The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.
A review of the possible associations between ambient PM2.5 exposures and the development of Alzheimer's disease
Abstract
PM2.5 particles in air pollution have been widely considered associated with respiratory and cardiovascular diseases. Recent studies have shown that PM2.5 can also cause central nervous system (CNS) diseases, including a variety of neurodegenerative diseases, such as Alzheimer's disease (AD). Activation of microglia in the central nervous system can lead to inflammatory and neurological damage. PM2.5 will reduce the methylation level of DNA and affect epigenetics. PM2.5 enters the human body through a variety of pathways to have pathological effects on CNS. For example, PM2.5 can destroy the integrity of the blood-brain barrier (BBB), so peripheral systemic inflammation easily crosses BBB and reaches CNS. The olfactory nerve is another way for PM2.5 particles to enter the brain. Surprisingly, PM2.5 can also enter the gastrointestinal tract, causing imbalances in the intestinal microecology to affect central nervous system diseases. The current work collected and discuss the mechanisms of PM2.5-induced CNS damage and PM2.5-induced neurodegenerative diseases.
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Cites
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Cited by
Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics
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Metadata
- Authors
- Shou, Y., Huang, Y., Zhu, X., Liu, C., Hu, Y., & Wang, H.
- Venue
- Ecotoxicology and Environmental Safety
- Publisher
- Elsevier BV
- Published
- 2019-06
- Volume
- 174
- Pages
- 344-352
- ISSN
- 0147-6513 (ISSN-L)
- OpenAlex
- W2919054694
- Cited by
- 303
- References
- 124
- FWCI
- 13.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shou, Y., Huang, Y., Zhu, X., Liu, C., Hu, Y., & Wang, H. (2019). A review of the possible associations between ambient PM2.5 exposures and the development of Alzheimer's disease. Ecotoxicology and Environmental Safety. https://doi.org/10.1016/j.ecoenv.2019.02.086
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
