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Cited by 17Substance Abuse Treatment and OutcomesAlcohol Consumption and Health EffectsNeurotransmitter Receptor Influence on Behavior

Effect of the threat of a disulfiram–ethanol reaction on cue reactivity in alcoholics

Skinner, Marilyn D., Coudert, Mathieu, Berlin, Ivan, Passeri, Elodie, Michel, Laurent, Aubin, Henri-Jean·2010·Drug and Alcohol Dependence
DOI 10.1016/j.drugalcdep.2010.06.011
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Abstract

Rationale Little is known about the effect of disulfiram on subjective and autonomic nervous system cue reactivity in the laboratory. The dissuasive psychological effect manifested as a threat would seem to prevail over the pharmacological effect.Objectives The primary objective was to determine whether there was a difference in cue reactivity responses during a threat condition compared to a neutral condition during alcohol cue exposure.Methods In a crossover randomized study, participants received threat and neutral messages during two cue exposure sessions. The threat condition consisted of leading the patients to believe they had ingested 500 mg of disulfiram and the neutral condition of informing them that they had ingested a placebo, while in both condition they received the same placebo.Results Physiological cue reactivity was demonstrated by a decrease in diastolic blood pressure during the threat compared to the neutral condition (p=0.04). Heart rate and subjective cue reactivity measures remained unchanged. There was a negative affect (assessed by the Positive and Negative Affect Scale) by condition by exposure interaction.Conclusions The threat of a disulfiram-ethanol reaction appears to affect cue reactivity physiologically rather than subjectively. While the data does not show changes in subjective ratings, it is possible that there are alternative beneficial effects arising from other cognitive processes that are not captivated by self-reported craving scales, reflected by decreases in negative affect and blood pressure. From this perspective, disulfiram might be recast to be more acceptable to patients.

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Crossref · 10.1016/j.drugalcdep.2010.06.011

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  • Disulfiram's mechanism of action for maintaining alcohol abstinence is thought to be primarily psychological.

    “Its mechanism of action for maintaining alcohol abstinence is thought to be primarily psychological [4], [5], [6], [7] and based on a highly disagreeable pharmacological effect if alcohol is consumed.”

    From Disulfiram Efficacy in the Treatment of Alcohol Dependence: A Meta-Analysis (2014) · cites this paper as [6]

  • The psychological or cognitive threat of a DER is thought to be dominant and active and thus dissuade use.

    “To prevent the first drink, however, the psychological or cognitive threat is thought to be dominant and active and thus dissuade use [5], [6], [7].”

    From Disulfiram Efficacy in the Treatment of Alcohol Dependence: A Meta-Analysis (2014) · cites this paper as [6]

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Authors
Skinner, M. D., Coudert, M., Berlin, I., Passeri, E., Michel, L., & Aubin, H.-J.
Affiliations
  • Université Paris-Sud (FR)
  • Assistance Publique – Hôpitaux de Paris (FR)
Corresponding author
Skinner, Marilyn D.
ORCID
Venue
Drug and Alcohol Dependence
Publisher
Elsevier BV
Published
2010-12
Volume
112
Issue
3
Pages
239-246
ISSN
0376-8716 (ISSN-L)
DOI
10.1016/j.drugalcdep.2010.06.011
OpenAlex
W2066807104
Cited by
17
References
58
Citations by year
2024: 1 · 2022: 2 · 2020: 1 · 2019: 3 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2012: 4
FWCI
0.93
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Drug and Alcohol Dependence (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
disulfiram, disulfiram-ethanol reaction, cue reactivity, alcohol cue exposure, alcoholism, negative affect, blood pressure, heart rate, craving, aversive conditioning
MeSH terms
Adult, Aged, Alcohol Drinking, Alcoholism, Autonomic Nervous System, Blood Pressure, Conditioning, Psychological, Cues, Disulfiram, Female, Heart Rate, Humans, Male, Middle Aged, Surveys and Questionnaires, Cross-Over Studies, Young Adult

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