Cholinesterase Inhibitors and Beyond

The cholinergic hypothesis of geriatric memory dysfunction

Bartus, R. T., Dean, R. L., Beer, B., & Lippa, A. S. (1982) · Science · doi:10.1126/science.7046051 · Cited by 5,545 · see citing works

SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE

DAVIES, P. (1976) · The Lancet · doi:10.1016/s0140-6736(76)91936-x · Cited by 3,565 · see citing works

The cholinergic hypothesis of Alzheimer’s disease: A review of progress

Francis, P. T., Palmer, A. M., Snape, M., & Wilcock, G. K. (1999) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.66.2.137 · Cited by 2,198 · cited 1× · see citing works

Cholinesterase inhibitors for Alzheimer's disease

Birks, J. S. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005593 · Cited by 1,906 · see citing works

Oral Tetrahydroaminoacridine in Long-Term Treatment of Senile Dementia, Alzheimer Type

Summers, W. K., Majovski, L. V., Marsh, G. M., Tachiki, K. H., & Kling, A. S. (1986) · New England Journal of Medicine · doi:10.1056/nejm198611133152001 · Cited by 1,161 · see citing works

Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme

Inestrosa, N. C., Alvarez, A. R., Pérez, C. A., Moreno, R. D., Vicente, M., Linker, C., Casanueva, O. I., Soto, C. A., & Garrido, J. (1996) · Neuron · doi:10.1016/s0896-6273(00)80108-7 · Cited by 1,107 · see citing works

Efficacy and safety of rivastigmine in patients with Alzheimer's disease: international randomised controlled trial Commentary: Another piece of the Alzheimer's jigsaw

Rosler, M., Anand, R., Cicin-Sain, A., Gauthier, S., Agid, Y., Dal-Bianco, P., Stahelin, H. B., Hartman, R., Gharabawi, M., & Bayer, T. (1999) · BMJ · doi:10.1136/bmj.318.7184.633 · Cited by 943 · see citing works

Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors

Nitsch, R. M., Slack, B. E., Wurtman, R. J., & Growdon, J. H. (1992) · Science · doi:10.1126/science.1411529 · Cited by 898 · see citing works

Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer β-amyloid peptide in rodent

Greig, N. H., Utsuki, T., Ingram, D. K., Wang, Y., Pepeu, G., Scali, C., Yu, Q.-S., Mamczarz, J., Holloway, H. W., Giordano, T., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508575102 · Cited by 745 · see citing works

The Efficacy and Safety of Donepezil in Patients with Alzheimer's Disease: Results of a US Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial

Rogers, S. L., & Friedhoff, L. T. (1996) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106895 · Cited by 743 · see citing works

Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid ß-protein

Selkoe, D. J. (2001) · Journal of Alzheimer s Disease · doi:10.3233/jad-2001-3111 · Cited by 538 · see citing works

Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: a meta-analysis of randomised controlled trials

Kavirajan, H., & Schneider, L. S. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70195-3 · Cited by 497 · see citing works

A Structural Motif of Acetylcholinesterase That Promotes Amyloid β-Peptide Fibril Formation

Ferrari, G. V. D., Canales, M. A., Shin, I., Weiner, L. M., Silman, I., & Inestrosa, N. C. (2001) · Biochemistry · doi:10.1021/bi0101392 · Cited by 415 · see citing works

Galantamine

Scott, L. J., & Goa, K. L. (2000) · Drugs · doi:10.2165/00003495-200060050-00008 · Cited by 383 · see citing works

Acetylcholinesterase inhibitors: novel activities of old molecules

Racchi, M. (2004) · Pharmacological Research · doi:10.1016/j.phrs.2003.12.027 · Cited by 291 · see citing works

Selectivity of Cholinesterase Inhibition

Weinstock, M. (1999) · CNS Drugs · doi:10.2165/00023210-199912040-00005 · Cited by 280 · see citing works

Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia

Mesulam, M. M., & Geula, C. (1994) · Annals of Neurology · doi:10.1002/ana.410360506 · Cited by 259 · see citing works

Neuroglial cholinesterases in the normal brain and in Alzheimer's disease: Relationship to plaques, tangles, and patterns of selective vulnerability

Wright, C. I., Geula, C., & Mesulam, M.-M. (1993) · Annals of Neurology · doi:10.1002/ana.410340312 · Cited by 237 · see citing works

Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease

Maelicke, A., & Albuquerque, E. X. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00093-5 · Cited by 222 · see citing works

Design, Synthesis, and Biological Evaluation of Dual Binding Site Acetylcholinesterase Inhibitors: New Disease-Modifying Agents for Alzheimer's Disease

Muñoz-Ruiz, P., Rubio, L., García‐Palomero, E., Dorronsoro, I., del Monte-Millán, M., Valenzuela, R., Usán, P., de Austria, C., Bartolini, M., Andrisano, V., et al. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm0503289 · Cited by 221 · see citing works

Effects of Rivastigmine on Cognitive Function in Dementia with Lewy Bodies: A Randomised Placebo-Controlled International Study Using the Cognitive Drug Research Computerised Assessment System

Wesnes, K. A., McKeith, I. G., Ferrara, R., Emre, M., del Ser, T., Spano, P., Cicin-Sain, A., Anand, R., & Spiegel, R. (2002) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000048651 · Cited by 209 · see citing works

Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors

Castro, A., & Martinez, A. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206778792985 · Cited by 207 · see citing works

Chronic treatment of old rats with donepezil or galantamine: effects on memory, hippocampal plasticity and nicotinic receptors

Barnes, C. A., Meltzer, J., Houston, F. P., Orr, G. W., McGann, K., & Wenk, G. L. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00180-9 · Cited by 193 · see citing works

Cholinesterases and the Pathology of Alzheimer Disease

Geula, C., & Mesulam, M. ‐. (1995) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199501002-00005 · Cited by 193 · see citing works

Metrifonate treatment of the cognitive deficits of Alzheimer's disease

Cummings, J. L., Cyrus, P., Bieber, F., Mas, J., Orazem, J. P., Gulanski, B., & The Metrifonate Study Group* (1998) · Neurology · doi:10.1212/wnl.50.5.1214 · Cited by 173 · see citing works

Degree of inhibition of cortical acetylcholinesterase activity and cognitive effects by donepezil treatment in Alzheimer's disease

Bohnen, N. I. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.038729 · Cited by 160 · see citing works

Current Research in Alzheimer Therapy

Frost, F. S. (1989) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/00002060-198910000-00019 · Cited by 145 · see citing works

Tacrine restores cholinergic nicotinic receptors and glucose metabolism in alzheimer patients as visualized by positron emission tomography

Nordberg, A. K., Lilja, A., Lundqvist, H., Hartvig, P., Amberla, K., Viitanen, M. H., Berglund, U. W., Johansson, M., Hellström‐Lindahl, E., Bjurling, P., et al. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90099-j · Cited by 141 · see citing works

Regional Effects of Donepezil and Rivastigmine on Cortical Acetylcholinesterase Activity in Alzheimer’s Disease

Kaasinen, V., Någren, K., Järvenpää, T., Roivainen, A., Yu, M., Oikonen, V., Kurki, T. J. I., & Rinne, J. O. (2002) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200212000-00012 · Cited by 138 · see citing works

Mechanisms Behind the Neuroprotective Actions of Cholinesterase Inhibitors in Alzheimer Disease

Nordberg, A. K. (2006) · Alzheimer Disease & Associated Disorders · doi:10.1097/01.wad.0000213804.59187.2d · Cited by 134 · see citing works

The Experimental Alzheimer’s Disease Drug Posiphen [(+)-Phenserine] Lowers Amyloid-β Peptide Levels in Cell Culture and Mice

Lahiri, D. K., Chen, D., Maloney, B., Holloway, H. W., Yu, Q.-S., Utsuki, T., Giordano, T., Sambamurti, K., & Greig, N. H. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.112102 · Cited by 134 · see citing works

Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model

Dam, D. V., Abramowski, D., Staufenbiel, M., & Deyn, P. P. D. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2132-z · Cited by 130 · see citing works

Acetylcholinesterase-Aβ Complexes Are More Toxic than Aβ Fibrils in Rat Hippocampus

Reyes, A. E., Chacón, M. A., Dinamarca, M. C., Cerpa, W. F., Morgan, C., & Inestrosa, N. C. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63774-1 · Cited by 129 · see citing works

Novel cholinesterase inhibitors as future effective drugs for the treatment of Alzheimer’s disease

Martı́nez, A., & Castro, A. (2005) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.15.1.1 · Cited by 127 · see citing works

Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer’s disease

Dong, H., Csernansky, C. A., Martin, M. V., Bertchume, A., Vallera, D., & Csernansky, J. G. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2230-6 · Cited by 114 · see citing works

Physostigmine and galanthamine: probes for a novel binding site on the alpha 4 beta 2 subtype of neuronal nicotinic acetylcholine receptors stably expressed in fibroblast cells.

Pereira, E. F. R., Alkondon, M., Reinhardt, S., Maelicke, A., Peng, X., Lindström, J., Whiting, P. J., & Albuquerque, E. X. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22435-1 · Cited by 108 · see citing works

An inverted U-shaped curve for heptylphysostigmine on radial maze performance in rats: comparison with other cholinesterase inhibitors

Braida, D., Paladini, E., Griffini, P., Lamperti, M., Maggi, A., & Sala, M. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00072-6 · Cited by 107 · see citing works

Effect of metrifonate on extracellular brain acetylcholine and object recognition in aged rats

Scali, C., Giovannini, M. G., Bartolini, L., Prosperi, C., Hinz, V. C., Schmidt, B. H., & Pepeu, G. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)00128-3 · Cited by 101 · see citing works

Comparative effects of huperzine A, donepezil and rivastigmine on cortical acetylcholine level and acetylcholinesterase activity in rats

Liang, Y. Q., & Tang, X. C. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2003.12.071 · Cited by 96 · see citing works

The effect of the selective reversible acetylcholinesterase inhibitor E2020 on extracellular acetylcholine and biogenic amine levels in rat cortex

Giacobini, E., Zhu, X., Williams, E., & Sherman, K. (1996) · Neuropharmacology · doi:10.1016/0028-3908(95)00157-3 · Cited by 89 · see citing works

E2020 — The Pharmacology of a Piperidine Cholinesterase Inhibitor

Rogers, S. L., Yamanishi, Y., & Yamatsu, K. (1991) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4899-6738-1_33 · Cited by 88 · see citing works

A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066

Snape, M., Misra, A., Murray, T. K., Souza, R. J. D., Williams, J. L., Cross, A. J., & Green, A. R. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(98)00164-6 · Cited by 85 · see citing works

Rivastigmine is a potent inhibitor of acetyl- and butyrylcholinesterase in Alzheimer's plaques and tangles.

Eskander, M. F., Nagykery, N., Leung, E., Khelghati, B., & Geula, C. (2005) · Brain Research · doi:10.1016/j.brainres.2005.08.039 · Cited by 84 · see citing works

A long-acting cholinesterase inhibitor reverses spatial memory deficits in mice

Sweeney, J. E., Höhmann, C. F., Moran, T. H., & COYLE, J. T. (1988) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(88)90325-5 · Cited by 82 · see citing works

Comparison of Galantamine and Donepezil for Effects on Nerve Growth Factor, Cholinergic Markers, and Memory Performance in Aged Rats

Hernandez, C. M., Gearhart, D. A., Parikh, V., Hohnadel, E. J., Davis, L. W., Middlemore, M.-L., Warsi, S., Waller, J. L., & Terry, A. V. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.093047 · Cited by 79 · see citing works

Amyloid Precursor Protein in Platelets of Patients With Alzheimer Disease

Borroni, B., Colciaghi, F., Pastorino, L., Pettenati, C., Cottini, E., Rozzini, L., Monastero, R., Lenzi, G. L., Cattabeni, F., Luca, M. D., et al. (2001) · Archives of Neurology · doi:10.1001/archneur.58.3.442 · Cited by 79 · see citing works

Anti-dementia drugs and hippocampal-dependent memory in rodents

Yuede, C. M., Dong, H., & Csernansky, J. G. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282da278d · Cited by 76 · see citing works

Non-cholinergic Effects of Huperzine A: Beyond Inhibition of Acetylcholinesterase

Zhang, H., Yan, H., & Tang, X. C. (2007) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-007-9163-z · Cited by 74 · see citing works

Muscarinic acetylcholine receptor inhibition in transgenic Alzheimer‐like Tg2576 mice by scopolamine favours the amyloidogenic route of processing of amyloid precursor protein

Liskowsky, W., & Schliebs, R. (2006) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2005.11.010 · Cited by 73 · see citing works

A novel cholinesterase and brain-selective monoamine oxidase inhibitor for the treatment of dementia comorbid with depression and Parkinson's disease

Weinstock, M., Gorodetsky, E. K., Poltyrev, T., Gross, A., Sagi, Y., & Youdim, M. B. H. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00053-8 · Cited by 73 · see citing works

Cholinesterase inhibitor effects on extracellular acetylcholine in rat striatum

Messamore, E. (1993) · Neuropharmacology · doi:10.1016/0028-3908(93)90114-i · Cited by 72 · see citing works

Huperzine A enhances the level of secretory amyloid precursor protein and protein kinase C-α in intracerebroventricular β-amyloid-(1–40) infused rats and human embryonic kidney 293 Swedish mutant cells

Zhang, H., Yan, H., & Tang, X. C. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.01.055 · Cited by 70 · see citing works

Nootropic drugs and brain cholinergic mechanisms

Pepeu, G., & Spignoli, G. (1989) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(89)90112-7 · Cited by 69 · see citing works

Cholinesterase inhibitors influence APP metabolism in Alzheimer disease patients

Zimmermann, M., Borroni, B., Cattabeni, F., Padovani, A., & Luca, M. D. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.01.002 · Cited by 67 · see citing works

Cholinesterase inhibitors reduce cortical Aβ in dementia with Lewy bodies

Ballard, C. G., Chalmers, K. A., Todd, C. E. C., McKeith, I. G., O'Brien, J. T., Wilcock, G. K., Love, S., & Perry, E. K. (2007) · Neurology · doi:10.1212/01.wnl.0000261920.03297.64 · Cited by 67 · see citing works

Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils.

Zhou, J., Zhang, H.-Y., & Tang, X.-C. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02265-0 · Cited by 66 · see citing works

Effect of subchronic administration of metrifonate, rivastigmine and donepezil on brain acetylcholine in aged F344 rats

Scali, C., Casamenti, F., Bellucci, A., Costagli, C., Schmidt, B. H., & Pepeu, G. (2002) · Journal of Neural Transmission · doi:10.1007/s007020200090 · Cited by 65 · see citing works

Pharmacological evaluation of phenyl-carbamates as CNS-selective acetylcholinesterase inhibitors.

Weinstock, M., Razin, M., Chorev, M., & Enz, A. (1994) · PubMed · Cited by 64 · see citing works

Psychoactive Drugs and Pilot Performance: A Comparison of Nicotine, Donepezil, and Alcohol Effects

Mumenthaler, M. S., Yesavage, J. A., Taylor, J. L., O'Hara, R. M., Friedman, L., Lee, H., & KRAEMER, H. C. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300202 · Cited by 62 · see citing works

Indicators of neuroprotection with galantamine

Geerts, H. (2004) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2004.11.002 · Cited by 61 · see citing works

Bis(7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: comparison with tacrine

Xiao, X. Q., Lee, N. T. K., Carlier, P. R., Pang, Y., & Han, Y. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01357-4 · Cited by 59 · see citing works

N1phenethyl-norcymserine, a selective butyrylcholinesterase inhibitor, increases acetylcholine release in rat cerebral cortex: A comparison with donepezil and rivastigmine

Cerbai, F., Giovannini, M. G., Melani, C., Enz, A., & Pepeu, G. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.06.053 · Cited by 59 · see citing works

Promising anti-Alzheimer’s dimer bis(7)-tacrine reduces β-amyloid generation by directly inhibiting BACE-1 activity

Fu, H., Li, W., Luo, J., Lee, N. T. K., Li, M., Tsim, K. W. K., Pang, Y., Youdim, M. B. H., & Han, Y. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.11.068 · Cited by 56 · see citing works

Cholinesterases in human brain: the effect of cholinesterase inhibitors on Alzheimer's disease and related disorders

Giacobini, E. (2006) · CRC Press eBooks · doi:10.1201/b14486-19 · Cited by 50 · see citing works

Cholinesterase Inhibitors Do More than Inhibit Cholinesterase

Giacobini, E. (1997) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4612-4116-4_29 · Cited by 49 · see citing works

Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students.

Sun, Q. Q., Xu, S., Pan, J. L., Guo, H. M., & Cao, W. Q. (1999) · PubMed · Cited by 47 · see citing works

Cognitive evaluation of disease-modifying efficacy of donepezil in the APP23 mouse model for Alzheimer’s disease

Dam, D. V., Coen, K., & Deyn, P. P. D. (2007) · Psychopharmacology · doi:10.1007/s00213-007-1010-x · Cited by 44 · see citing works

Imaging treatment effects in Alzheimer's disease

Venneri, A. (2007) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2007.02.004 · Cited by 43 · see citing works

Preliminary study of the safety and efficacy of donepezil hydrochloride in children with Down syndrome: A clinical report series

Spiridigliozzi, G. A., Heller, J. H., Crissman, B. G., Sullivan‐Saarela, J. A., Eells, R. L., Dawson, D., Li, J., & Kishnani, P. S. (2007) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.31790 · Cited by 42 · see citing works

Eptastigmine: Ten Years of Pharmacology, Toxicology, Pharmacokinetic, and Clinical Studies

Braida, D., & Sala, M. (2001) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2001.tb00205.x · Cited by 42 · see citing works

Effects of donepezil, nicotine and haloperidol on the central serotonergic system in mice: Implications for Tourette's syndrome

Hayslett, R. L., & Tizabi, Y. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.06.010 · Cited by 40 · see citing works

Cerebral glucose metabolism, cerebrospinal fluid-β-amyloid1–42 (CSF-Aβ42), tau and apolipoprotein E genotype in long-term rivastigmine and tacrine treated Alzheimer disease (AD) patients

Stefanova, E. D., Blennow, K., Almkvist, O., Hellström‐Lindahl, E., & Nordberg, A. K. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(02)01384-8 · Cited by 40 · see citing works

Second generation cholinesterase inhibitors: Effect of (L)‐huperzine‐A on cortical biogenic amines

Zhu, X. ‐., & Giacobini, E. (1995) · Journal of Neuroscience Research · doi:10.1002/jnr.490410613 · Cited by 39 · see citing works

Two-Year Treatment of Alzheimer’s Disease with Eptastigmine

Imbimbo, B. P., Verdelli, G., Martelli, P., Marchesini, D., & and the Eptastigmine Study Group (1999) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017114 · Cited by 38 · see citing works

Add-on Therapy With Acetylcholinesterase Inhibitors for Memory Dysfunction in Schizophrenia

Stip, É., Sepehry, A. A., & Chouinard, S. (2007) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e318059be76 · Cited by 35 · see citing works

Complementary and Alternative Medicines in the Treatment of Dementia

Diamond, B. J., Johnson, S. K., Torsney, K., Morodan, J., Prokop, B. J., Davidek, D., & Kramer, P. (2003) · Drugs & Aging · doi:10.2165/00002512-200320130-00003 · Cited by 35 · see citing works

Co-administration of memantine has no effect on the in vitro or ex vivo determined acetylcholinesterase inhibition of rivastigmine in the rat brain

Enz, A., & Gentsch, C. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.04.009 · Cited by 34 · see citing works

Nonmedical Influences on the Use of Cholinesterase Inhibitors in Dementia Care

Franz, C. E., Barker, J. C., Kravitz, R. L., Flores, Y. G., Krishnan, S., & Hinton, L. (2007) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3181461955 · Cited by 31 · see citing works

Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrine

Li, W., Lee, N. T. K., Fu, H., Kan, K. K. W., Pang, Y., Li, M., Tsim, K. W. K., Li, X., & Han, Y. (2006) · Neuroreport · doi:10.1097/01.wnr.0000209014.09094.72 · Cited by 28 · see citing works

The acetylcholinesterase inhibitor, ENA 713 (Exelon), attenuates the working memory impairment induced by scopolamine in an operant DNMTP task in rats

Ballard, T. M., & McAllister, K. H. (1999) · Psychopharmacology · doi:10.1007/s002130051082 · Cited by 25 · see citing works

Chronic treatments with tacrine and (−)-nicotine induce different changes of nicotinic and muscarinic acetylcholine receptors in the brain of aged rat

Zhang, X., Tian, J., Svensson, A., Gong, Z., Meyerson, B. J., & Nordberg, A. K. (2002) · Journal of Neural Transmission · doi:10.1007/s007020200030 · Cited by 25 · see citing works

Cerebral Acetylcholinesterase Imaging: Development of the Radioprobes

Kikuchi, T., Okamura, T., Fukushi, K., Takahashi, K., Toyohara, J., Okada, M., Zhang, M., & Irie, T. (2007) · Current Topics in Medicinal Chemistry · doi:10.2174/156802607782507466 · Cited by 25 · see citing works

Effects on Cholinergic Markers in Rat Brain and Blood after Short and Prolonged Administration of Donepezil

Haug, K. H., Bogen, I. L., Osmundsen, H., Walaas, I., & Fonnum, F. (2005) · Neurochemical Research · doi:10.1007/s11064-005-8828-6 · Cited by 24 · see citing works

Spatial discrimination deficits by excitotoxic lesions in the Morris water escape task

Spowart-Manning, L., & van der Staay, F. J. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.05.031 · Cited by 24 · see citing works

Tetrahydroaminoacridine induces opposite changes in muscarinic and nicotinic receptors in rat brain

Nilsson-Håkansson, L., Lai, Z., & Nordberg, A. K. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)90448-f · Cited by 22 · see citing works

Tetrahydroaminoacridine and Alzheimer's disease

Byrne, E. J., & Arie, T. (1994) · BMJ · doi:10.1136/bmj.308.6933.868 · Cited by 21 · see citing works

In vivo neurochemical effects of the acetylcholinesterase inhibitor ENA713 in rat hippocampus

Trabace, L., Coluccia, A. M. L., Gaetani, S., Tattoli, M., Cagiano, R., Pietra, C., Kendrick, K. M., & Cuomo, V. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02266-6 · Cited by 21 · see citing works

Cerebrospinal fluid biochemical markers in early detection and in differential diagnosis of dementia disorders in routine clinical practice

Parnetti, L., Lanari, A., Saggese, E., Spaccatini, C., & Gallai, V. (2003) · Neurological Sciences · doi:10.1007/s10072-003-0129-8 · Cited by 21 · see citing works

Effect of subchronic treatment with metrifonate and tacrine on brain cholinergic function in aged F344 rats

Giovannini, M. G., Scali, C., Bartolini, L., Schmidt, B. H., & Pepeu, G. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00429-4 · Cited by 17 · see citing works

CHF2819: Pharmacological Profile of a Novel Acetylcholinesterase Inhibitor

Trabace, L., Cassano, T., Loverre, A., Steardo, L., & Cuomo, V. (2002) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2002.tb00215.x · Cited by 15 · see citing works

Prescription patterns and efficacy of drugs for patients with dementia: physicians’ perspective in Italy

Frisoni, G. B., Canu, E., Geroldi, C., Brignoli, B., Anglani, L., Galluzzi, S., Zacchi, V., & Zanetti, O. O. (2007) · Aging Clinical and Experimental Research · doi:10.1007/bf03324714 · Cited by 15 · see citing works

Donepezil in the Treatment of Narcolepsy

Niederhofer, H. (2006) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.26438 · Cited by 14 · see citing works

Effects of chronic metrifonate treatment on cholinergic enzymes and the blood–brain barrier

Rakonczay, Z., & Papp, H. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(01)00006-7 · Cited by 13 · see citing works

Neurochemical and neurobehavioral effects of ganstigmine (CHF2819), a novel acetylcholinesterase inhibitor, in rat prefrontal cortex: An in vivo study

Trabace, L., Cassano, T., Colaianna, M., Castrignanò, S., Giustino, A., Amoroso, S., Steardo, L., & Cuomo, V. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.07.006 · Cited by 12 · see citing works

Repeated administration of tacrine to normal rats: Effects on cholinergic, glutamatergic, and GABAergic receptor subtypes in rat brain using receptor autoradiography

Sihver, W., Günther, P., Schliebs, R., & Bigl, V. (1997) · Neurochemistry International · doi:10.1016/s0197-0186(97)00010-7 · Cited by 12 · see citing works

Ameliorating Effects of SDZ ENA 713 on Age-Associated Decreases in Learning Performance and Brain Choline Acetyltransferase Activity in Rats

Ohara, T., Fukaya, H., Tanaka, K., & Seno, N. (1997) · Brain Research Bulletin · doi:10.1016/s0361-9230(96)00349-8 · Cited by 11 · see citing works

The cholinergic system in aging and neuronal degeneration

Schliebs, R., & Arendt, T. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.11.058 · Cited by 1,047 · see citing works

Modes and models of forebrain cholinergic neuromodulation of cognition

Hasselmo, M. E., & Sarter, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.104 · Cited by 733 · see citing works

Acetylcholinesterase inhibition-based biosensors for pesticide determination: a review.

Pundir, C., & Chauhan, N. (2012) · Analytical Biochemistry · doi:10.1016/j.ab.2012.06.025 · Cited by 313 · see citing works

Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer’s disease

Guzior, N., Wi.eckowska, A., Panek, D., & Malawska, B. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666141106122628 · Cited by 323 · see citing works

Revisiting the role of acetylcholinesterase in Alzheimer’s disease: cross-talk with P-tau and β-amyloid

García‐Ayllón, M. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00022 · Cited by 303 · see citing works

Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats

Mørk, A., Montezinho, L. P., Miller, S., Trippodi-Murphy, C., Plath, N., Li, Y., Gulinello, M. E., & Sánchez, C. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.01.019 · Cited by 298 · see citing works

Novel Tacrine−8-Hydroxyquinoline Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Neuroprotective, Cholinergic, Antioxidant, and Copper-Complexing Properties

Fernández‐Bachiller, M. I., Pérez, C., González-Muñoz, G. C., Conde, S., López, M. G., Villarroya, M., Garcı́a, A. G., & Rodrı́guez-Franco, M. I. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm100329q · Cited by 270 · see citing works

Drosophila melanogaster in the Study of Human Neurodegeneration

Hirth, F. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710791556104 · Cited by 236 · see citing works

The cholinergic system and spatial learning

Deiana, S., Platt, B., & Riedel, G. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.11.036 · Cited by 234 · see citing works

Design, Synthesis, and Evaluation of Multitarget-Directed Resveratrol Derivatives for the Treatment of Alzheimer’s Disease

Lu, C., Guo, Y., Yan, J., Luo, Z., Luo, H., Yan, M., Huang, L., & Li, X. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm400567s · Cited by 230 · see citing works

Subregional neuroanatomical change as a biomarker for Alzheimer's disease

Holland, D., Brewer, J. B., Hagler, D. J., Fennema-Notestine, C., Dale, A. M., Initiative, T. A. D. N., Weiner, M., Thal, L., Petersen, R., Jack, C. R., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906053106 · Cited by 210 · see citing works

Beyond the Cholinergic Hypothesis: Do Current Drugs Work in Alzheimer's Disease?

Martorana, A., Esposito, Z., & Koch, G. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00175.x · Cited by 174 · see citing works

Cholinergic systems mediate action from movement to higher consciousness

Woolf, N. J., & Butcher, L. L. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.046 · Cited by 163 · see citing works

Acetylcholinesterase inhibitors: a patent review (2008 – present)

Pohanka, M. (2012) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2012.701620 · Cited by 159 · see citing works

Cholinesterase inhibitors and memory

Pepeu, G., & Giovannini, M. G. (2009) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2009.11.018 · Cited by 134 · see citing works

Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer’s disease (1998–2018)

Mishra, P., Kumar, A., & Panda, G. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.01.025 · Cited by 128 · see citing works

From Single Target to Multitarget/Network Therapeutics in Alzheimer’s Therapy

Zheng, H., Fridkin, M., & Youdim, M. B. H. (2014) · Pharmaceuticals · doi:10.3390/ph7020113 · Cited by 119 · see citing works

Inhibition of flavonoids on acetylcholine esterase: binding and structure–activity relationship

Xie, Y., Yang, W., Chen, X., & Xiao, J. (2014) · Food & Function · doi:10.1039/c4fo00287c · Cited by 119 · see citing works

Design, synthesis and biological evaluation of new coumarin-dithiocarbamate hybrids as multifunctional agents for the treatment of Alzheimer's disease

Jiang, N., Huang, Q., Liu, J., Liang, N., Li, Q., Li, Q., & Xie, S. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.01.055 · Cited by 111 · see citing works

Benefits of combined cholinesterase inhibitor and memantine treatment in moderate–severe Alzheimer's disease

Gauthier, S. G., & Molinuevo, J. L. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.11.005 · Cited by 111 · see citing works

Design, synthesis, in-silico and biological evaluation of novel donepezil derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease

Mishra, C. B., Kumari, S., Manral, A., Prakash, A., Saini, V., Lynn, A. M., & Tiwari, M. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.09.057 · Cited by 108 · see citing works

Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation

Wu, M., Esteban, G., Brogi, S., Shionoya, M., Wang, L., Campiani, G., Unzeta, M., Inokuchi, T., Butini, S., & Marco‐Contelles, J. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.10.001 · Cited by 104 · see citing works

Scopolamine-induced learning impairment reversed by physostigmine in zebrafish

Kim, Y., Lee, Y., Kim, D., Jung, M. W., & Lee, C. (2010) · Neuroscience Research · doi:10.1016/j.neures.2010.03.003 · Cited by 100 · see citing works

Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation

Panek, D., Więckowska, A., Wichur, T., Bajda, M., Godyń, J., Jończyk, J., Mika, K., Janočková, J., Soukup, O., Knez, D., et al. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.09.078 · Cited by 98 · see citing works

Design, synthesis and evaluation of novel tacrine–rhein hybrids as multifunctional agents for the treatment of Alzheimer's disease

Li, S., Jiang, N., Xie, S., Wang, K. D. G., Wang, X., & Kong, L. (2013) · Organic & Biomolecular Chemistry · doi:10.1039/c3ob42010h · Cited by 96 · see citing works

Recent Advances in the Synthesis and Biological Activity of 8-Hydroxyquinolines

Saadeh, H. A., Sweidan, K., & Mubarak, M. S. (2020) · Molecules · doi:10.3390/molecules25184321 · Cited by 96 · see citing works

Anti-amyloid Aggregation Activity of Natural Compounds: Implications for Alzheimer’s Drug Discovery

Bu, X., Rao, P. P. N., & Wang, Y. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9301-4 · Cited by 93 · see citing works

Synthesis and biological evaluation of deferiprone-resveratrol hybrids as antioxidants, Aβ 1–42 aggregation inhibitors and metal-chelating agents for Alzheimer's disease

Xu, P., Zhang, M., Sheng, R., & Ma, Y. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.12.045 · Cited by 92 · see citing works

New multi-target-directed small molecules against Alzheimer's disease: a combination of resveratrol and clioquinol

Mao, F., Yan, J., Li, J., Jia, X., Miao, H., Sun, Y., Huang, L., & Li, X. (2014) · Organic & Biomolecular Chemistry · doi:10.1039/c4ob00998c · Cited by 91 · see citing works

Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease

Huang, L., Miao, H., Sun, Y., Meng, F., & Li, X. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.09.081 · Cited by 80 · see citing works

Synthesis, bioactivity and binding energy calculations of novel 3-ethoxysalicylaldehyde based thiosemicarbazone derivatives

Ishaq, M., Taslımı, P., Shafiq, Z., Khan, S., Salmas, R. E., Zangeneh, M. M., Saeed, A., Zangeneh, A., Sadeghian, N., Asari, A., et al. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.103924 · Cited by 79 · see citing works

Midlife predictors of Alzheimer's disease

Bendlin, B. B., Carlsson, C. M., Gleason, C. E., Johnson, S. C., Sodhi, A., Gallagher, C. L., Puglielli, L., Engelman, C. D., Ries, M. L., Xu, G., et al. (2009) · Maturitas · doi:10.1016/j.maturitas.2009.12.014 · Cited by 77 · see citing works

Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease

Li, Y., Qiang, X., Luo, L., Xia, Y., Xiao, G., Liu, Q., Ai, J., Tan, Z., & Deng, Y. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.12.009 · Cited by 75 · see citing works

Galantamine, an Acetylcholinesterase Inhibitor and Positive Allosteric Modulator of Nicotinic Acetylcholine Receptors, Attenuates Nicotine Taking and Seeking in Rats

Hopkins, T. J., Rupprecht, L. E., Hayes, M. R., Blendy, J. A., & Schmidt, H. D. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.83 · Cited by 71 · see citing works

Rivastigmine Lowers Aβ and Increases sAPPα Levels, Which Parallel Elevated Synaptic Markers and Metabolic Activity in Degenerating Primary Rat Neurons

Bailey, J. A., Ray, B., Greig, N. H., & Lahiri, D. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021954 · Cited by 70 · see citing works

Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and β-amyloid aggregation inhibitors with neuroprotective properties

Szałaj, N., Bajda, M., Skrok, M., Kurpiewska, K., Lewiński, K., Brus, B., Pišlar, A. H., Kos, J., Gobec, S., & Malawska, B. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.01.027 · Cited by 69 · see citing works

Neuroactive Multifunctional Tacrine Congeners with Cholinesterase, Anti-Amyloid Aggregation and Neuroprotective Properties

Kožurková, M., Hamuľaková, S., Gažová, Z., Paulíková, H., & Kristián, P. (2011) · Pharmaceuticals · doi:10.3390/ph4020382 · Cited by 68 · see citing works

Neuroprotective effects of donepezil against cholinergic depletion

Cutuli, D., Bartolo, P. D., Caporali, P., Tartaglione, A. M., Oddi, D., D'Amato, F. R., Nobili, A., D’Amelio, M., & Petrosini, L. (2013) · Alzheimer s Research & Therapy · doi:10.1186/alzrt215 · Cited by 68 · see citing works

Activation of Neurotensin Receptor 1 Facilitates Neuronal Excitability and Spatial Learning and Memory in the Entorhinal Cortex: Beneficial Actions in an Alzheimer's Disease Model

Xiao, Z., Cilz, N. I., Kurada, L., Hu, B., Yang, C., Wada, E., Combs, C. K., Porter, J. E., Lesage, F., & Lei, S. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0408-14.2014 · Cited by 64 · see citing works

Design, Synthesis, and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium‐like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors

Pisani, L., Catto, M., Giangreco, I., Leonetti, F., Nicolotti, O., Stefanachi, A., Cellamare, S., & Carotti, A. (2010) · ChemMedChem · doi:10.1002/cmdc.201000210 · Cited by 64 · see citing works

Pharmacological targeting of cognitive impairment in depression: recent developments and challenges in human clinical research

Colwell, M., Tagomori, H., Chapman, S., Gillespie, A. L., Cowen, P. J., Harmer, C. J., & Murphy, S. E. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02249-6 · Cited by 63 · see citing works

O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: Multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-β aggregation

Mao, F., Huang, L., Luo, Z., Liu, A., Lu, C., Xie, Z., & Li, X. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.07.045 · Cited by 63 · see citing works

Acetylcholinesterase inhibitors and the risk of hip fracture in Alzheimer's disease patients: A case-control study

Tamimi, I., Ojea, T., Sánchez-Siles, J.-M., Rojas, F., Martin, I., Gormaz, I., Perez, A., Dawid-Milner, M. S., Mendez, L., & Tamimi, F. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1616 · Cited by 62 · see citing works

Design, synthesis, and biological evaluation of 2-arylethenylquinoline derivatives as multifunctional agents for the treatment of Alzheimer's disease

Wang, X., Xia, C., Chen, S.-B., Tan, J., Ou, T., Huang, S., Li, D., Gu, L., & Huang, Z. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.10.018 · Cited by 60 · see citing works

Design, synthesis and anti-Alzheimer's disease activity study of xanthone derivatives based on multi-target strategy

Kou, X., Song, L., Wang, Y., Yu, Q., Ju, H., Yang, A., & Shen, R. (2019) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2019.126927 · Cited by 59 · see citing works

Design, synthesis and evaluation of chromone-2-carboxamido-alkylbenzylamines as multifunctional agents for the treatment of Alzheimer’s disease

Liu, Q., Qiang, X., Li, Y., Sang, Z., Li, Y., Tan, Z., & Deng, Y. (2015) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2015.01.042 · Cited by 58 · see citing works

DL0410 Ameliorates Memory and Cognitive Impairments Induced by Scopolamine via Increasing Cholinergic Neurotransmission in Mice

Lian, W., Fang, J., Xu, L., Zhou, W., Kang, D., Xiong, W., Jia, H., Liu, A., & Du, G. (2017) · Molecules · doi:10.3390/molecules22030410 · Cited by 58 · see citing works

New multifunctional melatonin-derived benzylpyridinium bromides with potent cholinergic, antioxidant, and neuroprotective properties as innovative drugs for Alzheimer's disease

Luo, X., Wang, C., Liu, Y., & Huang, Z. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.08.052 · Cited by 57 · see citing works

Design, Synthesis and Evaluation of Novel 2‐(Aminoalkyl)‐isoindoline‐1,3‐dione Derivatives as Dual‐Binding Site Acetylcholinesterase Inhibitors

Ignasik, M., Bajda, M., Szałaj, N., Prinz, M., Holzgrabe, U., & Malawska, B. (2012) · Archiv der Pharmazie · doi:10.1002/ardp.201100423 · Cited by 56 · see citing works

The ethics of elective psychopharmacology

Mohamed, A. D., & Sahakian, B. J. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114571100037x · Cited by 55 · see citing works

Synthesis and evaluation of novel GSK-3β inhibitors as multifunctional agents against Alzheimer's disease

Shi, X., Wu, J., Liu, P., & Liu, Z. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.02.001 · Cited by 55 · see citing works

Chromone and donepezil hybrids as new multipotent cholinesterase and monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease

Wang, X., Yin, F., Huang, M. Y., Jiang, N., Lan, J., & Kong, L. (2020) · RSC Medicinal Chemistry · doi:10.1039/c9md00441f · Cited by 54 · see citing works

Rivastigmine for Refractory REM Behavior Disorder in Mild Cognitive Impairment

Brunetti, V., Losurdo, A., Testani, E., Lapenta, L., Mariotti, P., Marra, C., Rossini, P. M., & Marca, G. D. (2014) · Current Alzheimer Research · doi:10.2174/1567205011666140302195648 · Cited by 53 · see citing works

Design, synthesis and evaluation of novel indandione derivatives as multifunctional agents with cholinesterase inhibition, anti-β-amyloid aggregation, antioxidant and neuroprotection properties against Alzheimer’s disease

Mishra, C. B., Manral, A., Kumari, S., Saini, V., & Tiwari, M. (2016) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2016.06.027 · Cited by 53 · see citing works

Synthesis and evaluation of clioquinol-rolipram/roflumilast hybrids as multitarget-directed ligands for the treatment of Alzheimer’s disease

Hu, J., Pan, T., An, B., Li, Z., Li, X., & Huang, L. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.12.013 · Cited by 53 · see citing works

Cholinergic and serotonergic modulation of resting state functional brain connectivity in Alzheimer's disease

Klaassens, B. L., van Gerven, J., Klaassen, E. S., van der Grond, J., & Rombouts, S. A. R. B. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.05.044 · Cited by 52 · see citing works

Do Cholinesterase Inhibitors Act Primarily on Attention Deficit? A Naturalistic Study in Alzheimer's Disease Patients

Bracco, L., Bessi, V., Padiglioni, S., Marini, S., & Pepeu, G. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131154 · Cited by 51 · see citing works

Molecular docking and receptor-specific 3D-QSAR studies of acetylcholinesterase inhibitors

Deb, P. K., Sharma, A., Piplani, P., & Akkinepally, R. R. (2012) · Molecular Diversity · doi:10.1007/s11030-012-9394-x · Cited by 51 · see citing works

Selective Acetyl- and Butyrylcholinesterase Inhibitors Reduce Amyloid-β Ex Vivo Activation of Peripheral Chemo-cytokines From Alzheimer’s Disease Subjects: Exploring the Cholinergic Anti-inflammatory Pathway

Reale, M., Nicola, M. D., Velluto, L., D’Angelo, C., Costantini, E., Lahiri, D. K., Kamal, M. A., Yu, Q.-S., & Greig, N. H. (2014) · Current Alzheimer Research · doi:10.2174/1567205010666131212113218 · Cited by 51 · see citing works

Design, synthesis and evaluation of quinolinone derivatives containing dithiocarbamate moiety as multifunctional AChE inhibitors for the treatment of Alzheimer’s disease

Fu, J., Bao, F., Gu, M., Liu, J., Zhang, Z., Ding, J., Xie, S., & Ding, J. (2019) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2019.1687460 · Cited by 50 · see citing works

Galantamine protects against lipopolysaccharide-induced acute lung injury in rats

Li, G., Zhou, C., Zhou, Q., & Zou, H. (2016) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20155008 · Cited by 46 · see citing works

Novel chromanone-dithiocarbamate hybrids as multifunctional AChE inhibitors with β-amyloid anti-aggregation properties for the treatment of Alzheimer’s disease

Jiang, N., Ding, J., Liu, J., Sun, X., Zhang, Z., Mo, Z., Li, X., Yin, H. Z., Tang, W., & Xie, S. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.103027 · Cited by 46 · see citing works

Synthesis and Biological Evaluation of Some Pyrazoline Derivatives Bearing a Dithiocarbamate Moiety as New Cholinesterase Inhibitors

Altıntop, M. D., Özdemır, A., Kaplancıklı, Z. A., Turan‐Zitouni, G., Temel, H. E., & Çiftçi, G. A. (2013) · Archiv der Pharmazie · doi:10.1002/ardp.201200384 · Cited by 43 · see citing works

Cholinergic Signaling Dynamics and Cognitive Control of Attention

Parikh, V., & Bangasser, D. A. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_133 · Cited by 42 · see citing works

The dual-acting AChE inhibitor and H3 receptor antagonist UW-MD-72 reverses amnesia induced by scopolamine or dizocilpine in passive avoidance paradigm in rats

Sadek, B. S., Khan, N., Darras, F. H., Pockes, S., & Decker, M. W. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.08.022 · Cited by 42 · see citing works

Rivastigmine patch reduces the incidence of postoperative delirium in older patients with cognitive impairment

Youn, Y. C., Shin, H., Choi, B., Kim, S., Lee, J.-Y., & Ha, Y. (2016) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4569 · Cited by 42 · see citing works

Concomitant Use of Cholinesterase Inhibitors and Anticholinergics: Prevalence and Outcomes

Boudreau, D. M., Yu, O., Gray, S. L., Raebel, M. A., Johnson, J., & Larson, E. B. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03654.x · Cited by 42 · see citing works

Synthesis and Evaluation of Paeonol Derivatives as Potential Multifunctional Agents for the Treatment of Alzheimer’s Disease

Zhou, A., Wu, H., Pan, J., Wang, X., Li, J., Wu, Z., & Hui, A. (2015) · Molecules · doi:10.3390/molecules20011304 · Cited by 41 · see citing works

Discovery of boron-containing compounds as Aβ aggregation inhibitors and antioxidants for the treatment of Alzheimer's disease

Lu, C., Hu, J., Wang, Z., Xie, S., Pan, T., Huang, L., & Li, X. (2018) · MedChemComm · doi:10.1039/c8md00315g · Cited by 40 · see citing works

New Pharmacological Approaches to the Cholinergic System: An Overview on Muscarinic Receptor Ligands and Cholinesterase Inhibitors

Greig, N. H., Reale, M., & Tata, A. M. (2013) · Recent Patents on CNS Drug Discovery · doi:10.2174/1574889811308020003 · Cited by 41 · see citing works

The dual-acting H3 receptor antagonist and AChE inhibitor UW-MD-71 dose-dependently enhances memory retrieval and reverses dizocilpine-induced memory impairment in rats

Khan, N., Saad, A. K., Nurulain, S. M., Darras, F. H., Decker, M. W., & Sadek, B. S. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.10.022 · Cited by 40 · see citing works

Dual functional cholinesterase and PDE4D inhibitors for the treatment of Alzheimer’s disease: Design, synthesis and evaluation of tacrine-pyrazolo[3,4-b]pyridine hybrids

Pan, T., Xie, S., Zhou, Y., Hu, J., Luo, H., Li, X., & Huang, L. (2019) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2019.06.056 · Cited by 40 · see citing works

Receptor-Mediated Suppression of Potassium Currents Requires Colocalization within Lipid Rafts

Oldfield, S., Hancock, J. M., Mason, A., Hobson, S. A., Wynick, D., Kelly, E., Randall, A. D., & Marrion, N. V. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.058008 · Cited by 39 · see citing works

Synthesis and biological evaluation of some thiazole derivatives as new cholinesterase inhibitors

Turan‐Zitouni, G., Özdemır, A., Kaplancıklı, Z. A., Altıntop, M. D., Temel, H. E., & Çiftçi, G. A. (2012) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2011.653355 · Cited by 38 · see citing works

Donepezil regulates energy metabolism and favors bone mass accrual

Eimar, H. A., Alebrahim, S., Manickam, G., Alsubaie, A., Nada, L. A., Murshed, M., & Tamimi, F. (2015) · Bone · doi:10.1016/j.bone.2015.12.009 · Cited by 37 · see citing works

Derivatives and Analogues of Resveratrol: Recent Advances in Structural Modification

Li, Q., Li, Y., Deora, G. S., & Ruan, B. (2019) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557519666190128093840 · Cited by 36 · see citing works

Alzheimer’s disease biomarker discovery in symptomatic and asymptomatic patients: Experimental approaches and future clinical applications

Ho, L., Fivecoat, H. C., Wang, J., & Pasinetti, G. M. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.09.007 · Cited by 37 · see citing works

AChE as a spark in the Alzheimer’s blaze – Antagonizing effect of a cyclized variant

Behl, T., Kaur, I., Sehgal, A., Singh, S., Sharma, N., Gupta, S., Albratty, M., Najmi, A., Alhazmi, H. A., & BUNGAU, S. G. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101787 · Cited by 34 · see citing works

Acetylcholinesterase inhibitors and healing of hip fracture in Alzheimer's disease patients: a retrospective cohort study.

Eimar, H. A., Lara, A. P., Tamimi, I., Sánchez, P. M., Talavera, I. G., Tomba, F. R., de la Oliva, T. G., & Tamimi, F. (2013) · PubMed · Cited by 34 · see citing works

Design, synthesis and biological evaluation of novel carboline-cinnamic acid hybrids as multifunctional agents for treatment of Alzheimer’s disease

Liao, Q., Li, Q., Zhao, Y., Jiang, P. H., Yan, Y., Sun, H., Liu, W., Feng, F., & Qu, W. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.103844 · Cited by 33 · see citing works

Kinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving group

Bartolucci, C., Stojan, J., Yu, Q., Greig, N. H., & Lamba, D. (2012) · Biochemical Journal · doi:10.1042/bj20111675 · Cited by 31 · see citing works

Ethoxylated Head of Chalcones as a New Class of Multi‐Targeted MAO Inhibitors

Lakshminarayanan, B., Baek, S. C., Lee, J. P., Kannappan, N., Mangiatordi, G. F., Nicolotti, O., Subburaju, T., Kim, H., & Mathew, B. (2019) · ChemistrySelect · doi:10.1002/slct.201901093 · Cited by 31 · see citing works

A Unique GSK-3β inhibitor B10 Has a Direct Effect on Aβ, Targets Tau and Metal Dyshomeostasis, and Promotes Neuronal Neurite Outgrowth

Shi, X., Yan, N., Cui, Y., & Liu, Z. (2020) · Cells · doi:10.3390/cells9030649 · Cited by 31 · see citing works

Promising heterocycle-based scaffolds in recent (2019–2021) anti-Alzheimer's drug design and discovery

Dorababu, A. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174847 · Cited by 31 · see citing works

Cognitive Enhancers (Nootropics). Part 2: Drugs Interacting with Enzymes

Froestl, W., Muhs, A., & Pfeifer, A. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-121537 · Cited by 31 · see citing works

Behavioral, neuromorphological, and neurobiochemical effects induced by omega-3 fatty acids following basal forebrain cholinergic depletion in aged mice

Cutuli, D., Landolfo, E., Nobili, A., Bartolo, P. D., Sacchetti, S., Chirico, D., Marini, F., Pieroni, L., Ronci, M., D’Amelio, M., et al. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00705-3 · Cited by 29 · see citing works

Aged dogs demonstrate both increased sensitivity to scopolamine impairment and decreased muscarinic receptor density

Araujo, J. A., Nóbrega, J. N., Raymond, R., & Milgram, N. W. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.01.005 · Cited by 28 · see citing works

Design, synthesis and evaluation of clioquinol–ebselen hybrids as multi-target-directed ligands against Alzheimer's disease

Wang, Z., Li, W., Wang, Y., Li, X., Huang, L., & Li, X. (2016) · RSC Advances · doi:10.1039/c5ra26797h · Cited by 29 · see citing works

Dual‐Acting Diether Derivatives of Piperidine and Homopiperidine with Histamine H3 Receptor Antagonistic and Anticholinesterase Activity

Bajda, M., Kuder, K., Łażewska, D., Kieć‐Kononowicz, K., Więckowska, A., Ignasik, M., Szałaj, N., Jończyk, J., & Malawska, B. (2012) · Archiv der Pharmazie · doi:10.1002/ardp.201200018 · Cited by 28 · see citing works

Solanocapsine derivatives as potential inhibitors of acetylcholinesterase: Synthesis, molecular docking and biological studies

García, M. E., Borioni, J. L., Cavallaro, V., Puiatti, M., Pierini, A. B., Murray, A. P., & Peñéñory, A. B. (2015) · Steroids · doi:10.1016/j.steroids.2015.09.001 · Cited by 27 · see citing works

Cilostazol improves hippocampus-dependent long-term memory in mice

Yanai, S., Semba, Y., Ito, H., & Endo, S. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3442-4 · Cited by 27 · see citing works

Donepezil, an acetylcholinesterase inhibitor, attenuates nicotine self‐administration and reinstatement of nicotine seeking in rats

Kimmey, B. A., Rupprecht, L. E., Hayes, M. R., & Schmidt, H. D. (2012) · Addiction Biology · doi:10.1111/adb.12014 · Cited by 29 · see citing works

Cardiovascular Dementia - A Different Perspective

Kumari, U., & Heese, K. (2010) · The Open Biochemistry Journal · doi:10.2174/1874091x01004010029 · Cited by 27 · see citing works

Synthesis and evaluation of 8-hydroxyquinolin derivatives substituted with (benzo[d][1,2]selenazol-3(2H)-one) as effective inhibitor of metal-induced Aβ aggregation and antioxidant

Wang, B., Wang, Z., Chen, H., Lu, C., & Li, X. (2016) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2016.08.017 · Cited by 25 · see citing works

Anxiolytic effects of an acetylcholinesterase inhibitor, physostigmine, in the adult zebrafish

Cho, H., Lee, C., Choi, J., Hwang, J., & Lee, Y. (2011) · Animal Cells and Systems · doi:10.1080/19768354.2011.642084 · Cited by 25 · see citing works

Synthesis and Biological Evaluation of a Series of Dithiocarbamates as New Cholinesterase Inhibitors

Altıntop, M. D., Gurkan‐Alp, A. S., Özkay, Y., & Kaplancıklı, Z. A. (2013) · Archiv der Pharmazie · doi:10.1002/ardp.201300045 · Cited by 24 · see citing works

PDE3 Inhibitors Repurposed as Treatments for Age-Related Cognitive Impairment

Yanai, S., & Endo, S. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1374-4 · Cited by 24 · see citing works

Identification of Potent and Selective Acetylcholinesterase/Butyrylcholinesterase Inhibitors by Virtual Screening

Xu, T., Li, S., Li, A. J., Zhao, J., Sakamuru, S., Huang, W., Xia, M., & Huang, R. (2023) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.3c00230 · Cited by 24 · see citing works

Discovery of butyrylcholinesterase inhibitors among derivatives of azaphenothiazines

Lodarski, K., Jończyk, J., Szałaj, N., Bajda, M., Gładysz, J., Walczyk, J., Jeleń, M., MORAK-MŁODAWSKA, B. I., Pluta, K., & Malawska, B. (2014) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2014.889127 · Cited by 24 · see citing works

Discovery of 4′-OH-flurbiprofen Mannich base derivatives as potential Alzheimer’s disease treatment with multiple inhibitory activities

Liu, H., Qiang, X., Song, Q., Li, W., He, Y., Ye, C., Tan, Z., & Deng, Y. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.01.040 · Cited by 25 · see citing works

Acetylcholinesterase Inhibitors and Alzheimer’s Disease

Kaduszkiewicz, H., & van den Bussche, H. (2009) · Elsevier eBooks · doi:10.1016/b978-008045046-9.01129-3 · Cited by 6 · see citing works

A Clinical Overview of Cholinesterase Inhibitors in Alzheimer’s Disease

Farlow, M. R. (2002) · International Psychogeriatrics · doi:10.1017/s1041610203008688 · Cited by 100 · see citing works

Cholinesterase Inhibitors for Alzheimer??s Disease

Grutzendler, J., & Morris, J. C. (2001) · Drugs · doi:10.2165/00003495-200161010-00005 · Cited by 270 · see citing works

O4–03–03: The evidence for cholinesterase inhibitors for Alzheimer's disease

Birks, J. (2006) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2006.05.311 · Cited by 2 · see citing works

Cholinesterase Inhibitors for Alzheimer's Disease: Multitargeting Strategy Based on Anti-Alzheimer's Drugs Repositioning

Kabir, M. T., Uddin, M. S., Begum, M. M., Thangapandiyan, S., Rahman, M. S., Aleya, L., Mathew, B., Ahmed, M., Barreto, G. E., & Ashraf, G. M. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191008103141 · Cited by 119 · see citing works