Quality of life among alcohol-dependent patients: How satisfactory are the available instruments? A systematic review

Luquiens, A.; Reynaud, M.; Falissard, B.; Aubin, H.J.

doi:10.1016/j.drugalcdep.2012.08.012

Cited by 57Substance Abuse Treatment and OutcomesHealth Systems, Economic Evaluations, Quality of LifeAlcohol Consumption and Health Effects

Quality of life among alcohol-dependent patients: How satisfactory are the available instruments? A systematic review

Luquiens, A., Reynaud, M., Falissard, B., Aubin, H.J.·2012·Drug and Alcohol Dependence

DOI 10.1016/j.drugalcdep.2012.08.012

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Abstract

Aim The purpose of this systematic review was to compare quality-of-life instruments used as outcome measures in randomized clinical trials for alcohol-dependence treatment.Methods Randomized controlled clinical trials, indexed in the EMBASE, PubMed and PsycINFO databases since 1981, which aimed at improving the quality of life in alcohol-dependent patients and used as instrument to measure the quality of life, as specifically designated by the authors, were included.Results Of the 331 articles screened, 18 studies were included in the review. Eight different quality-of-life instruments were used as outcome measures. Twenty-seven life domains were explored. Between-scale heterogeneity was high. The scale most frequently used was the medical outcomes study 36-item short-form health survey (SF-36). Only 1 clinical trial demonstrated a significant difference between intervention groups at all endpoints, using the quality of life enjoyment and satisfaction questionnaire (Q-LES-Q).Conclusion Because many different instruments were used, it is difficult to compare quality-of-life improvement between trials. The most frequently used instrument was a generic health status measure that may not be well suited as a quality-of-life measure for subjects with alcohol dependence. The construction and validation of a specific patient-reported outcome based on alcohol-dependent patients' concerns would effectively contribute to the assessment of treatment efficacy.

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Variables that do not directly measure consumption could be a more representative indicator of the effectiveness of treatment for patients and healthcare providers, including quality of life.
“It was noted that variables that do not directly measure consumption could be a more representative indicator of the effectiveness of treatment for patients and healthcare providers, including quality of life.38–40”
From Feasibility, acceptability and preliminary outcomes of a mindfulness-based relapse prevention program in a naturalistic setting among treatment-seeking patients with alcohol use disorder: A prospective observational study (2019) · cites this paper as [40]
Quality of life has been identified as an important variable in assessing treatment outcomes in patients with AUD from their perspective and appears to be a good predictor for treatment success.
“Moreover, quality of life has been identified as an important variable in assessing treatment outcomes in patients with AUD from their perspective45–47 and appears to be a good predictor for treatment success.37”
From Feasibility, acceptability and preliminary outcomes of a mindfulness-based relapse prevention program in a naturalistic setting among treatment-seeking patients with alcohol use disorder: A prospective observational study (2019) · cites this paper as [47]

The Cochrane Collaboration's tool for assessing risk of bias in randomised trials
Higgins, J. P. T., Altman, D. G., Gotzsche, P. C., Juni, P., Moher, D., Oxman, A. D., Savovic, J., Schulz, K. F., Weeks, L., Sterne, J. A. C., et al. (2011) · BMJ · doi:10.1136/bmj.d5928 · Cited by 33,817 · see citing works
Untitled work
(1992) · PubMed · Cited by 33,716 · see citing works
The MOS 36-ltem Short-Form Health Survey (SF-36): I. Conceptual Framework and Item Selection
Ware, J. E., & Sherbourne, C. D. (1992) · Medical Care · doi:10.1097/00005650-199206000-00002 · Cited by 30,033 · see citing works
A 12-Item Short-Form Health Survey: Construction of Scales and Preliminary Tests of Reliability and Validity
WARE, J. E., KOSINSKI, M., & KELLER, S. D. (1996) · Medical Care · doi:10.1097/00005650-199603000-00003 · Cited by 17,392 · see citing works
EuroQol: a new facility for the measurement of health-related quality of life
(1990) · Health Policy · doi:10.1016/0168-8510(90)90421-9 · Cited by 15,736 · see citing works
The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and Clinical Tests of Validity in Measuring Physical and Mental Health Constructs
MCHORNEY, C. A., JOHNE, W., & ANASTASIAE, R. (1993) · Medical Care · doi:10.1097/00005650-199303000-00006 · Cited by 6,681 · see citing works
Validating the SF-36 health survey questionnaire: new outcome measure for primary care.
Brazier, J. E., Harper, R., Jones, N. M., O’Cathain, A., Thomas, K. J., Usherwood, T. P., & Westlake, L. (1992) · BMJ · doi:10.1136/bmj.305.6846.160 · Cited by 4,660 · see citing works
SF-36 Health Survey Update
Ware, J. E. (2000) · Spine · doi:10.1097/00007632-200012150-00008 · Cited by 4,455 · see citing works
Graphic representation of pain
Scott, J., & Huskisson, E. C. (1976) · Pain · doi:10.1016/0304-3959(76)90113-5 · Cited by 2,706 · see citing works
Quality of life and pharmacoeconomics in clinical trials
Pater, J. L. (1996) · Controlled Clinical Trials · doi:10.1016/s0197-2456(97)82191-5 · Cited by 2,412 · see citing works
Untitled work
(1993) · PubMed · Cited by 1,900 · see citing works
Quality of life and pharmacoeconomics in clinical trials
Spilker, B. (1996) · DigitalGeorgetown (Georgetown University Library) · Cited by 1,862 · see citing works
Quality-of-Life Impairment in Depressive and Anxiety Disorders
Rapaport, M. H., Clary, C., Fayyad, R., & Endicott, J. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.6.1171 · Cited by 914 · see citing works
Is quality of life determined by expectations or experience?
Carr, A., Gibson, B., & Robinson, P. G. (2001) · BMJ · doi:10.1136/bmj.322.7296.1240 · Cited by 844 · see citing works
The Drinker Inventory of Consequences (DrInC)
Miller, W. R., Tonigan, J. S., & Longabaugh, R. (1995) · PsycEXTRA Dataset · doi:10.1037/e563232012-001 · Cited by 402 · see citing works
Quality of life as an outcome measure in alcoholism treatment research.
Donovan, D., Mattson, M. E., Cisler, R. A., Longabaugh, R., & Zweben, A. (2005) · Journal of Studies on Alcohol, Supplement · doi:10.15288/jsas.2005.s15.119 · Cited by 237 · see citing works
The relationship between alcohol dependence and alcohol–related problems in a clinical population
Drummond, C. (1990) · British Journal of Addiction · doi:10.1111/j.1360-0443.1990.tb00652.x · Cited by 188 · see citing works
Alcohol: No Ordinary Commodity – a summary of the second edition
Alcohol and Public Policy Group (2010) · Addiction · doi:10.1111/j.1360-0443.2010.02945.x · Cited by 185 · see citing works
A Randomized Trial of Integrated Outpatient Treatment for Medically Ill Alcoholic Men
Willenbring, M. L., & Olson, D. H. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.16.1946 · Cited by 174 · see citing works
Oral Topiramate Reduces the Consequences of Drinking and Improves theQuality of Life of Alcohol-Dependent Individuals
Johnson, B. A., Ait‐Daoud, N., Akhtar, F. Z., & Ma, J. Z. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.9.905 · Cited by 156 · see citing works
A randomized, multicentre, open-label, comparative trial of disulfiram, naltrexone and acamprosate in the treatment of alcohol dependence
Лааксонен, Э., Koski‐Jännes, A., Salaspuro, M. P., Ahtinen, H., & Alho, H. (2007) · Alcohol and Alcoholism · doi:10.1093/alcalc/agm136 · Cited by 146 · see citing works
Double-Blind, Randomized Comparison of Memantine and Escitalopram for the Treatment of Major Depressive Disorder Comorbid With Alcohol Dependence
Muhonen, L. H., Lönnqvist, J. K., Juva, K., & Alho, H. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0308 · Cited by 118 · see citing works
MOS-SF-36 in Evaluating Health-Related Quality of Life in Alcohol-Dependent Patients
Daeppen, J., Krieg, M.-A., Burnand, B., & Yersin, B. (1998) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952999809019617 · Cited by 113 · see citing works
What should we be aiming for in the treatment of addiction?
Miller, P. G., & Miller, W. R. (2009) · Addiction · doi:10.1111/j.1360-0443.2008.02514.x · Cited by 98 · see citing works
A Double‐Blind, Placebo‐Controlled Trial to Assess the Efficacy of Quetiapine Fumarate XR in Very Heavy‐Drinking Alcohol‐Dependent Patients
Litten, R. Z., Fertig, J. B., Falk, D. E., Ryan, M. L., Mattson, M. E., Collins, J. F., Murtaugh, C., Ciraulo, D. A., Green, A. I., Johnson, B. A., et al. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01649.x · Cited by 94 · see citing works
Discordance between physicians' estimations and breast cancer patients' self-assessment of side-effects of chemotherapy: an issue for quality of care
Macquart-Moulin, G., Viens, P., Bouscary, M.-L., Genre, D., Resbeut, M., Gravis, G., Camerlo, J., Maraninchi, D., & Moatti, J. P. (1997) · British Journal of Cancer · doi:10.1038/bjc.1997.610 · Cited by 91 · see citing works
Quantification of the level descriptors for the standard EQ-5D three-level system and a five-level version according to two methods
Janssen, M. F., Birnie, E., & Bonsel, G. J. (2008) · Quality of Life Research · doi:10.1007/s11136-008-9318-5 · Cited by 84 · see citing works
Development of a Composite Measure for Assessing Alcohol Treatment Outcome: Operationalization and Validation
Cisler, R. A., & Zweben, A. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04109.x · Cited by 83 · see citing works
Quality of life and substance use: concepts and recent tendencies
Zúbaran, C., & Foresti, K. (2009) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e328328d154 · Cited by 76 · see citing works
Background and design of the new U.S. trial on diet and drug treatment of “mild” hypertension (TOMHS)
Stamler, J., Prineas, R. J., Neaton, J. D., Grimm, R. H., McDonald, R. H., Schnaper, H. W., Schoenberger, J. A., Elmer, P. J., & Cutler, J. A. (1987) · The American Journal of Cardiology · doi:10.1016/0002-9149(87)90158-5 · Cited by 71 · see citing works
A Double‐Blind, Placebo‐Controlled Study With Quetiapine as Adjunct Therapy With Lithium or Divalproex in Bipolar I Patients With Coexisting Alcohol Dependence
Stedman, M., Pettinati, H. M., Brown, E. S., Kotz, M., Calabrese, J. R., & Raines, S. (2010) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01270.x · Cited by 70 · see citing works
Using Topiramate or Naltrexone for the Treatment of Alcohol‐Dependent Patients
Flórez, G., García‐Portilla, M. P., Álvarez, S., Sáiz, P. A., Nogueiras, L., & Bobes, J. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00680.x · Cited by 69 · see citing works
The FDA guidance for industry on PROs: the point of view of a pharmaceutical company
Arpinelli, F., & Bamfi, F. (2006) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-4-85 · Cited by 67 · see citing works
The Alcohol Problems Questionnaire: reliability and validity
Williams, B. T. R., & Drummond, C. (1994) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(94)90080-9 · Cited by 64 · see citing works
Is Controlled Drinking an Acceptable Goal in the Treatment of Alcohol Dependence? A Survey of French Alcohol Specialists
Luquiens, A., Reynaud, M., & Aubin, H. J. (2011) · Alcohol and Alcoholism · doi:10.1093/alcalc/agr083 · Cited by 64 · see citing works
Self-citation
Yoga: A tool for improving the quality of life in chronic pancreatitis
Sareen, S. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i3.391 · Cited by 63 · see citing works
The EQ-5D in alcohol dependent patients: Relationships among health-related quality of life, psychopathology and social functioning
Günther, O., Roick, C., Angermeyer, M. C., & König, H. (2006) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2006.07.001 · Cited by 61 · see citing works
Topiramate for the Treatment of Alcohol Dependence: Comparison with Naltrexone
Flórez, G., Sáiz, P. A., García‐Portilla, M. P., Álvarez, S., Nogueiras, L., & Bobes, J. (2010) · European Addiction Research · doi:10.1159/000320471 · Cited by 59 · see citing works
Effect of Extended‐Release Naltrexone (XR‐NTX) on Quality of Life in Alcohol‐Dependent Patients
Pettinati, H. M., Gastfriend, D. R., Dong, Q., Kranzler, H. R., & O’Malley, S. S. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00843.x · Cited by 53 · see citing works
A Double‐Blind, Placebo‐Controlled Trial Assessing the Efficacy of Levetiracetam Extended‐Release in Very Heavy Drinking Alcohol‐Dependent Patients
Fertig, J. B., Ryan, M. L., Falk, D. E., Litten, R. Z., Mattson, M. E., Ransom, J. H., Rickman, W. J., Scott, C., Ciraulo, D. A., Green, A. I., et al. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01716.x · Cited by 53 · see citing works
Alcohol Treatment Effects on Secondary Nondrinking Outcomes and Quality of Life: The COMBINE Study
LoCastro, J. S., Youngblood, M., Cisler, R. A., Mattson, M. E., Zweben, A., Anton, R. F., & Donovan, D. M. (2009) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2009.70.186 · Cited by 51 · see citing works
A PRAGMATIC TRIAL OF ACAMPROSATE IN THE TREATMENT OF ALCOHOL DEPENDENCE IN PRIMARY CARE
Kiritze-Topor, P., Huas, D., ROSENZWEIG, C., Comte, S., Paillé, F., & Lehert, P. (2004) · Alcohol and Alcoholism · doi:10.1093/alcalc/agh088 · Cited by 50 · see citing works
SERTRALINE FOR THE PREVENTION OF RELAPSE IN DETOXICATED ALCOHOL DEPENDENT PATIENTS WITH A COMORBID DEPRESSIVE DISORDER: A RANDOMIZED CONTROLLED TRIAL
Gual, A. (2003) · Alcohol and Alcoholism · doi:10.1093/alcalc/agg124 · Cited by 49 · see citing works
ALQOL 9 FOR MEASURING QUALITY OF LIFE IN ALCOHOL DEPENDENCE
Malet, L., Llorca, P., BERINGUIER, B., Lehert, P., & Falissard, B. (2006) · Alcohol and Alcoholism · doi:10.1093/alcalc/agl001 · Cited by 46 · see citing works
Self-citation
Measuring Outcome in Interventions for Alcohol Dependence and Problem Drinking: Executive Summary of a Conference Sponsored by the National Institute on Alcohol Abuse and Alcoholism
Allen, J. P. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000091223.72517.13 · Cited by 45 · see citing works
THE SECCAT SURVEY: II. THE ALCOHOL RELATED PROBLEIN QUESTIONNAIRE AS A PROXY FOR RESOURCE COSTS AND QUA OF LIFE IN ALCOHOLISM TREATMENT
Patience, D. A., Buxton, M. J., Chick, J., Howlett, H. C. S., McKENNA, M., & Ritson, B. (1997) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a008237 · Cited by 36 · see citing works
Responsiveness of EQ-5D utility indices in alcohol-dependent patients
Günther, O. H., Roick, C., Angermeyer, M. C., & König, H. (2007) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2007.07.016 · Cited by 24 · see citing works
Les mesures de la qualité de vie
Leplège, A. (1999) · Presses Universitaires de France eBooks · Cited by 23 · see citing works
Assertive Community Treatment for alcohol dependence (ACTAD): study protocol for a randomised controlled trial
Gilburt, H., Burns, T., Copello, A. G., Coulton, S., Crawford, M., Day, E., Deluca, P., Godfrey, C., Parrott, S., Rose, A. K., et al. (2012) · Trials · doi:10.1186/1745-6215-13-19 · Cited by 18 · see citing works
Cost-Effectiveness of Home Visits in the Outpatient Treatment of Patients with Alcohol Dependence
Moraes, E., de Campos, G. M., Figlie, N. B., Laranjeira, R., & Ferraz, M. B. (2009) · European Addiction Research · doi:10.1159/000268107 · Cited by 15 · see citing works
Effectiveness of Sequential Combined Treatment in Comparison with Treatment as Usual in Preventing Relapse in Alcohol Dependence
Neto, D., Lambaz, R., Aguiar, P. M. V., & Chick, J. (2008) · Alcohol and Alcoholism · doi:10.1093/alcalc/agn075 · Cited by 15 · see citing works
A randomised controlled trial of extended brief intervention for alcohol dependent patients in an acute hospital setting (ADPAC)
Owens, L., Butcher, G. P., Gilmore, I. T., Kolamunnage‐Dona, R., Oyee, J., Perkins, L., Walley, T., Williamson, P. R., Wilson, K., & Pirmohamed, M. (2011) · BMC Public Health · doi:10.1186/1471-2458-11-528 · Cited by 11 · see citing works
Beyond the Ubiquitous Relapse Curve: A Data-Informed Approach
Zywiak, W. H., Kenna, G. A., & Westerberg, V. S. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00012 · Cited by 4 · see citing works

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Mann, K., Aubin, H.-J., & Witkiewitz, K. (2017) · European Addiction Research · doi:10.1159/000481348 · Cited by 93 · see citing works
Self-citation
Health-related quality of life in alcohol dependence: A systematic literature review with a specific focus on the role of depression and other psychopathology
Levola, J. M., Aalto, M., Holopainen, A., Cieza, A., & Pitkänen, T. (2013) · Nordic Journal of Psychiatry · doi:10.3109/08039488.2013.852242 · Cited by 81 · see citing works
Baclofen as Add-On to Standard Psychosocial Treatment for Alcohol Dependence: a Randomized, Double-Blind, Placebo-Controlled Trial With 1 Year Follow-Up
Ponizovsky, A. M., Rosca, P., Aronovich, E., Weizman, A., & Grinshpoon, A. (2014) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2014.11.007 · Cited by 80 · see citing works
Randomized controlled trial of harm reduction treatment for alcohol (HaRT-A) for people experiencing homelessness and alcohol use disorder
Collins, S. E., Clifasefi, S. L., Nelson, L. A., Stanton, J., Goldstein, S. C., Taylor, E. M., Hoffmann, G., King, V. L., Hatsukami, A. S., Cunningham, Z. L., et al. (2019) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2019.01.002 · Cited by 63 · see citing works
Combining behavioral harm-reduction treatment and extended-release naltrexone for people experiencing homelessness and alcohol use disorder in the USA: a randomised clinical trial
Collins, S. E., Duncan, M. H., Saxon, A. J., Taylor, E. M., Mayberry, N., Merrill, J. O., Hoffmann, G., Clifasefi, S. L., & Ries, R. K. (2021) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30489-2 · Cited by 55 · see citing works
Quality of Life Depends on the Drinking Pattern in Alcohol-Dependent Patients
Daeppen, J., Faouzi, M., Sanchez, N., Rahhali, N., Bineau, S., & Bertholet, N. (2014) · Alcohol and Alcoholism · doi:10.1093/alcalc/agu027 · Cited by 54 · see citing works
“Thus, the information it collects may not be completely relevant or specific for individuals with alcohol dependence, and may not be the ideal quality-of-life measure in this group (Luquiens et al., 2012).”
Background
Viability of the World Health Organization quality of life measure to assess changes in quality of life following treatment for alcohol use disorder
Kirouac, M., Stein, E. R., Pearson, M. R., & Witkiewitz, K. A. (2017) · Quality of Life Research · doi:10.1007/s11136-017-1631-4 · Cited by 54 · see citing works
“als, QoL may be overlooked completely [25].”
Psychiatric comorbidity and severity of dependence on substance users: how it impacts on their health-related quality of life?
Lozano, O. M., Tejada, A. J. R., & Fernández‐Calderón, F. (2016) · Journal of Mental Health · doi:10.1080/09638237.2016.1177771 · Cited by 52 · see citing works
“, 2010; McPherson & Martin, 2013), they may not be sufficiently sensitive to detect the singularities of SUD patients with other pathologies such as psychiatric disorders (Luquiens et al., 2012; Ugochukwu et al., 2013).”
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Luquiens, A., Whalley, D., Crawford, S. R., Laramée, P., Doward, L. C., Price, M. A., Hawken, N. A., Dorey, J., Owens, L., Llorca, P., et al. (2014) · Quality of Life Research · doi:10.1007/s11136-014-0865-7 · Cited by 47 · see citing works
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Laramée, P., Brodtkorb, T., Rahhali, N., Knight, C., Barbosa, C., François, C., Toumi, M., Daeppen, J., & Rehm, J. T. (2014) · BMJ Open · doi:10.1136/bmjopen-2014-005376 · Cited by 43 · see citing works
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Aubin, H., Reimer, J., Nutt, D., Bladström, A., Torup, L., François, C., & Chick, J. (2015) · European Addiction Research · doi:10.1159/000371547 · Cited by 40 · see citing works
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Picci, R. L., Oliva, F., Zuffranieri, M., Vizzuso, P., Ostacoli, L., Sodano, A. J., & Furlan, P. M. (2014) · Quality of Life Research · doi:10.1007/s11136-014-0735-3 · Cited by 36 · see citing works
“However, as reported in two recent reviews [15, 16], two types of QOL assessment can be distinguished in addiction research: The Health-related QOL (HQOL) assessment focused on functional limitations due to illness and treatment and the Overall QOL (OQOL) assessment, which takes into account both the objective well-be…”
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Psychometric validation of the Japanese version of Alcohol Quality of Life Scale (AQoLS-Japan) in the treatment of patients with alcohol use disorder
Higuchi, S., Moriguchi, Y., & Tan, K. H. X. (2019) · Quality of Life Research · doi:10.1007/s11136-019-02310-w · Cited by 19 · see citing works
Health-related quality of life in outpatients with substance use disorder: evolution over time and associated factors
Simirea, M., Baumann, C., Bisch, M., Rousseau, H., Patrizio, P. D., Viennet, S., & Bourion-Bédès, S. (2022) · Health and Quality of Life Outcomes · doi:10.1186/s12955-022-01935-9 · Cited by 18 · see citing works
A systematic review of quality of life and health-related quality of life as outcomes in substance and behavioural addictions.
Dyer, A., Boehnke, J., Curran, D. B., McGrath, K., & Toner, P. (2023) · Drug and Alcohol Review · doi:10.1111/dar.13717 · Cited by 18 · see citing works
Determinants of health-related quality of life in recently detoxified patients with severe alcohol use disorder
Lahbairi, N., Lanièpce, A., Segobin, S. H., Cabé, N., Boudehent, C., Vabret, F., Rauchs, G., & Pitel, A. (2022) · Health and Quality of Life Outcomes · doi:10.1186/s12955-022-02058-x · Cited by 16 · see citing works
Alcohol risk drinking, quality of life and health state among patients treated at the Sobering Unit in the emergency department – One year follow-up study
Koivunen, M. H., Harju, S., Kauko, T., & Valimaki, M. A. (2016) · International Emergency Nursing · doi:10.1016/j.ienj.2016.06.003 · Cited by 14 · see citing works
Quality of life in veterans with alcohol dependence and co-occurring mental illness
Ralevski, E., Gianoli, M. O., McCarthy, E., & Petrakis, I. L. (2013) · Addictive Behaviors · doi:10.1016/j.addbeh.2013.06.002 · Cited by 13 · see citing works
Outpatient Addiction Treatment for Problematic Alcohol Use: What Makes Patients Who Dropped Out Different from Those Who Did Not?
Wagner, V., Acier, D., & Dietlin, J.-E. (2018) · Substance Use & Misuse · doi:10.1080/10826084.2018.1441310 · Cited by 11 · see citing works
Health-related quality of life in alcohol dependence: Similar cross-cultural impact beyond specific drinking habits
Luquiens, A., Owens, L., Whalley, D., Rahhali, N., Laramée, P., Crawford, R., Llorca, P., Falissard, B., & Aubin, H. (2017) · Journal of Ethnicity in Substance Abuse · doi:10.1080/15332640.2017.1355765 · Cited by 9 · see citing works
“Using scales giving a large place to physical problems to assess HRQOL among patients with alcohol use disorder could then be an issue, as has been hypothesized in previous research (Luquiens et al., 2012).”
BackgroundResultSelf-citation
Correlates of health-related quality of life in Thai patients with alcohol dependence
Saengcharnchai, P., Likhitsathian, S., Yingwiwattanapong, J., Wittayanookulluk, A., Uttawichai, K., Boonchareon, H., & Srisurapanont, M. (2015) · Journal of Ethnicity in Substance Abuse · doi:10.1080/15332640.2015.1022628 · Cited by 9 · see citing works
“No specific tool has been developed for assessing drinkers’ HRQoL (Luquiens et al., 2012).”
Method
Neurocognitive, psychosocial and functional status of individuals with alcohol-related brain damage (ARBD) on admission to specialist residential care
Horton, L., Duffy, T., & Martin, C. R. (2015) · Drugs Education Prevention and Policy · doi:10.3109/09687637.2015.1050997 · Cited by 8 · see citing works
The Clinical Benefits of Non-abstinent Outcomes in Alcohol Use Disorder Treatment: Evidence from Clinical Trials and Treatment Implications
Votaw, V. R., & Witkiewitz, K. A. (2023) · Springer eBooks · doi:10.1007/978-3-031-32483-3_20 · Cited by 7 · see citing works
Factors associated with quality of life trajectories among inpatients treated for alcohol use disorders: A prospective cohort study
Andersson, H. W., & Nordfjærn, T. (2020) · Addictive Behaviors Reports · doi:10.1016/j.abrep.2020.100285 · Cited by 6 · see citing works
“within physical, mental health, and social domains) independent of other health conditions (Luquiens et al., 2012).”
Background
De vuelta a las raíces culturales de la mano de la ia: mid journey para el fortalecimiento de la identidad cultural yukpa
Kimonis, V. E., Hamorsky, K., Surampalli, A., Wencel, M., Khare, M., & Kimonis, V. E. (2014) · International Journal of Biotechnology for Wellness Industries · doi:10.6000/1927-3037.2014.03.02.2 · Cited by 5 · see citing works
“The VCPQoL used for VCP disease incorporated questions from the 36-item short-form health survey (SF-36), The Behavioral Risk Factor Surveillance System (BRFSS-CDC) and Inclusion body myositis functional rating scale (IBMFRS) [23-25].”
Method
Systematic review of patient contribution to the development of alcohol craving measurements
Zeganadin, L., López‐Castromán, J., Auriacombe, M., & Luquiens, A. (2024) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.15409 · Cited by 5 · see citing works
Self-citation
Acupuncture Combined With Emotional Therapy of Chinese Medicine Treatment for Improving Depressive Symptoms in Elderly Patients With Alcohol Dependence During the COVID-19 Epidemic
Zhao, F., Tong, X., & Wang, C. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.635099 · Cited by 5 · see citing works
“Criteria for Evaluation of Efficacy The SF-36 scale, which is widely used to assess alcohol dependence, was used to assess the score (Daeppen et al., 1998; Zhang, 2005; Luquiens et al., 2012).”
Method
Validity of the PARADISE24 questionnaire in people with substance use disorders: A measure to assess psychosocial difficulties
de la Fuente, J., Cabello, M., Levola, J. M., Caballero, F. F., Ayuso‐Mateos, J. L., & Pitkänen, T. (2018) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2018.02.012 · Cited by 5 · see citing works
Improvement in quality of life among women and men aged 60 years and older following treatment for alcohol use disorder
Tryggedsson, J. S. J., Andersen, K., Behrendt, S., Bilberg, R., Bogenschutz, M. P., Buehringer, G., & Nielsen, A. S. (2023) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.15170 · Cited by 4 · see citing works
AQoLS-Brief: Development and psychometric properties of a short version of the alcohol quality of life scale
Luquiens, A., Panjo, H., Dereux, A., Louville, P., Donnadieu, H., Bronnec, M., Benyamina, A., Perney, P., Carré, A., & Pelletier-Fleury, N. (2025) · PLoS ONE · doi:10.1371/journal.pone.0321365 · Cited by 2 · see citing works
“The TRAIN study was funded by a French national grant of the ministry of health PHRC-N 2016. or relationships with family and social support [13,17].”
Self-citation
Quality of life and well-being from the perspective of patients on opioid agonist maintenance treatment: study protocol for a systematic review of qualitative research and a scoping review of measures
Solà, I., Trujols, J., Ribalta, E., Alcaraz, S., Robleda, G., Olid, C. S., & Cobos, J. P. D. L. (2019) · Systematic Reviews · doi:10.1186/s13643-019-1237-8 · Cited by 2 · see citing works
Operationalising the quality of life construct in studies of alcohol and drug residential rehabilitation programme clients: A systematic review
Fischer, J. A., ROCHE, A. M., & Kostadinov, V. (2019) · Drug and Alcohol Review · doi:10.1111/dar.12981 · Cited by 1 · see citing works
“This finding is consistent with the recent literature on assessing and applying the QOL construct in various areas of the AOD field [7,27,29,30,38].”
BackgroundResult
Willingness to pay vs lottery equivalent to value the impact of alcohol misuse on quality of life
Rodriguez, E. M., & Nogueira, J. M. (2021) · Expert Review of Pharmacoeconomics & Outcomes Research · doi:10.1080/14737167.2022.2004124 · Cited by 1 · see citing works
“These dimensions are in line with the primary domains mentioned in the literature on alcohol use disorder [58] and reinforce some empirical evidence on the limitations that instruments such as the EQ-5D and SF-6D (usually used in cost-utility analysis) may have when collecting quality of life losses derived from this…”
Result
Health-related quality of life in patients with alcohol use disorder: comparing instruments and mapping from clinical measures to preference-based measures
Rodriguez, E. M., & Nogueira, J. M. (2025) · The European Journal of Health Economics · doi:10.1007/s10198-025-01816-0 · Cited by 1 · see citing works
“Small samples are common when the population under study consists of patients diagnosed with alcohol problems; in Luquiens et al.’s review [7], less than a third of such studies featured sample sizes larger than 225 participants.”
Quality of life assessment instruments used in clinical trials for alcohol use disorder: A systematic review
Tryggedsson, J. S. J., Andersen, K., Nielsen, A. S., Olsen, C. D. H., & Mellentin, A. I. (2025) · Journal of Substance Use and Addiction Treatment · doi:10.1016/j.josat.2025.209793 · Cited by 1 · see citing works
Long-Term Abstinence and Quality of Life After a Socioecological Treatment Program: An Italian Experience
Pivetti, M., Scattino, F., Dattola, A., & Gioga, G. (2016) · Alcoholism Treatment Quarterly · doi:10.1080/07347324.2016.1113107 · Cited by 1 · see citing works
Vulnerabilidade ao stress e qualidade de vida em familiares de pessoas com alcoolismo
VALENTİM, O. M. M. D. S., Santos, C., & Ribeiro, J. L. P. (2015) · Revista Portuguesa de Enfermagem de Saúde Mental · doi:10.19131/jpmhn.0009 · Cited by 1 · see citing works
Quality of life and its correlates in alcohol dependent males: rehab inpatients and shelter or hostel homeless persons
Czarnecki, D., Ziółkowski, M., Chodkiewicz, J., Danek, M., Łangowska-Grodzka, B., & Zając-Lamparska, L. (2017) · Alcoholism and Drug Addiction · doi:10.5114/ain.2017.68344 · Cited by 1 · see citing works
Évaluation de l’impact des traitements résidentiels en matière d’addiction auprès d’une population luxembourgeoise adulte
Lambrette, G., Flayelle, M., & Billieux, J. (2021) · Psychotropes · doi:10.3917/psyt.271.0175 · Cited by 1 · see citing works
Beyond pleasure: a study into the quality of life of drug users
Fischer, J. (2015) · The University of Queensland · doi:10.14264/uql.2015.876 · Cited by 1 · see citing works
The Patient Experience of Alcohol use Disorder
Whalley, D., Luquiens, A., Crawford, S. R., Laramée, P., Doward, L. C., Price, M. A., Hawken, N. A., Dorey, J., Owens, L., Llorca, P., et al. (2014) · Value in Health · doi:10.1016/j.jval.2014.08.1283
Self-citation
La terapia farmacologica dell'alcolismo: l'acamprosato e il nalmefene gli ultimi due farmaci anti-alcol approvati dagli organismi regolatori per la pratica clinica. Parte IV
Manzato, E., Nava, F. A., Manzato, G., Rosa, S., & Caputo, F. (2017) · MISSION · doi:10.3280/mis47-2016oa4656
La asimetría informativa y la tutela del consumidor (y del mercado)
Mere, Y. V. (1994) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · doi:10.26439/advocatus1994.n006.2196
Health-related quality of life in outpatients with substance dependence: evolution over time and associated factorsPreprint
Simirea, M., Baumann, C., Bisch, M., Rousseau, H., Patrizio, P. D., Viennet, S., & Bourion-Bédès, S. (2021) · Research Square · doi:10.21203/rs.3.rs-961623/v1
The effects of smartphone alcohol interventions on symptoms of depression, anxiety and health-related quality of life among alcohol-dependent adults: Secondary outcomes of a randomised controlled trial
Östh, J., Lundin, A., Wennberg, P., Andréasson, S., & Danielsson, A. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.121025
Developing a utility value set for the Alcohol Quality of Life Scale–Brief (AQoLS-Brief) using a discrete choice experiment
Luquiens, A., Panjo, H., & Pelletier‐Fleury, N. (2026) · Health and Quality of Life Outcomes · doi:10.1186/s12955-026-02501-3
“Indeed, a systematic review conducted prior to the AQoLS development showed that almost all studies demonstrating the efficacy of an intervention on drinking outcomes failed to demonstrate a significant improvement in HRQoL when assessed using generic instruments in randomized clinical trials [13].”
Self-citation
Profil et évolutions à six mois des patients d'un centre de soins ambulatoires en addictologie : comprendre le changement : une histoire de trajectoire(s) et de temps
Wagner, V. (2018) · theses.fr (ABES) · doi:10.70675/48f1c9b2z5effz4662z85ffzec13069fcf14
Mindfulness et addictions : évaluation du programme MBRP (Mindfulness-Based Relapse Prevention) chez des patients présentant une addiction avec ou sans substance
von Hammerstein, C. (2018) · theses.fr (ABES) · doi:10.70675/40f493f6ze751z4db4zbf93z0a2b243b0c7c

P-57 - How to assess quality of life in alcohol dependent patients?
Luquiens, A., Falissard, B., Reynaud, M., & Aubin, H. (2012) · European Psychiatry · doi:10.1016/s0924-9338(12)74224-4
Self-citation
Quality of life assessment instruments used in clinical trials for alcohol use disorder: A systematic review
Tryggedsson, J. S. J., Andersen, K., Nielsen, A. S., Olsen, C. D. H., & Mellentin, A. I. (2025) · Journal of Substance Use and Addiction Treatment · doi:10.1016/j.josat.2025.209793 · Cited by 1 · see citing works
The Importance of Quality of Life in Patients with Alcohol Abuse and Dependence
Ugochukwu, C., Bagot, K. S., Delaloye, S., Pi, S., Vien, L. P., Garvey, T., Bolotaulo, N. I., Kumar, N., & IsHak, W. W. (2013) · Harvard Review of Psychiatry · doi:10.1097/hrp.0b013e31827fd8aa · Cited by 77 · see citing works
A review of the measurement properties of the 36‐item short‐form health survey (SF‐36) to determine its suitability for use in an alcohol‐dependent population
McPherson, A., & Martin, C. R. (2012) · Journal of Psychiatric and Mental Health Nursing · doi:10.1111/j.1365-2850.2012.01896.x · Cited by 22 · see citing works
MOS-SF-36 in Evaluating Health-Related Quality of Life in Alcohol-Dependent Patients
Daeppen, J., Krieg, M.-A., Burnand, B., & Yersin, B. (1998) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952999809019617 · Cited by 113 · see citing works

Authors: Luquiens, A., Reynaud, M., Falissard, B., & Aubin, H. J.
Affiliations: Inserm (FR)
Corresponding author: Luquiens, A.
ORCID: Luquiens, A.
Reynaud, M.
Falissard, B.
Aubin, H.J.
Venue: Drug and Alcohol Dependence
Publisher: Elsevier BV
Published: 2012-10
Volume: 125
Issue: 3
Pages: 192-202
ISSN: 0376-8716 (ISSN-L)
DOI: 10.1016/j.drugalcdep.2012.08.012
OpenAlex: W2063397537
Cited by: 57
References: 53
Citations by year: 2026: 1 · 2025: 4 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 1 · 2019: 5 · 2018: 5 · 2017: 6 · 2016: 4 · 2015: 7 · 2014: 9 · 2013: 3
FWCI: 0.76
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Drug and Alcohol Dependence (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords: quality of life, alcoholism, quality of life instruments, outcome measures, alcoholism treatment, SF-36, Q-LES-Q, patient-reported outcomes, instrument validation, treatment efficacy assessment
MeSH terms: Alcoholism, Clinical Trials as Topic, Health Status, Humans, Neuropsychological Tests, Personal Satisfaction, Quality of Life, Surveys and Questionnaires, Reproducibility of Results, Randomized Controlled Trials as Topic

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Quality of life among alcohol-dependent patients: How satisfactory are the available instruments? A systematic review

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