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Cited by 371

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Polymersome carriers: From self-assembly to siRNA and protein therapeutics

Open access
Christian, David A., Cai, Shenshen, Bowen, Diana M., Kim, Younghoon, Pajerowski, J. David, Discher, Dennis E.·2009·European Journal of Pharmaceutics and Biopharmaceutics

Abstract

Polymersomes are polymer-based vesicular shells that form upon hydration of amphiphilic block copolymers. These high molecular weight amphiphiles impart physicochemical properties that allow polymersomes to stably encapsulate or integrate a broad range of active molecules. This robustness together with recently described mechanisms for controlled breakdown of degradable polymersomes as well as escape from endolysosomes suggests that polymersomes might be usefully viewed as having structure/property/function relationships somewhere between lipid vesicles and viral capsids. Here we summarize the assembly and development of controlled release polymersomes to encapsulate therapeutics ranging from small molecule anti-cancer drugs to siRNA and therapeutic proteins.

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Crossref · 10.1016/j.ejpb.2008.09.025

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Metadata

Authors
Christian, D. A., Cai, S., Bowen, D. M., Kim, Y., Pajerowski, J. D., & Discher, D. E.
Venue
European Journal of Pharmaceutics and Biopharmaceutics
Publisher
Elsevier BV
Published
2009-03
Volume
71
Issue
3
Pages
463-474
ISSN
0939-6411 (ISSN-L)
OpenAlex
W1983203635
Cited by
371
References
3
FWCI
9.70
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Polymersome carriers: From self-assembly to siRNA and protein therapeutics. https://app.cochat.ai/papers/10.1016/j.ejpb.2008.09.025
The paper
Christian, D. A., Cai, S., Bowen, D. M., Kim, Y., Pajerowski, J. D., & Discher, D. E. (2009). Polymersome carriers: From self-assembly to siRNA and protein therapeutics. European Journal of Pharmaceutics and Biopharmaceutics. https://doi.org/10.1016/j.ejpb.2008.09.025

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.