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Artificial intelligence in drug development: present status and future prospects
Abstract
Artificial intelligence (AI) uses personified knowledge and learns from the solutions it produces to address not only specific but also complex problems. Remarkable improvements in computational power coupled with advancements in AI technology could be utilised to revolutionise the drug development process. At present, the pharmaceutical industry is facing challenges in sustaining their drug development programmes because of increased R&D costs and reduced efficiency. In this review, we discuss the major causes of attrition rates in new drug approvals, the possible ways that AI can improve the efficiency of the drug development process and collaboration of pharmaceutical industry giants with AI-powered drug discovery firms.
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“Many more examples are available [3,32,33,34,35,36,37], showing that AI-based methods can accelerate the drug discovery process and enable the development of more effective medications.”
From The role of AI in drug discovery: challenges, opportunities, and strategies (2023) · cites this paper as [36]
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Metadata
- Authors
- Mak, K.-K., & Pichika, M. R.
- Affiliations
- IMU University (MY)
- Corresponding author
- Pichika, Mallikarjuna Rao
- Venue
- Drug Discovery Today
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 24
- Issue
- 3
- Pages
- 773-780
- ISSN
- 1359-6446 (ISSN-L)
- OpenAlex
- W2901411193
- Cited by
- 1,018
- References
- 73
- Citations by year
- 2026: 161 · 2025: 196 · 2024: 190 · 2023: 170 · 2022: 99 · 2021: 119 · 2020: 63 · 2019: 18
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drug Discovery Today (publishedVersion)
- PubMed (publishedVersion)
- Funders
- International Medical University
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Computational Drug Discovery Methods
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Physical Sciences › Computer Science › Artificial Intelligence › Artificial Intelligence Applications
- Keywords
- artificial intelligence, drug development, drug discovery, attrition rates, research and development costs, pharmaceutical industry
- MeSH terms
- Artificial Intelligence, Drug Industry, Humans, Drug Discovery
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