Pulmonary hypertension is frequent in hyperthyroidism and normalizes after therapy
Abstract
Background In recent years, many authors have described several cases revealing an association between hyperthyroidism and pulmonary hypertension. This observational study was designed to evaluate the prevalence of pulmonary hypertension in hyperthyroidism and to determine the role of methimazole in regulating pulmonary vascular resistance in these patients.Methods We studied 114 patients, 78 women and 36 men, whose mean age was 51+/-13years. Forty-seven had Graves' disease and 67 had a nodular goiter. All subjects were ambulatory and were recruited in a consecutive order. The control group (group 2) included 20 healthy subjects matched for age and sex. Transthoracic Doppler echocardiography was performed and systolic pulmonary artery pressure (PAPs) was determined by the tricuspid regurgitation method using the Bernoulli's equation. We performed a 120-day follow-up in the patients with pulmonary hypertension and we divided them into two subgroups: group 1A (n=33), patients treated with methimazole, and group 1B (n=17), subjects treated with partial thyroidectomy.Results We found a mild pulmonary hypertension in 50 patients in group 1 (43%) and in none of those in the control group. The mean+/-SD PAPs was 27.77+/-6.56 in group 1 and 21.32+/-2.55 in group 2. A negative correlation was found between the T.S.H. value and the level of PAPs (r=-0.85; p<0.001). During the follow-up, group 1A went from a PAPs value of 34.3+/-3.2 to 29.2+/-3.3 after 15days of therapy and group 1B from 34.3+/-3.0 to 34.1+/-2.9 (p<0.001).Conclusions The results of the present study demonstrate a frequent association between hyperthyroidism and mild and transient pulmonary hypertension. Subjects treated with methimazole have a more rapid drop in PAPs.
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The pulmonary vasculature is less responsive to the vasodilatory effects of thyroid hormone than the systemic vasculature.
“The pulmonary vasculature is not as responsive to the vasodilatory effects TH as is the systemic vasculature (19).”
From Thyroid Hormones and Cardiovascular Function and Diseases (2018) · cites this paper as [19]
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- Authors
- Marvisi, M., Zambrelli, P., Brianti, M., Civardi, G., Lampugnani, R., & Delsignore, R.
- Affiliations
- University of Parma (IT)
- Corresponding author
- Marvisi, Maurizio
- ORCID
- Marvisi, Maurizio
- Venue
- European Journal of Internal Medicine
- Publisher
- Elsevier BV
- Published
- 2006-07
- Volume
- 17
- Issue
- 4
- Pages
- 267-271
- ISSN
- 0953-6205 (ISSN-L)
- OpenAlex
- W2074451403
- Cited by
- 114
- References
- 19
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 4 · 2023: 6 · 2022: 13 · 2021: 5 · 2020: 4 · 2019: 7 · 2018: 6 · 2017: 8 · 2016: 7 · 2015: 6 · 2014: 5 · 2013: 4 · 2012: 7
- FWCI
- 4.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
- Keywords
- pulmonary hypertension, hyperthyroidism, Graves' disease, nodular goiter, methimazole, antithyroid drug therapy, pulmonary vascular resistance, thyroid-stimulating hormone, tricuspid regurgitation, pulmonary artery systolic pressure, partial thyroidectomy
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