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Cited by 195Pituitary Gland Disorders and TreatmentsAdrenal and Paraganglionic TumorsNeuroendocrine Tumor Research Advances

Cushing's Syndrome

Pivonello, Rosario, De Martino, Maria Cristina, De Leo, Monica, Lombardi, Gaetano, Colao, Annamaria·2008·Endocrinology and Metabolism Clinics of North America
DOI 10.1016/j.ecl.2007.10.010
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Abstract

Cushing's syndrome is a rare endocrine disease characterized by cortisol hypersecretion, induced mainly by a pituitary tumor (Cushing's disease) or, rarely, by an adrenal or an ectopic neuroendocine tumor. Cushing's syndrome is associated with severe morbidities and an increased mortality. The major systemic complications and the main cause of death are represented by cardiovascular disease. The prognosis of the disease is mainly affected by the difficulties in the diagnosis and treatment of the disease, which remain a considerable challenge.

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Crossref · 10.1016/j.ecl.2007.10.010

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  • ACTH-dependent Cushing syndrome accounts for 80% to 85% of cases.

    “ACTH-dependent CS accounts for 80% to 85% of cases and ACTH-independent accounts for 15% to 20% (2, 4, 5).”

    From Approach to the Patient: Diagnosis of Cushing Syndrome (2022) · cites this paper as [4]

  • ACTH-independent Cushing syndrome accounts for 15% to 20% of cases.

    “ACTH-dependent CS accounts for 80% to 85% of cases and ACTH-independent accounts for 15% to 20% (2, 4, 5).”

    From Approach to the Patient: Diagnosis of Cushing Syndrome (2022) · cites this paper as [4]

  • Cushing disease occurs when a pituitary adenoma secretes ACTH, which stimulates supraphysiologic secretion of cortisol from the adrenal glands.

    “Cushing disease, the most common cause of ACTH-dependent CS accounting for approximately 80% of cases, occurs when a pituitary adenoma secretes ACTH, which in turn stimulates supraphysiologic secretion of cortisol from the adrenal glands (2, 4, 5, 73).”

    From Approach to the Patient: Diagnosis of Cushing Syndrome (2022) · cites this paper as [4]

  • Cushing disease is the most common cause of ACTH-dependent CS, accounting for approximately 80% of cases.

    “Cushing disease, the most common cause of ACTH-dependent CS accounting for approximately 80% of cases, occurs when a pituitary adenoma secretes ACTH, which in turn stimulates supraphysiologic secretion of cortisol from the adrenal glands (2, 4, 5, 73).”

    From Approach to the Patient: Diagnosis of Cushing Syndrome (2022) · cites this paper as [4]

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Authors
Pivonello, R., De Martino, M. C., De Leo, M., Lombardi, G., & Colao, A.
Affiliations
Federico II University Hospital (IT)
Corresponding author
Pivonello, Rosario
ORCID
Venue
Endocrinology and Metabolism Clinics of North America
Publisher
Elsevier BV
Published
2008-03
Volume
37
Issue
1
Pages
135-149
ISSN
0889-8529 (ISSN-L)
DOI
10.1016/j.ecl.2007.10.010
OpenAlex
W3021600979
Cited by
195
References
57
Citations by year
2026: 4 · 2025: 11 · 2024: 8 · 2023: 13 · 2022: 10 · 2021: 19 · 2020: 6 · 2019: 9 · 2018: 8 · 2017: 9 · 2016: 10 · 2015: 14 · 2014: 11 · 2013: 10 · 2012: 15
FWCI
1.66
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Endocrinology and Metabolism Clinics of North America (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
Keywords
Cushing's syndrome, cortisol hypersecretion, Cushing's disease, pituitary tumors, adrenal tumors, ectopic ACTH syndrome, cardiovascular disease, prognosis, diagnosis, treatment
MeSH terms
Adrenocorticotropic Hormone, Cushing Syndrome, Enzyme Inhibitors, Humans, Hydrocortisone, Neurotransmitter Agents

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