The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
Triazole derivatives and their antiplasmodial and antimalarial activities
Abstract
Malaria, caused by protozoan parasites of the genus Plasmodium especially by the most prevalent parasite Plasmodium falciparum, represents one of the most devastating and common infectious disease globally. Nearly half of the world population is under the risk of being infected, and more than 200 million new clinical cases with around half a million deaths occur annually. Drug therapy is the mainstay of antimalarial therapy, yet current drugs are threatened by the development of resistance, so it's imperative to develop new antimalarials with great potency against both drug-susceptible and drug-resistant malaria. Triazoles, bearing a five-membered heterocyclic ring with three nitrogen atoms, exhibit promising in vitro antiplasmodial and in vivo antimalarial activities. Moreover, several triazole-based drugs have already used in clinics for the treatment of various diseases, demonstrating the excellent pharmaceutical profiles. Therefore, triazole derivatives have the potential for clinical deployment in the control and eradication of malaria. This review covers the recent advances of triazole derivatives especially triazole hybrids as potential antimalarials. The structure-activity relationship is also discussed to provide an insight for rational designs of more efficient antimalarial candidates.
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Citations
Cites
Weltgesundheitsorganisation (2005) · Cited by 3,799
Triazoles and tetrazoles: Prime ligands to generate remarkable coordination materials
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Medicinal attributes of 1,2,3-triazoles: Current developments
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The 1,2,3-triazole ring as a bioisostere in medicinal chemistry
Bonandi, E., Christodoulou, M. S., Fumagalli, G., Perdicchia, D., Rastelli, G., & Passarella, D. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.05.014 · Cited by 743
Quinolines and structurally related heterocycles as antimalarials
Kaur, K., Jain, M., Reddy, R. P., & Jain, R. (2010) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2010.04.011 · Cited by 727
Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view
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An insight on medicinal attributes of 1,2,4-triazoles
Aggarwal, R., & Sumran, G. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112652 · Cited by 317
Pillaiyar, T., Meenakshisundaram, S., Manickam, M., & Sankaranarayanan, M. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112275 · Cited by 140
Novel 1, 2, 4‐Triazoles as Antifungal Agents
Kazeminejad, Z., Marzi, M., Shiroudi, A., Kouhpayeh, S. A., Farjam, M., & Zarenezhad, E. (2022) · BioMed Research International · doi:10.1155/2022/4584846 · Cited by 102
Metadata
- Authors
- Chu, X.-M., Wang, C., Wang, W.-L., Liang, L.-L., Liu, W., Gong, K.-K., & Sun, K.-L.
- Venue
- European Journal of Medicinal Chemistry
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 166
- Pages
- 206-223
- ISSN
- 0223-5234 (ISSN-L)
- OpenAlex
- W2914146788
- Cited by
- 287
- References
- 77
- FWCI
- 27.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chu, X.-M., Wang, C., Wang, W.-L., Liang, L.-L., Liu, W., Gong, K.-K., & Sun, K.-L. (2019). Triazole derivatives and their antiplasmodial and antimalarial activities. European Journal of Medicinal Chemistry. https://doi.org/10.1016/j.ejmech.2019.01.047
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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