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Cannabis use and cannabis use disorders and their relationship to mental disorders: A 10-year prospective-longitudinal community study in adolescents
Open accessAbstract
Background Whereas the role of externalizing disorders is relatively well established in predicting the onset of cannabis use (CU) or cannabis use disorder (CUD), the status of anxiety and mood disorders in predicting CU and CUD remains controversial.Objective (1) To examine cross-sectional and prospective associations of CU and CUD with a range of mental disorders and whether anxiety and mood disorders are associated with CU/CUD after adjusting for externalizing disorders.Methods N=1395 community subjects aged 14-17 at baseline were followed-up at three waves prospectively over 10 years. Substance use, substance disorders and mental disorders were assessed using the DSM-IV/M-CIDI.Results (1) The baseline prevalence rates where 19.3% at t(0) for CU and 2.6% for CUD. Cumulative incidence rates at t(3) were 54.3% for CU and 13.7% for CUD. (2) In cross-sectional and prospective analyses other substance use disorders, mood and anxiety disorders were associated with CU and CUD. (3) Associations of panic-anxiety with CU and of depressive and bipolar disorders with CU and CUD were significant after controlling for externalizing disorders.Conclusion A range of psychopathological conditions, including depressive, bipolar and less consistently anxiety disorders as well as the degree of their comorbidity are significantly associated with incident CU and progression to CUD, even when controlling for externalising disorders. A better understanding of this complex interplay may result in better aetiological models and intervention strategies.
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“another found the highest risk in childhood internalizing disorders, 9”
From Childhood Psychiatric Disorders as Risk Factor for Subsequent Substance Abuse: A Meta-Analysis. (2017) · cites this paper as [9]
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“The disorders included in anxiety disorders appear to have a differential risk for substance-related disorders.”
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Britton, E. M., Taisir, R., Cooper, A., Li, Y., Sousa, S., Chorny, Y., MacKillop, J. M., & Costello, M. J. (2024) · Cannabis · doi:10.26828/cannabis/2024/000260
“Research prior to legalization shows that people with psychiatric disorders, and in particular those with SUDs, tend to use cannabis at elevated rates and are more likely to have a cannabis use disorder (CUD; Lev-Ran, Le Foll, et al., 2013; Wittchen et al., 2007).”
Comorbid Cannabis Use and Mood Disorders Among Adolescents
Strong, S. J., Thomas, H. A., Adams, Z. W., & Hulvershorn, L. A. (2025) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20240049 · Cited by 1
Modulation of Serotonin Firing Activity Through CB1 Agonists and FAAH Inhibitors
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Correlates of alcohol use and alcohol use disorder among youth with bipolar disorder
Sultan, A. A., Wong, C. H., & Goldstein, B. I. (2026) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2026.01.045
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Metadata
- Authors
- Wittchen, H.-U., Fröhlich, C., Behrendt, S., Günther, A., Rehm, J., Zimmermann, P., Lieb, R., & Perkonigg, A.
- Affiliations
- Technische Universität Dresden (DE)
- Centre for Addiction and Mental Health (CA)
- Max Planck Society (DE)
- Venue
- Drug and Alcohol Dependence
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 88
- Pages
- S60-S70
- ISSN
- 0376-8716 (ISSN-L)
- OpenAlex
- W2103849723
- Cited by
- 311
- References
- 50
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 12 · 2023: 13 · 2022: 10 · 2021: 16 · 2020: 20 · 2019: 22 · 2018: 14 · 2017: 23 · 2016: 18 · 2015: 15 · 2014: 17 · 2013: 24 · 2012: 21
- FWCI
- 11.96
- Type
- journal article
- Language
- en
- Open access
- green
- tud.qucosa.de
- Licence
- Locations
- Drug and Alcohol Dependence (publishedVersion)
- PubMed (publishedVersion)
- Qucosa (Saxon State and University Library Dresden) (submittedVersion, other-oa)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (WI 709/8-1, WI 709/7-1, WI2246/1‐1, LA1148/1‐1)
- Bundesministerium für Bildung und Forschung (LA1148/1-1, 01EB9901/6, EB 0142, WI2246/1-1, WI 709/7-1, 01EB0140, WI 709/8-1, 01EB9405/6, EB01016200, 01EB0440)
- National Institutes of Health
- U.S. Public Health Service (303-7028)
- National Institute of Mental Health
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- cannabis use, cannabis use disorder, adolescents, anxiety disorders, mood disorders, depressive disorders, bipolar disorder, externalizing disorders, substance use disorders, comorbidities, substance use onset, substance use progression
- MeSH terms
- Adolescent, Mental Disorders, Cannabis, Marijuana Abuse, Humans, Internal-External Control, Prospective Studies, Residence Characteristics
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