Future of the Particle Replication in Nonwetting Templates (PRINT) Technology
Open accessAbstract
Particle replication in nonwetting templates (PRINT) is a continuous, roll‐to‐roll, high‐resolution molding technology which allows the design and synthesis of precisely defined micro‐ and nanoparticles. This technology adapts the lithographic techniques from the microelectronics industry and marries these with the roll‐to‐roll processes from the photographic film industry to enable researchers to have unprecedented control over particle size, shape, chemical composition, cargo, modulus, and surface properties. In addition, PRINT is a GMP‐compliant (GMP=good manufacturing practice) platform amenable for particle fabrication on a large scale. Herein, we describe some of our most recent work involving the PRINT technology for application in the biomedical and material sciences.
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Recent advances in synthetic techniques using high-precision fabrication show promise for the production of more precisely defined microparticles and nanoparticles.
“Recent advances in synthetic techniques using high-precision fabrication, such as particle replication in non-wetting templates and microfluidic-based reaction chemistry, show promise for the production of more precisely defined microparticles and nanoparticles51,52.”
From How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation (2018) · cites this paper as [52]
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- Authors
- Xu, J., Wong, D. H. C., Byrne, J. D., Chen, K., Bowerman, C., & DeSimone, J. M.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- DeSimone, Joseph M.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2013-05-13
- Volume
- 52
- Issue
- 26
- Pages
- 6580-6589
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- PMC
- PMC4157646
- OpenAlex
- W1982248450
- Cited by
- 208
- References
- 81
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 18 · 2023: 9 · 2022: 21 · 2021: 17 · 2020: 19 · 2019: 19 · 2018: 19 · 2017: 14 · 2016: 18 · 2015: 18 · 2014: 7 · 2013: 7
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Science Foundation (0906985, 0923604)
- National Institutes of Health (5u54ca151652-05, DP1OD006432)
- U.S. Public Health Service (IDP10D006432)
- National Cancer Institute (U54‐CA151652)
- National Institute of Biomedical Imaging and Bioengineering (R01EB009565)
- Division of Materials Research
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanofabrication and Lithography Techniques
- Physical Sciences › Materials Science › Materials Chemistry › Pickering emulsions and particle stabilization
- Physical Sciences › Materials Science › Materials Chemistry › Block Copolymer Self-Assembly
- Keywords
- prints, GMP manufacturing, biomedical applications, materials science applications, particle size and shape control
- MeSH terms
- Biopharmaceutics, Electromagnetic Fields, Electronics, Humans, Materials Testing, Particle Size, Prodrugs, Surface Properties, Drug Design, RNA, Small Interfering, Nanotechnology, Nanomedicine, Nanoparticles
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