Cited by 77Cannabis and Cannabinoid ResearchBacterial Infections and VaccinesNeuroinflammation and Neurodegeneration Mechanisms

Cannabidiol reduces host immune response and prevents cognitive impairments in Wistar rats submitted to pneumococcal meningitis

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Barichello, Tatiana, Ceretta, Renan A., Generoso, Jaqueline S., Moreira, Ana Paula, Simões, Lutiana R., Comim, Clarissa M., Quevedo, João, Vilela, Márcia Carvalho +3 more·2012·European Journal of Pharmacology

Abstract

Pneumococcal meningitis is a life-threatening disease characterized by an acute infection affecting the pia matter, arachnoid and subarachnoid space. The intense inflammatory response is associated with a significant mortality rate and neurologic sequelae, such as, seizures, sensory-motor deficits and impairment of learning and memory. The aim of this study was to evaluate the effects of acute and extended administration of cannabidiol on pro-inflammatory cytokines and behavioral parameters in adult Wistar rats submitted to pneumococcal meningitis. Male Wistar rats underwent a cisterna magna tap and received either 10μl of sterile saline as a placebo or an equivalent volume of S. pneumoniae suspension. Rats subjected to meningitis were treated by intraperitoneal injection with cannabidiol (2.5, 5, or 10mg/kg once or daily for 9 days after meningitis induction) or a placebo. Six hours after meningitis induction, the rats that received one dose were killed and the hippocampus and frontal cortex were obtained to assess cytokines/chemokine and brain-derived neurotrophic factor levels. On the 10th day, the rats were submitted to the inhibitory avoidance task. After the task, the animals were killed and samples from the hippocampus and frontal cortex were obtained. The extended administration of cannabidiol at different doses reduced the TNF-α level in frontal cortex. Prolonged treatment with canabidiol, 10mg/kg, prevented memory impairment in rats with pneumococcal meningitis. Although descriptive, our results demonstrate that cannabidiol has anti-inflammatory effects in pneumococcal meningitis and prevents cognitive sequel.

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Crossref · 10.1016/j.ejphar.2012.09.053

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Authors
Barichello, T., Ceretta, R. A., Generoso, J. S., Moreira, A. P., Simões, L. R., Comim, C. M., Quevedo, J., Vilela, M. C., Zuardi, A. W., Crippa, J. A., & Teixeira, A. L.
Affiliations
  • Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (BR)
  • Universidade Federal de Minas Gerais (BR)
  • Universidade de São Paulo (BR)
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
2012-12
Volume
697
Issue
1-3
Pages
158-164
ISSN
0014-2999 (ISSN-L)
OpenAlex
W2041192028
Cited by
76
References
50
Citations by year
2026: 4 · 2025: 3 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 10 · 2020: 8 · 2019: 6 · 2018: 3 · 2017: 3 · 2016: 8 · 2015: 7 · 2014: 5 · 2013: 2
FWCI
3.29
Type
journal article
Language
en
Open access
Locations
  • European Journal of Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
  • Americanae (AECID Library) (submittedVersion, other-oa)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Funders
  • Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina
  • Instituto Nacional de Ciência e Tecnologia Translacional em Medicina
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • Universidade do Extremo Sul Catarinense
  • Fundação de Amparo à Pesquisa do Estado de Minas Gerais
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
cannabidiol, pneumococcal meningitis, Streptococcus pneumoniae, neuroinflammation, inflammatory cytokines, TNF-α, brain-derived neurotrophic factor, chemokines, cognitive impairment, memory impairment, passive avoidance, hippocampus, frontal cortex, anti-inflammatory activity, neuroprotection
MeSH terms
Animals, Anti-Inflammatory Agents, Behavior, Animal, Cannabidiol, Cognition, Cognition Disorders, Disease Models, Animal, Frontal Lobe, Hippocampus, Injections, Intraperitoneal, Male, Memory, Meningitis, Pneumococcal, Streptococcus pneumoniae, Time Factors, Tumor Necrosis Factor-alpha, Down-Regulation, Interleukin-6, Rats, Wistar, Inflammation Mediators, Brain-Derived Neurotrophic Factor, Rats, Interleukin-1beta, Chemokine CXCL1

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