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Anticonvulsant effect of cannabidiol in the pentylenetetrazole model: Pharmacological mechanisms, electroencephalographic profile, and brain cytokine levels

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Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor

Rodríguez-Muñoz, M., Onetti, Y., Cortés‐Montero, E., Garzón, J., & Sánchez‐Blázquez, P. (2018) · Molecular Brain · doi:10.1186/s13041-018-0395-2 · Cited by 122 · see citing works

Phytochemicals and Their Potential Usefulness in Inflammatory Bowel Disease

Somani, S. J., Modi, K., Majumdar, A. S., & Sadarani, B. N. (2015) · Phytotherapy Research · doi:10.1002/ptr.5271 · Cited by 124 · see citing works

The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids

McAllister, S. D., Soroceanu, L., & Desprez, P. (2015) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9608-y · Cited by 139 · see citing works

Is the cardiovascular system a therapeutic target for cannabidiol?

Stanley, C. P., Hind, W. H., & O’Sullivan, S. E. (2012) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04351.x · Cited by 121 · see citing works

The neuroprotection of cannabidiol against MPP + -induced toxicity in PC12 cells involves trkA receptors, upregulation of axonal and synaptic proteins, neuritogenesis, and might be relevant to Parkinson's disease

dos Santos, N. A. G., Martins, N. M., Sisti, F., Fernandes, L. S., Ferreira, R. S., Queiróz, R. H. C., & dos Santos, A. C. (2015) · Toxicology in Vitro · doi:10.1016/j.tiv.2015.11.004 · Cited by 119 · see citing works

Cannabidiol improves lung function and inflammation in mice submitted to LPS-induced acute lung injury

Ribeiro, A. B., de Almeida, V. I., Costola-de-Souza, C., Ferraz-de-Paula, V., Pinheiro, M. L., Vitoretti, L. B., Gimenes-Júnior, J. A., Akamine, A. T., Crippa, J. A. S., Tavares-de-Lima, W., et al. (2014) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923973.2014.976794 · Cited by 111 · see citing works

Anti-Aversive Effects of Cannabidiol on Innate Fear-Induced Behaviors Evoked by an Ethological Model of Panic Attacks Based on a Prey vs the Wild Snake Epicrates cenchria crassus Confrontation Paradigm

Uribe-Mariño, A., Biagioni, A. F., Castiblanco-Urbina, M. A., Twardowschy, A., Salgado-Rohner, C. J., Crippa, J. A. S., Hallak, J. E. C., Zuardi, A. W., & Coimbra, N. C. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.188 · Cited by 111 · see citing works

Assessment of antiviral potencies of cannabinoids against SARS-CoV-2 using computational and in vitro approaches

Raj, V., Park, J. G., Cho, K.-H., Choi, P., Kim, T., Ham, J., & Lee, J. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.12.020 · Cited by 106 · see citing works

Cannabis use in pregnancy and early life and its consequences: animal models

Schneider, M. (2009) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-009-0026-0 · Cited by 100 · see citing works

Cannabis and Its Derivatives: Review of Medical Use

Leung, L. (2011) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.2011.04.100280 · Cited by 102 · see citing works

Cannabidiol attenuates mechanical allodynia in streptozotocin-induced diabetic rats via serotonergic system activation through 5-HT1A receptors

Jesus, C. H. A., Redivo, D. D. B., Gasparin, A. T., Sotomaior, B. B., de Carvalho, M. C., Genaro, K., Zuardi, A. W., Hallak, J. E. C., Crippa, J. A. S., Zanoveli, J. M., et al. (2019) · Brain Research · doi:10.1016/j.brainres.2019.03.014 · Cited by 102 · see citing works

Cannabidiol for the treatment of <i>cannabis</i> withdrawal syndrome: a case report: CBD and cannabis withdrawal

Crippa, J. A. S., Hallak, J. E. C., Machado-de-Sousa, J. P., Queiroz, R. H. C., Bergamaschi, M., Chagas, M. H. N., & Zuardi, A. W. (2013) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.12018 · Cited by 101 · see citing works

Cannabinoids in intestinal inflammation and cancer

Izzo, A. A., & Camilleri, M. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.03.008 · Cited by 101 · see citing works

Is cannabis treatment for anxiety, mood, and related disorders ready for prime time?

Turna, J., Patterson, B. A., & Ameringen, M. V. (2017) · Depression and Anxiety · doi:10.1002/da.22664 · Cited by 101 · see citing works

GPR3 and GPR6, novel molecular targets for cannabidiol

Laun, A. S., & Song, Z.-H. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.05.165 · Cited by 99 · see citing works

Cannabidiol in the Treatment of Epilepsy

von Wrede, R. D., Helmstaedter, C., & Surges, R. (2021) · Clinical Drug Investigation · doi:10.1007/s40261-021-01003-y · Cited by 99 · see citing works

Cannabidiol causes endothelium-dependent vasorelaxation of human mesenteric arteries via CB1activation

Stanley, C. P., Hind, W. H., Tufarelli, C., & O’Sullivan, S. E. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv179 · Cited by 100 · see citing works

Cannabidiol injected into the bed nucleus of the stria terminalis reduces the expression of contextual fear conditioning via 5-HT _1A receptors

Gomes, F. V., Reis, D. G., Alves, F. H., Corrêa, F. M., Guimarães, F. S., & Resstel, L. B. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881110389095 · Cited by 97 · see citing works

Cannabidiol prescription in clinical practice: an audit on the first 400 patients in New Zealand

Gulbransen, G., Xu, W., & Arroll, B. (2020) · BJGP Open · doi:10.3399/bjgpopen20x101010 · Cited by 97 · see citing works

A Systematic Review and Meta-Analysis of the Haemodynamic Effects of Cannabidiol

Sultan, S. R., Millar, S. A., England, T. J., & O'Sullivan, S. E. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00081 · Cited by 95 · see citing works

Cannabidivarin Treatment Ameliorates Autism-Like Behaviors and Restores Hippocampal Endocannabinoid System and Glia Alterations Induced by Prenatal Valproic Acid Exposure in Rats

Zamberletti, E., Gabaglio, M., Woolley-Roberts, M., Bingham, S., Rubino, T., & Parolaro, D. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00367 · Cited by 95 · see citing works

A novel CB receptor GPR55 and its ligands are involved in regulation of gut movement in rodents

Lin, X. ‐., Yuece, B., Li, Y. ‐., Feng, Y., Feng, J. ‐., Yu, L. ‐., Li, K., Li, Y.-X., & Storr, M. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01742.x · Cited by 94 · see citing works

Emerging evidence for the antidepressant effect of cannabidiol and the underlying molecular mechanisms

Silote, G. P., Sartim, A. G., Sales, A. J., Eskelund, A., Guimarães, F. S., Wegener, G., & Joca, S. R. L. (2019) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2019.04.006 · Cited by 93 · see citing works

Cannabidiol exhibits anxiolytic but not antipsychotic property evaluated in the social interaction test

de Almeida, V., Levin, R. R., Peres, F. F., Niigaki, S. T., Calzavara, M. B., Zuardi, A. W., Hallak, J. E. C., Crippa, J. A. S., & Abílio, V. C. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.10.024 · Cited by 90 · see citing works

Cannabinoid-related Agents in the Treatment of Anxiety Disorders: Current Knowledge and Future Perspectives

Tambaro, S., & Bortolato, M. (2011) · Recent Patents on CNS Drug Discovery · doi:10.2174/157488912798842269 · Cited by 89 · see citing works

Latest advances in cannabinoid receptor agonists

Thakur, G. A., Tichkule, R. B., Bajaj, S., & Makriyannis, A. (2009) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543770903436505 · Cited by 87 · see citing works

Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders

Fagherazzi, E. V., Garcia, V. A., Maurmann, N., Bervanger, T., Halmenschlager, L. H., Busato, S. B., Hallak, J. E., Zuardi, A. W., Crippa, J. A., & Schröder, N. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2449-3 · Cited by 87 · see citing works

Cannabidiol Drugs Clinical Trial Outcomes and Adverse Effects

Pauli, C. S., Conroy, M., Heuvel, B. D. V., & Park, S. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00063 · Cited by 88 · see citing works

Administration of cannabidiol and imipramine induces antidepressant-like effects in the forced swimming test and increases brain-derived neurotrophic factor levels in the rat amygdala

Réus, G. Z., Stringari, R. B., Ribeiro, K. F., Luft, T., Abelaira, H. M., Fries, G. R., Aguiar, B. W., Kapczinski, F., Hallak, J. E., Zuardi, A. W., et al. (2011) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2011.00579.x · Cited by 86 · see citing works

Uso terapêutico dos canabinoides em psiquiatria

Crippa, J. A. S., Zuardi, A. W., & Hallak, J. E. C. (2010) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462010000500009 · Cited by 85 · see citing works

Abuse potential and psychoactive effects of δ-9-tetrahydrocannabinol and cannabidiol oromucosal spray (Sativex), a new cannabinoid medicine

Robson, P. (2011) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2011.575778 · Cited by 84 · see citing works

Targeting multiple cannabinoid anti‐tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer

Murase, R., Kawamura, R., Singer, E. A., Pakdel, A., Sarma, P., Judkins, J., Elwakeel, E., Dayal, S., Martínez-Martínez, E., Mukkanti, A., et al. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12803 · Cited by 84 · see citing works

The interplay of cannabinoid and NMDA glutamate receptor systems in humans: preliminary evidence of interactive effects of cannabidiol and ketamine in healthy human subjects

Hallak, J. E. C., Dursun, S. M., Bosi, D. C., de Macedo, L. R. H., Machado-de-Sousa, J. P., Abrão, J., Crippa, J. A. S., McGuire, P., Krystal, J. H., Baker, G. B., et al. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.11.002 · Cited by 83 · see citing works

Interaction between cannabidiol (CBD) and ∆9-tetrahydrocannabinol (THC): influence of administration interval and dose ratio between the cannabinoids

Zuardi, A. W., Hallak, J. E. C., & Crippa, J. A. S. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2495-x · Cited by 84 · see citing works

Cannabis for Inflammatory Bowel Disease

Naftali, T., Mechulam, R., Schleider, L. B., & Konikoff, F. M. (2014) · Digestive Diseases · doi:10.1159/000358155 · Cited by 82 · see citing works

Cannabinoids: Novel Medicines for the Treatment of Huntingtons Disease

Sagredo, O., Pazos, M. R., Valdeolivas, S., & Fernández‐Ruíz, J. (2011) · Recent Patents on CNS Drug Discovery · doi:10.2174/157488912798842278 · Cited by 82 · see citing works

Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells

Kozela, E., Juknat, A., Gao, F., Kaushansky, N., Coppola, G., & Vogel, Z. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0603-x · Cited by 82 · see citing works

Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats

Chagas, M. H. N., Crippa, J. A. S., Zuardi, A. W., Hallak, J. E. C., Machado‐de‐Sousa, J. P., Hirotsu, C., Maia, L. O., Tufik, S. B., & Andersen, M. L. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881112474524 · Cited by 81 · see citing works

The case for assessing cannabidiol in epilepsy

Cilio, M. R., Thiele, E. A., & Devinsky, O. (2014) · Epilepsia · doi:10.1111/epi.12635 · Cited by 80 · see citing works

Evaluation of Serum Cytokines Levels and the Role of Cannabidiol Treatment in Animal Model of Asthma

Vuolo, F. S., Petronilho, F. C., Sonai, B., Ritter, C., Hallak, J. E. C., Zuardi, A. W., Crippa, J. A. S., & Dal‐Pizzol, F. (2015) · Mediators of Inflammation · doi:10.1155/2015/538670 · Cited by 80 · see citing works

Pitfalls in the analysis of phytocannabinoids in cannabis inflorescence

Citti, C., Russo, F., Sgrò, S., Gallo, A., Zanotto, A., Forni, F., Vandelli, M. A., Laganà, A., Montone, C. M., Gigli, G., et al. (2020) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-020-02554-3 · Cited by 79 · see citing works

Cannabidiol enhances xenobiotic permeability through the human placental barrier by direct inhibition of breast cancer resistance protein: an ex vivo study

Feinshtein, V., Erez, O., Ben‐Zvi, Z., Eshkoli, T., Sheizaf, B., Sheiner, E., & Holcberg, G. (2013) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2013.08.005 · Cited by 77 · see citing works

Enhancement of specialized metabolites using CRISPR/Cas gene editing technology in medicinal plants

Das, S., Kwon, M., & Kim, J. (2024) · Frontiers in Plant Science · doi:10.3389/fpls.2024.1279738 · Cited by 81 · see citing works

Historical perspective on the therapeutic potential of cannabidiol

Guimarães, F. S. (2024) · International review of neurobiology · doi:10.1016/bs.irn.2024.03.008 · Cited by 3 · see citing works

Cannabidiol: brief compilation over a versatile molecule

de Paula, C. B. C. O., Baldacci, E. A., Cheng, L. C., Gozzi, M. B., Shibuya, P. T., Nicolau, L. A. D., Medeiros, J. V. R., Anghinah, R., de Oliveira, J. V., Gehrke, F. D. S., et al. (2021) · Research Society and Development · doi:10.33448/rsd-v10i14.22239 · Cited by 2 · see citing works

THERAPEUTIC POTENTIAL OF CANNABIDIOL: THE MOST IMPORTANT ACHIEVEMENTS ON THE WAY TO A NEW ERA

Shevchuk, M. M., & Volos, L. I. (2023) · Medical Science of Ukraine (MSU) · doi:10.32345/2664-4738.2.2023.17 · Cited by 1 · see citing works

Analogues and Derivatives of Cannabidiol: Pharmacological Insights and Recent Efforts in the Search for Novel Drug Candidates for Inflammation and Pain - a Brief Review Over the Past 3 Decades

de Souza, M. L., Franco, G. R. R., Massuda, L. E., Gontijo, V. S., & Viegas, C. (2024) · Journal of the Brazilian Chemical Society · doi:10.21577/0103-5053.20240155

Cannabidiol (CBD) and its analogs: a review of their effects on inflammation.

Burstein, S. (2015) · Bioorganic &amp; Medicinal Chemistry · doi:10.1016/j.bmc.2015.01.059 · Cited by 573 · see citing works