Cited by 161Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryDrug Solubulity and Delivery Systems

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Poly (lactide-co-glycolide) particles of different physicochemical properties and their uptake by peyer's patches in mice

Shakweh, Monjed, Besnard, Madeleine, Nicolas, Valérie, Fattal, Elias·2005·European Journal of Pharmaceutics and Biopharmaceutics

DOI 10.1016/j.ejpb.2005.04.006

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Abstract

Nano-and microparticles of poly(lactide-co-glycolide) (PLGA) were formulated using poly(vinyl alcohol) (PVA) or hydrophobically modified hydroxyethylcellulose (HMHEC) or polyethyleneimine (PEI) as stabilizers. The uptake by murine Peyer's patches (PPs) and the binding to Peyer's patches-free tissue (PPFT) of these particles was investigated using fluorescence microscopy providing qualitative information about the tissue distribution of particles. Observations of intestinal cryo-sections showed significant discrimination in the uptake by PP of nano-and microparticles. The uptake by PPs of PLGA-PVA and PLGA-HMHEC nano-and microparticles, of negative and neutral zeta potential, respectively, was comparable, whereas a smaller number was observed in the case of nano-and microparticles of PLGA-PEI, positively charged. Moreover, particle uptake by PPs appeared to be strongly size-dependent. The number of particles of mean diameter around 0.3 and 1 microm observed in PPs was much greater than that of particles of diameter average close to 3 microm. However, in all cases, particles were found in the PPFT for at least 48 h. In conclusion, regarding the tissue samples we have observed, it appeared that the uptake of particles by PPs and binding to PPFT could be influenced by the physicochemical properties of the particles but this may not have been true at all sites of the intestine and may differ between animals.

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“significantly influence their uptake route [23] and toxicokinetics”
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BackgroundMethodInfluential
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“…depending on their size particles could be retained within the lymphoid tissue (>3 μm) (Florence, 2005), or they could be internalized by phagocytic cells and subsequently transported to another lymphoid tissue through the lymphatic vessels that innervate the PP dome area (Shakweh et al., 2005).”
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Background
Rat, ovine and bovine Peyer's patches mounted in horizontal diffusion chambers display sampling function
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Authors: Shakweh, M., Besnard, M., Nicolas, V., & Fattal, E.
Affiliations: Université Paris-Sud (FR)
ORCID: Nicolas, Valérie
Fattal, Elias
Venue: European Journal of Pharmaceutics and Biopharmaceutics
Publisher: Elsevier BV
Published: 2005-09
Volume: 61
Issue: 1-2
Pages: 1-13
ISSN: 0939-6411 (ISSN-L)
DOI: 10.1016/j.ejpb.2005.04.006
OpenAlex: W1984520012
Cited by: 161
References: 27
Citations by year: 2026: 2 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 7 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 8 · 2017: 7 · 2016: 11 · 2015: 7 · 2014: 18 · 2013: 8 · 2012: 14
FWCI: 7.82
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Journal of Pharmaceutics and Biopharmaceutics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Keywords: poly(lactic-co-glycolic acid), PLGA nanoparticles, PLGA microspheres, Peyer's patches, particle uptake, polyvinyl alcohol, polyethyleneimine, zeta potential, particle size, oral drug delivery, intestinal mucosa
MeSH terms: Administration, Oral, Animals, Drug Carriers, Drug Stability, Male, Mice, Inbred Strains, Microscopy, Electron, Scanning, Particle Size, Peyer's Patches, Polyglactin 910, Surface Properties, Nanostructures, Mice

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Poly (lactide-co-glycolide) particles of different physicochemical properties and their uptake by peyer's patches in mice

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