Cited by 516Advanced Drug Delivery SystemsDrug Solubulity and Delivery SystemsProteins in Food Systems

Is the oral route possible for peptide and protein drug delivery?

Morishita, Mariko, Peppas, Nicholas A.·2006·Drug Discovery Today

Abstract

Oral delivery of peptides and proteins remains an attractive alternative to parenteral delivery and has challenged various attempts at delivery development. Incorporation of new tools into the delivery systems that can raise membrane permeability of macromolecules is essential to attain high oral bioavailability that is acceptable in clinical applications. In developing oral protein delivery systems with high bioavailability, three practical approaches might be most helpful: (1) modification of the physicochemical properties of macromolecules; (2) addition of novel function to macromolecules; or (3) use of improved delivery carriers. Clearly, it is essential that these approaches maintain the biological activity of the proteins.

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Registry

Crossref · 10.1016/j.drudis.2006.08.005

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76 of 76 references verified0 citation errors · 0 not checkable

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  • The limited bioavailability of orally administered mAbs is due to limited penetration across the intestinal epithelium and susceptibility to enzymatic degradation by proteases and peptidases in the intestinal lumen.

    “The limited bioavailability of orally administered mAbs is due to their limited penetration across the intestinal epithelium16 and susceptibility to enzymatic degradation by proteases and peptidases in the intestinal lumen.17”

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Authors
Morishita, M., & Peppas, N. A.
Affiliations
  • Hoshi University (JP)
  • The University of Texas at Austin (US)
Corresponding author
Morishita, Mariko
Venue
Drug Discovery Today
Publisher
Elsevier BV
Published
2006-10
Volume
11
Issue
19-20
Pages
905-910
ISSN
1359-6446 (ISSN-L)
OpenAlex
W2055249600
Cited by
515
References
82
Citations by year
2026: 7 · 2025: 12 · 2024: 12 · 2023: 21 · 2022: 21 · 2021: 17 · 2020: 33 · 2019: 34 · 2018: 26 · 2017: 37 · 2016: 35 · 2015: 33 · 2014: 43 · 2013: 40 · 2012: 30
FWCI
2.18
Type
journal article
Language
en
Open access
closed
Locations
  • Drug Discovery Today (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
Keywords
oral drug delivery, peptide therapeutics, protein drugs, oral bioavailability, membrane permeability, carrier proteins, bioactivity retention
MeSH terms
Administration, Oral, Animals, Humans, Peptides, Proteins, Drug Delivery Systems

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