The local antinociceptive effects of paracetamol in neuropathic pain are mediated by cannabinoid receptors
Abstract
Paracetamol analgesic mechanism of action is still poorly defined but mainly involves central inhibition of cyclooxygenases. Here we tested the peripheral antinociceptive effects of paracetamol (intraplantar injections) in a rat model of neuropathic pain. Paracetamol dose-dependently decreased mechanical allodynia and lowered nociceptive scores associated with hyperalgesia testing. These effects were inhibited by the administration of cannabinoid CB(1) (AM251) and CB(2) (AM630) receptor antagonists. The participation of the peripheral cannabinoid system in paracetamol analgesia is suggested.
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Locally injected paracetamol suppressed mechanical allodynia and thermal hyperalgesia present following partial sciatic nerve ligation, and these effects are blocked by local administration of either a CB1 or a CB2 antagonist.
“Locally injected (i.paw) paracetamol suppressed mechanical allodynia and thermal hyperalgesia present following partial sciatic nerve ligation and these effects are blocked by local administration of either a CB1 or a CB2 antagonist.76”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [76]
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- Authors
- Dani, M., Guindon, J., Lambert, C., & Beaulieu, P.
- Affiliations
- Centre Hospitalier de l’Université de Montréal (CA)
- Corresponding author
- Beaulieu, Pierre
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 573
- Issue
- 1-3
- Pages
- 214-215
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2057217973
- Cited by
- 115
- References
- 8
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 7 · 2019: 3 · 2018: 2 · 2017: 9 · 2016: 6 · 2015: 6 · 2014: 15 · 2013: 13 · 2012: 6
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- paracetamol, neuropathic pain, cannabinoid receptors, CB1 receptor, CB2 receptor, antinociception, mechanical allodynia, hyperalgesia, analgesic mechanism, intraplantar administration
- MeSH terms
- Acetaminophen, Animals, Arachidonic Acids, Disease Models, Animal, Dose-Response Relationship, Drug, Hot Temperature, Hindlimb, Hyperalgesia, Indoles, Male, Neuralgia, Pain Measurement, Piperidines, Pyrazoles, Sciatic Nerve, Rats, Wistar, Analgesics, Non-Narcotic, Receptors, Cannabinoid, Receptor, Cannabinoid, CB1, Receptor, Cannabinoid, CB2, Rats, Cannabinoid Receptor Antagonists
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