Cited by 8Diabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Health and Risk FactorsCardiac Health and Mental Health

Gender difference in the association between Framingham Risk Score with cardio-metabolic risk factors and psychological distress in patients with metabolic syndrome

Farhangi, Mahdieh Abbasalizad, Jahangiry, Leila·2020·Diabetes & Metabolic Syndrome: Clinical Research & Reviews

Abstract

Background In the current study we aimed to evaluate the gender-specific associations between metabolic and psychological risk factors of cardiovascular disease (CVD) and Framingham Risk Score (FRS) in patients with metabolic syndrome. Methods In a cross-sectional study of 256 patients with metabolic syndrome (157 men, 99 women), the cardiovascular disease risk was evaluated using the FRS scoring system by a pre-defined computerized algorithm. Psychological distress was also assessed by general health questionnaire (GHQ)-12. Evaluation of the biochemical parameters including fasting serum glucose (FSG), lipid profile, liver enzymes and adiponectin concentrations were also performed using the enzymatic methods. Results The prevalence of low, intermediate and high risk of CVD in men was significantly higher than women (P < 0.05). Both genders in high risk of CVD had significantly higher age, systolic blood pressure (SBP) and FSG concentrations compared with male and females in intermediate and low risk of CVD (P < 0.05). In multiple logistic regression, being single was in the highest relationship with high psychological distress values compared with married or divorced/separated marital status. Moreover, high SBP and low high density lipoprotein (HDL) concentrations were also potent determinants of high psychological distress (P < 0.05). Conclusions In the current study, the prevalence of CVD risk factors were higher in men compared with women. Moreover, higher age, SBP and FSG were potent determinants of FRS in both genders. Marital status and serum HDL were in relation with psychological distress among patients with metabolic syndrome.

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Crossref · 10.1016/j.dsx.2019.12.009

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Authors
Farhangi, M. A., & Jahangiry, L.
Affiliations
Tabriz University of Medical Sciences (IR)
Corresponding author
Farhangi, Mahdieh Abbasalizad
Venue
Diabetes & Metabolic Syndrome: Clinical Research & Reviews
Publisher
Elsevier BV
Published
2020-03
Volume
14
Issue
2
Pages
71-75
ISSN
1871-4021 (ISSN-L)
OpenAlex
W2996782607
Cited by
8
References
25
Citations by year
2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2
FWCI
1.13
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes & Metabolic Syndrome Clinical Research & Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
Tabriz University of Medical Sciences
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords
metabolic syndrome, Framingham risk score, cardiovascular risk, psychological distress, sex differences, systolic blood pressure, fasting serum glucose, HDL cholesterol, marital status, adiponectin, liver enzymes, lipid profile
MeSH terms
Adult, Cardiovascular Diseases, Cross-Sectional Studies, Female, Humans, Iran, Male, Middle Aged, Risk Factors, Sex Characteristics, Stress, Psychological, Metabolic Syndrome

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