Dopamine release in the nucleus accumbens (shell) of two lines of rats selectively bred to prefer or avoid ethanol
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Lower tissue levels of dopamine and 5-hydroxytryptamine (5-HT) have been found in the nucleus accumbens of alcohol-naïve rats selectively bred to prefer ethanol than in rats bred to avoid it. These findings have led to the hypothesis that differences in the dopamine and 5-HT tone may be linked to ethanol preference. In the present study we used the in vivo microdialysis technique to determine the actual extracellular levels of dopamine, its metabolites 3,4-dihydroxyphenyl acetaldehyde (DOPALD), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-HT and 5-hydroxyindolacetic acid (5-HIAA) in the shell of nucleus accumbens of rat lines selectively bred as either high-ethanol (UChB) or low-ethanol (UChA) drinkers. Basal extracellular levels of dopamine, DOPALD, DOPAC and HVA were lower in the shell of nucleus accumbens of ethanol-naïve UChB than in UChA rats. In agreement, when perfused with 100 microM d-amphetamine or 100 mM KCl lower dopamine increases were observed in nucleus accumbens of UChB rats compared to UChA rats, indicating lower cytosolic (d-amphetamine releasable) and vesicular (KCl releasable) dopamine pools in UChB animals. Since the experiments were performed in ethanol-naïve rats, the present results suggest an innate deficiency in the mesolimbic dopamine system of UChB rats. There were no line differences in basal, d-amphetamine or KCl stimulated 5-HT levels. Thus, the present findings support a role of dopamine, but not of 5-HT, as predictor of ethanol preference in UChB rats. Overall, data obtained are in agreement with previous reports in other rat lines showing that lower dopamine levels and its metabolites are associated with a genetic predisposition to ethanol preference.
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Alcohol-naïve mice or rats selectively bred to prefer ethanol display decreased basal dopamine levels in the nucleus accumbens, and alcohol preference in these animals is reversed by direct dopamine receptor activation.
“Indeed, alcohol-naïve mice (George et al., 1995) or rats (Gongwer et al., 1989; Quintanilla et al., 2007) selectively bred to prefer ethanol display decreased basal dopamine levels in the nucleus accumbens, and alcohol preference in these animals is reversed by direct dopamine receptor activation (George et al., 1995).”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Quintanilla et al., 2007
Cites
The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959 · see citing works
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Neurogenetic Adaptive Mechanisms in Alcoholism
Cloninger, C. R. (1987) · Science · doi:10.1126/science.2882604 · Cited by 2,203 · see citing works
Cellular and molecular mechanisms of drug dependence
Koob, G. F., & Bloom, F. E. (1988) · Science · doi:10.1126/science.2903550 · Cited by 2,070 · see citing works
Kelly, P. H., Seviour, P. W., & Iversen, S. D. (1975) · Brain Research · doi:10.1016/0006-8993(75)90233-4 · Cited by 1,740 · see citing works
Alheid, G. F., & Heimer, L. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90217-5 · Cited by 1,217 · see citing works
The release and uptake of excitatory amino acids
Nicholls, D. G., & Attwell, D. (1990) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(90)90129-v · Cited by 1,089 · see citing works
Nucleus accumbens shell and core dopamine: differential role in behavior and addiction
Di Chiara, G. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00286-3 · Cited by 996 · see citing works
Impérato, A., & Chiara, G. D. (1986) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23929-5 · Cited by 858 · see citing works
Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area
Gessa, G. L., Francesco Muntoni, A., Collu, M., Vargiu, L., & Mereu, G. (1985) · Brain Research · doi:10.1016/0006-8993(85)90381-6 · Cited by 770 · see citing works
Weiss, F., Lorang, M. T., Bloom, F. E., & Koob, G. F. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39420-6 · Cited by 751 · see citing works
Mechanisms of Amphetamine Action Revealed in Mice Lacking the Dopamine Transporter
Jones, S. R., Gainetdinov, R. R., Wightman, R. M., & Caron, M. G. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-06-01979.1998 · Cited by 626 · see citing works
McBride, W. J., Murphy, J. M., & Ikemoto, S. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00022-4 · Cited by 574 · see citing works
Taylor, J. R., & Robbins, T. W. (1984) · Psychopharmacology · doi:10.1007/bf00555222 · Cited by 440 · see citing works
The role of reward pathways in the development of drug dependence
Wise, R. A. (1987) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(87)90108-2 · Cited by 432 · see citing works
Matthews, R. T., & German, D. C. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90048-4 · Cited by 426 · see citing works
Amphetamine and Related Compounds
Cole, M. (2003) · Analytical techniques in the sciences · doi:10.1002/0470868007.ch2 · Cited by 326 · see citing works
Murphy, J. M., Stewart, R. B., Bell, R. L., Badia‐Elder, N. E., Carr, L. G., McBride, W. J., Lumeng, L., & Li, T. (2002) · Behavior Genetics · doi:10.1023/a:1020266306135 · Cited by 325 · see citing works
Selective breeding for alcohol preference and associated responses
Li, T., Lumeng, L., & Doolittle, D. P. (1993) · Behavior Genetics · doi:10.1007/bf01067421 · Cited by 324 · see citing works
Ethanol preferentially stimulates dopamine release in the nucleus accumbens of freely moving rats
Chiara, G. D., & Impérato, A. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90598-9 · Cited by 287 · see citing works
Murphy, J. M., McBride, W. J., Lumeng, L., & Li, T. (1987) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(87)90134-1 · Cited by 280 · see citing works
Preferential stimulation of ventral tegmental area dopaminergic neurons by nicotine
Mereu, G., Yoon, K.-W. P., Boi, V., Gessa, G. L., Naes, L., & Westfall, T. C. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90556-5 · Cited by 271 · see citing works
Regional brain levels of monoamines in alcohol-preferring and -nonpreferring lines of rats
Murphy, J. M., McBride, W. J., Lumeng, L., & Li, T. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90026-0 · Cited by 257 · see citing works
Alcohol and Aldehyde Metabolizing Systems-IV
Thurman, R. G. (1980) · Springer eBooks · doi:10.1007/978-1-4757-1419-7 · Cited by 245 · see citing works
Nowend, K. L., Arizzi, M. N., Carlson, B. B., & Salamone, J. D. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00524-x · Cited by 223 · see citing works
Thirty-two years of selection of rats by ethanol preference: UChA and UChB strains.
Mardones, J. R., & Segovia-Riquelme, N. (1983) · PubMed · Cited by 211 · see citing works
Ungerstedt, U., Herrera‐Marschitz, M., Jungnelius, U., et al. (1982) · Elsevier eBooks · doi:10.1016/b978-0-08-027391-4.50025-3 · Cited by 210 · see citing works
Self-citation“Perestroika” in the basal forebrain: Opening the border between neurology and psychiatry
Heimer, L., de Olmos, J. S., Alheid, G. F., & Záborszky, L. (1991) · Progress in brain research · doi:10.1016/s0079-6123(08)63050-2 · Cited by 203 · see citing works
Erwin, V. G., & Deitrich, R. A. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99864-9 · Cited by 203 · see citing works
Gongwer, M. A., Murphy, J. M., McBride, W. J., Lumeng, L., & Li, T.-K. (1989) · Alcohol · doi:10.1016/0741-8329(89)90089-x · Cited by 179 · see citing works
Rodent lines selected for factors affecting alcohol consumption.
Li, T., Lumeng, L., McBride, W. J., & Murphy, J. M. (1987) · PubMed · Cited by 179 · see citing works
Shiosaka, S., Takatsuki, K., Sakanaka, M., Inagaki, S., Takagi, H., Senba, E., Kawai, Y., Iida, H., Minagawa, H., Hara, Y., et al. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902040302 · Cited by 177 · see citing works
Cousins, M. S., Sokolowski, J. D., & Salamone, J. D. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90226-j · Cited by 172 · see citing works
Herrera‐Marschitz, M., You, Z. ‐., Goiny, M., et al. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66041726.x · Cited by 167 · see citing works
Self-citationREVIEW: The UChA and UChB rat lines: metabolic and genetic differences influencing ethanol intake
Quintanilla, M. E., Israel, Y., Sapag, A., & Tampier, L. (2006) · Addiction Biology · doi:10.1111/j.1369-1600.2006.00030.x · Cited by 137 · see citing works
Self-citationESBRA-NORDMANN 1996 AWARD LECTURE: ETHANOL DRINKING BEHAVIOUR IN SARDINIAN ALCOHOL-PREFERRING RATS
Colombo, G. (1997) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a008279 · Cited by 129 · see citing works
Immunostained serotonergic fibers are decreased in selected brain regions of alcohol-preferring rats
Zhou, F. C., Bledsoe, S. B., Lumeng, L., & Li, T. (1991) · Alcohol · doi:10.1016/s0741-8329(91)90034-t · Cited by 110 · see citing works
Smith, A. D., & Weiss, F. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38077-2 · Cited by 106 · see citing works
George, S. R., Fan, T., Ng, G., Jung, S., O’Dowd, B. F., & Naranjo, C. A. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)09574-6 · Cited by 103 · see citing works
Ambroziak, W., & Pietruszko, R. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98796-x · Cited by 102 · see citing works
Cooke, J. D., & Quastel, D. M. J. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010094 · Cited by 102 · see citing works
Mesolimbic dopamine system in alcohol-preferring rats
Zhou, F. C., Zhang, J. K., Lumeng, L., & Li, T. (1995) · Alcohol · doi:10.1016/0741-8329(95)00010-o · Cited by 102 · see citing works
Enzymology and subcellular localization of aldehyde oxidation in rat liver
Tank, A. W., Weiner, H., & Thurman, J. A. (1981) · Biochemical Pharmacology · doi:10.1016/0006-2952(81)90598-0 · Cited by 99 · see citing works
Bassareo, V., Tanda, G., Petromilli, P., Giua, C., & Chiara, G. D. (1996) · Psychopharmacology · doi:10.1007/bf02247433 · Cited by 93 · see citing works
Keung, W. M., & Vallée, B. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2198 · Cited by 78 · see citing works
Early prenatal development of substance P and enkephalin‐containing neurons in the rat
Pickel, V. M., Sumal, K. K., & Miller, R. J. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902100407 · Cited by 77 · see citing works
Bustamante, D., You, Z., Castel, M., Johansson, S., Goiny, M., Terenius, L. Y., Hökfelt, T. G. M., & Herrera‐Marschitz, M. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01171.x · Cited by 74 · see citing works
Self-citationCarboni, E., Silvagni, A., Valentini, V., & Chiara, G. D. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.08.008 · Cited by 70 · see citing works
Enzymatic Reduction of "Biogenic" Aldehydes in Brain
Tabakoff, B., Anderson, R., & Alivisatos, S. G. A. (1973) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13947-3 · Cited by 70 · see citing works
Heredity of Experimental Alcohol Preference in Rats; II. Coefficient of Heredity
Mardones, J. R., Segovia, N., & Hederra, A. D. (1953) · Quarterly Journal of Studies on Alcohol · doi:10.15288/qjsa.1953.14.001 · Cited by 69 · see citing works
Finn, P., Sharkansky, E. J., Viken, R. J., West, T. L., Sandy, J., & Bufferd, G. M. (1997) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.106.1.26 · Cited by 67 · see citing works
Foster, G. A., & Schultzberg, M. (1984) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(84)90075-3 · Cited by 66 · see citing works
Finn, P. R., Sharkansky, E. J., Viken, R. J., et al. (1997) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.106.1.26 · Cited by 56 · see citing works
Herrera‐Marschitz, M., Meana, J. J., O'Connor, W. T., et al. (1992) · Amino Acids · doi:10.1007/bf00806086 · Cited by 53 · see citing works
Self-citationGenetic Selection for High and Low Alcohol Consumption in a Limited‐Access Paradigm
Lê, A. D., Israel, Y., Juzytsch, W., Quan, B. H., & Harding, S. E. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02168.x · Cited by 52 · see citing works
Self-citationWest, C. H. K., Boss-Williams, K. A., & Weiss, J. M. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00064-3 · Cited by 40 · see citing works
Casu, M. A., Pisu, C., Lobina, C., & Pani, L. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1663-z · Cited by 37 · see citing works
Strother, W. N., Lumeng, L., Li, T., & McBride, W. J. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.11.003 · Cited by 33 · see citing works
Effect of low doses of ethanol on spontaneous locomotor activity in UChB and UChA rats
Quintanilla, M. E. (1999) · Addiction Biology · doi:10.1080/13556219971434 · Cited by 33 · see citing works
Self-citationSong, D. D., & Harlan, R. E. (1994) · Developmental Brain Research · doi:10.1016/0165-3806(94)00145-6 · Cited by 30 · see citing works
Differences in ethanol sensitivity and acute tolerance between UChA and UChB rats.
Tampier, L., & Mardones, J. R. (1999) · Journal of Studies on Alcohol · doi:10.15288/jsa.1999.60.168 · Cited by 26 · see citing works
Self-citationMontis, M. G. D., Grappi, S., Gambarana, C., Leggio, B., Nanni, G., Scheggi, S., & Tagliamonte, A. (2004) · Brain Research · doi:10.1016/j.brainres.2004.01.043 · Cited by 24 · see citing works
Sapag, A., Tampier, L., Valle-Prieto, A., Quintanilla, M. E., Moncada, C., & Israel, Y. (2003) · Pharmacogenetics · doi:10.1097/00008571-200308000-00009 · Cited by 24 · see citing works
Self-citationFernández, E., Koek, W., Ran, Q., Gerhardt, G. A., France, C. P., & Strong, R. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00200.x · Cited by 23 · see citing works
McKinzie, D. L., McBride, W. J., Murphy, J. M., Lumeng, L., & Li, T. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00610-4 · Cited by 21 · see citing works
Colzi, A., Musolino, A., Iuliano, A., et al. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66041510.x · Cited by 18 · see citing works
Lead attenuates the antipunishment effects of ethanol
Nation, J. R., Grover, C. A., & Bratton, G. R. (1991) · Alcohol · doi:10.1016/0741-8329(91)91104-a · Cited by 18 · see citing works
Adachi, Y., Watanabe, K., Higuchi, H., et al. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00619-0 · Cited by 15 · see citing works
Quintanilla, M. E., Tampier, L., Valle-Prieto, A., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-2172com · Cited by 15 · see citing works
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Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity
Trifilieff, P., & Martinez, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.031 · Cited by 171 · see citing works
- Authors
- Quintanilla, M. E., Bustamante, D., Tampier, L., Israel, Y., & Herrera-Marschitz, M.
- Affiliations
- Thomas Jefferson University (US)
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 573
- Issue
- 1-3
- Pages
- 84-92
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2038908006
- Cited by
- 26
- References
- 69
- Citations by year
- 2026: 2 · 2025: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 3 · 2012: 1
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Universidad de Chile (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- dopamine release, nucleus accumbens shell, ethanol preference, mesolimbic dopamine system, dopamine metabolites, DOPAC, homovanillic acid, serotonin, d-amphetamine, potassium chloride, genetic predisposition to alcoholism, extracellular dopamine
- MeSH terms
- Alcohol Drinking, Alcoholism, Anesthesia, Inhalation, Animals, Breeding, Chromatography, High Pressure Liquid, Dextroamphetamine, Dopamine, Female, Homovanillic Acid, Hydroxyindoleacetic Acid, Isoflurane, Male, Nucleus Accumbens, Potassium Chloride, Rats, Inbred Strains, Serotonin, Stereotaxic Techniques, 3,4-Dihydroxyphenylacetic Acid, Microdialysis, Genetic Predisposition to Disease, Rats
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