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Cited by 158Thyroid Disorders and TreatmentsAdrenal Hormones and DisordersThermal Regulation in Medicine

Myxedema coma

Wartofsky, Leonard·2006·Endocrinology and Metabolism Clinics of North America
DOI 10.1016/j.ecl.2006.09.003
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Abstract

Myxedema coma is the term given to the most severe presentation of profound hypothyroidism and is often fatal in spite of therapy. Decompensation of the hypothyroid patient into a coma may be precipitated by a number of drugs, systemic illnesses (eg, pneumonia), and other causes. It typically presents in older women in the winter months and is associated with signs of hypothyroidism, hypothermia, hyponatremia, hypercarbia, and hypoxemia. Treatment must be initiated promptly in an intensive care unit setting. Although thyroid hormone therapy is critical to survival, it remains uncertain whether it should be administered as thyroxine, triiodothyronine, or both. Adjunctive measures, such as ventilation, warming, fluids, antibiotics, pressors, and corticosteroids, may be essential for survival.

Integrity signals

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Crossref · 10.1016/j.ecl.2006.09.003

Cites

36 of 36 references verified0 citation errors · 0 not checkable

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  • Striking features of myxoedema coma are hypothermia, bradycardia, altered mental status, profound lethargy, and ultimately multiorgan failure and death.

    “Striking features of myxoedema coma are hypothermia, bradycardia, altered mental status, profound lethargy, and ultimately multiorgan failure and death.104”

    From Hypothyroidism (2024) · cites this paper as [104]

  • There is a wide spectrum of disease presentation, ranging from mildly abnormal blood test results in an asymptomatic patient to myxoedema coma, which is a rare endocrine emergency with a mortality rate of 25-70%.

    “There is a wide spectrum of disease presentation, ranging from mildly abnormal blood test results in an asymptomatic patient to myxoedema coma, which is a rare endocrine emergency with a mortality rate of 25-70%.104”

    From Hypothyroidism (2024) · cites this paper as [104]

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Authors
Wartofsky, L.
Affiliations
MedStar Washington Hospital Center (US)
Corresponding author
Wartofsky, Leonard
ORCID
Wartofsky, Leonard
Venue
Endocrinology and Metabolism Clinics of North America
Publisher
Elsevier BV
Published
2006-12
Volume
35
Issue
4
Pages
687-698
ISSN
0889-8529 (ISSN-L)
DOI
10.1016/j.ecl.2006.09.003
OpenAlex
W4248029140
Cited by
158
References
36
Citations by year
2026: 7 · 2025: 7 · 2024: 16 · 2023: 6 · 2022: 8 · 2021: 5 · 2020: 7 · 2019: 8 · 2018: 6 · 2017: 12 · 2016: 9 · 2015: 9 · 2014: 7 · 2013: 11 · 2012: 8
FWCI
0.66
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Endocrinology and Metabolism Clinics of North America (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
Keywords
myxedema coma, hypothyroidism, thyroid hormone replacement, thyroxine, triiodothyronine, hyponatremia, hypothermia, hypercapnia, hypoxemia, intensive care management, drug-induced hypothyroidism
MeSH terms
Aged, Coma, Female, Glucocorticoids, Humans, Hyponatremia, Hypotension, Hypothermia, Male, Myxedema, Thyrotropin, Thyroxine

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