Application of nanotechnology to improve the therapeutic benefits of statins
Abstract
Hyperlipidemia is defined as an elevated level of lipids and lipoproteins in the blood and is considered to be a significant risk factor for accelerating the process of atherosclerosis and, consequently, cardiovascular disease. The level of cholesterol, especially low-density lipoprotein cholesterol (LDL-C), is commonly elevated in hyperlipidemia and represents the primary therapeutic target. Statins are a group of drugs that function by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and are extremely efficacious in reducing elevated LDL-C in the serum and preventing atherosclerotic cardiovascular disease. However, statins have some limitations, such as poor aqueous solubility, low oral absorption, and, consequently, limited bioavailability when administered by the oral route. The field of nanotechnology is now well developed and some of these newer nanotechnology strategies offer systems with enhanced aqueous solubility of the statin, increased absorption, bioavailability, and controlled release of the statin at the site of administration. Here, we discuss nano-sized drug delivery systems to enhance the therapeutic potential of statins.
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Lipid-based nanoparticles (liposomes, SLNs, NLCs) and polymeric nanoparticles have been investigated as nanosystems.
“A wide range of nanosystems has been investigated, including lipid‐based nanoparticles, such as liposomes, solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs), as well as polymeric nanoparticles [27].”
From Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies (2025) · cites this paper as [27]
Encapsulation protects statins from chemical and enzymatic degradation and facilitates sustained and targeted delivery, optimizing drug concentration at the intended site of action.
“Encapsulation not only protects statins from chemical and enzymatic degradation but also facilitates sustained and targeted delivery, thereby optimizing drug concentration at the intended site of action.”
From Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies (2025) · cites this paper as [27]
Nanoparticle-based carriers such as lipid nanoparticles, polymeric nanocapsules, and liposomes can enhance ATV's solubility, stability, and targeted delivery to infection sites, improving therapeutic efficacy and reducing systemic exposure.
“Nanoparticle‐based carriers such as lipid nanoparticles, polymeric nanocapsules, and liposomes can enhance ATV's solubility, stability, and targeted delivery to infection sites, thereby improving therapeutic efficacy and reducing systemic exposure [27].”
From Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies (2025) · cites this paper as [27]
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- Authors
- Korani, S., Korani, M., Bahrami, S., Johnston, T. P., Butler, A. E., Banach, M., & Sahebkar, A.
- Affiliations
- Kermanshah University of Medical Sciences (IR)
- Mashhad University of Medical Sciences (IR)
- Shahid Beheshti University (IR)
- University of Missouri–Kansas City (US)
- Medical University of Lodz (PL)
- Corresponding author
- Sahebkar, Amirhossein
- ORCID
- Venue
- Drug Discovery Today
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 24
- Issue
- 2
- Pages
- 567-574
- ISSN
- 1359-6446 (ISSN-L)
- OpenAlex
- W2894700193
- Cited by
- 51
- References
- 62
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 8 · 2023: 8 · 2022: 9 · 2021: 9 · 2020: 8 · 2019: 1
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drug Discovery Today (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- statins, nanotechnology, drug delivery systems, hyperlipidemia, LDL cholesterol, HMG-CoA reductase inhibition, bioavailability, water solubility, oral absorption, controlled release, atherosclerosis, cardiovascular disease
- MeSH terms
- Animals, Biological Availability, Humans, Intestinal Absorption, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Nanotechnology
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