Diagnostic accuracy of cancer antigen 125 for endometriosis: A systematic review and meta-analysis
Abstract
BACKGROUND: The development of a non-invasive and accurate diagnostic biomarker for endometriosis is urgently needed. OBJECTIVE: Evaluate the diagnostic accuracy of serum cancer antigen 125 (CA 125) for endometriosis. SEARCH STRATEGY: We searched EMBASE, MEDLINE, and Web of Science from inception to January 2016. SELECTION CRITERIA: Diagnostic accuracy studies of serum CA 125 (index test) for histologically confirmed endometriosis (reference standard) were included. DATA COLLECTION AND ANALYSIS: Two authors independently selected trials, extracted study characteristics and data. Methodological quality was assessed using Quality Assessment of Comparative Diagnostic Accuracy Studies (QUADAS-2) checklist. MAIN RESULTS: Twenty-two studies (16 cohort, six case-control), 3626 participants, were identified. Bivariate hierarchical models were used to pool accuracy data of 14 studies (2920 participants) using CA 125 ≥ 30 units/ml. Pooled specificity was 93% (95% CI 89-95%) and sensitivity 52% (95% CI 38-66%). CA 125 was significantly more sensitive for the diagnosis of moderate or severe endometriosis compared with minimal disease (63%, 95% CI 47-77% versus 24%, 95%CI 19-32%, P-value = 0.001). CONCLUSIONS: CA 125 performs well as a rule-in test facilitating expedited diagnosis and ensuring investigation and treatment can be confidently tailored for the management of endometriosis. Unfortunately, a negative test, CA 125 < 30 units/ml, is unable to rule out endometriosis. TWEETABLE ABSTRACT: Blood test CA 125: a rule-in test for the diagnosis of women presenting with symptoms of endometriosis.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In endometriosis, CA 125 is up-regulated by stimulation of the coelomic epithelia, but it is not an endometriosis-specific marker.
“In endometriosis, CA 125 is up-regulated by stimulation of the coelomic epithelia, however, it is not an endometriosis-specific marker [26].”
From Diagnostic Significance of Selected Serum Inflammatory Markers in Women with Advanced Endometriosis (2021) · cites this paper as [26]
The sensitivity of Ca-125 is characteristic of the advanced form of the disease, but its specificity is low because it is often elevated in other gynecological diseases.
“The sensitivity of Ca-125 is characteristic of the advanced form of the disease, but its specificity is low because it is often elevated in other gynecological diseases [156].”
From Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) (2021) · cites this paper as [156]
Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823 · see citing works
QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies
Whiting, P. F., Rutjes, A. W. S., Westwood, M. E., Mallett, S., Deeks, J. J., Reitsma, J. B., Leeflang, M. M. G., Sterne, J. A. C., Bossuyt, P. M. M., & the QUADAS-2 Group* (2011) · Annals of Internal Medicine · doi:10.7326/0003-4819-155-8-201110180-00009 · Cited by 14,199 · see citing works
Reitsma, J. B., Glas, A. S., Rutjes, A. W. S., Scholten, R. J. P. M., Bossuyt, P. M., & Zwinderman, A. H. (2005) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2005.02.022 · Cited by 3,369 · see citing works
Revised American Society for Reproductive Medicine classification of endometriosis: 1996
American Society for Reproductive Medicine (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)81391-x · Cited by 3,018 · see citing works
Revised American Fertility Society Classification of Endometriosis: 1985
(1985) · Fertility and Sterility · doi:10.1016/s0015-0282(16)48430-x · Cited by 1,803 · see citing works
Simoens, S., Dunselman, G., Dirksen, C., Hummelshoj, L., Bokor, A., Brandes, I., Brodszky, V., Canis, M., Colombo, G. L., DeLeire, T., et al. (2012) · Human Reproduction · doi:10.1093/humrep/des073 · Cited by 1,070 · see citing works
The social and psychological impact of endometriosis on women's lives: a critical narrative review
Culley, L. A., Law, C., Hudson, N., Denny, E., Mitchell, H., Baumgarten, M. N., & Raine‐Fenning, N. (2013) · Human Reproduction Update · doi:10.1093/humupd/dmt027 · Cited by 689 · see citing works
Peripheral biomarkers of endometriosis: a systematic review
May, K. E., Conduit-Hulbert, S. A., Villar, J., Kirtley, S., Kennedy, S. H., & Becker, C. M. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmq009 · Cited by 418 · see citing works
The performance of CA-125 measurement in the detection of endometriosis: a meta-analysis
Mol, B. W. J., Bayram, N., Lijmer, J. G., Wiegerinck, M. A. H. M., Bongers, M. Y., van der Veen, F., & Bossuyt, P. M. M. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00355-0 · Cited by 355 · see citing works
Elevated serum concentrations of CA-125 in patients with advanced endometriosis
Barbieri, R. L., Niloff, J. M., Bast, R. C., Schaetzl, E., Kistner, R. W., & KNAPP, R. C. (1986) · Fertility and Sterility · doi:10.1016/s0015-0282(16)49333-7 · Cited by 320 · see citing works
ORONASAL OBSTRUCTION, LUNG VOLUMES, AND ARTERIAL OXYGENATION
Rodenstein, D. O., & Stănescu, D. C. (1988) · The Lancet · doi:10.1016/s0140-6736(88)91643-1 · Cited by 213 · see citing works
Evaluation of a panel of 28 biomarkers for the non-invasive diagnosis of endometriosis
Vodolazkaia, A., El-Aalamat, Y., Popovic, D., Mihalyi, A., Bossuyt, X., Kyama, C. M., Fassbender, A., Bokor, A., Schols, D., Huskens, D., et al. (2012) · Human Reproduction · doi:10.1093/humrep/des234 · Cited by 189 · see citing works
Koninckx, P. R., Meuleman, C., Oosterlynck, D., & Cornillie, F. J. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58086-8 · Cited by 183 · see citing works
REVIEW: Accuracy of laparoscopy in the diagnosis of endometriosis: a systematic quantitative review
Wykes, C. B., Clark, T. J., & Khan, K. S. (2004) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2004.00433.x · Cited by 177 · see citing works
Self-citationThe use of CA-125 in the diagnosis and management of endometriosis
Pittaway, D. E., & Fayez, J. A. (1986) · Fertility and Sterility · doi:10.1016/s0015-0282(16)49812-2 · Cited by 165 · see citing works
Non-invasive diagnosis of endometriosis based on a combined analysis of six plasma biomarkers
Mihalyi, A., Gevaert, O., Kyama, C. M., Simsa, P., Pochet, N., De Smet, F., De Moor, B., Meuleman, C., Billen, J., Blanckaert, N., et al. (2010) · Human Reproduction · doi:10.1093/humrep/dep425 · Cited by 161 · see citing works
Fassbender, A., Vodolazkaia, A., Saunders, P., Lebovic, D., Waelkens, E., De Moor, B., & D'Hooghe, T. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.01.097 · Cited by 150 · see citing works
Usefulness of CA19-9 versus CA125 for the diagnosis of endometriosis
Harada, T., Kubota, T., & Asô, T. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)03328-9 · Cited by 113 · see citing works
Kitawaki, J., Ishihara, H., Koshiba, H., Kiyomizu, M., Teramoto, M., Kitaoka, Y., & Honjo, H. (2005) · Human Reproduction · doi:10.1093/humrep/deh890 · Cited by 112 · see citing works
Koninckx, P. R., Riittinen, L., Seppala, M., & Cornillie, F. J. (1992) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54894-8 · Cited by 112 · see citing works
The use of biochemical markers in the diagnosis of pelvic endometriosis
Abrao, M. S., Podgaec, S., Filho, B. M., Ramos, L. O., Pinotti, J. A., & de Oliveira, R. M. (1997) · Human Reproduction · doi:10.1093/humrep/12.11.2523 · Cited by 100 · see citing works
Neutrophil-to-lymphocyte ratio as an adjunct to CA-125 for the diagnosis of endometriosis
Cho, S., Cho, H., Nam, A., Kim, H. Y., Choi, Y. S., Park, K. H., Cho, D. J., & Lee, B. S. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.03.061 · Cited by 100 · see citing works
What do we know about the origin of CA 125?
Bischof, P. (1993) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0028-2243(93)90131-u · Cited by 89 · see citing works
CA-125 levels in endometriosis
Patton, P. E., Field, C. S., Harms, R. W., & Coulam, C. B. (1986) · Fertility and Sterility · doi:10.1016/s0015-0282(16)49390-8 · Cited by 77 · see citing works
Chen, F., Soong, Y., Lee, N., & Lo, S. K. (1998) · Acta Obstetricia et Gynecologica Scandinavica · doi:10.1034/j.1600-0412.1998.770615.x · Cited by 73 · see citing works
Socolov, R. V., Buţureanu, S., Angioni, S. L., Sindilar, A., Boiculese, L. V., Cozma, L. G., & Socolov, D. G. (2010) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2010.10.008 · Cited by 65 · see citing works
Seeber, B., Sammel, M. D., Fan, X., Gerton, G. L., Shaunik, A., Chittams, J. L., & Barnhart, K. T. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.12.121 · Cited by 59 · see citing works
Gagné, D., Rivard, M., Pagé, M., Lépine, M., Platon, C., Shazand, K., Hugo, P., & Gosselin, D. R. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(03)01153-1 · Cited by 54 · see citing works
Identification and validation of novel serum markers for early diagnosis of endometriosis
Gajbhiye, R., Sonawani, A., Khan, S., Suryawanshi, A., Kadam, S., Warty, N., Raut, V., & Khole, V. (2012) · Human Reproduction · doi:10.1093/humrep/der410 · Cited by 53 · see citing works
Serum CA-125 in the diagnosis of endometriosis
Silva, A. C. J. S. R. E., Silva, J. C. R. E., & Ferriani, R. A. (2007) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2006.11.016 · Cited by 52 · see citing works
do Amaral, V. F., Ferriani, R. A., de Sá, M. F. S., Nogueira, A. A., Silva, J. C. R. E., Silva, A. C. J. D. S. R. E., & de Moura, M. D. (2006) · Sao Paulo Medical Journal · doi:10.1590/s1516-31802006000400010 · Cited by 52 · see citing works
Comparison of the clinical value of CA 19-9 versus CA 125 for the diagnosis of endometriosis
Kurdoğlu, Z., Gursoy, R., Kurdoğlu, M., Erdem, M., Erdem, Ö., & Erdem, A. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.05.022 · Cited by 51 · see citing works
High serum follistatin levels in women with ovarian endometriosis
Florio, P., Reis, F. M., Torres, P. B., Calonaci, F., Abrao, M. S., Nascimento, L. L., Franchini, M., Cianferoni, L., & Petraglia, F. (2009) · Human Reproduction · doi:10.1093/humrep/dep195 · Cited by 51 · see citing works
Diagnostic value of serum CA125, CA19-9 and CA15-3 in endometriosis: A meta-analysis
Shen, A., Xu, S., Ma, Y., Guo, H., Li, C., Yang, C. C., & Zou, S. (2015) · Journal of International Medical Research · doi:10.1177/0300060515583076 · Cited by 44 · see citing works
Investigation of diagnostic potentials of nine different biomarkers in endometriosis
Ozhan, E., Kokcu, A., Yanik, K., & Gunaydin, M. (2014) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2014.04.037 · Cited by 44 · see citing works
Endometriosis: Use of a new CA 125 assay in the diagnosis of endometriosis*
Hornstein, M. D., Harlow, B. L., Thomas, P. P., et al. (1995) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a136064 · Cited by 40 · see citing works
Increased Serum Cancer Antigen-125 Is a Marker for Severity of Deep Endometriosis
Santulli, P., Streuli, I., Melonio, I., Marcellin, L., Mbaye, M. B. D., Bititi, A., Borghese, B., Lafay-Pillet, M.-C., & Chapron, C. (2014) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2014.10.013 · Cited by 38 · see citing works
Are we employing the most effective CA 125 and CA 19-9 cut-off values to detect endometriosis?
Xavier, P. A. F., Beires, J., Belo, L., Rebelo, I., Martinez‐de‐Oliveira, J., Lunet, N., & Barros, H. (2005) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2005.04.003 · Cited by 38 · see citing works
Comparison of ovarian cancer markers in endometriosis favours HE4 over CA125
McKinnon, B. D., Mueller, M. D., Nirgianakis, K., & Bersinger, N. A. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4062 · Cited by 38 · see citing works
Yang, H., Zhu, L., Wang, S., Lang, J., & Xu, T. (2015) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2013.06.003 · Cited by 37 · see citing works
CA 125 levels measured in different phases of the menstrual cycle in screening for endometriosis.
O'Shaughnessy, A., Check, J. H., Nowroozi, K., & Lurie, D. (1993) · PubMed · Cited by 35 · see citing works
Mohamed, M. L., El Behery, M. M., & Mansour, S. A. E.-A. (2013) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-012-2539-4 · Cited by 35 · see citing works
Endometrial antibodies versus CA-125 for the detection of endometriosis
Wild, R. A., Hirisave, V., Bianco, A., Podczaski, E. S., & Demers, L. M. (1991) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54065-5 · Cited by 34 · see citing works
Jing, J., Qiao, Y., Suginami, H., Taniguchi, F., Shi, H., & Wang, X. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.08.078 · Cited by 34 · see citing works
Serum and peritoneal lavage fluid CA-125 levels in endometriosis
Moretuzzo, R. W., DiLauro, S., Jenison, E. L., Chen, S. L., Reindollar, R. H., & McDonough, P. G. (1988) · Fertility and Sterility · doi:10.1016/s0015-0282(16)60127-9 · Cited by 32 · see citing works
Clinical usefulness of CA-125 levels in the menstrual discharge in patients with endometriosis
Takahashi, K., Nagata, H., Musa, A. A., Shibukawa, T., Yamasaki, H., & Kitao, M. (1990) · Fertility and Sterility · doi:10.1016/s0015-0282(16)53721-2 · Cited by 31 · see citing works
Serum and peritoneal fluid CA-125 levels in patients with endometriosis
Barbati, A., Cosmi, E. V., Spaziani, R., Ventura, R., & Montanino, G. (1994) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56572-8 · Cited by 28 · see citing works
Serum Prolactin and CA-125 Levels as Biomarkers of Peritoneal Endometriosis
Bilibio, J. P., de Souza, C. A. B., Rodini, G. P., Andreoli, C., Genro, V. K., Conto, E. D., & Cunha‐Filho, J. S. (2014) · Gynecologic and Obstetric Investigation · doi:10.1159/000362272 · Cited by 28 · see citing works
Identification of anti-syntaxin 5 autoantibody as a novel serum marker of endometriosis
Nabeta, M., Abe, Y., Takaoka, Y., Kusanagi, Y., & Ito, M. (2011) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2011.04.012 · Cited by 26 · see citing works
SCREENING FOR OVARIAN CANCER BY CA-125 MEASUREMENT
Jacobs, I. J. (1988) · The Lancet · doi:10.1016/s0140-6736(88)91642-x · Cited by 22 · see citing works
Serum anti-PDIK1L autoantibody as a novel marker for endometriosis
Nabeta, M., Abe, Y., Haraguchi, R., Kito, K., Kusanagi, Y., & Ito, M. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.03.008 · Cited by 22 · see citing works
Serum CA 125 antigen levels and disease severity in patients with endometriosis.
Moloney, Thornton, J., & Eh, C. (1989) · PubMed · Cited by 22 · see citing works
The value of urocortin and Ca-125 in the diagnosis of endometrioma
Tokmak, A., Ugur, M., Tonguc, E., Var, T., Moraloğlu, O., & Ozaksit, G. (2011) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-010-1505-2 · Cited by 21 · see citing works
Kruitwagen, R. F. P. M., Thomas, C. M. G., Poels, L. G., Koster, A. M., Willemsen, W. N. P., & Rolland, R. (1991) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54656-1 · Cited by 20 · see citing works
Serum levels of the tumour‐associated trypsin inhibitor in patients with endometriosis
Medl, M., Ogris, E., Peters-Engl, C., Mierau, M., Buxbaum, P., & Leodolter, S. (1997) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1997.tb10653.x · Cited by 19 · see citing works
Serum CA 125 levels before, during and after treatment for endometriosis
Özakşit, G., Ȼaǧlar, T., Ȼiçek, N., Kuşçu, E., Batioǧlu, S., & Gökmen, O. (1995) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(95)02456-m · Cited by 19 · see citing works
Evaluation of CA-125 and soluble CD-23 in patients with pelvic endometriosis: a case-control study
Luna Ramos, I. M. D., Podgaec, S., Abrão, M. S., Oliveira, R. D., & Baracat, E. C. (2012) · Revista da Associação Médica Brasileira · doi:10.1590/s0104-42302012000100011 · Cited by 18 · see citing works
CA-125 in peritoneal fluid from patients with nonmalignant gynecologic disorders.
Ismail, M. A., Rotmensch, J., Mercer, L. J., Block, B. S. B., Salti, G. I., & Holt, J. A. (1994) · PubMed · Cited by 17 · see citing works
Serum CA-125 levels in the diagnosis and management of endometriosis.
Lanzone, A., Marana, R., Muscatello, R., Fulghesu, A. M., Dell'Acqua, S., Caruso, A., & Mancuso, S. (1991) · PubMed · Cited by 15 · see citing works
Serum and Peritoneal Fluid CA-125 Levels in Early Stage Endometriosis
Gürgan, T., Kişnişçi, H. A., Yaralı́, H., et al. (2010) · Gynecologic and Obstetric Investigation · doi:10.1159/000293228 · Cited by 12 · see citing works
Serum cytokine and growth factor levels in patients with endometriosis
Kubatova, A., Erdem, A., Erdem, M., FiratMutlu, M., & Korucuoğlu, Ü. (2013) · Central European Journal of Immunology · doi:10.5114/ceji.2013.39768 · Cited by 12 · see citing works
Preoperative assessment and diagnosis of endometriosis
Hirsch, M., & Davis, C. (2015) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000188 · Cited by 12 · see citing works
Self-citationAdamyan, A. L. V., Nd, F., Ml, A., YeN, A., YeA, N., & Jahan, I. (1993) · PubMed · Cited by 12 · see citing works
Evaluation of CA-125 and soluble CD-23 in patients with pelvic endometriosis: a case-control study
Ramos, I. M. D. L., Podgaec, S., Abrão, M. S., de Oliveira, R. S., & Baracat, E. C. (2012) · Revista da Associação Médica Brasileira · doi:10.1016/s0104-4230(12)70151-3 · Cited by 12 · see citing works
Multiple serum marker assay in the diagnosis of endometriosis
Muscatello, R., Cucinelli, F., Fulghesu, A. M., Lanzone, A., Caruso, A., & Mancuso, S. (1992) · Gynecological Endocrinology · doi:10.3109/09513599209024989 · Cited by 11 · see citing works
[Serum and peritoneal fluid CA-125 concentration in women with endometriosis].
Kraśnicki, D. (2001) · PubMed · Cited by 11 · see citing works
Correlación entre valores del marcador Ca-125 con la presencia y severidad de endometriosis pelviana
Marcelo Bianchi, P., Rodrigo Macaya, P., Durruty, G., V, & Alejandro Manzur, Y. (2003) · Revista médica de Chile · doi:10.4067/s0034-98872003000400003 · Cited by 10 · see citing works
CA 125 in peritoneal fluid and serum of patients with endometriosis
Fisk, N. M., & Tan, C. E. (1988) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0028-2243(88)90142-6 · Cited by 9 · see citing works
Preoperative serum CA-125 and CA-72 in predicting endometriosis in infertility patients.
Molo, M. W., Kelly, M., Radwańska, E., & Binor, Z. (1994) · PubMed · Cited by 7 · see citing works
Prediction of pelvic pathology in subfertile women with combined Chlamydia antibody and CA-125 tests
Penninx, J., Brandes, M., de Bruin, J. P., Schneeberger, P. M., & Hamilton, C. J. C. M. (2009) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2009.08.004 · Cited by 7 · see citing works
Sayan, C. D. (2013) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-1205-85 · Cited by 7 · see citing works
Serum Ca-125 concentrations in endometriosis.
Fedele, L., Arcaini, L., Vercellini, P., et al. (1990) · PubMed · Cited by 6 · see citing works
Relevance of CA-125 in the evaluation of endometriosis.
Colacurci, N., Fortunato, N., FRANCISCIS, P. D., et al. (1996) · PubMed · Cited by 5 · see citing works
The Correlation between Serum and Peritoneal Fluid CA125 Level in Women with Pelvic Endometriosis
Institue, R., Salehpour, S., Sene, A. A., et al. (2009) · doi:10.22074/ijfs.2009.45743 · Cited by 4 · see citing works
Salehpour, S., Sene, A. A., Mehrjerdi, E. K., et al. (2009) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 3 · see citing works
Berral, J. A., Puertas, P. I. C., Avisbal, M. T., et al. (1996) · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
ESHRE guideline: endometriosis
Becker, C. M., Bokor, A., Heikinheimo, O., Horne, A., Jansen, F., Kiesel, L., King, K., Kvaskoff, M., Nap, A., Petersen, K., et al. (2022) · Human Reproduction Open · doi:10.1093/hropen/hoac009 · Cited by 1,712 · see citing works
Smolarz, B., Szyłło, K., & Romanowicz, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910554 · Cited by 560 · see citing works
Diagnostic Significance of Selected Serum Inflammatory Markers in Women with Advanced Endometriosis
Kokot, I., Piwowar, A., Jędryka, M., Sołkiewicz, K., & Kratz, E. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052295 · Cited by 76 · see citing works
“CA 125 is a well-known peritoneal inflammation parameter and, at the same time, the most often investigated non-invasive marker of epithelial cell ovarian cancer [11,26].”
BackgroundInfluentialNew biomarkers in endometriosis
(2019) · Advances in clinical chemistry · doi:10.1016/bs.acc.2018.12.002 · Cited by 72 · see citing works
Sasamoto, N., DePari, M., Vitonis, A. F., Laufer, M. R., Missmer, S. A., Shafrir, A. L., & Terry, K. L. (2020) · PLOS ONE · doi:10.1371/journal.pone.0238043 · Cited by 31 · see citing works
Schoeman, E. M., Bringans, S., Peters, K., Casey, T., Andronis, C., Chen, L., Duong, M., Girling, J. E., Healey, M., Boughton, B. A., et al. (2025) · Human Reproduction · doi:10.1093/humrep/deae278 · Cited by 27 · see citing works
- Authors
- Hirsch, M., Duffy, J., Davis, C., Nieves Plana, M., Khan, K., & on behalf of the International Collaboration to Harmonise Outcomes and Measures for Endometriosis
- Affiliations
- Queen Mary University of London (GB)
- Balliol College University of Oxford Oxford UK
- Madrid Cochrane Collaboration Centre Francisco de Vitoria University Madrid Spain
- Women's Health Research Unit The Blizard Institute Barts and the London School of Medicine and Dentistry London UK
- Corresponding author
- Hirsch, M
- ORCID
- Hirsch, M
- Venue
- BJOG: An International Journal of Obstetrics & Gynaecology
- Publisher
- Wiley
- Published
- 2016-05-12
- Volume
- 123
- Issue
- 11
- Pages
- 1761-1768
- ISSN
- 0306-5456 (ISSN-L)
- 1470-0328
- 1471-0528
- OpenAlex
- W2370846123
- Cited by
- 156
- References
- 76
- Citations by year
- 2026: 14 · 2025: 16 · 2024: 19 · 2023: 21 · 2022: 26 · 2021: 13 · 2020: 12 · 2019: 15 · 2018: 11 · 2017: 7 · 2016: 2
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- BJOG An International Journal of Obstetrics & Gynaecology (publishedVersion)
- PubMed (publishedVersion)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion)
- Funders
- Queen Mary University of London
- National Institute for Health and Care Research (DRF-2014-07-051)
- University of Oxford
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, CA125, serum biomarkers, diagnostic accuracy, sensitivity and specificity, non-invasive diagnosis, disease severity
- MeSH terms
- Adult, Endometriosis, Female, Humans, Membrane Proteins, Predictive Value of Tests, Sensitivity and Specificity, Biomarkers, CA-125 Antigen
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
