Protective effects of mangiferin on cerebral ischemia-reperfusion injury and its mechanisms
Abstract
The aim of our study was to investigate the protective properties of mangiferin, a natural glucosyl xanthone found in both mango and papaya on the cerebral ischemia-reperfusion injury and the underlying mechanism. Wistar male rats were subjected to middle cerebral artery occlusion for 2h followed by 24h of reperfusion. Mangiferin (25, 50, and 100mg/kg, ig) or 0.5% carboxymethyl cellulose sodium was administered three times before ischemia and once at 2h after the onset of ischemia. Neurological score, infarct volume, and brain water content, some oxidative stress markers and inflammatory cytokines were evaluated after 24h of reperfusion. Treatment with mangiferin significantly ameliorated neurologic deficit, infarct volume and brain water content after cerebral ischemia reperfusion. Mangiferin also reduced the content of malondialdehyde (MDA), IL-1β and TNF-α, and up-regulated the activities of superoxide dismutase (SOD), glutathione (GSH) and IL-10 levels in the brain tissue of rats with the cerebral ischemia-reperfusion injury. Moreover, mangiferin up-regulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream anti-oxidant protein heme oxygenase-1 (HO-1). The results indicate that mangiferin can play a certain protective role in the cerebral ischemia-reperfusion injury, and the protective effect of mangiferin may be related to the improvement on the antioxidant capacity of brain tissue and the inhibition of overproduction of inflammator…
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Mangiferin ameliorates activities of SOD, glutathione and IL-10, which has a protective role in oxidative stress induced by cerebral IR injury.
“Furthermore, mangiferin ameliorates the activities of SOD, glutathione and IL-10, which has a protective role in oxidative stress induced by cerebral IR injury (Fig. 4).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [75]
In Wistar male rats with cerebral IR injury, activation of the Nrf2/HO-1 cascade is promoted in a dose-dependent manner by mangiferin.
“In addition, in Wistar male rats with cerebral IR injury, the activation of Nrf2/HO-1 cascade is promoted in a dose-dependent manner by mangiferin (75).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [75]
Cites
Role of nrf2 in oxidative stress and toxicity
Ma, Q. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140320 · Cited by 4,903 · see citing works
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Mangiferin: A xanthonoid with multipotent anti‐inflammatory potential
Saha, S., Sadhukhan, P., & Sil, P. C. (2016) · BioFactors · doi:10.1002/biof.1292 · Cited by 159 · see citing works
Mangiferin: An effective therapeutic agent against several disorders (Review)
Du, S., Liu, H., Lei, T., Xie, X., Wang, H., He, X., Tong, R., & Wang, Y. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9529 · Cited by 139 · see citing works
“In addition, in Wistar male rats with cerebral IR injury, the activation of Nrf2/HO-1 cascade is promoted in a dose-dependent manner by mangif-erin (75).”
Neuroprotective mechanisms of mangiferin in neurodegenerative diseases
Liu, T., Song, Y., & Hu, A. (2021) · Drug Development Research · doi:10.1002/ddr.21783 · Cited by 43 · see citing works
Tang, Z., Lai, C., Luo, J., Ding, Y., Chen, Q., & Guan, Z. (2021) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22705 · Cited by 26 · see citing works
- Authors
- Yang, Z., Weian, C., Susu, H., & Hanmin, W.
- Affiliations
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Corresponding author
- Hanmin, Wang
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 771
- Pages
- 145-151
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2181425336
- Cited by
- 135
- References
- 1
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 9 · 2023: 17 · 2022: 17 · 2021: 30 · 2020: 20 · 2019: 8 · 2018: 11 · 2017: 10 · 2016: 3
- FWCI
- 15.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Keywords
- mangiferin, cerebral ischemia-reperfusion injury, neuroprotection, Nrf2/HO-1 pathway, oxidative stress, inflammatory cytokines, ischemic stroke, middle cerebral artery occlusion, antioxidant defense, glutathione, superoxide dismutase, malondialdehyde, IL-10, IL-1β, TNF-α
- MeSH terms
- Animals, Body Water, Brain Chemistry, Cerebral Infarction, Brain Ischemia, Gene Expression Regulation, Male, Reperfusion Injury, Cytokines, Rats, Wistar, Oxidative Stress, Xanthones, Rats
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