Cited by 144Computational Drug Discovery MethodsHistorical Medical Research and TreatmentsPharmaceutical Economics and Policy

A medicinal chemistry perspective of drug repositioning: Recent advances and challenges in drug discovery

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Pillaiyar, Thanigaimalai, Meenakshisundaram, Sangeetha, Manickam, Manoj, Sankaranarayanan, Murugesan·2020·European Journal of Medicinal Chemistry

Abstract

Drug repurposing is a strategy consisting of finding new indications for already known marketed drugs used in various clinical settings or highly characterized compounds despite they can be failed drugs. Recently, it emerges as an alternative approach for the rapid identification and development of new pharmaceuticals for various rare and complex diseases for which lack the effective drug treatments. The success rate of drugs repurposing approach accounts for approximately 30% of new FDA approved drugs and vaccines in recent years. This review focuses on the status of drugs repurposing approach for various diseases including skin diseases, infective, inflammatory, cancer, and neurodegenerative diseases. Efforts have been made to provide structural features and mode of actions of drugs.

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Crossref · 10.1016/j.ejmech.2020.112275

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  • Drug repurposing can shorten the research timeline for discovering new molecules by approximately 50%-60% by utilizing chemically well-characterized and biologically safe molecules.

    “One of the main goals of drug repurposing is to shorten the research timeline for discovering new molecules by approximately 50%–60% by utilizing chemically well‐characterized and biologically safe molecules [91].”

    From Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies (2025) · cites this paper as [91]

    The Introduction says repurposing uses known drugs or highly characterized compounds and can bypass early development stages, reducing time to market. The Conclusions and perspectives likewise describe established safety and substantial time savings. Neither passage supports the specific 50%–60% reduction, and the paper describes finding new uses for known compounds rather than discovering new molecules. (LLM, conf=0.87)

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4 of the 202 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

  1. [80]Broughton T. Sington J. Beales I.L.B. Statin use is associated with a reduced incidence of colorectal cancer: a colonoscopy-controlled case-control study BMC Gastroenterol. 12 2012 36 44 22530742 PMC3423077
  2. [184]https://content.iospress.com/articles/journal-of-parkinsons-disease/jpd190002

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Authors
Pillaiyar, T., Meenakshisundaram, S., Manickam, M., & Sankaranarayanan, M.
Affiliations
  • University of Bonn (DE)
  • PSG INSTITUTE OF TECHNOLOGY AND APPLIED RESEARCH (IN)
Corresponding author
Pillaiyar, Thanigaimalai
Venue
European Journal of Medicinal Chemistry
Publisher
Elsevier BV
Published
2020-06
Volume
195
Pages
112275
ISSN
0223-5234 (ISSN-L)
OpenAlex
W3013498471
Cited by
140
References
202
Citations by year
2026: 13 · 2025: 25 · 2024: 18 · 2023: 25 · 2022: 26 · 2021: 15 · 2020: 17 · 2019: 1
FWCI
1.91
Type
journal article
Language
en
Open access
Locations
  • European Journal of Medicinal Chemistry (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • PSG
  • PSG Institute of Technology and Applied Research
Topics
  • Physical Sciences › Computer Science › Computational Theory and Mathematics › Computational Drug Discovery Methods
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Historical Medical Research and Treatments
  • Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Pharmaceutical Economics and Policy
Keywords
drug repurposing, marketed drugs, rare diseases, skin diseases, infectious diseases, inflammatory diseases, cancer, neurodegenerative diseases, structural features, mechanism of action
MeSH terms
Animals, Chemistry, Pharmaceutical, Humans, Drug Discovery, Drug Repositioning

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