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Cited by 24Infant Development and Preterm CareMaternal and Perinatal Health InterventionsNeonatal and fetal brain pathology

The association between cord pH at birth and intellectual function in childhood

Svirko, Elena, Mellanby, Jane, Impey, Lawrence·2008·Early Human Development
DOI 10.1016/j.earlhumdev.2007.02.002
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Abstract

Background Acidemia at birth is very common but little is known about its long-term consequences.Aim To determine if pH at birth is related to established tests of intellectual function.Subjects School children aged 6-8, for whom obstetric data were available, who had been delivered after labour at term, and had an umbilical cord arterial pH>7.00 (i.e. that was not extremely acidemic). STUDY DESIGN/OUTCOMES: Retrospective cohort study correlating birth and arterial pH data with childhood tests for non-verbal intelligence, grammar comprehension and literacy.Methods Relationships between pH and cognitive measures were analysed with parametric correlations. Partial correlations were used to examine these relationships, controlling for possible confounding factors.Results Arterial pH was significantly negatively correlated with literacy (p=0.001) and with non-verbal intelligence (p=0.033).Conclusions Lower arterial pH is associated with higher scores on literacy and non-verbal intelligence tests at ages 6-8. This is unlikely to be a chance finding and is further evidence that acidemia in isolation should not be considered an adverse outcome. Further research on the relationship between labour and long-term cognitive measures is required.

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Crossref · 10.1016/j.earlhumdev.2007.02.002

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  • At a moderate degree of cord artery acidemia but with pH maintained >7.00, Svirko et al found an inverse relation between pH and childhood literacy and intelligence.

    “Actually, at a moderate degree of cord artery acidemia but with pH maintained >7.00, Svirko et al 48 found an inverse relation between pH and childhood literacy and intelligence.”

    From Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility. (2023) · cites this paper as [48]

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Authors
Svirko, E., Mellanby, J., & Impey, L.
Affiliations
  • University of Oxford (GB)
  • John Radcliffe Hospital (GB)
Corresponding author
Mellanby, Jane
ORCID
Venue
Early Human Development
Publisher
Elsevier BV
Published
2008-01
Volume
84
Issue
1
Pages
37-41
ISSN
0378-3782 (ISSN-L)
DOI
10.1016/j.earlhumdev.2007.02.002
OpenAlex
W1981749000
Cited by
24
References
22
Citations by year
2024: 1 · 2023: 3 · 2021: 2 · 2020: 1 · 2019: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 1
FWCI
1.59
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Early Human Development (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
  • Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
Keywords
umbilical artery pH, neonatal acidemia, nonverbal intelligence, literacy, grammar comprehension, elementary school students, long-term cognitive outcomes, term birth
MeSH terms
Child, Female, Fetal Blood, Humans, Hydrogen-Ion Concentration, Infant, Newborn, Intelligence, Intelligence Tests, Pregnancy, Retrospective Studies, Cohort Studies

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