cells

de Jong, D. S., Steegenga, W. T., Hendriks, J. M. A., van Zoelen, E. J. J., Olijve, W., & Dechering, K. J. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.05.150 · Cited by 74 · see citing works

Untitled work

Harper (2016) · doi:10.1161/circresaha.116.307962 · Cited by 74 · see citing works

BMP9 and BMP10 Act Directly on Vascular Smooth Muscle Cells for Generation and Maintenance of the Contractile State

Wang, L., Rice, M., Swist, S., Kubin, T., Wu, F., Wang, S., Kraut, S., Weißmann, N., Böttger, T., Wheeler, M., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.047375 · Cited by 74 · see citing works

Increased plasma BMP-2 levels are associated with atherosclerosis burden and coronary calcification in type 2 diabetic patients

Zhang, M., Sara, J. D. S., Wang, F., Liu, L., Su, L.-X., Jing, Z., Wu, X., & Liu, J. (2015) · Cardiovascular Diabetology · doi:10.1186/s12933-015-0214-3 · Cited by 73 · see citing works

Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature

Frank, D. B., Lowery, J. W., Anderson, L., Brink, M., Reese, J., & deCaestecker, M. P. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00034.2007 · Cited by 71 · see citing works

Transforming Growth Factor-β Blockade Down-Regulates the Renin-Angiotensin System and Modifies Cardiac Remodeling after Myocardial Infarction

Ellmers, L. J., Scott, N. J. A., Medicherla, S., Pilbrow, A. P., Bridgman, P. G., Yandle, T. G., Richards, M., Protter, A. A., & Cameron, V. A. (2008) · Endocrinology · doi:10.1210/en.2008-0165 · Cited by 68 · see citing works

BMP ‐9 regulates the osteoblastic differentiation and calcification of vascular smooth muscle cells through an ALK 1 mediated pathway

Zhu, D., Mackenzie, N. C. W., Shanahan, C. M., Shroff, R. C., Farquharson, C., & MacRae, V. E. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12373 · Cited by 67 · see citing works

BMP-7 Treatment Increases M2 Macrophage Differentiation and Reduces Inflammation and Plaque Formation in Apo E-/- Mice

Singla, D. K., Singla, R. D., & Wang, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147897 · Cited by 67 · see citing works

Loss of Endothelial Endoglin Promotes High-Output Heart Failure Through Peripheral Arteriovenous Shunting Driven by VEGF Signaling

Tual‐Chalot, S., Garcia-Collado, M., Redgrave, R. E., Singh, E., Davison, B., Park, C., Lin, H., Luli, S., Jin, Y., Wang, Y., et al. (2019) · Circulation Research · doi:10.1161/circresaha.119.315974 · Cited by 67 · see citing works

KLF2 Mediates the Suppressive Effect of Laminar Flow on Vascular Calcification by Inhibiting Endothelial BMP/SMAD1/5 Signaling

Huang, J., Pu, Y., Zhang, H., Xie, L., He, L., Zhang, C., Cheng, C. K., Huo, Y., Wan, S., Chen, S., et al. (2021) · Circulation Research · doi:10.1161/circresaha.120.318690 · Cited by 67 · see citing works

Arterial calcifications

Rennenberg, R. J. M. W., Schurgers, L. J., Kroon, A. A., & Stehouwer, C. D. A. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01139.x · Cited by 65 · see citing works

Impact of Glutathione Peroxidase-1 Deficiency on Macrophage Foam Cell Formation and Proliferation: Implications for Atherogenesis

Cheng, F., Torzewski, M., Degreif, A., Rossmann, H., Canisius, A., & Lackner, K. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072063 · Cited by 63 · see citing works

Bone morphogenetic protein 9 (BMP9) and BMP10 enhance tumor necrosis factor-α-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2

Mitrofan, C., Appleby, S. L., Nash, G. B., Mallat, Z., Chilvers, E. R., Upton, P. D., & Morrell, N. W. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.778506 · Cited by 63 · see citing works

Endothelial BMPR2 Loss Drives a Proliferative Response to BMP (Bone Morphogenetic Protein) 9 via Prolonged Canonical Signaling

Theilmann, A. L., Hawke, L. G., Hilton, L., Whitford, M. K., Cole, D. V., Mackeil, J., Dunham‐Snary, K. J., Mewburn, J. D., James, P. D., Maurice, D. H., et al. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.313357 · Cited by 62 · see citing works

Transforming Growth Factor-β1 Represses Bone Morphogenetic Protein–Mediated Smad Signaling in Pulmonary Artery Smooth Muscle Cells via Smad3

Upton, P. D., Davies, R. J., Tajsic, T., & Morrell, N. W. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0470oc · Cited by 61 · see citing works

Bone morphogenetic protein-7 represses hepatic stellate cell activation and liver fibrosis via regulation of TGF-β/Smad signaling pathway

Zou, G.-L., Zuo, S., Lu, S., Hu, R.-H., Lu, Y., Yang, J., Deng, K., Wu, Y., Mu, M., Zhu, J., et al. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i30.4222 · Cited by 61 · see citing works

Identification and validation of a novel pathogenic variant in GDF2 ( BMP9 ) responsible for hereditary hemorrhagic telangiectasia and pulmonary arteriovenous malformations

Balachandar, S., Graves, T. J., Shimonty, A., Kerr, K., Kilner, J., Xiao, S., Slade, R., Sroya, M., Alikian, M., Curetean, E., et al. (2021) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.62584 · Cited by 61 · see citing works

The BMP-7–Smad1/5/8 Pathway Promotes Kidney Repair After Obstruction Induced Renal Injury

Manson, S. R., Niederhoff, R. A., Hruska, K. A., & Austin, P. F. (2011) · The Journal of Urology · doi:10.1016/j.juro.2011.01.034 · Cited by 60 · see citing works

BMP-7 attenuates adverse cardiac remodeling mediated through M2 macrophages in prediabetic cardiomyopathy

Urbina, P., & Singla, D. K. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00367.2014 · Cited by 60 · see citing works

SM22α-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis

El‐Bizri, N., Guignabert, C., Wang, L., Cheng, A., Stankunas, K., Chang, C., Mishina, Y. M., & Rabinovitch, M. (2008) · Development · doi:10.1242/dev.017863 · Cited by 58 · see citing works

Comparison of American and European Guidelines for Primary Prevention of Cardiovascular Disease

Fegers‐Wustrow, I., Gianos, E., Halle, M., & Yang, E. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.02.001 · Cited by 58 · see citing works

BMP-6 accelerates both chondrogenesis and mineral maturation in differentiating chick limb-bud mesenchymal cell cultures

Boskey, A. L., Paschalis, E. P., Binderman, I., & Doty, S. B. (2002) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10032 · Cited by 57 · see citing works

BMP-7 attenuated silica-induced pulmonary fibrosis through modulation of the balance between TGF-β/Smad and BMP-7/Smad signaling pathway

Liang, D., Wang, Y., Zhu, Z., Yang, G., An, G., Li, X., Niu, P., Chen, L., & Tian, L. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.11.012 · Cited by 57 · see citing works

Dysregulation of interaction between LOXhigh fibroblast and smooth muscle cells contributes to the pathogenesis of aortic dissection

Chen, Y., Zhang, T., Yao, F., Gao, X., Li, D., Shufang, F., Mao, L., Liu, F., Zhang, X., Xu, Y., et al. (2021) · Theranostics · doi:10.7150/thno.66059 · Cited by 57 · see citing works

BMP10 preserves cardiac function through its dual activation of SMAD-mediated and STAT3-mediated pathways

Qu, X., Liu, Y., Cao, D., Chen, J., Liu, Z., Ji, H., Chen, Y., Zhang, W., Zhu, P., Xiao, D., et al. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010943 · Cited by 56 · see citing works

Bone morphogenetic protein-7 inhibits silica-induced pulmonary fibrosis in rats

Yang, G., Zhu, Z., Wang, Y., Gao, A., Niu, P., & Tian, L. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.04.017 · Cited by 55 · see citing works

BMP-2/7 heterodimer strongly induces bone regeneration in the absence of increased soft tissue inflammation

Kaito, T., Morimoto, T., Mori, Y., Kanayama, S., Makino, T., Takenaka, S., Sakai, Y., Otsuru, S., Yoshioka, Y., & Yoshikawa, H. (2017) · The Spine Journal · doi:10.1016/j.spinee.2017.07.171 · Cited by 55 · see citing works

Bmp signaling repressesVegfato promote outflow tract cushion development

Bai, Y., Wang, J., Morikawa, Y., Bonilla-Claudio, M., Klysik, E. A., & Martin, J. F. (2013) · Development · doi:10.1242/dev.097360 · Cited by 54 · see citing works

Hydrogen Sulfide Improves Endothelial Dysfunction via Downregulating BMP4/COX‐2 Pathway in Rats with Hypertension

Xiao, L., Dong, J., Jin, S., Xue, H., Guo, Q., Teng, X., & Wu, Y. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8128957 · Cited by 54 · see citing works

Signaling molecules, transcription growth factors and other regulators revealed from in-vivo and in-vitro models for the regulation of cardiac development

Meganathan, K., Sotiriadou, I., Natarajan, K., Hescheler, J., & Sachinidis, A. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.01.049 · Cited by 53 · see citing works

BMP-7 attenuates left ventricular remodelling under pressure overload and facilitates reverse remodelling and functional recovery

Merino, D., Villar, A. V., García, R., Tramullas, M., Ruiz‐Guerrero, L., Ribas, C., Cabezudo, S., Nistal, J. F., & Hurlé, M. A. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvw076 · Cited by 53 · see citing works

FGF12 (Fibroblast Growth Factor 12) Inhibits Vascular Smooth Muscle Cell Remodeling in Pulmonary Arterial Hypertension

Yeo, Y., Yi, E. S., Kim, J., Jo, E.-K., Seo, S., Kim, R.-I., Kim, K. L., Sung, J., Park, S. G., & Suh, W. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.15068 · Cited by 53 · see citing works

Bone morphogenetic protein‐7 inhibits endothelial‐mesenchymal transition in pulmonary artery endothelial cell under hypoxia

Zhang, H., Liu, Y., Yan, L., Du, W., Zhang, X., Zhang, M., Chen, H., Zhang, Y., Zhou, J., Sun, H., et al. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26195 · Cited by 52 · see citing works

Bone morphogenetic protein 10: a novel risk marker of ischaemic stroke in patients with atrial fibrillation

Hijazi, Z., Benz, A. P., Lindbäck, J., Alexander, J. H., Connolly, S. J., Eikelboom, J. W., Granger, C. B., Kastner, P., Lópes, R. D., Ziegler, A., et al. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac632 · Cited by 52 · see citing works

Synergistic Effects of Vg1 and Wnt Signals in the Specification of Dorsal Mesoderm and Endoderm

Cui, Y., Tian, Q., & Christian, J. L. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0281 · Cited by 51 · see citing works

Bone morphogenetic proteins and growth differentiation factors as drug targets in cardiovascular and metabolic disease

Tobin, J. F., & Celeste, A. J. (2006) · Drug Discovery Today · doi:10.1016/j.drudis.2006.03.016 · Cited by 50 · see citing works

Bone Morphogenetic Protein-10 induces cardiomyocyte proliferation and improves cardiac function after myocardial infarction

Sun, L., Yu, J., Qi, S., Hao, Y., Liu, Y., & Li, Z. (2014) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24856 · Cited by 50 · see citing works

Unraveling the Connection between Fibroblast Growth Factor and Bone Morphogenetic Protein Signaling

Schliermann, A., & Nickel, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103220 · Cited by 50 · see citing works

BMP4-mediated browning of perivascular adipose tissue governs an anti-inflammatory program and prevents atherosclerosis

Mu, W., Qian, S., Song, Y.-J., Yang, L., Song, S., Yang, Q., Liu, H., Liu, Y., Pan, D., Tang, Y., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101979 · Cited by 50 · see citing works

Overexpression of TGF-ß1 in Macrophages Reduces and Stabilizes Atherosclerotic Plaques in ApoE-Deficient Mice

Reifenberg, K., Cheng, F., Orning, C., Crain, J., Küpper, I., Wiese, E., Protschka, M., Blessing, M., Lackner, K. J., & Torzewski, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040990 · Cited by 49 · see citing works

Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy

Nakano, N., Hori, H., Abe, M., Shibata, H., Arimura, T., Sasaoka, T., Sawabe, M., Chida, K., Arai, T., Nakahara, K., et al. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00311.2007 · Cited by 47 · see citing works

Smooth Muscle Protein 22α–Mediated Patchy Deletion of Bmpr1a Impairs Cardiac Contractility but Protects Against Pulmonary Vascular Remodeling

El‐Bizri, N., Wang, L., Merklinger, S. L., Guignabert, C., Desai, T., Urashima, T., Sheikh, A. Y., Knutsen, R. H., Mecham, R. P., Mishina, Y. M., et al. (2007) · Circulation Research · doi:10.1161/circresaha.107.161059 · Cited by 47 · see citing works

Bone Morphogenetic Protein-7 Modulates Genes that Maintain the Vascular Smooth Muscle Cell Phenotype in Culture

Dorai, H., & Sampath, T. K. (2001) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200100001-00010 · Cited by 45 · see citing works

Growth Differentiation Factor 5 Regulates Cardiac Repair After Myocardial Infarction

Zaidi, S. H. E., Huang, Q., Momen, A., Riazi, A., & Husain, M. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.08.041 · Cited by 45 · see citing works

Growth differentiation factor-11 supplementation improves survival and promotes recovery after ischemic stroke in aged mice

Hudobenko, J., Ganesh, B. P., Jiang, J., Mohan, E. C., Lee, S., Sheth, S. A., Morales‐Scheihing, D., Zhu, L., Kofler, J., Pautler, R. G., et al. (2020) · Aging · doi:10.18632/aging.103122 · Cited by 45 · see citing works

Treatment with low‐dose tacrolimus inhibits bleeding complications in a patient with hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension

Sommer, N., Droege, F., Gamen, E., Geisthoff, U. W., Gall, H. J., Tello, K., Richter, M. J., Deubner, L., Schmiedel, R., Hecker, M., et al. (2018) · Pulmonary Circulation · doi:10.1177/2045894018805406 · Cited by 44 · see citing works

BMP-2 and -4 produced by vascular smooth muscle cells from atherosclerotic lesions induce monocyte chemotaxis through direct BMPRII activation

Sato, A. Y. S., Bub, G. L., & Campos, A. H. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.03.030 · Cited by 42 · see citing works

Bone Morphogenetic Protein-7 Inhibits Vascular Calcification Induced by High Vitamin D in Mice

Kang, Y. H., Jin, J. S., Yi, D. W., & Son, S. M. (2010) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.221.299 · Cited by 42 · see citing works

Approaches to treat pulmonary arterial hypertension by targeting BMPR2: from cell membrane to nucleus

Dunmore, B. J., Jones, R. J., Toshner, M. R., Upton, P. D., & Morrell, N. W. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa350 · Cited by 42 · see citing works

Cardioprotective factors against myocardial infarction selected in vivo from an AAV secretome library

Ruozi, G., Bortolotti, F., Mura, A., Tomczyk, M., Falcione, A., Martinelli, V. C., Vodret, S., Braga, L., Ferro, M. D., Cannata, A. N., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abo0699 · Cited by 42 · see citing works

Oral Administration of Recombinant Adeno-associated Virus-mediated Bone Morphogenetic Protein-7 Suppresses CCl4-induced Hepatic Fibrosis in Mice

Hao, Z., Cai, M., Lv, Y., Huang, Y., & Li, H.-H. (2012) · Molecular Therapy · doi:10.1038/mt.2012.148 · Cited by 41 · see citing works

The versatility and paradox of GDF 11

Jamaiyar, A., Wan, W., Janota, D., Enrick, M., Chilian, W. M., & Yin, L. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.032 · Cited by 41 · see citing works

Sp1 Plays an Important Role in Vascular Calcification Both In Vivo and In Vitro

Zhang, X., Li, R., Qin, X., Wang, L., Xiao, J., Song, Y. M., Sheng, X., Guo, M., & Ji, X. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.007555 · Cited by 41 · see citing works

TGFβ receptor activation enhances cardiac apoptosis via SMAD activation and concomitant NO release

Heger, J., Warga, B., Meyering, B., Abdallah, Y., Schlüter, K., Piper, H. M., & Euler, G. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22619 · Cited by 38 · see citing works

Inhibition of Bone Morphogenic Protein 4 Restores Endothelial Function in db/db Diabetic Mice

Zhang, Y., Liu, J., Tian, X. Y., Wong, W. T., Chen, Y., Wang, L., Luo, J., Cheang, W. S., Lau, C. W., Kwan, K. M., et al. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.302696 · Cited by 38 · see citing works

Bone Morphogenetic Protein-7 Antagonizes Myocardial Fibrosis Induced by Atrial Fibrillation by Restraining Transforming Growth Factor-β (TGF-β)/Smads Signaling

Chen, X., Xu, J., Jiang, B., & Liu, D. (2016) · Medical Science Monitor · doi:10.12659/msm.897560 · Cited by 38 · see citing works

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Schmid, C. D., Olsavszky, V., Reinhart, M., Weyer, V., Trogisch, F. A., Sticht, C., Winkler, M., Kürschner, S. W., Hoffmann, J., Ola, R., et al. (2022) · Hepatology · doi:10.1002/hep.32641 · Cited by 38 · see citing works

Transforming Growth Factor-β and Angiotensin in Fibrosis and Burn Injuries

Gabriel, V. (2009) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e3181a28ddb · Cited by 37 · see citing works

Berberine attenuates hypoxia‐induced pulmonary arterial hypertension via bone morphogenetic protein and transforming growth factor‐β signaling

Chen, M., Shen, H., Zhu, L., Yang, H., Ye, P., Liu, P., Gu, Y., & Chen, S. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28370 · Cited by 37 · see citing works

BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in mice

Shao, Y. X., Zhao, C. M., Pan, J., Zeng, C., Zhang, H., Liu, L., Fan, K., Liu, X., Luo, B., Fang, H., et al. (2021) · Aging · doi:10.18632/aging.202708 · Cited by 37 · see citing works

Bone Morphogenetic Protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis

Bramlage, C. P., Tampe, B., Koziolek, M. J., Maatouk, I., Bevanda, J., Bramlage, P., Ahrens, K., Lange, K., Schmid, H., Cohen, C. D., et al. (2010) · BMC Nephrology · doi:10.1186/1471-2369-11-31 · Cited by 35 · see citing works

BMP ‐2 induces human mononuclear cell chemotaxis and adhesion and modulates monocyte‐to‐macrophage differentiation

Pardali, E., Makowski, L., Leffers, M., Borgscheiper, A., & Waltenberger, J. L. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13814 · Cited by 35 · see citing works

Heart development before beating

Nakajima, Y., Sakabe, M., Matsui, H., Sakata, H., Yanagawa, N., & Yamagishi, T. (2009) · Anatomical Science International · doi:10.1007/s12565-009-0025-2 · Cited by 34 · see citing works

The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension

Morikawa, M., Mitani, Y., Holmborn, K., Kato, T., Koinuma, D., Maruyama, J., Vasilaki, E., Sawada, H., Kobayashi, M., Ozawa, T., et al. (2019) · Science Signaling · doi:10.1126/scisignal.aay4430 · Cited by 34 · see citing works

Protein and mRNA expression levels of VEGF-A and TGF-β1 in different types of human coronary atherosclerotic lesions

Panutsopulos, D., Papalambros, E. L., Sigala, F., Zafiropoulos, A., Arvanitis, D. L., & Spandidos, D. A. (2005) · International Journal of Molecular Medicine · doi:10.3892/ijmm.15.4.603 · Cited by 33 · see citing works

Regeneration of infarcted mouse hearts by cardiovascular tissue formed via the direct reprogramming of mouse fibroblasts

Cho, J., Kim, S., Lee, H., Rah, W., Cho, H. C., Kim, N. K., Bae, S., Shin, D. H., Lee, M. G., Park, I., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00783-0 · Cited by 33 · see citing works

BMP4 Enhances Foam Cell Formation by BMPR-2/Smad1/5/8 Signaling

Feng, J., Gao, J., Li, Y., Yang, Y., Dang, L., Ye, Y., Deng, J., & Li, A. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15045536 · Cited by 32 · see citing works

Vascular Calcification: Molecular Networking, Pathological Implications and Translational Opportunities

Ortega, M. A., León-Oliva, D. D., Gimeno, M. J., Boaru, D. L., Fraile‐Μartinez, O., Montero, C. G., de Castro, A. V., Barrena-Blázquez, S., López-González, L., Amor, S., et al. (2024) · Biomolecules · doi:10.3390/biom14030275 · Cited by 51 · see citing works

Circulating BMP10 Levels Associate With Late Postoperative Atrial Fibrillation and Left Atrial Endomysial Fibrosis

Winters, J., Kawczynski, M. J., Gilbers, M. D., Isaacs, A. J., Zeemering, S., Bidar, E., Maesen, B. A. E., Rienstra, M., Gelder, I. C. V., Verheule, S., et al. (2024) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2024.03.003 · Cited by 26 · see citing works

Angiogenesis within atherosclerotic plaques: Mechanical regulation, molecular mechanism and clinical diagnosis

Chen, H., Peng, C.-Y., Fang, F., Li, Y., Liu, X., Hu, Y., Wang, G., Liu, X., & Shen, Y. (2025) · Mechanobiology in Medicine · doi:10.1016/j.mbm.2025.100114 · Cited by 15 · see citing works

Pericardial Fluid of Patients With Coronary Artery Disease Can Drive Fibrosis Via TGF-Beta Pathway

Hassanabad, A. F., Belke, D. D., Gordon, P. M. K., Teng, G., Dundas, J. A., Zarzycki, A. N., Turnbull, J., Deniset, J., & Fedak, P. W. M. (2024) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2024.06.007 · Cited by 10 · see citing works

Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failure

Peterson, T. E., Hahn, V. S., Moaddel, R., Zhu, M., Haberlen, S., Palella, F. J., Plankey, M. W., Bader, J. S., Lima, J. A. C., Gerszten, R. E., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-55911-0 · Cited by 10 · see citing works

Notch signalling in alveolar bone development and regeneration: A critical regulator for osteoblasts to osteocytes transitioning

Cai, D., Shao, J., & Xiao, Y. (2026) · Dental Research · doi:10.1016/j.dtrs.2026.100025 · Cited by 9 · see citing works

A Lifelike guided journey through the pathophysiology of pulmonary hypertension—from measured metabolites to the mechanism of action of drugs

Weinstein, N., Carlsen, J., Schulz, S., Stapleton, T., Henriksen, H., Travnik, E., & Johansson, P. I. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1341145 · Cited by 8 · see citing works

Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humansPreprint

Xiang, Y., Tanwar, V., Singh, P. P., Follette, L. L., Narayan, V. P., & Kapahi, P. (2024) · eLife · doi:10.7554/elife.102447 · Cited by 8 · see citing works

Discovery of highly potent and ALK2/ALK1 selective kinase inhibitors using DNA-encoded chemistry technology

Jimmidi, R., Monsivais, D., Ta, H. M., Sharma, K. L., Bohren, K. M., Chamakuri, S., Liao, Z., Li, F., Hakenjos, J. M., Li, J., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2413108121 · Cited by 7 · see citing works

Nitrogen-containing bisphosphonate induces enhancement of OPG expression and inhibition of RANKL expression via inhibition of farnesyl pyrophosphate synthase to inhibit the osteogenic differentiation and calcification in vascular smooth muscle cells

Xu, W., Gong, L., Tang, W., & Lu, G. (2024) · BMC Cardiovascular Disorders · doi:10.1186/s12872-024-04048-x · Cited by 6 · see citing works

Exosomes Derived from Dialysis Patients' Serum Enhance Endothelial–Mesenchymal Transition and Calcification in Endothelial Cells

Cohen‐Hagai, K., Kuchuk, E., Matalon, S. T., Benchetrit, S., & Zitman‐Gal, T. (2025) · Kidney360 · doi:10.34067/kid.0000000678 · Cited by 6 · see citing works

Melatonin Promotes Cerebral Angiogenesis in Ischemic Mice via BMP6/Smad1/5/9 Pathway

Li, L., Yuan, Y., Zhang, C., Li, Y., Xu, R., Zhang, X., & Shang, W. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04969-4 · Cited by 6 · see citing works

The Prognostic Potential of Insulin-like Growth Factor-Binding Protein 1 for Cardiovascular Complications in Peripheral Artery Disease

Li, B., Shaikh, F., Younes, H. K., AbuHalimeh, B. J., Zamzam, A., Abdin, R., & Qadura, M. (2025) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd12070253 · Cited by 4 · see citing works

Kielin/chordin‐like protein deficiency aggravates pressure overload‐induced cardiac dysfunction and remodeling via P53 / P21 / CCNB1 signaling in mice

Xu, Y., Zheng, Z., Pan, H., Zhao, M., Zhang, J., Peng, S., Liu, J., Pan, W. D., Yin, Z., Xu, S., et al. (2024) · The FASEB Journal · doi:10.1096/fj.202301841r · Cited by 4 · see citing works

Dysregulations in Cardiogenic Mechanisms by TGF-beta and Angiotensin II in Cardiac Remodeling Post-Ischemic Injury: a systematic reviewPreprint

Shafi, O., Zahra, K., & Shah, H. H. (2024) · medRxiv · doi:10.1101/2024.07.11.24310260 · Cited by 4 · see citing works

Keratin Scaffold Formulation Impacts rhBMP-2 Biodistribution and Bone Regeneration in a Rat Femur Defect Model

Saul, J. M., Bohnert, J. S., O’Brien, M., Alnuaimi, S., Carnwath, T. P., Dunivan, Q., Coffin, D. W., & Smith, T. L. (2025) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-025-00747-4 · Cited by 3 · see citing works

Microenvironmental and structural regulation of BMP signaling: insights into the prodomain-growth factor interface

Spanou, C. E. S., & Sengle, G. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00500.2025 · Cited by 3 · see citing works

BMP7 attenuates myocardial injury and preserves cardiac function after myocardial infarction by inhibiting cardiomyocyte pyroptosis

Liu, M., Pei, J., Zeng, C., Xin, Y., Tang, P., & Hu, X. (2026) · APOPTOSIS · doi:10.1007/s10495-026-02264-8 · Cited by 3 · see citing works

Role of BMP-7 in Cardiovascular Diseases: From Molecular Mechanisms to Therapeutic Horizons

Bansal, P., Kajal, K., Sharma, S., & Mazumder, A. (2025) · Current Drug Targets · doi:10.2174/0113894501421956251014101956 · Cited by 2 · see citing works

Extracellular vesicles secreted by LRP1+ ligament-derived stem cells promote tendon-bone healing after ACL reconstruction via miR-708-5p/Bambi axis

Yao, P., Yang, Y., Yuan, F., Lin, Z., Qin, Y., Liu, S., Mao, Y., Wang, L., Du, R., Xu, Y., et al. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.123977 · Cited by 2 · see citing works

Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humans

Xiang, Y., Tanwar, V., Singh, P. P., Follette, L. L., Narayan, V. P., & Kapahi, P. (2025) · eLife · doi:10.7554/elife.102447.4 · Cited by 1 · see citing works

Clinical and Histological Outcomes of Autologous Dentin Matrix in Post-Extraction Alveolar Healing: A Pilot Randomized Clinical Trial

Jáquez, M., Algar, J., Collins, J. R., Hernández, G., & Aragoneses, J. M. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15020606 · Cited by 1 · see citing works

BMP10 in Cardiovascular Disease: From Pathogenesis to Therapeutic Strategies

Jiang, Q., Li, C., Jiang, Y., Ye, Z., Xu, G. X., Zhang, Y., Yang, F., Xiao, J., & Li, C. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl31356 · Cited by 1 · see citing works

Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humansPreprint

Xiang, Y., Tanwar, V., Singh, P. P., Follette, L. L., Narayan, V. P., & Kapahi, P. (2025) · eLife · doi:10.7554/elife.102447.2 · Cited by 1 · see citing works

Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humansPreprint

Xiang, Y., Tanwar, V., Singh, P. P., Follette, L. L., Narayan, V. P., & Kapahi, P. (2025) · eLife · doi:10.7554/elife.102447.3 · Cited by 1 · see citing works

Expression pattern of the bone morphogenetic protein-4 and its relationship with inflammation, vascular injury in patients suffered the arterial occlusive diseases.

Zhang, W., Hu, M. S., Yang, L. C., Zhou, Z., Chen, R., & Liu, Z. (2024) · PubMed Central · doi:10.11817/j.issn.1672-7347.2024.230264

Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humansPreprint

Xiang, Y., Tanwar, V., Singh, P. P., Follette, L. L., & Kapahi, P. (2024) · eLife · doi:10.7554/elife.102447.1

Case Report: Pulmonary arterial hypertension in children caused by a new mutation in the BMPR2 gene

Tang, T. A., Wu, S., Peng, C., & Wang, L. (2025) · Frontiers in Pediatrics · doi:10.3389/fped.2025.1572733

Implication of novel variants of BMP2 in isolated congenital heart disease: Functional characterization by in silico and invitro approachesPreprint

Maddhesiya, J., Dixit, R., Kumar, A., & Mohapatra, B. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.29.672127

Study of some biochemical and genetic markers in patients with congenital heart defects undergoing surgical correction: A case-control study

Hassan, M. H., Hofni, A., Ghoneim, A., Abdelnaby, A. A., El-Sawy, S. A., Okasha, M., Abdelbary, M. E., Farouk, A., Taye, A., & Hafez, M. F. A. (2025) · Heart Vessels and Transplantation · doi:10.24969/hvt.2025.599

Additional file 1 of Nitrogen-containing bisphosphonate induces enhancement of OPG expression and inhibition of RANKL expression via inhibition of farnesyl pyrophosphate synthase to inhibit the osteogenic differentiation and calcification in vascular smooth muscle cells

Xu, W., Gong, L., Tang, W., & Lu, G. (2024) · Figshare · doi:10.6084/m9.figshare.27049172

Recurrent evolution of ligand-binding domain multiplicity fine-tunes TGFβ signaling in vertebrates

Jatzlau, J., Trumpp, M., Kühlwein, J., Obendorf, L., Le, Y., Kuhl, H., Preußner, M., Mendez, P., Burkert, H., Burdzinski, W., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-73340-5

Electrophysiological and molecular characterization of a TGF-β1 goat modelPreprint

Regouski, M., Fillmore, J., Larsen, R., Marriott, C. M., Patrick, T., Sweat, A., Stott, R. D., Thomas, A., Wettere, A. J. V., Cutler, M. J., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10232704/v1

GRAIL-heart: A graph attention network for inferring ligand-receptor interactions in spatial transcriptomics

Kgabeng, T., Wang, L., Ngwangwa, H., Nemavhola, F. J., & Pandelani, T. (2026) · MethodsX · doi:10.1016/j.mex.2026.104093

Vascular calcification: pathogenic mechanisms, signaling crosstalk and translational therapeutics

Hua, R., Qiao, B., Liu, X., Jiang, B., Wu, J., Zhang, C., Liu, H., Wang, B., Wei, S., & Chen, Y. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02884-1

Single-cell RNA sequencing highlights the heterogeneity of neutrophils in granulomatosis with polyangiitis

Guo, S., Zhou, Y., Pang, D., Li, G., Lyu, Y., Xu, X., Li, J., & Tian, X. (2026) · Rheumatology and Immunology Research · doi:10.1515/rir-2026-0032

Bone morphogenetic protein 12: a novel target for cardiovascular disease

Isaza, S. C., Hernández-García, M. Á., Fernández-García, C. E., Pérez-Utrera, C., Álvarez‐Rubal, M., Muñoz, J. M., Friera, A., García‐Monzón, C., Gómez‐Hernández, A., Landete, P., et al. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00609-y

Targeting BMP signalling in cardiovascular disease and anaemia

Morrell, N. W., Bloch, D. B., ten Dijke, P., Goumans, M., Hata, A., Smith, J., Yu, P. B., & Bloch, K. D. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.156 · Cited by 223 · see citing works

Regulators and effectors of bone morphogenetic protein signalling in the cardiovascular system

Luo, J., Zhang, Y., Wang, L., & Huang, Y. (2015) · The Journal of Physiology · doi:10.1113/jp270207 · Cited by 31 · see citing works

Bone Morphogenetic Protein Signaling in Pulmonary Arterial Hypertension

Yang, P. B., & Yu, P. B. (2017) · Springer eBooks · doi:10.1007/978-3-319-47507-3_13

TGF-β and BMPR2 Signaling in PAH: Two Black Sheep in One Family

Rol, N., Kurakula, K., Happé, C. M., Bogaard, H. J., & Goumans, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092585 · Cited by 128 · see citing works

BMP signaling in vascular diseases

Cai, J., Pardali, E., Sánchez‐Duffhues, G., & ten Dijke, P. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.04.030 · Cited by 269 · see citing works