Cannabidiol reduces host immune response and prevents cognitive impairments in Wistar rats submitted to pneumococcal meningitis
Open accessAbstract
Pneumococcal meningitis is a life-threatening disease characterized by an acute infection affecting the pia matter, arachnoid and subarachnoid space. The intense inflammatory response is associated with a significant mortality rate and neurologic sequelae, such as, seizures, sensory-motor deficits and impairment of learning and memory. The aim of this study was to evaluate the effects of acute and extended administration of cannabidiol on pro-inflammatory cytokines and behavioral parameters in adult Wistar rats submitted to pneumococcal meningitis. Male Wistar rats underwent a cisterna magna tap and received either 10μl of sterile saline as a placebo or an equivalent volume of S. pneumoniae suspension. Rats subjected to meningitis were treated by intraperitoneal injection with cannabidiol (2.5, 5, or 10mg/kg once or daily for 9 days after meningitis induction) or a placebo. Six hours after meningitis induction, the rats that received one dose were killed and the hippocampus and frontal cortex were obtained to assess cytokines/chemokine and brain-derived neurotrophic factor levels. On the 10th day, the rats were submitted to the inhibitory avoidance task. After the task, the animals were killed and samples from the hippocampus and frontal cortex were obtained. The extended administration of cannabidiol at different doses reduced the TNF-α level in frontal cortex. Prolonged treatment with canabidiol, 10mg/kg, prevented memory impairment in rats with pneumococcal meningitis. Although descriptive, our results demonstrate that cannabidiol has anti-inflammatory effects in pneumococcal meningitis and prevents cognitive sequel.
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CBD prevented cognitive impairments.
“In addition, CBD increased mitochondrial complex and creatine kinase activity (91), reversed oxidative stress parameters (TBARS formation and protein carbonyls) (92), and prevented cognitive impairments (92, 93).”
From Translational investigation of the therapeutic potential of Cannabidiol (CBD): Toward a new age (2018) · cites this paper as [93]
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Targets for adjunctive therapy in pneumococcal meningitis
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- Authors
- Barichello, T., Ceretta, R. A., Generoso, J. S., Moreira, A. P., Simões, L. R., Comim, C. M., Quevedo, J., Vilela, M. C., Zuardi, A. W., Crippa, J. A., & Teixeira, A. L.
- Affiliations
- Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (BR)
- Universidade Federal de Minas Gerais (BR)
- Universidade de São Paulo (BR)
- ORCID
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 697
- Issue
- 1-3
- Pages
- 158-164
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2041192028
- Cited by
- 76
- References
- 50
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 10 · 2020: 8 · 2019: 6 · 2018: 3 · 2017: 3 · 2016: 8 · 2015: 7 · 2014: 5 · 2013: 2
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 501 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- Americanae (AECID Library) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina
- Instituto Nacional de Ciência e Tecnologia Translacional em Medicina
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidade do Extremo Sul Catarinense
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- cannabidiol, pneumococcal meningitis, Streptococcus pneumoniae, neuroinflammation, inflammatory cytokines, TNF-α, brain-derived neurotrophic factor, chemokines, cognitive impairment, memory impairment, passive avoidance, hippocampus, frontal cortex, anti-inflammatory activity, neuroprotection
- MeSH terms
- Animals, Anti-Inflammatory Agents, Behavior, Animal, Cannabidiol, Cognition, Cognition Disorders, Disease Models, Animal, Frontal Lobe, Hippocampus, Injections, Intraperitoneal, Male, Memory, Meningitis, Pneumococcal, Streptococcus pneumoniae, Time Factors, Tumor Necrosis Factor-alpha, Down-Regulation, Interleukin-6, Rats, Wistar, Inflammation Mediators, Brain-Derived Neurotrophic Factor, Rats, Interleukin-1beta, Chemokine CXCL1
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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