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Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice

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Novel Tacrine–Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography

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Toward Highly Potent Cancer Agents by Modulating the C‑2 Group of the Arylthioindole Class of Tubulin Polymerization Inhibitors

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Design, Synthesis, and Evaluation of Orally Available Clioquinol-Moracin M Hybrids as Multitarget-Directed Ligands for Cognitive Improvement in a Rat Model of Neurodegeneration in Alzheimer’s Disease

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The Flavonoid Apigenin Protects Brain Neurovascular Coupling against Amyloid-β25-35-Induced Toxicity in Mice

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The Case for Abandoning Therapeutic Chelation of Copper Ions in Alzheimer's Disease

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New multi-target-directed small molecules against Alzheimer's disease: a combination of resveratrol and clioquinol

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Novel 8‐Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer′s Disease

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Development of Multifunctional Pyrimidinylthiourea Derivatives as Potential Anti-Alzheimer Agents

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Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer’s disease

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PET Imaging of Copper Trafficking in a Mouse Model of Alzheimer Disease

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The Second Cu(II)-Binding Site in a Proton-Rich Environment Interferes with the Aggregation of Amyloid-β(1−40) into Amyloid Fibrils

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Capturing a Reactive State of Amyloid Aggregates

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Blood–brain barrier permeable anticholinesterase aurones: Synthesis, structure–activity relationship, and drug-like properties

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Repurposing of Copper(II)-chelating Drugs for the Treatment of Neurodegenerative Diseases

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Effects of a tacrine-8-hydroxyquinoline hybrid (IQM-622) on Aβ accumulation and cell death: Involvement in hippocampal neuronal loss in Alzheimer's disease

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Changes in PDE4D Isoforms in the Hippocampus of a Patient With Advanced Alzheimer Disease

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Copper( i ) targeting in the Alzheimer's disease context: a first example using the biocompatible PTA ligand

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Molecular Dynamics Study on the Inhibition Mechanisms of Drugs CQ1–3 for Alzheimer Amyloid-β40 Aggregation Induced by Cu2+

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Nanoprobing of the Effect of Cu2+ Cations on Misfolding, Interaction and Aggregation of Amyloid β Peptide

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New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment

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Novel Vilazodone–Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation

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Design, Synthesis, and Biological Evaluation of Dual-Target Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 9A (PDE9A) for the Treatment of Alzheimer’s Disease

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Lack of synaptic vesicle protein SV2B protects against amyloid-β25–35-induced oxidative stress, cholinergic deficit and cognitive impairment in mice

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Synthesis and evaluation of 8-hydroxyquinolin derivatives substituted with (benzo[d][1,2]selenazol-3(2H)-one) as effective inhibitor of metal-induced Aβ aggregation and antioxidant

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Is Brain Copper Deficiency in Alzheimer's, Lewy Body, and Creutzfeldt Jakob Diseases the Common Key for a Free Radical Mechanism and Oxidative Stress-Induced Damage?

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Computer-assisted designed “selenoxy–chinolin”: a new catalytic mechanism of the GPx-like cycle and inhibition of metal-free and metal-associated Aβ aggregation

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Dihydropyrimidine-Thiones and Clioquinol Synergize To Target β-Amyloid Cellular Pathologies through a Metal-Dependent Mechanism

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2‐Phenylethynyl‐butyltellurium attenuates amyloid‐β peptide(25–35)‐induced learning and memory impairments in mice

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Insights of 8-hydroxyquinolines: A novel target in medicinal chemistry

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Molecular Hybridization as a Tool in the Design of Multi-target Directed Drug Candidates for Neurodegenerative Diseases

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Alzheimer's disease: Updated multi-targets therapeutics are in clinical and in progress

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Multitarget Therapeutic Strategies for Alzheimer’s Disease: Review on Emerging Target Combinations

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Novel small molecule therapeutic agents for Alzheimer disease: Focusing on BACE1 and multi-target directed ligands

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Advancements in the development of multi-target directed ligands for the treatment of Alzheimer's disease.

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Recent Advances in the Synthesis and Biological Activity of 8-Hydroxyquinolines

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Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease

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Unravelling the interaction mechanism between clioquinol and bovine serum albumin by multi-spectroscopic and molecular docking approaches

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Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease

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Inhibition of phosphodiesterase: A novel therapeutic target for the treatment of mild cognitive impairment and Alzheimer’s disease

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A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors

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Direct electrochemical reductive amination between aldehydes and amines with a H/D-donor solvent

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Novel pharmacological strategies to treat cognitive dysfunction in chronic obstructive pulmonary disease

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Design, Synthesis and Biological Evaluation of Xanthone Derivatives for Possible Treatment of Alzheimer's Disease Based on Multi‐Target Strategy

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Critical evaluation of current Alzheimer’s drug discovery (2018–19) & futuristic Alzheimer drug model approach

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Roflumilast: A potential drug for the treatment of cognitive impairment?

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Emerging phosphodiesterase inhibitors for treatment of neurodegenerative diseases

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Analysis of skeletal diversity of multi-target directed ligands (MTDLs) targeting Alzheimer's disease

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Alzheimer’s disease: Key developments support promising perspectives for therapy

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Roflumilast and cognition enhancement: A translational perspective

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Neuroprotective Effects of Cilomilast and Chlorogenic Acid Against Scopolamine-Induced Memory Deficits via Modulation of the cAMP/PKA–CREB–BDNF Pathway

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Biological evaluation of 7-O-amide hesperetin derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease

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Opportunities and perspectives of small molecular phosphodiesterase inhibitors in neurodegenerative diseases

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Deciphering Copper Homeostasis and Cuproptosis: Biological Mechanisms, Disease Connections, and Cutting-Edge Copper-Based Nanomedicine

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Tackling Alzheimer’s Disease with Existing Drugs: A Promising Strategy for Bypassing Obstacles

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Roflumilast attenuates doxorubicin and cyclophosphamide combination-induced chemobrain in rats through modulation of NLRP3/ASC/caspase-1/GSDMD axis

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Phosphodiesterase 4 Inhibition in Neuropsychiatric Disorders Associated with Alzheimer’s Disease

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Accelerating and Automating the Free Energy Perturbation Absolute Binding Free Energy Calculation with the RED-E Function

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Carnoquinolines Target Copper Dyshomeostasis, Aberrant Protein–Protein Interactions, and Oxidative Stress

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Design, Synthesis, and Biological Evaluation of Novel Multifunctional Rolipram–Tranilast Hybrids As Potential Treatment for Traumatic Brain Injury

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