CoChat
Sign Up
Cited by 7Endometriosis Research and TreatmentReproductive tract infections researchGynecological conditions and treatments

Prediction of pelvic pathology in subfertile women with combined Chlamydia antibody and CA-125 tests

Penninx, Josien, Brandes, Monique, de Bruin, Jan Peter, Schneeberger, Peter M., Hamilton, Carl J.C.M.·2009·European Journal of Obstetrics & Gynecology and Reproductive Biology
DOI 10.1016/j.ejogrb.2009.08.004
Open this paper in CoChat — free account

Abstract

Objectives Chlamydia antibody test (CAT) has been proposed to predict tubal disease. A correlation between CA-125 and the extent of endometriosis has been found by others. In this study we explored whether a combination of the two tests adds to the predictive value of the individual tests for predicting tubal disease or endometriosis. We also used the combination of tests as a new index test to screen for severe pelvic pathology.Study design This retrospective study compares the findings of 240 laparoscopies with the serological test results. Findings were classified according to the existing ASRM scoring systems for adnexal adhesions, distal tubal occlusion and endometriosis. Severe pelvic pathology was defined as the presence of ASRM classes III and IV tubal disease or ASRM classes III and IV endometriosis. The predictive value was calculated for both tests separately and for the combined test. The combined test was positive if at least one test result was abnormal (CAT positive and/or CA-125 > or =35 IU/ml).Results 67/240 women had tubal disease, 81/240 had some degree of endometriosis. The odds ratios (ORs) of the CAT and the combined test to diagnose severe tubal disease were 6.6 (2.6-17.0) and 7.3 (2.9-19.3), respectively. The ORs of the CA-125 and the combined test to diagnose severe endometriosis were 15.6 (6.2-40.2) and 3.0 (1.2-8.0), respectively. Severe pelvic pathology was present in 65/240 women (27%). The ORs for severe pelvic pathology of the CAT, CA-125 and the combined test were 2.5 (1.4-5.3), 4.9 (1.9-9.6) and 6.6 (3.3-13.4), respectively. If the combined test was normal 15 out 131 women (11%) were shown to have severe pelvic pathology.Conclusions The combined test adds hardly anything to the predictive value of CAT alone to diagnose severe tubal disease. The combined test is better than the CAT to predict severe pelvic pathology, but is not significantly better than the CA-125. If both the CAT and CA-125 are normal one could consider not performing a laparoscopy.

Integrity signals

Registry

Crossref · 10.1016/j.ejogrb.2009.08.004

Cites

16 of 16 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Combinations of CA-125 with urocortin, chlamydia antibody, CD23, and inflammatory cytokines did not provide sufficiently high sensitivity or specificity for endometriosis and results remained unvalidated.

    “CA-125 has been measured simultaneously with urocortin [34], chlamydia antibody [35], CD23 [39], and inflammatory cytokines [32]. However, none of these combinations provided a sufficiently high sensitivity or specificity for endometriosis and results remained unvalidated.”

    From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [35]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Penninx, J., Brandes, M., de Bruin, J. P., Schneeberger, P. M., & Hamilton, C. J. C. M.
Affiliations
Jeroen Bosch Ziekenhuis (NL)
Corresponding author
Hamilton, Carl J.C.M.
ORCID
Venue
European Journal of Obstetrics & Gynecology and Reproductive Biology
Publisher
Elsevier BV
Published
2009-12
Volume
147
Issue
2
Pages
178-182
ISSN
  • 0028-2243 (ISSN-L)
  • 0301-2115
DOI
10.1016/j.ejogrb.2009.08.004
OpenAlex
W1975640214
Cited by
7
References
16
Citations by year
2020: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2012: 1
FWCI
0.79
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • European Journal of Obstetrics & Gynecology and Reproductive Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
Keywords
CA125, pelvic pathology, tubal disease, endometriosis, subfertility, diagnostic predictive value, adnexal adhesions, distal tubal occlusion, laparoscopic findings
MeSH terms
Adult, Antibodies, Bacterial, Chlamydia, Endometriosis, Fallopian Tube Diseases, Female, Humans, Hysterosalpingography, Predictive Value of Tests, Retrospective Studies, CA-125 Antigen

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review