Advances in the Prediction and Natural History of Type 1 Diabetes
Abstract
Type 1 diabetes (T1D) has the hallmark characteristics of autoimmunity superimposed on genetic susceptibility. Both genes (HLA) and immune markers (autoantibodies) have been validated as predictive markers of the subsequent development of the disease in higher-risk relatives and the lower-risk general population. Over the last three decades, using a combination of genes, immune, and metabolic markers, clinicians are now able to quantify an individual's disease risk from 1 in 100,000 to more than 1 in 2. This article reviews these biomarkers and T1D prediction strategies, and discusses potential implications of prediction and natural history for the pathogenesis of T1D.
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In most individuals, changes in insulin secretion and glucose tolerance occur months to decades after multiple islet autoantibodies are detected.
“In most individuals, changes in insulin secretion and glucose tolerance occur months to decades after multiple islet autoantibodies are detected.79”
From Type 1 diabetes (2014) · cites this paper as [79]
Cites
Incidence of diabetes in youth in the United States
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Diabetes Antibody Standardization Program: first assay proficiency evaluation
Bingley, P. J., Bonifacio, E., Mueller, P. W., & Laboratories, P. (2003) · Diabetes · doi:10.2337/diabetes.52.5.1128 · Cited by 362 · see citing works
Self-citationConcordance for islet autoimmunity among monozygotic twins
Redondo, M. J., Jeffrey, J., Fain, P. R., Eisenbarth, G. S., & Orban, T. (2008) · New England Journal of Medicine · doi:10.1056/nejmc0805398 · Cited by 353 · see citing works
Bonifacio, E., Yu, L., Williams, A. K., Eisenbarth, G. S., Bingley, P. J., Marcovina, S. M., Adler, K., Ziegler, A. G., Mueller, P. W., Schatz, D. A., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0293 · Cited by 291 · see citing works
Self-citationTörn, C., Mueller, P. W., Schlosser, M., Bonifacio, E., Bingley, P. J., & Laboratories, P. (2008) · Diabetologia · doi:10.1007/s00125-008-0967-2 · Cited by 284 · see citing works
Self-citationDendrou, C. A., Plagnol, V., Fung, E., Yang, J. H. M., Downes, K., Cooper, J. D., Nutland, S., Coleman, G., Himsworth, M., Hardy, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.434 · Cited by 274 · see citing works
Wenzlau, J. M., Liu, Y., Yu, L., Moua, O., Fowler, K. T., Rangasamy, S., Walters, J., Eisenbarth, G. S., Davidson, H. W., & Hutton, J. C. (2008) · Diabetes · doi:10.2337/db08-0522 · Cited by 205 · see citing works
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Atkinson, M. A., Eisenbarth, G. S., & Michels, A. W. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60591-7 · Cited by 2,713 · see citing works
New frontiers in the treatment of type 1 diabetes
Warshauer, J. T., Bluestone, J. A., & Anderson, M. S. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2019.11.017 · Cited by 259 · see citing works
- Authors
- Bonifacio, E., & Ziegler, A. G.
- Affiliations
- Center for Regenerative Therapies Dresden (DE)
- TUM Klinikum (DE)
- Corresponding author
- Bonifacio, Ezio
- Venue
- Endocrinology and Metabolism Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 39
- Issue
- 3
- Pages
- 513-525
- ISSN
- 0889-8529 (ISSN-L)
- OpenAlex
- W2057966927
- Cited by
- 61
- References
- 7
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 6 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 5 · 2012: 6
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology and Metabolism Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Site cant be reached (submittedVersion)
- Funders
- Bundesministerium für Bildung und Forschung
- National Institute of Diabetes and Digestive and Kidney Diseases
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- type 1 diabetes, disease prediction, natural history (disease), HLA genes, autoantibodies, genetic susceptibility, disease risk assessment, biomarkers, pathogenesis, at-risk relatives
- MeSH terms
- Autoantibodies, Diabetes Mellitus, Type 1, Diagnostic Techniques, Endocrine, Family Health, Humans, Islets of Langerhans, Prognosis, Risk Factors, Disease Progression, Genetic Predisposition to Disease
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