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Cannabis use and cannabis use disorders and their relationship to mental disorders: A 10-year prospective-longitudinal community study in adolescents
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Background Whereas the role of externalizing disorders is relatively well established in predicting the onset of cannabis use (CU) or cannabis use disorder (CUD), the status of anxiety and mood disorders in predicting CU and CUD remains controversial.Objective (1) To examine cross-sectional and prospective associations of CU and CUD with a range of mental disorders and whether anxiety and mood disorders are associated with CU/CUD after adjusting for externalizing disorders.Methods N=1395 community subjects aged 14-17 at baseline were followed-up at three waves prospectively over 10 years. Substance use, substance disorders and mental disorders were assessed using the DSM-IV/M-CIDI.Results (1) The baseline prevalence rates where 19.3% at t(0) for CU and 2.6% for CUD. Cumulative incidence rates at t(3) were 54.3% for CU and 13.7% for CUD. (2) In cross-sectional and prospective analyses other substance use disorders, mood and anxiety disorders were associated with CU and CUD. (3) Associations of panic-anxiety with CU and of depressive and bipolar disorders with CU and CUD were significant after controlling for externalizing disorders.Conclusion A range of psychopathological conditions, including depressive, bipolar and less consistently anxiety disorders as well as the degree of their comorbidity are significantly associated with incident CU and progression to CUD, even when controlling for externalising disorders. A better understanding of this complex interplay may result in better aetiological models and intervention strategies.
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“The disorders included in anxiety disorders appear to have a differential risk for substance-related disorders.”
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Associations Between Adolescent Cannabis Use Trajectories and Anxiety
Duperrouzel, J. C. (2019) · FIU - Digital Commons (Florida International University) · doi:10.25148/etd.fidc008985
“highlight differences between varying levels of cannabis use and anxiety symptoms, lending support to theoretical models that support the theory that early onset substance use impacts mental health (Wittchen et al., 2007).”
Result(2011) · Wiley eBooks · doi:10.1002/9781118101056.refs
Epidemiology of simultaneous narcological and mental disorders in adolescence
Panov, A. S., Zastrozhin, M. S., Skryabin, V. Y., Ea, K., Brun, E. V., & Brun, E. A. (2021) · Vestnik nevrologii psihiatrii i nejrohirurgii (Bulletin of Neurology Psychiatry and Neurosurgery) · doi:10.33920/med-01-2110-05
Deuchar, R., McLean, R., & Holligan, C. (2021) · Bristol University Press eBooks · doi:10.51952/9781529210576.bm003
Alkohol- und andere Abhängigkeitserkrankungen in der allgemeinmedizinischen Praxis
Scheibenbogen, O., Dürlinger, F., & Glehr, R. (2023) · Allgemeinmedizin up2date · doi:10.1055/a-1945-6112
“Essstörungen (5%) oder Störungen aus dem schizophrenen Formenkreis (5%) machen einen verhältnismäßig kleineren Teil aus [10, 11].”
BackgroundEffects of Cannabis Exposure on Adolescent Health and Development: A Narrative Review
Li, R. L., & Tao, F. (2024) · Current Drug Research Reviews · doi:10.2174/0125899775273727231224185028
“A 10-year prospective study of 1395 adolescents aged 14 to 17 has demonstrated that mood and anxiety disorders are tightly correlated with cannabis use [24].”
Hong, J., Triana, R. R., Khan, M. T. F., Tewari, A., Yin, B., & Krishnan, D. G. (2024) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2024.04.001
Tanner, A. S., Lanser, I., & Wolitzky-Taylor, K. B. (2024) · CBT: science into practice · doi:10.1007/978-3-031-62971-6_6
Metadata
- Authors
- Wittchen, H.-U., Fröhlich, C., Behrendt, S., Günther, A., Rehm, J., Zimmermann, P., Lieb, R., & Perkonigg, A.
- Affiliations
- Technische Universität Dresden (DE)
- Centre for Addiction and Mental Health (CA)
- Max Planck Society (DE)
- Venue
- Drug and Alcohol Dependence
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 88
- Pages
- S60-S70
- ISSN
- 0376-8716 (ISSN-L)
- OpenAlex
- W2103849723
- Cited by
- 311
- References
- 50
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 12 · 2023: 13 · 2022: 10 · 2021: 16 · 2020: 20 · 2019: 22 · 2018: 14 · 2017: 23 · 2016: 18 · 2015: 15 · 2014: 17 · 2013: 24 · 2012: 21
- FWCI
- 11.96
- Type
- journal article
- Language
- en
- Open access
- green
- tud.qucosa.de
- Licence
- Locations
- Drug and Alcohol Dependence (publishedVersion)
- PubMed (publishedVersion)
- Qucosa (Saxon State and University Library Dresden) (submittedVersion, other-oa)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (WI 709/8-1, WI 709/7-1, WI2246/1‐1, LA1148/1‐1)
- Bundesministerium für Bildung und Forschung (LA1148/1-1, 01EB9901/6, EB 0142, WI2246/1-1, WI 709/7-1, 01EB0140, WI 709/8-1, 01EB9405/6, EB01016200, 01EB0440)
- National Institutes of Health
- U.S. Public Health Service (303-7028)
- National Institute of Mental Health
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- cannabis use, cannabis use disorder, adolescents, anxiety disorders, mood disorders, depressive disorders, bipolar disorder, externalizing disorders, substance use disorders, comorbidities, substance use onset, substance use progression
- MeSH terms
- Adolescent, Mental Disorders, Cannabis, Marijuana Abuse, Humans, Internal-External Control, Prospective Studies, Residence Characteristics
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