The DOI matches its Crossref record; 152 of the 152 references it cites were found in a registry or an index.
Animal models of Multiple Sclerosis
Open accessAbstract
Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) which involves a complex interaction between immune system and neural cells. Animal modeling has been critical for addressing MS pathogenesis. The three most characterized animal models of MS are (1) the experimental autoimmune/allergic encephalomyelitis (EAE); (2) the virally-induced chronic demyelinating disease, known as Theiler׳s murine encephalomyelitis virus (TMEV) infection and (3) the toxin-induced demyelination. All these models, in a complementary way, have allowed to reach a good knowledge of the pathogenesis of MS. Specifically, EAE is the model which better reflects the autoimmune pathogenesis of MS and is extremely useful to study potential experimental treatments. Furthermore, both TMEV and toxin-induced demyelination models are suitable for characterizing the role of the axonal injury/repair and the remyelination process in MS. In conclusion, animal models, despite their limitations, remain the most useful instrument for implementing the study of MS.
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Cites
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Bile acid signaling in neurodegenerative and neurological disorders
Grant, S. M., & DeMorrow, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21175982 · Cited by 185
The Cuprizone Model: Dos and Do Nots
Zhan, J., Mann, T., Joost, S., Behrangi, N., Frank, M., & Kipp, M. (2020) · Cells · doi:10.3390/cells9040843 · Cited by 171
“A comparison of histopathological characteristics between different MS animal models is given in [6,74,75].”
BackgroundThe role of chemokines and chemokine receptors in multiple sclerosis
Cui, L.-Y., Chu, S.-F., & Chen, N.-H. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106314 · Cited by 135
Waltl, I., Käufer, C., Gerhauser, I., Chhatbar, C., Ghita, L., Kalinke, U., & Löscher, W. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.09.006 · Cited by 124
Metadata
- Authors
- Procaccini, C., De Rosa, V., Pucino, V., Formisano, L., & Matarese, G.
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 759
- Pages
- 182-191
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2000631468
- Cited by
- 366
- References
- 152
- FWCI
- 15.60
- Type
- journal article
- Language
- en
- Open access
- green
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- Procaccini, C., De Rosa, V., Pucino, V., Formisano, L., & Matarese, G. (2015). Animal models of Multiple Sclerosis. European Journal of Pharmacology. https://doi.org/10.1016/j.ejphar.2015.03.042
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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