The DOI matches its Crossref record; 134 of the 136 references it cites were found in a registry or an index.
Nanoparticle technology for treatment of Parkinson’s disease: The role of surface phenomena in reaching the brain
Abstract
The absence of a definitive treatment for Parkinson's disease has driven the emerging investigation in the search for novel therapeutic alternatives. At present, the formulation of different drugs on nanoparticles has represented several advantages over conventional treatments. This type of multifunctional carrier, owing to its size and composition, has different interactions in biological systems that can lead to a decrease in ability to cross the blood-brain barrier. Therefore, this review focuses on the latest advances in obtaining nanoparticles for Parkinson's disease and provides an overview of technical aspects in the design of brain drug delivery of nanoparticles and an analysis of surface phenomena, a key aspect in the development of functional nanoparticles for Parkinson's disease.
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“A high percentage of phytochemicals with high molecular weight and a high degree of lipophilicity will not be able to cross into the brain compartment, combined with chemical instability in the bloodstream [208].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [208]
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Cites
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2 of the 136 references couldn’t be matched to a known paper.
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- Leyva-Gomez, 2014, Evaluation of the anxiolytic effect produced by clonazepam-solid lipid nanoparticles, Lat. Am. J. Pharm., 33, 307
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Items 101–102 of 102
Sharma, S., Sharma, U., Sethiya, N. K., & Singh, L. (2026) · Current Aging Science · doi:10.2174/0118746098373086251201095903
Controllable preparation of poly(lactic-co-glycolic acid) microspheres in capillary microreactors
Zhang, Z., & Liu, D. (2026) · Powder Technology · doi:10.1016/j.powtec.2026.122778
Metadata
- Authors
- Leyva-Gómez, G., Cortés, H., Magaña, J. J., Leyva-García, N., Quintanar-Guerrero, D., & Florán, B.
- Affiliations
- Instituto Nacional de Rehabilitación (MX)
- Venue
- Drug Discovery Today
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 20
- Issue
- 7
- Pages
- 824-837
- ISSN
- 1359-6446 (ISSN-L)
- OpenAlex
- W2005325784
- Cited by
- 102
- References
- 136
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 12 · 2023: 8 · 2022: 7 · 2021: 12 · 2020: 20 · 2019: 6 · 2018: 6 · 2017: 9 · 2016: 6 · 2015: 5
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drug Discovery Today (publishedVersion)
- PubMed (publishedVersion)
- Funders
- PAPIIT
- CONACyT
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- Parkinson's disease, nanoparticles, brain drug delivery, blood-brain barrier, surface phenomena, nanoparticle design, drug carriers, neurodegenerative disease treatment
- MeSH terms
- Animals, Antiparkinson Agents, Blood-Brain Barrier, Chemistry, Pharmaceutical, Drug Carriers, Humans, Parkinson Disease, Permeability, Polymers, Solubility, Technology, Pharmaceutical, Nanomedicine, Nanoparticles
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