Hypophysitis
Abstract
In this article, an overview is presented of hypophysitis in terms of current clinical and experimental findings, with discussion of the anatomic and histopathologic classification of primary hypophysitis and factors associated with secondary hypophysitis. In addition, discusses the pathophysiology, clinical features, management, and prognosis associated with this disease are discussed.
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Lymphocytic hypophysitis presents commonly with isolated ACTH deficiency, with or without TSH deficiency, while gonadotropins tend to be preserved.
“However, lymphocytic hypophysitis presents commonly with isolated ACTH deficiency, with or without TSH deficiency, while gonadotropins tend to be preserved 3 See Fig. 5. 4 Tumour, hypophysitis, empty sella; pituitary stalk interruption; pituitary infiltrative disease.5 Traumatic brain injury; vascular accident; iron overload or haemochromatosis.(Fukuoka, 2015).”
From The hypothalamus-pituitary-thyroid (HPT)-axis and its role in physiology and pathophysiology of other hypothalamus-pituitary functions (2021) · cites this paper as Fukuoka, 2015
Cites
Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
Hodi, F. S., O'Day, S. J., McDermott, D. F., Weber, R. W., Sosman, J. A., Haanen, J. B., Gonzalez, R., Robert, C., Schadendorf, D., Hassel, J. C., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1003466 · Cited by 15,155 · see citing works
Diagnosis and treatment of hyperprolactinemia: an Endocrine Society Clinical Practice Guideline
Melmed, S., Casanueva, F. F., Hoffman, A. R., Kleinberg, D. L., Montori, V. M., Schlechte, J. A., & Wass, J. A. H. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1692 · Cited by 1,844 · see citing works
Molitch, M. E., Clemmons, D. R., Malozowski, S., Merriam, G. R., & Vance, M. L. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0179 · Cited by 1,047 · see citing works
Iwama, S., De Remigis, A., Callahan, M. K., Slovin, S. F., Wolchok, J. D., & Caturegli, P. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008002 · Cited by 715 · see citing works
A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details
Umehara, H., Okazaki, K., Masaki, Y., et al. (2012) · Modern Rheumatology · doi:10.3109/s10165-011-0508-6 · Cited by 694 · see citing works
Caturegli, P., Newschaffer, C. J., Olivi, A., Pomper, M. G., Burger, P. C., & Rose, N. R. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0011 · Cited by 607 · see citing works
Lymphocytic Infundibuloneurohypophysitis as a Cause of Central Diabetes Insipidus
Imura, H., Nakao, K., Shimatsu, A., et al. (1993) · New England Journal of Medicine · doi:10.1056/nejm199309023291002 · Cited by 458 · see citing works
Endocrine Side Effects Induced by Immune Checkpoint Inhibitors
Corsello, S. M., Barnabei, A., Marchetti, P., De Vecchis, L., Salvatori, R., & Torino, F. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-4075 · Cited by 403 · see citing works
IgG4-Related Hypophysitis: A New Addition to the Hypophysitis Spectrum
Leporati, P., Landek‐Salgado, M. A., Lupi, I., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2970 · Cited by 267 · see citing works
Lymphocytic hypophysitis: Disease spectrum and approach to diagnosis and therapy
Rivera, J.-A. (2006) · Pituitary · doi:10.1007/s11102-006-6598-z · Cited by 178 · see citing works
Primary hypophysitis: a single-center experience in 16 cases
Leung, G., Lopes, M.-B. S., Thorner, M. O., Vance, M. L., & Laws, E. R. (2004) · Journal of neurosurgery · doi:10.3171/jns.2004.101.2.0262 · Cited by 178 · see citing works
Pituitary autoimmunity: 30 years later
Caturegli, P., Lupi, I., Landek‐Salgado, M. A., Kimura, H. J., & Rose, N. R. (2008) · Autoimmunity Reviews · doi:10.1016/j.autrev.2008.04.016 · Cited by 174 · see citing works
Shimatsu, A., Oki, Y., Fujisawa, I., et al. (2009) · Endocrine Journal · doi:10.1507/endocrj.k09e-277 · Cited by 169 · see citing works
Lymphocytic Adenohypophysitis and Lymphocytic Infundibuloneurohypophysitis.
Hashimoto, K., Takao, T., & Makino, S. (1997) · Endocrine Journal · doi:10.1507/endocrj.44.1 · Cited by 156 · see citing works
Bando, H., Iguchi, G., Fukuoka, H., Taniguchi, M., Yamamoto, M., Matsumoto, R., Suda, K., Nishizawa, H., Takahashi, M., Kohmura, E., et al. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0642 · Cited by 130 · see citing works
Self-citationLymphocytic and granulocytic hypophysitis: a single centre experience
Buxton, N., & Robertson, I. J. A. (2001) · British Journal of Neurosurgery · doi:10.1080/02688690120057664 · Cited by 108 · see citing works
Treatment of Neurohypophyseal Diabetes Insipidus
Oiso, Y., Robertson, G. L., Nørgaard, J. P., & Juul, K. V. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2326 · Cited by 101 · see citing works
Yamamoto, M., Iguchi, G., Takeno, R., Okimura, Y., Sano, T., Takahashi, M., Nishizawa, H., Handayaningsih, A. E., Fukuoka, H., Tobita, M., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci44073 · Cited by 96 · see citing works
Self-citationPrimary (autoimmune) hypophysitis: a single centre experience
Khare, S., Jagtap, V. S., Budyal, S. R., et al. (2013) · Pituitary · doi:10.1007/s11102-013-0550-9 · Cited by 92 · see citing works
Idiopathic granulomatous hypophysitis: a systematic review of 82 cases in the literature
Hunn, B. H. M., Martin, W. G., Simpson, S., & McLean, C. (2013) · Pituitary · doi:10.1007/s11102-013-0510-4 · Cited by 88 · see citing works
Diagnosis and classification of autoimmune hypophysitis
Falorni, A., Minarelli, V., Bartoloni, E., Alunno, A., & Gerli, R. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.01.021 · Cited by 86 · see citing works
Bellis, A. D., Sinisi, A. A., Pane, E., Iacovo, A. D., Bellastella, G., Scala, G. D., Falorni, A., Giavoli, C., Gasco, V., Giordano, R., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2269 · Cited by 62 · see citing works
Bellis, A. D., Pane, E., Bellastella, G., Sinisi, A. A., Colella, C., Giordano, R., Giavoli, C., Lania, A. G., Ambrosio, M. R., Somma, C. D., et al. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04056.x · Cited by 61 · see citing works
Bellastella, G., Rotondi, M., Pane, E., Iacovo, A. D., Pirali, B., Mora, L. D., Falorni, A., Sinisi, A. A., Bizzarro, A., Colao, A., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0551 · Cited by 59 · see citing works
Gamma Knife surgery for lymphocytic hypophysitis
Ray, D. K., Yen, C. P., Vance, M. L., et al. (2009) · Journal of neurosurgery · doi:10.3171/2009.6.jns081176 · Cited by 53 · see citing works
Abe, T. (2008) · Brain Tumor Pathology · doi:10.1007/s10014-008-0234-8 · Cited by 53 · see citing works
Smith, C. J. A., Bensing, S., Burns, C., et al. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-1015 · Cited by 52 · see citing works
A Case of Lymphocytic Infundibuloneurohypophysitis Associated with Systemic Lupus Erythematosus.
Hashimoto, K., Asaba, K., Tamura, K., et al. (2002) · Endocrine Journal · doi:10.1507/endocrj.49.605 · Cited by 47 · see citing works
From Japan With Love: Another Tessera in the Hypophysitis Mosaic
Caturegli, P., & Iwama, S. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1912 · Cited by 41 · see citing works
Gal, R., Schwartz, A., Gukovsky-Oren, S., et al. (1986) · PubMed · Cited by 37 · see citing works
Xanthomatous Hypophysitis Mimicking a Pituitary Adenoma: Case Report and Review of the Literature
Aste, L., Bellinzona, M., Meleddu, V., et al. (2010) · Journal of Oncology · doi:10.1155/2010/195323 · Cited by 36 · see citing works
Sudden Death Due to Lymphoplasmacytic Hypophysitis
Blisard, K. S., Pfalzgraf, R. R., & Balko, M. G. (1992) · American Journal of Forensic Medicine & Pathology · doi:10.1097/00000433-199209000-00007 · Cited by 26 · see citing works
Kanoke, A., Ogawa, Y., Watanabe, M., et al. (2013) · BMC Research Notes · doi:10.1186/1756-0500-6-560 · Cited by 25 · see citing works
HASHIMOTO, K.-I., Yamakita, N., Ikeda, T., et al. (2006) · Endocrine Journal · doi:10.1507/endocrj.k06-055 · Cited by 18 · see citing works
Sudden Unexpected Death In Lymphocytic Hypophysitis
Gonzalez‐Cuyar, L. F., Tavora, F., Shaw, K., et al. (2009) · American Journal of Forensic Medicine & Pathology · doi:10.1097/paf.0b013e3181873851 · Cited by 15 · see citing works
Placenta suppresses experimental autoimmune hypophysitis through soluble TNF receptor 1
Landek‐Salgado, M. A., Rose, N. R., & Caturegli, P. (2011) · Journal of Autoimmunity · doi:10.1016/j.jaut.2011.07.001 · Cited by 13 · see citing works
Lymphocytic Hypophysitis Accompanied by Aseptic Meningitis Mimics Subacute Meningoencephalitis
Suzuki, K., Izawa, N., Nakamura, T., et al. (2011) · Internal Medicine · doi:10.2169/internalmedicine.50.5386 · Cited by 11 · see citing works
Mizokami, T., Inokuchi, K., Okamura, K., et al. (1996) · Internal Medicine · doi:10.2169/internalmedicine.35.135 · Cited by 10 · see citing works
Intermediate lobe immunoreactivity in a patient with suspected lymphocytic hypophysitis
Smith, C. J. A., Bensing, S., Maltby, V. E., et al. (2013) · Pituitary · doi:10.1007/s11102-013-0461-9 · Cited by 3 · see citing works
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- Authors
- Fukuoka, H.
- Affiliations
- Kobe University Hospital (JP)
- Corresponding author
- Fukuoka, Hidenori
- ORCID
- Fukuoka, Hidenori
- Venue
- Endocrinology and Metabolism Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 44
- Issue
- 1
- Pages
- 143-149
- ISSN
- 0889-8529 (ISSN-L)
- OpenAlex
- W4246433542
- Cited by
- 50
- References
- 39
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 7 · 2016: 4 · 2015: 2
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology and Metabolism Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
- Keywords
- hypophysitis, primary hypophysitis, histological classification, pathophysiology, clinical features, prognosis
- MeSH terms
- Humans, Pituitary Diseases
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