The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Maternal high-fat diets cause insulin resistance through inflammatory changes in fetal adipose tissue
Open accessAbstract
Objectives Epidemiological and animal studies have shown that maternal obesity predisposes the offspring to obesity and the metabolic syndrome, possibly via late-onset metabolic programming of the fetus. Little is known, however, about the metabolic effect of maternal obesity on the fetus. This study investigated the effect of a maternal high-fat diet (HFD) on fetal growth and glucose metabolism using a diet-induced obesity mouse model. Study design Female mice (6 weeks old; C57BL/6N) were fed either a normal chow diet (NCD, 10 kcal% fat) or an HFD (60 kcal% fat) for 4 weeks before mating and throughout pregnancy. At 17 days of gestation, gene expression of inflammatory markers and adipokines in fetal subcutaneous adipose tissue was analyzed by quantitative real-time polymerase chain reaction. Results HFD mice were overweight, glucose intolerant and insulin resistant compared with NCD mice of the same gestational age. Although fetal body weight was not significantly different, fetal plasma glucose and insulin levels were higher in the HFD group than the NCD group. Furthermore, examination of fetal subcutaneous adipose tissue in the HFD group revealed hypertrophy with an increase in the levels of cluster of differentiation-68, chemokine receptor-2 and tumor necrosis factor-α mRNA, but a decrease in the level of glucose transporter-4 mRNA. Conclusion Maternal HFD causes inflammatory changes in the adipose tissue of offspring.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“They also often show increased inflammatory marker expression and a higher infiltration of macrophages and other immune cells in their adipose tissue [89, 91, 92], which may reflect lipotoxicity and likely contributed to the glucose intolerance seen in such offspring.”
From Developmental programming of offspring adipose tissue biology and obesity risk (2021) · cites this paper as [91]
In the citing paper
“Offspring from obese/high-fat diet-fed mothers show increased adiposity [88–90] and adipocyte hypertrophy postnatally [89, 91].”
From Developmental programming of offspring adipose tissue biology and obesity risk (2021) · cites this paper as [91]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543
Kanda, H. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26498 · Cited by 2,682
Boring, L., Gosling, J., Cleary, M., & Charo, I. F. (1998) · Nature · doi:10.1038/29788 · Cited by 1,965
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
Abel, E. D., Peroni, O. D., Kim, J. K., Kim, Y., Boss, O., Hadro, E., Minnemann, T., Shulman, G. I., & Kahn, B. B. (2001) · Nature · doi:10.1038/35055575 · Cited by 1,276
Scherer, P. E. (2006) · Diabetes · doi:10.2337/db06-0263 · Cited by 1,092
Suganami, T., Nishida, J., & Ogawa, Y. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000183883.72263.13 · Cited by 1,056
Samuelsson, A.-M., Matthews, P. A., Argenton, M., Christie, M. R., McConnell, J. M., Jansen, E. H. J. M., Piersma, A. H., Ozanne, S. E., Twinn, D. F., Remacle, C., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.101477 · Cited by 923
Catalano, P., & Ehrenberg, H. M. (2006) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.00989.x · Cited by 828
TNF-α Is a Predictor of Insulin Resistance in Human Pregnancy
Kirwan, J. P., Hauguel-De Mouzon, S., Lepercq, J., Challier, J.-C., Huston-Presley, L., Friedman, J. E., Kalhan, S. C., & Catalano, P. M. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2207 · Cited by 738
Potential Role of TNF-α in the Pathogenesis of Insulin Resistance and Type 2 Diabetes
Moller, D. E. (2000) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(00)00272-1 · Cited by 730
Fetuses of obese mothers develop insulin resistance in utero
Catalano, P. M., Presley, L., Minium, J., & Hauguel-de Mouzon, S. (2009) · Diabetes Care · doi:10.2337/dc08-2077 · Cited by 655
Stephens, J. M., Lee, J., & Pilch, P. F. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.2.971 · Cited by 553
Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice.
Miki, T., Nagashima, K., Tashiro, F., Kotake, K., Yoshitomi, H., Tamamoto, A., Gonoi, T., Iwanaga, T., Miyazaki, J., & Seino, S. (1998) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.95.18.10402 · Cited by 541
Role of premature leptin surge in obesity resulting from intrauterine undernutrition
Yura, S., Itoh, H., Sagawa, N., Yamamoto, H., Masuzaki, H., Nakao, K., Kawamura, M., 竹村, 真., Kakui, K., Ogawa, Y., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.005 · Cited by 398
Self-citationStephens, J. M., & Pekala, P. H. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54714-1 · Cited by 370
Di Gregorio, G. B., Yao-Borengasser, A., Rasouli, N., Varma, V., Lu, T., Miles, L. M., Ranganathan, G., Peterson, C. A., McGehee, R. E., & Kern, P. A. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2305 · Cited by 362
Developmental Origins of Obesity and the Metabolic Syndrome: The Role of Maternal Obesity
Armitage, J. A., Poston, L., & Taylor, P. D. (2008) · KARGER eBooks · doi:10.1159/000115355 · Cited by 255
Molecular Mechanism of Insulin Resistance and Obesity
Kadowaki, T., Hara, K., Yamauchi, T., Terauchi, Y., Tobe, K., & Nagai, R. (2003) · Experimental Biology and Medicine · doi:10.1177/153537020322801003 · Cited by 198
Tulloch-Reid, M. K., Hanson, R. L., Sebring, N. G., Reynolds, J. C., Premkumar, A., Genovese, D. J., & Sumner, A. E. (2004) · Obesity Research · doi:10.1038/oby.2004.170 · Cited by 104
The inflammatory changes of adipose tissue in late pregnant mice
Zhang, L., Sugiyama, T., 村林, 奈., Umekawa, T., Ma, N., Kamimoto, Y., Ogawa, Y., & Sagawa, N. (2011) · Journal of Molecular Endocrinology · doi:10.1530/jme-11-0030 · Cited by 48
Self-citationUmekawa, T., Sugiyama, T., Kihira, T., 村林, 奈., Zhang, L., Nagao, K., Kamimoto, Y., Ma, N., Yodoi, J., & Sagawa, N. (2008) · Endocrinology · doi:10.1210/en.2007-1682 · Cited by 32
Self-citationKondo, E., Sugiyama, T., Kusaka, H., & Toyoda, N. (2004) · Hormone and Metabolic Research · doi:10.1055/s-2004-825726 · Cited by 25
Self-citationPotential Role of TNF-a in the Pathogenesis of Insulin Resistance and Type 2 Diabetes
Moller, D. E. (2000) · Cited by 21
The inflammatory changes of adipose tissue in late pregnant mice
張, 凌. (2012) · Institutional Repositories DataBase (IRDB) · Cited by 4
Sohlström, A., Petterson, U., & Forsum, E. (1998) · Annals of Nutrition and Metabolism · doi:10.1159/000012718 · Cited by 2
Cited by
Sorted by citations
Inflammation in maternal obesity and gestational diabetes mellitus
Pantham, P., Aye, I. L. M. H., & Powell, T. L. (2015) · Placenta · doi:10.1016/j.placenta.2015.04.006 · Cited by 599
Maternal obesity and neurodevelopmental and psychiatric disorders in offspring
Edlow, A. G. (2016) · Prenatal Diagnosis · doi:10.1002/pd.4932 · Cited by 326
Maternal obesity and high-fat diet program offspring metabolic syndrome
Desai, M., Jellyman, J. K., Han, G., Beall, M., Lane, R. H., & Ross, M. G. (2014) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2014.03.025 · Cited by 244
Maternal Obesity, Inflammation, and Developmental Programming
Segovia, S. A., Vickers, M. H., Gray, C. L., & Reynolds, C. M. (2014) · BioMed Research International · doi:10.1155/2014/418975 · Cited by 233
The initiation of metabolic inflammation in childhood obesity
Singer, K., & Lumeng, C. N. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88882 · Cited by 194
Metadata
- Authors
- Murabayashi, N., Sugiyama, T., Zhang, L., Kamimoto, Y., Umekawa, T., Ma, N., & Sagawa, N.
- Affiliations
- Tohoku University (JP)
- Mie University (JP)
- Suzuka University of Medical Science (JP)
- Corresponding author
- Sugiyama, T.
- Venue
- European Journal of Obstetrics & Gynecology and Reproductive Biology
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 169
- Issue
- 1
- Pages
- 39-44
- ISSN
- 0028-2243 (ISSN-L)
- 0301-2115
- OpenAlex
- W2065422716
- Cited by
- 114
- References
- 27
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 5 · 2023: 5 · 2022: 9 · 2021: 8 · 2020: 10 · 2019: 12 · 2018: 5 · 2017: 11 · 2016: 14 · 2015: 9 · 2014: 10 · 2013: 4
- FWCI
- 10.46
- Type
- journal article
- Language
- en
- Open access
- green
- mie-u.repo.nii.ac.jp
- Licence
- Locations
- European Journal of Obstetrics & Gynecology and Reproductive Biology (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Funders
- Japan Society for the Promotion of Science (25462548, 23791830)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Keywords
- maternal high-fat diet, maternal obesity, fetal adipose tissue, insulin resistance, fetal glucose metabolism, fetal growth, inflammation, adipokines, CD68, CCR2, TNF-α, GLUT4, diet-induced obesity, metabolic programming
- MeSH terms
- CD68 Molecule, Adipose Tissue, Animals, Female, Fetus, Inflammation, Insulin, Insulin Resistance, Mice, Inbred C57BL, Obesity, Pregnancy, Prenatal Exposure Delayed Effects, RNA, Messenger, Tumor Necrosis Factor-alpha, Antigens, Differentiation, Myelomonocytic, Antigens, CD, Fetal Development, Subcutaneous Fat, Glucose Transporter Type 4, Mice, Receptors, CCR2, Diet, High-Fat
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
