Fatigue and anaemia in patients with chronic heart failure
Abstract
BACKGROUND: Fatigue is common in patients with chronic heart failure (CHF) and has great impact on functional ability and daily activity. Although anaemia is associated with fatigue, the relationship between fatigue and anaemia is unclear in CHF. The aim of this study was to describe the fatigue experience and its relationship to haemoglobin (Hb) concentration and to evaluate its effect on health-related quality of life in an unselected hospitalised CHF population. METHODS: Ninety three consecutive patients hospitalised with a diagnosis of CHF, enrolled in the EuroHeart Failure Survey, completed the Multidimensional Fatigue Inventory Scale (MFI-20). New York Heart Association (NYHA) functional class, quality of life and haemoglobin were also assessed. RESULTS: Anaemia (Hb < or = 125 g/L) was found in 31 (33%) patients. The perception of fatigue differed significantly between patients with CHF and healthy individuals. Anaemic patients reported significantly more fatigue compared to non-anaemic patients. Decreased haemoglobin and higher NYHA class explained 30% of the variance in General Fatigue. Perceived fatigue was also inversely related to global health and quality of life. CONCLUSION: Our findings suggest that the subjective experience of fatigue in patients with CHF is associated with low haemoglobin concentration and reduced functional status after controlling for age and sex.
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Despite not being validated in CHF, the 20-item Multidimensional Fatigue Inventory has been frequently utilized in CHF studies.
“Despite not being validated in CHF, the 20‐item Multidimensional Fatigue Inventory has been frequently utilized in CHF studies. 14 , 47”
From Prioritizing symptom management in the treatment of chronic heart failure (2020) · cites this paper as [47]
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Self-citation
- Authors
- Falk, K., Swedberg, K., Gaston-Johansson, F., & Ekman, I.
- Affiliations
- University of Gothenburg (SE)
- Sahlgrenska University Hospital (SE)
- Institute of Nursing, Faculty of Health and Caring Sciences, The Sahlgrenska Academy at Góteborg University , Box 457, S-405 30, Góteborg ,
- Corresponding author
- Falk, Kristin
- Venue
- European Journal of Heart Failure
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-10-28
- Volume
- 8
- Issue
- 7
- Pages
- 744-749
- ISSN
- 1388-9842 (ISSN-L)
- 1879-0844
- OpenAlex
- W1979281775
- Cited by
- 59
- References
- 45
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 3 · 2016: 4 · 2015: 3 · 2014: 1 · 2013: 5 · 2012: 1
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Heart Failure (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- chronic heart failure, fatigue, anemia, hemoglobin, health-related quality of life, NYHA functional class, Multidimensional Fatigue Inventory, functional status, hospitalized patients
- MeSH terms
- Aged, Anemia, Fatigue, Female, Gender Identity, Heart Failure, Hemoglobins, Hospitalization, Humans, Male, Prospective Studies, Quality of Life, Surveys and Questionnaires
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