Cited by 208Nanofabrication and Lithography TechniquesPickering emulsions and particle stabilizationBlock Copolymer Self-Assembly

Future of the Particle Replication in Nonwetting Templates (PRINT) Technology

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Xu, Jing, Wong, Dominica H. C., Byrne, James D., Chen, Kai, Bowerman, Charles, DeSimone, Joseph M.·2013·Angewandte Chemie International Edition

Abstract

Particle replication in nonwetting templates (PRINT) is a continuous, roll‐to‐roll, high‐resolution molding technology which allows the design and synthesis of precisely defined micro‐ and nanoparticles. This technology adapts the lithographic techniques from the microelectronics industry and marries these with the roll‐to‐roll processes from the photographic film industry to enable researchers to have unprecedented control over particle size, shape, chemical composition, cargo, modulus, and surface properties. In addition, PRINT is a GMP‐compliant (GMP=good manufacturing practice) platform amenable for particle fabrication on a large scale. Herein, we describe some of our most recent work involving the PRINT technology for application in the biomedical and material sciences.

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  • Recent advances in synthetic techniques using high-precision fabrication show promise for the production of more precisely defined microparticles and nanoparticles.

    “Recent advances in synthetic techniques using high-precision fabrication, such as particle replication in non-wetting templates and microfluidic-based reaction chemistry, show promise for the production of more precisely defined microparticles and nanoparticles51,52.”

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Authors
Xu, J., Wong, D. H. C., Byrne, J. D., Chen, K., Bowerman, C., & DeSimone, J. M.
Affiliations
University of North Carolina at Chapel Hill (US)
Corresponding author
DeSimone, Joseph M.
Venue
Angewandte Chemie International Edition
Publisher
Wiley
Published
2013-05-13
Volume
52
Issue
26
Pages
6580-6589
ISSN
  • 1433-7851 (ISSN-L)
  • 1521-3773
OpenAlex
W1982248450
Cited by
208
References
81
Citations by year
2026: 7 · 2025: 15 · 2024: 18 · 2023: 9 · 2022: 21 · 2021: 17 · 2020: 19 · 2019: 19 · 2018: 19 · 2017: 14 · 2016: 18 · 2015: 18 · 2014: 7 · 2013: 7
FWCI
1.55
Type
journal article
Language
en
Open access
Locations
  • Angewandte Chemie International Edition (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • UNC Libraries
Funders
  • National Science Foundation (0906985, 0923604)
  • National Institutes of Health (5u54ca151652-05, DP1OD006432)
  • U.S. Public Health Service (IDP10D006432)
  • National Cancer Institute (U54‐CA151652)
  • National Institute of Biomedical Imaging and Bioengineering (R01EB009565)
  • Division of Materials Research
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Nanofabrication and Lithography Techniques
  • Physical Sciences › Materials Science › Materials Chemistry › Pickering emulsions and particle stabilization
  • Physical Sciences › Materials Science › Materials Chemistry › Block Copolymer Self-Assembly
Keywords
prints, GMP manufacturing, biomedical applications, materials science applications, particle size and shape control
MeSH terms
Biopharmaceutics, Electromagnetic Fields, Electronics, Humans, Materials Testing, Particle Size, Prodrugs, Surface Properties, Drug Design, RNA, Small Interfering, Nanotechnology, Nanomedicine, Nanoparticles

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