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Quality of life in type 2 diabetes mellitus after a very low calorie diet and exercise
Abstract
Objective To evaluate whether the addition of exercise to a very low calorie diet (VLCD) has beneficial short- and long-term effects on health-related quality of life (QoL) in obese patients with type 2 diabetes mellitus (T2DM). Methods We included 27 obese, insulin-dependent T2DM patients in a 16-week VLCD study, of whom 13 participated simultaneously in an exercise program (VLCD+E). Before, immediately after and 18 months after the intervention anthropometric measurements, glucoregulation and QoL (SF-36, HADS, NHP and MFI-20) were assessed. Patients were compared to healthy lean and obese (matched for body mass index) controls matched for gender and age. Results At baseline, T2DM patients had significantly worse QoL scores in 18 and 14 of the 22 subscales of the QoL questionnaires, compared to lean and obese controls, resp. The 16-week VLCD (n=27) decreased bodyweight (-25.4±1.3 kg, p Conclusion A 16-week VLCD induces considerable weight loss, metabolic amelioration, and major improvements in QoL in obese T2DM patients. The addition of exercise is of paramount importance for the maintenance of better QoL.
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Although the number of randomized clinical trials assessing the efficacy of VLCD in subjects with T2DM is limited, data suggest considerable weight loss, improved beta-cell function, and improved quality of life associated with short-term VLCD.
“Although the number of randomized clinical trials assessing the efficacy of VLCD in subjects with T2DM is limited, data suggest considerable weight loss, improved beta-cell function, and improved quality of life associated with short-term VLCD.5, 6, 7, 8, 9, 10, 11”
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Brown, A., Guess, N., Dornhorst, A., Taheri, S., & Frost, G. (2017) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13009 · Cited by 113
Rehackova, L., Arnott, B., Araujo‐Soares, V., Adamson, A. A., Taylor, R., & Sniehotta, F. F. (2016) · Diabetic Medicine · doi:10.1111/dme.13005 · Cited by 60
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Hartmann-Boyce, J., Theodoulou, A., Oke, J. L., Butler, A. R., Bastounis, A., Dunnigan, A., Byadya, R., Cobiac, L. J., Scarborough, P., Hobbs, F. D. R., et al. (2023) · Circulation: Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.122.009348 · Cited by 53
Metadata
- Authors
- Snel, M., Sleddering, M. A., vd Peijl, I. D., Romijn, J. A., Pijl, H., Meinders, A. E., & Jazet, I. M.
- Venue
- European Journal of Internal Medicine
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 23
- Issue
- 2
- Pages
- 143-149
- ISSN
- 0953-6205
- Cited by
- 33
- References
- 2
- Language
- en
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