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Substance abuse treatment entry, retention, and outcome in women: A review of the literature
Open accessAbstract
This paper reviews the literature examining characteristics associated with treatment outcome in women with substance use disorders. A search of the English language literature from 1975 to 2005 using Medline and PsycInfo databases found 280 relevant articles. Ninety percent of the studies investigating gender differences in substance abuse treatment outcomes were published since 1990, and of those, over 40% were published since the year 2000. Only 11.8% of these studies were randomized clinical trials. A convergence of evidence suggests that women with substance use disorders are less likely, over the lifetime, to enter treatment compared to their male counterparts. Once in treatment, however, gender is not a significant predictor of treatment retention, completion, or outcome. Gender-specific predictors of outcome do exist, however, and individual characteristics and treatment approaches can differentially affect outcomes by gender. While women-only treatment is not necessarily more effective than mixed-gender treatment, some greater effectiveness has been demonstrated by treatments that address problems more common to substance-abusing women or that are designed for specific subgroups of this population. There is a need to develop and test effective treatments for specific subgroups such as older women with substance use disorders, as well as those with co-occurring substance use and psychiatric disorders such as eating disorders. Future research on effectiveness and cost-effectiveness of gender-specific versus standard treatments, as well as identification of the characteristics of women and men who can benefit from mixed-gender versus single-gender treatments, would advance the field.
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“yet, in several literature reviews and meta-analyses (see Greenfield et al., 2007 for review), gender does not appear to be a specific predictor of treatment outcomes (e.g., relapse).”
From Influences of victimization and comorbid conditions on latency to illicit drug use among adolescents and young adults (2020) · cites this paper as Greenfield et al., 2007
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Metadata
- Authors
- Greenfield, S. F., Brooks, A. J., Gordon, S. M., Green, C. A., Kropp, F., McHugh, R. K., Lincoln, M., Hien, D., & Miele, G. M.
- Affiliations
- Harvard University (US)
- University of Arizona (US)
- Seabrook (US)
- Kaiser Permanente (US)
- University of Cincinnati (US)
- McLean Hospital (US)
- Columbia University (US)
- Corresponding author
- Greenfield, Shelly F.
- ORCID
- Venue
- Drug and Alcohol Dependence
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 86
- Issue
- 1
- Pages
- 1-21
- ISSN
- 0376-8716 (ISSN-L)
- PMC
- PMC3532875
- OpenAlex
- W2090169982
- Cited by
- 1,055
- References
- 245
- Citations by year
- 2026: 36 · 2025: 50 · 2024: 43 · 2023: 53 · 2022: 60 · 2021: 79 · 2020: 81 · 2019: 77 · 2018: 60 · 2017: 67 · 2016: 66 · 2015: 66 · 2014: 56 · 2013: 64 · 2012: 48
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Drug and Alcohol Dependence (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5k24da019855-10, 5u10da013043-15)
- National Institute on Drug Abuse (DA 019855, U10-DA-013043, U10 DA99004, U10DA013035, U10DA13043, K24-DA019855, U10DA013732, U10DA015815, DA15434, U10DA015831, R01DA015434)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Keywords
- substance use disorders, women, gender differences, treatment entry, treatment retention, treatment outcomes, predictors of treatment outcome, older women, co-occurring psychiatric disorders, eating disorders, cost-effectiveness
- MeSH terms
- Adult, Age Factors, Female, Hospitalization, Humans, Male, Middle Aged, Retention, Psychology, Sex Factors, Treatment Outcome, Substance-Related Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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