Brain-kidney cross-talk: Definition and emerging evidence
Abstract
Cross-talk is broadly defined as endogenous homeostatic signaling between vital organs such as the heart, kidneys and brain. Kidney-brain cross-talk remains an area with excitingly few publications despite its purported clinical relevance in the management of currently undertreated conditions such as resistant hypertension. Therefore, this review aims to establish an organ-specific definition for kidney-brain cross-talk and review the available and forthcoming literature on this topic.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Impaired renorenal reflex in hypertension and chronic kidney disease leads to augmented sympathetic excitation to blood vessels, heart and kidney.
“An impaired renorenal reflex in hypertension and CKD leads to augmented sympathetic excitation to the blood vessels, heart and kidney161.”
From The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease (2018) · cites this paper as [161]
Cites
High Survival Rates of Kidney Transplants from Spousal and Living Unrelated Donors
Terasaki, P. I., Cecka, J. M., Gjertson, D. W., & Takemoto, S. K. (1995) · New England Journal of Medicine · doi:10.1056/nejm199508103330601 · Cited by 1,214 · see citing works
Normal and Pathologic Concentrations of Uremic Toxins
Duranton, F., Cohen, G., Smet, R. D., Rodríguez, M., Jankowski, J., Vanholder, R. C., & Argilés, À. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011121175 · Cited by 965 · see citing works
Forette, F. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.18.2046 · Cited by 898 · see citing works
US Renal Data System 2011 Annual Data Report
Collins, A. J., Foley, R. N., Chavers, B. M., Gilbertson, D. T., Herzog, C. A., Johansen, K. L., Kasiske, B. L., Kutner, N. G., Liu, J., Peter, W. L. S., et al. (2011) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2011.11.015 · Cited by 819 · see citing works
Is Breakdown of the Blood-Brain Barrier Responsible for Lacunar Stroke, Leukoaraiosis, and Dementia?
Wardlaw, J. M., Sandercock, P. A. G., Dennis, M. S., & Starr, J. (2003) · Stroke · doi:10.1161/01.str.0000058480.77236.b3 · Cited by 628 · see citing works
Cognitive Disorders and Dementia in CKD
Bugnicourt, J., Godefroy, O., Chillon, J., Choukroun, G. J., & Massy, Z. A. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012050536 · Cited by 614 · see citing works
Collins, A. J., Kasiske, B. L., Herzog, C. A., Chavers, B. M., Foley, R. N., Gilbertson, D. T., Grimm, R. A., Liu, J., Louis, T. A., Manning, W., et al. (2005) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2004.10.009 · Cited by 461 · see citing works
Chronic Kidney Disease and Cognitive Impairment in the Elderly
Tamura, M. K., Chertow, G. M., Fried, L. F., Cummings, S. R., Harris, T. B., Simonsick, E. M., Satterfield, S., Ayonayon, H. N., & Yaffe, K. S. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005010005 · Cited by 459 · see citing works
Acute Kidney Injury Leads to Inflammation and Functional Changes in the Brain
Liu, M., Liang, Y., Chigurupati, S., Lathia, J. D., Pletnikov, M. V., Sun, Z., Crow, M. T., Ross, C. A., Mattson, M. P., & Rabb, H. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007080901 · Cited by 402 · see citing works
Neurological complications in renal failure: a review
Brouns, R., & De Deyn, P. P. (2004) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2004.07.012 · Cited by 392 · see citing works
Haorah, J., Ramirez, S. H., Schall, K. A., Smith, D. L., Pandya, R., & Persidsky, Y. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04393.x · Cited by 334 · see citing works
Yaffe, K. S., Ackerson, L., Tamura, M. K., LeBlanc, P., Kusek, J. W., Sehgal, A. R., Cohen, D. L., Anderson, C. A. M., Appel, L. J., DeSalvo, K. B., et al. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02670.x · Cited by 313 · see citing works
Lung–Kidney Cross-Talk in the Critically Ill Patient
Husain‐Syed, F., Slutsky, A. S., & Ronco, C. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201602-0420cp · Cited by 297 · see citing works
Antihypertensive drugs and incidence of dementia: the Rotterdam Study
in’t Veld, B. A., Ruitenberg, A., Hofman, A., Stricker, B. H. C., & Breteler, M. M. B. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00241-4 · Cited by 254 · see citing works
Brain water and electrolyte metabolism in uremia: Effects of slow and rapid hemodialysis
Arieff, A. I., Massry, S. G., Barrientos, A., & Kleeman, C. R. (1973) · Kidney International · doi:10.1038/ki.1973.100 · Cited by 233 · see citing works
Stroke in Patients on Maintenance Hemodialysis: A 22-Year Single-Center Study
Toyoda, Ḱ., Fujii, K., Fujimi, S., Kumai, Y., Tsuchimochi, H., Ibayashi, S., & Iida, M. (2005) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2005.02.028 · Cited by 215 · see citing works
Kidney–brain crosstalk in the acute and chronic setting
Lu, R., Kiernan, M. C., Murray, A. M., Rosner, M. H., & Ronco, C. (2015) · Nature Reviews Nephrology · doi:10.1038/nrneph.2015.131 · Cited by 211 · see citing works
Nguyen, D. N., Spapen, H. D., Su, F., Schiettecatte, J., Shi, L., Hachimi-Idrissi, S., & Huyghens, L. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000217218.51381.49 · Cited by 210 · see citing works
Cognitive Impairment in Peritoneal Dialysis Patients
Kalirao, P., Pederson, S. L., Foley, R. N., Kolste, A., Tupper, D. E., Zaun, D. A., Buot, V., & Murray, A. M. (2011) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2010.11.026 · Cited by 180 · see citing works
Diffusion tensor imaging to assess axonal regeneration in peripheral nerves
Lehmann, H. C., Zhang, J., Mori, S., & Sheikh, K. A. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.10.012 · Cited by 175 · see citing works
Gu, Y. (2011) · Frontiers in Bioscience-Scholar · doi:10.2741/222 · Cited by 162 · see citing works
Albuminuria, Cognitive Functioning, and White Matter Hyperintensities in Homebound Elders
Weiner, D. E., Bartolomei, K., Scott, T. M., Price, L. L., Griffith, J. L., Rosenberg, I. H., Levey, A. S., Folstein, M. F., & Sarnak, M. J. (2008) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2008.08.022 · Cited by 155 · see citing works
Nongnuch, A., Panorchan, K., & Davenport, A. (2014) · Critical Care · doi:10.1186/cc13907 · Cited by 153 · see citing works
TLR2 and TLR4 in the Brain Injury Caused by Cerebral Ischemia and Reperfusion
Wang, Y., Ge, P., & Zhu, Y. (2013) · Mediators of Inflammation · doi:10.1155/2013/124614 · Cited by 144 · see citing works
Chesterton, L. J., Sigrist, M. K., Bennett, T., Taal, M. W., & McIntyre, C. W. (2005) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfh808 · Cited by 142 · see citing works
Diffusion tensor imaging and tractography of distal peripheral nerves at 3 T
Hiltunen, J., Suortti, T., Arvela, S., Seppä, M., Joensuu, R., & Hari, R. (2005) · Clinical Neurophysiology · doi:10.1016/j.clinph.2005.05.014 · Cited by 138 · see citing works
Renorenal reflex responses to mechano- and chemoreceptor stimulation in the dog and rat
Kopp, U. C., Olson, L. A., & DiBona, G. F. (1984) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1984.246.1.f67 · Cited by 135 · see citing works
Fournier, A., Oprisiu-Fournier, R., Sérot, J., Godefroy, O., Achard, J., Faure, S., Mazouz, H., Temmar, M., Albu, A., Bordet, R., et al. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.89 · Cited by 134 · see citing works
Impaired endothelial function in isolated human uremic resistance arteries
Morris, S., McMurray, J. J. V., Spiers, A., & Jardine, A. G. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.0600031077.x · Cited by 134 · see citing works
Effects of brain death on organ quality and transplant outcome
Floerchinger, B., Oberhuber, R., & Tullius, S. G. (2012) · Transplantation Reviews · doi:10.1016/j.trre.2011.10.001 · Cited by 130 · see citing works
Murray, A. M., Pederson, S. L., Tupper, D. E., Hochhalter, A. K., Miller, W. A., Li, Q., Zaun, D. A., Collins, A. J., Kane, R. L., & Foley, R. N. (2007) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2007.05.010 · Cited by 129 · see citing works
Peripheral Nerve Diffusion Tensor Imaging: Assessment of Axon and Myelin Sheath Integrity
Heckel, A., Weiler, M., Xia, A., Ruetters, M., Pham, M., Bendszus, M., Heiland, S., & Bäumer, P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130833 · Cited by 125 · see citing works
Robertson, G. L. (1987) · PubMed · Cited by 123 · see citing works
Davey, A., Elias, M., Robbins, M. A., Seliger, S., & Dore, G. (2013) · Nephrology, Dialysis and Transplantation · doi:10.1093/ndt/gfs470 · Cited by 113 · see citing works
Cationic amino acid transport across the blood-brain barrier is mediated exclusively by system y+
O’Kane, R. L., Vinã, J. R., Simpson, I. A., Zaragozá, R., Mokashi, A. S., & Hawkins, R. A. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00007.2006 · Cited by 109 · see citing works
McIntyre, C. W., & Goldsmith, D. J. A. (2015) · Kidney International · doi:10.1038/ki.2015.62 · Cited by 107 · see citing works
Self-citationAquaporin Water Channels in Kidney
Agre, P. C. (2000) · Journal of the American Society of Nephrology · doi:10.1681/asn.v114764 · Cited by 104 · see citing works
Systematic Review of Structural and Functional Neuroimaging Findings in Children and Adults with CKD
Moodalbail, D. G., Reiser, K. A., Detre, J. A., Schultz, R. T., Herrington, J. D., Davatzikos, C. A., Doshi, J. J., Erus, G., Liu, H.-S., Radcliffe, J., et al. (2013) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.11601112 · Cited by 96 · see citing works
Jassal, S. V., Devins, G. M., Chan, C. T., Bozanovic, R., & Rourke, S. B. (2006) · Kidney International · doi:10.1038/sj.ki.5001691 · Cited by 90 · see citing works
Risk of Dementia in Peritoneal Dialysis Patients Compared with Hemodialysis Patients
Wolfgram, D. F., Szabó, A., Murray, A. M., & Whittle, J. (2015) · Peritoneal Dialysis International · doi:10.3747/pdi.2014.00213 · Cited by 90 · see citing works
Antihypertensive Treatments, Cognitive Decline, and Dementia
Duron, E., & Hanon, O. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091552 · Cited by 81 · see citing works
Categorization of the hemodynamic response to hemodialysis: The importance of baroreflex sensitivity
Chesterton, L. J., Selby, N. M., Burton, J. O., Fialová, J., Chan, C., & McIntyre, C. W. (2009) · Hemodialysis International · doi:10.1111/j.1542-4758.2009.00403.x · Cited by 81 · see citing works
Eating Behavior Disorders in Uremia: A Question of Balance in Appetite Regulation
Aguilera, A. I., Codoceo, R., Bajo, M. A., Iglesias, P., Díez, J. J., Barril, G., Cigarrán, S., Álvarez, V., Celadilla, O., Perpen, A. C. F., et al. (2004) · Seminars in Dialysis · doi:10.1046/j.0894-0959.2004.16086.x · Cited by 79 · see citing works
Kim, C., Lee, H.-J., Kim, D.-J., Kim, B. S., Shin, S. K., Do, J.-Y., Jang, M.-H., Park, S.-H., Kim, Y., & Kim, Y.-L. (2007) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2007.03.019 · Cited by 79 · see citing works
Nishi, E. E., Bergamaschi, C. T., & Campos, R. R. (2015) · Experimental Physiology · doi:10.1113/expphysiol.2014.079889 · Cited by 73 · see citing works
Martínez-Vea, A., Salvadó, E., Bardajı́, A., Gutiérrez, C., Ramos, A., García, C., Compte, T., Peralta, C., Broch, M., Pastor, R., et al. (2006) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2005.10.029 · Cited by 73 · see citing works
Cerebrovascular reactivity and dynamic autoregulation in ischaemic subcortical white matter disease
Birns, J., Jarosz, J., Markus, H. S., & Kalra, L. (2009) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2009.174607 · Cited by 72 · see citing works
Practical guidance for dialyzing a hemodialysis patient following acute brain injury
Davenport, A. (2008) · Hemodialysis International · doi:10.1111/j.1542-4758.2008.00271.x · Cited by 69 · see citing works
Nitric oxide in uremia: Effects of several potentially toxic guanidino compounds
Deyn, P. P. D., Vanholder, R. C., & D’Hooge, R. (2003) · Kidney International · doi:10.1046/j.1523-1755.63.s84.9.x · Cited by 68 · see citing works
High Prevalence of Intracranial Artery Calcification in Stroke Patients with CKD
Bugnicourt, J., Chillon, J., Massy, Z. A., Canaple, S., Lamy, C., Deramond, H., & Godefroy, O. (2009) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.02140508 · Cited by 66 · see citing works
Central nervous dysfunction in uremia
Smogorzewski, M. J. (2001) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2001.27419 · Cited by 64 · see citing works
Impaired renorenal reflexes in two-kidney, one clip hypertensive rats.
Kopp, U. C., & Buckley-Bleiler, R. (1989) · Hypertension · doi:10.1161/01.hyp.14.4.445 · Cited by 64 · see citing works
Native and recombinant ASIC1a receptors conduct negligible Ca2+ entry
Samways, D. S. K., Harkins, A. B., & Egan, T. M. (2009) · Cell Calcium · doi:10.1016/j.ceca.2008.12.002 · Cited by 63 · see citing works
The Brain in Kidney Disease (BRINK) Cohort Study: Design and Baseline Cognitive Function
Murray, A. M., Bell, E. J., Tupper, D. E., Davey, C. S., Pederson, S. L., Amiot, E., Miley, K. M., McPherson, L. E., Heubner, B. M., Gilbertson, D. T., et al. (2015) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2015.11.008 · Cited by 63 · see citing works
Effect of chronic kidney disease on the expression of thiamin and folic acid transporters
Bukhari, F., Moradi, H., Gollapudi, P., Kim, H. J., Vaziri, N. D., & Said, H. M. (2010) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfq675 · Cited by 62 · see citing works
The Brain and the Kidney – Organ Cross Talk and Interactions
Davenport, A. (2008) · Blood Purification · doi:10.1159/000167800 · Cited by 61 · see citing works
Kielstein, H., Suntharalingam, M., Perthel, R., Song, R., Schneider, S. M., Martens‐Lobenhoffer, J., Jäger, K., Bode‐Böger, S. M., & Kielstein, J. T. (2015) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfv253 · Cited by 58 · see citing works
FGF ‐23 and cognitive performance in hemodialysis patients
Drew, D. A., Tighiouart, H., Scott, T. M., Lou, K. V., Fan, L., Shaffi, S. K., Weiner, D. E., & Sarnak, M. J. (2013) · Hemodialysis International · doi:10.1111/hdi.12100 · Cited by 57 · see citing works
Umemura, T., Kawamura, T., Sakakibara, T., Mashita, S., Hotta, N., & Sobue, G. (2012) · American Journal of Hypertension · doi:10.1038/ajh.2011.254 · Cited by 51 · see citing works
Davenport, A., Goel, S., & Mackenzie, J. C. (1992) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(12)70234-2 · Cited by 51 · see citing works
Cerebral Structural Changes in Diabetic Kidney Disease: African American–Diabetes Heart Study MIND
Sink, K. M., Divers, J., Whitlow, C. T., Palmer, N. D., Smith, S. C., Xu, J., Hugenschmidt, C. E., Wagner, B., Williamson, J. D., Bowden, D. W., et al. (2014) · Diabetes Care · doi:10.2337/dc14-1231 · Cited by 48 · see citing works
Brain Atrophy in Peritoneal Dialysis and CKD Stages 3-5: A Cross-sectional and Longitudinal Study
Tsuruya, K., Yoshida, H., Kuroki, Y., Nagata, M., Mizumasa, T., Mitsuiki, K., Yoshiura, T., Hirakawa, M., Kanai, H., Hori, K., et al. (2014) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2014.07.011 · Cited by 43 · see citing works
Low 25-Hydroxyvitamin D Levels and Cognitive Impairment in Hemodialysis Patients
Shaffi, S. K., Tighiouart, H., Scott, T. M., Lou, K. V., Drew, D. A., Weiner, D. E., & Sarnak, M. J. (2013) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.10651012 · Cited by 43 · see citing works
Kobayashi, M., Hirawa, N., Morita, S., Yatsu, K., Kobayashi, Y., Yamamoto, Y., Saka, S., Toya, Y., Yasuda, G., & Umemura, S. (2010) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2010.03.018 · Cited by 39 · see citing works
Evaluation of Neurocognition in Youth with CKD Using a Novel Computerized Neurocognitive Battery
Hartung, E. A., Kim, J. Y., Laney, N. C., Hooper, S. R., Radcliffe, J., Port, A. M., Gur, R. C., & Furth, S. L. (2015) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.02110215 · Cited by 39 · see citing works
Smogorzewski, M. J., Koureta, P., Fadda, G. Z., Perna, A. F., & Massry, S. G. (1991) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1101162 · Cited by 37 · see citing works
Distribution of Cerebral Microbleeds Determines Their Association with Impaired Kidney Function
Song, T.-J., Kim, J., Lee, H. S., Nam, C. M., Nam, H. S., Kim, Y. D., & Heo, J. H. (2014) · Journal of Clinical Neurology · doi:10.3988/jcn.2014.10.3.222 · Cited by 34 · see citing works
Tsuruya, K., Yoshida, H., Haruyama, N., Fujisaki, K., Hirakata, H., & Kitazono, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143706 · Cited by 34 · see citing works
Up-Regulation of TLR-4 in the Brain After Ischemic Kidney-Induced Encephalopathy in the Rat
Salama, M., Farrag, S., abulasrar, S., Amin, M., Abdel‐Aziz, A., Sheashaa, H., Sobh, M. A. K., & Arias-Carrión, Ó. (2013) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527311312050006 · Cited by 30 · see citing works
Murea, M., Hsu, F., Cox, A. J., Hugenschmidt, C. E., Xu, J., Adams, J. N., Raffield, L. M., Whitlow, C. T., Maldjian, J. A., Bowden, D. W., et al. (2015) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfv030 · Cited by 26 · see citing works
Renocardiac Syndromes: Physiopathology and Treatment Stratagems
Kingma, J. G., Simard, D., & Rouleau, J. R. (2015) · Canadian Journal of Kidney Health and Disease · doi:10.1186/s40697-015-0075-4 · Cited by 22 · see citing works
Brain Activation in Uremic Anorexia
Aguilera, A. I., Sánchez-Tomero, J. A., & Selgas, R. (2007) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2006.10.020 · Cited by 21 · see citing works
Sag, A. A., Sos, T. A., Benli, C., Sal, O., Rossignol, P., Ortíz, A., Solak, Y., & Kanbay, M. (2016) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2016.02.005 · Cited by 17 · see citing works
Self-citationSag, A. A., İnal, I., Okcuoglu, J., Rossignol, P., Ortíz, A., Afşar, B., Sos, T. A., & Kanbay, M. (2016) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2016.02.009 · Cited by 12 · see citing works
Self-citationDavenport, A., Davison, A., Ej, W., Newton, K. E., & Toothill, C. (1991) · QJM · doi:10.1093/oxfordjournals.qjmed.a068561 · Cited by 10 · see citing works
One year follow-up effect of renal sympathetic denervation in patients with resistant hypertension.
Pourmoghaddas, M., Khosravi, A., Akhbari, M., Akbari, M., Pourbehi, M., Ziaei, F., Salehizade, L., Sistan, N., Esmaeili, M., & Bidram, P. (2016) · PubMed Central · Cited by 9 · see citing works
T1 Hyperintense Disc in Alkaptonuria
Sag, A. A., Silbergleit, R., Olson, R. E., Wilson, J. D., & Krishnan, A. S. (2012) · Spine · doi:10.1097/brs.0b013e318266e4ab · Cited by 8 · see citing works
Self-citation
Flagged first, then by citations
1 of the 78 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease
Yang, T., Richards, E. M., Pepine, C. J., & Raizada, M. K. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0018-2 · Cited by 753 · see citing works
Neuroinflammation and peripheral immunity: Focus on ischemic stroke
Wang, H., Zhang, S., Xie, L., Zhe, Z., & Yan, F. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110332 · Cited by 121 · see citing works
Li, N., Wang, Y., Wei, P., Yu, M., Yu, M., Zhou, G., Yuan, G., Sun, J., Dai, H., Zhou, E., et al. (2023) · Nutrients · doi:10.3390/nu15020360 · Cited by 77 · see citing works
Zhu, J., Fu, Y., Olovo, C. V., Xu, J., Wu, Q., Wei, W., Jiang, K., & Zheng, X. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1535356 · Cited by 31 · see citing works
Jiang, F., Su, L., Xiang, H., Zhang, X., Xu, D., Zhang, Z., & Peng, Z. (2019) · Blood Purification · doi:10.1159/000499029 · Cited by 29 · see citing works
Gut microbiota axis: potential target of phytochemicals from plant-based foods
Shi, R., Huang, C., Gao, Y., Li, X., Zhang, C., & Li, M. (2023) · Food Science and Human Wellness · doi:10.1016/j.fshw.2023.02.001 · Cited by 30 · see citing works
Evidence of Brain Alterations in Noncerebral Falciparum Malaria
Mohanty, S., Sahu, P. K., Pattnaik, R., Majhi, M., Maharana, S., Bage, J., Mohanty, A., Mohanty, A., Bendszus, M., Patterson, C., et al. (2021) · Clinical Infectious Diseases · doi:10.1093/cid/ciab907 · Cited by 25 · see citing works
Huang, B., Huang, Z., Wang, H., Zhu, G., Liao, H., Wang, Z., Yang, B., & Ran, J. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175905 · Cited by 18 · see citing works
Busceti, C. L., Cotugno, M., Bianchi, F., Forte, M., Stanzione, R., Marchitti, S., Battaglia, G., Nicoletti, F., Fornai, F., & Rubattu, S. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124289 · Cited by 16 · see citing works
Association between the Estimated Glomerular Filtration Rate and Brain Atrophy in Older Adults
Grasing, M., Sharma, P., Lepping, R. J., Honea, R. A., Burns, J. M., Brooks, W. M., Gupta, A., & Initiative, A. D. N. (2022) · American Journal of Nephrology · doi:10.1159/000521892 · Cited by 16 · see citing works
Wang, Z., Xue, F., Zhang, J., Wang, Y., Hu, E., Zheng, Y., Luo, X., Li, H., & Qiao, B. (2024) · Fitoterapia · doi:10.1016/j.fitote.2024.106098 · Cited by 9 · see citing works
Mu, J., Ma, L., Ding, D., Ma, X., Li, P., Li, R., Zhang, M., & Liu, J. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00376-6 · Cited by 9 · see citing works
Headache changes after kidney transplant
Viticchi, G., Falsetti, L., Salvemini, S., Bartolini, M., Ranghino, A., Buratti, L., & Silvestrini, M. (2021) · Acta Neurologica Belgica · doi:10.1007/s13760-021-01637-x · Cited by 9 · see citing works
Evaluating the effect of kidney function on brain volumes and dementia risk in the UK Biobank
Huang, X., Yuan, S., Ling, Y., Cheng, H., Tan, S., Xu, A., & Lyu, J. (2023) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2023.105157 · Cited by 8 · see citing works
Mo, H., Fan, F., Liu, J., Zhang, W., Wang, Q., & Yuan, X. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1286592 · Cited by 7 · see citing works
Zhang, S., Zhang, Y., Wen, Z., Yang, Y., Bu, T., Wei, R., Chen, Y., & Ni, Q. (2024) · Phytomedicine · doi:10.1016/j.phymed.2023.155297 · Cited by 7 · see citing works
Wang, Y., Luo, Y., Yang, S., Jiang, M., & Chu, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310459 · Cited by 7 · see citing works
Gupta, N. (2020) · Physiology in clinical neurosciences · doi:10.1007/978-981-15-2325-0_3 · Cited by 6 · see citing works
Hyperlactatemia and other perioperative metabolic disturbances in neuroanesthesia
Klimek, M., de Smalen, P., & Janssen, J. W. (2022) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000001180 · Cited by 5 · see citing works
Brain Crosstalk with Other Organs in ICU Patient
Saran, S., & Gurjar, M. (2019) · Journal of Neuroanaesthesiology and Critical Care · doi:10.1055/s-0039-3399474 · Cited by 5 · see citing works
Liver Transplantation for Acute Liver Failure in Presence of Acute Kidney Injury
Choudhary, N. S., Saigal, S., Saraf, N., & Soin, A. S. (2019) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2019.07.009 · Cited by 4 · see citing works
Si, J., Chen, X., Qi, K., Li, D., Bingbing, L. I. U., ZHENG, Y., Ji, E., & Yang, S. (2024) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(24)60640-0 · Cited by 4 · see citing works
Genetic influences on the shape of brain ventricular and subcortical structuresPreprint
Zhao, B., Li, T., Yang, X., Shu, J., Wang, X., Luo, T., Yang, Y., Wu, Z., Fan, Z., Jiang, Z., et al. (2022) · medRxiv · doi:10.1101/2022.09.26.22279691 · Cited by 4 · see citing works
Lei, J., Li, J., Wu, W. D., Xiong, R., Liu, Y., & Tang, Y. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01688-6 · Cited by 3 · see citing works
Chronic Kidney Disease in Patients with Hip Fracture: Prevalence and Outcomes
Fisher, A., Wang, J.-W. D., & Smith, P. N. (2024) · International Journal of Clinical Practice · doi:10.1155/2024/4456803 · Cited by 3 · see citing works
Association between Acute Kidney Injury and Dementia: A Multi-Database Cohort Study
Guo, Z., She, C., Lin, Y., Zhou, S., Luo, F., Cao, L., Sun, Y., Chen, R., Pang, M., Shao, X., et al. (2025) · Kidney Diseases · doi:10.1159/000545963 · Cited by 2 · see citing works
Brain health across the lifespan and the impact of nutrition, exercise, microbiota, and sleep
Shin, A. C., Haque, Z. F., Galyean, S., Hefner, M., Esmaeili, M., Lawrence, J. J., & Watkins, B. A. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103245 · Cited by 2 · see citing works
Monnerat, J. A. D. S., Mota, B. F., Cardoso, L. M. D. F., Fiochi, R. D. S. F., Pimenta, N. D. M. A., Silva, I. W. S. D. M., Ramalho, R. B. D. R., Teixeira, C. C., Chagas, M. A., Barroso, S. G., et al. (2020) · Brazilian Journal of Development · doi:10.34117/bjdv6n1-105 · Cited by 2 · see citing works
Aortic Stiffness and Alzheimer’s Disease: The Medin Connection
Triposkiadis, F. K., Xanthopoulos, A. V., Boudoulas, H. K., & Brutsaert, D. L. (2025) · Biomolecules · doi:10.3390/biom15081148 · Cited by 2 · see citing works
Cognitive Impairment and Related Causes in Hemodialysis Patients
Shahraki, E., Shakiba, M., Yazdi, M. G., & Sargolzaie, N. (2022) · Thrita · doi:10.5812/thrita.115833 · Cited by 1 · see citing works
Poskotinova, L. V., Васильевна, К. А., & Kudryavtsev, A. V. (2023) · Brain Sciences · doi:10.3390/brainsci13121664 · Cited by 1 · see citing works
Renal dysfunction as a complication of acute brain damage
Basantsova, N. Y., Shishkin, A. N., Тибекина, Л. М., Владимирович, Э. М., Воловникова, В. А., Semenova, O. I., & Tyapkina, V. S. (2020) · Arterial’naya Gipertenziya (Arterial Hypertension) · doi:10.18705/1607-419x-2019-25-6-674-681
Kidney–Brain Crosstalk in Acute Kidney Injury
Patti, M., Grynszpan, F., Ristagno-Ruiz, V., & Videla, C. G. (2023) · Springer eBooks · doi:10.1007/978-3-031-36789-2_8
Crosstalk between brain and the kidneys
Gupta, N., & Chamania, G. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-22268-9.00007-7
Hyperuricemia and the nephrocerebral continuum
Yusupov, F. A., Токтосунович, Ы. И., & Yuldashev, A. A. (2025) · Nephrology (Saint-Petersburg) · doi:10.36485/1561-6274-2025-29-2-9-16
Mahajan, C. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-22273-3.00036-5
Lin, Y., She, J., Cai, L., Yu, L., Jin, S., Chen, X., Gao, W., & Zhu, R. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1598371
Acute kidney injury: Is it a risk factor for long-term cognitive decline
Afşar, B., Afşar, R. E., Maddukuri, G. S., & Lentine, K. L. (2025) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2025.12.001
Zhang, L., Li, J., Aldali, F., Li, Y., 韩肖华, & Deng, C. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03896-y
Hsu, C., & Tain, Y. (2026) · Antioxidants · doi:10.3390/antiox15060769
Li, H., Ou, Y., & Li, S. (2026) · The Nephron journals/Nephron journals · doi:10.1159/000552915
The Challenge of Multi-Organ Crosstalk Research
Pennekamp, J., Lohmöller, J., Wu, Z., Lehmann, K.-V., Hoos, H. H., Jankowski, J., Kobbelt, L. P., Wehrle, K., & Schaub, M. T. (2026) · ACM Transactions on Computing for Healthcare · doi:10.1145/3833379
Xu, Y., Li, W., Dong, C., & Zhang, A. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1856616
Beyond Creatinine: D-Amino Acids as Emerging Indicators of Kidney Function and Disease
Uifălean, A., Iacobescu, M., Mureșan, X. M., Hegheş, S. C., Salanță, L. C., Moldovan, R.-C., & Iuga, C. A. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18101207
- Authors
- Afsar, B., Sag, A. A., Yalcin, C. E., Kaya, E., Siriopol, D., Goldsmith, D., Covic, A., & Kanbay, M.
- Affiliations
- Koç University (TR)
- Grigore T. Popa University of Medicine and Pharmacy (RO)
- Guy's Hospital (GB)
- Corresponding author
- Kanbay, Mehmet
- Venue
- European Journal of Internal Medicine
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 36
- Pages
- 7-12
- ISSN
- 0953-6205 (ISSN-L)
- OpenAlex
- W2507825272
- Cited by
- 44
- References
- 78
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 5 · 2023: 9 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 1
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Keywords
- resistant hypertension, kidney-brain axis, neuroendocrinology
- MeSH terms
- Blood Pressure, Blood-Brain Barrier, Brain, Brain Diseases, Renal Dialysis, Humans, Kidney, Osmolar Concentration, Leukoaraiosis, Renal Insufficiency, Chronic, Renal Insufficiency
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review