Cited by 44Blood Pressure and Hypertension StudiesRenin-Angiotensin System StudiesChronic Kidney Disease and Diabetes

Brain-kidney cross-talk: Definition and emerging evidence

Afsar, Baris, Sag, Alan A., Yalcin, Can Ege, Kaya, Eren, Siriopol, Dimitrie, Goldsmith, David, Covic, Adrian, Kanbay, Mehmet·2016·European Journal of Internal Medicine

Abstract

Cross-talk is broadly defined as endogenous homeostatic signaling between vital organs such as the heart, kidneys and brain. Kidney-brain cross-talk remains an area with excitingly few publications despite its purported clinical relevance in the management of currently undertreated conditions such as resistant hypertension. Therefore, this review aims to establish an organ-specific definition for kidney-brain cross-talk and review the available and forthcoming literature on this topic.

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Crossref · 10.1016/j.ejim.2016.07.032

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Authors
Afsar, B., Sag, A. A., Yalcin, C. E., Kaya, E., Siriopol, D., Goldsmith, D., Covic, A., & Kanbay, M.
Affiliations
  • Koç University (TR)
  • Grigore T. Popa University of Medicine and Pharmacy (RO)
  • Guy's Hospital (GB)
Corresponding author
Kanbay, Mehmet
Venue
European Journal of Internal Medicine
Publisher
Elsevier BV
Published
2016-12
Volume
36
Pages
7-12
ISSN
0953-6205 (ISSN-L)
OpenAlex
W2507825272
Cited by
44
References
78
Citations by year
2026: 7 · 2025: 8 · 2024: 5 · 2023: 9 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 1
FWCI
0.24
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
Keywords
resistant hypertension, kidney-brain axis, neuroendocrinology
MeSH terms
Blood Pressure, Blood-Brain Barrier, Brain, Brain Diseases, Renal Dialysis, Humans, Kidney, Osmolar Concentration, Leukoaraiosis, Renal Insufficiency, Chronic, Renal Insufficiency

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