The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
Classification of scaffold-hopping approaches
Open accessAbstract
The general goal of drug discovery is to identify novel compounds that are active against a preselected biological target with acceptable pharmacological properties defined by marketed drugs. Scaffold hopping has been widely applied by medicinal chemists to discover equipotent compounds with novel backbones that have improved properties. In this review, scaffold hopping is classified into four major categories, namely heterocycle replacements, ring opening or closure, peptidomimetics, and topology-based hopping. The structural diversity of original and final scaffolds with respect to each category will be reviewed. The advantages and limitations of small, medium, and large-step scaffold hopping will also be discussed. Software that is frequently used to facilitate different kinds of scaffold hopping methods will be summarized.
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Metadata
- Authors
- Sun, H., Tawa, G., & Wallqvist, A.
- Venue
- Drug Discovery Today
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 17
- Issue
- 7-8
- Pages
- 310-324
- ISSN
- 1359-6446 (ISSN-L)
- OpenAlex
- W2067300585
- Cited by
- 375
- References
- 95
- FWCI
- 11.66
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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